Sensitive gravity-gradiometry with atom interferometry: progress towards an improved determination of the gravitational constant

We here present a high sensitivity gravity-gradiometer based on atom interferometry. In our apparatus, two clouds of laser-cooled rubidium atoms are launched in fountain configuration and interrogated by a Raman interferometry sequence to probe the gradient of gravity field. We recently implemented a high-flux atomic source and a newly designed Raman lasers system in the instrument set-up. We discuss the applications towards a precise determination of the Newtonian gravitational constant G. The long-term stability of the instrument and the signal-to-noise ratio demonstrated here open interesting perspectives for pushing the measurement precision below the 100 ppm level

The role of hysteroscopy in the diagnostic work-up of infertile asymptomatic patients

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Influence of the thermomechanical characteristics of low-density polyethylene substrates on the thermoresistive properties of graphite nanoplatelet coatings

Morphological, structural, and thermoresistive properties of films deposited on low-density polyethylene (LDPE) substrates are investigated for possible application in flexible electronics. Scanning and transmission electron microscopy analyses, and X-ray diffraction measurements show that the films consist of overlapped graphite nanoplatelets (GNP) each composed on average of 41 graphene layers. Differential scanning calorimetry and dynamic-mechanical-thermal analysis indicate that irreversible phase transitions and large variations of mechanical parameters in the polymer substrates can be avoided by limiting the temperature variations between −40 and 40◦ C. Electrical measurements performed in such temperature range reveal that the resistance of GNP films on LDPE substrates increases as a function of the temperature, unlike the behavior of graphite-based materials in which the temperature coefficient of resistance is negative. The explanation is given by the strong influence of the thermal expansion properties of the LDPE substrates on the thermo-resistive features of GNP coating films. The results show that, narrowing the temperature range from 20 to 40◦ C, the GNP on LDPE samples can work as temperature sensors having linear temperature-resistance relationship, while keeping constant the temperature and applying mechanical strains in the 0–4.2 × 10−3 range, they can operate as strain gauges with a gauge factor of about 48

Environmental Monitoring of Legionella in Hospitals in the Campania Region: A 5-Year Study

: Legionella is a pathogen that colonizes soils, freshwater, and building water systems. People who are most affected are those with immunodeficiencies, so it is necessary to monitor its presence in hospitals. The purpose of this study was to evaluate the presence of Legionella in water samples collected from hospitals in the Campania region, Southern Italy. A total of 3365 water samples were collected from January 2018 to December 2022 twice a year in hospital wards from taps and showers, tank bottoms, and air-treatment units. Microbiological analysis was conducted in accordance with the UNI EN ISO 11731:2017, and the correlations between the presence of Legionella and water temperature and residual chlorine were investigated. In total, 708 samples (21.0%) tested positive. The most represented species was L. pneumophila 2-14 (70.9%). The serogroups isolated were 1 (27.7%), 6 (24.5%), 8 (23.3%), 3 (18.9%), 5 (3.1%), and 10 (1.1%). Non-pneumophila Legionella spp. represented 1.4% of the total. Regarding temperature, the majority of Legionella positive samples were found in the temperature range of 26.0-40.9 °C. An influence of residual chlorine on the presence of the bacterium was observed, confirming that chlorine disinfection is effective for controlling contamination. The positivity for serogroups other than serogroup 1 suggested the need to continue environmental monitoring of Legionella and to focus on the clinical diagnosis of other serogroups

Optic pathway glioma in type 1 neurofibromatosis: Review of its pathogenesis, diagnostic assessment, and treatment recommendations

Type 1 neurofibromatosis (NF1) is a dominantly inherited condition predisposing to tumor development. Optic pathway glioma (OPG) is the most frequent central nervous system tumor in children with NF1, affecting approximately 15-20% of patients. The lack of well-established prognostic markers and the wide clinical variability with respect to tumor progression and visual outcome make the clinical management of these tumors challenging, with significant differences among distinct centers. We reviewed published articles on OPG diagnostic protocol, follow-up and treatment in NF1. Cohorts of NF1 children with OPG reported in the literature and patients prospectively collected in our center were analyzed with regard to clinical data, tumor anatomical site, diagnostic workflow, treatment and outcome. In addition, we discussed the recent findings on the pathophysiology of OPG development in NF1. This review provides a comprehensive overview about the clinical management of NF1-associated OPG, focusing on the most recent advances from preclinical studies with genetically engineered models and the ongoing clinical trials

Lanthanide-Induced Photoluminescence in Lead-Free Cs2AgBiBr6Bulk Perovskite: Insights from Optical and Theoretical Investigations

Emphasis was recently placed on the Cs2AgBiBr6 double perovskite as a possible candidate to substitute toxic lead in metal halide perovskites. However, its poor light-emissive features currently make it unsuitable for solid-state lighting. Lanthanide doping is an established strategy to implement luminescence in poorly emissive materials, with the additional advantage of fine-tuning the emission wavelength. We discuss here the impact of Eu and Yb doping on the optical properties of Cs2AgBiBr6 thin films, obtained from the solution processing of hydrothermally synthesized bulk crystalline powders, by combining experiments and density functional theory calculations. Eu(III) incorporation does not lead to the characteristic 5D0 → 7F2 emission feature at 2 eV, while only a weak trap-assisted sub-band gap radiative emission is reported. Oppositely, we demonstrate that incorporated Yb(III) leads to an intense and exclusive photoluminescence emission in the near-infrared as a result of the efficient sensitization of the lanthanide 2F5/2 → 2F7/2 transition

Lanthanide Induced Photoluminescence in Lead-Free Cs₂AgBiBr₆ Bulk Perovskite: Insights From Optical and Theoretical Investigations

The search for materials substituting toxic lead in metal halide perovskites has recently placed emphasis on the Cs2AgBiBr6 double perovskite as a possible candidate. The poor light-emissive features of this species, mainly associated to the indirect nature of the band gap and the strongly bound exciton, however, currently make it unsuitable for solid-state lighting applications. Doping with lanthanides is an established strategy to implement luminescence in poorly emissive materials, with the additional advantage of tuning the wavelength of emission independently from the host band structure. We discuss here the impact of Eu- and Yb-doping on the absorption and emission properties of Cs2AgBiBr6 polycrystalline thin films, obtained from solution-processing of hydrothermally synthesized bulk crystalline powders, by combining experiments and density functional theory calculations. Eu(III) incorporation does not lead to the characteristic 5D0→7F2 emission feature at 2 eV, while only a weak sub band-gap radiative emission ascribed to a trap-assisted recombination process is reported. On the other hand, we demonstrate that Yb(III) incorporated in the bulk double perovskite leads to an intense and exclusive photoluminescence emission in the near-infrared (NIR) from thin films, as a result of the efficient sensitization of the lanthanide centered 2F5/2→2F7/2 transition, with favorable mid-gap energetic position. Yb-doping may be thus exploited for the future development of stable and sustainable perovskite NIR-light emitters

CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes

CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced. However, regarding CD69 gene expression and its regulatory mechanisms in monocytes, only scarce data are available. Here, we report that CD69 mRNA expression, analogous to that of 5-lipoxygenase, is induced by the physiologic stimuli transforming growth factor-β (TGF-β) and 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in monocytic cells. Comparison with T- and B-cell lines showed that the effect was specific for monocytes. CD69 expression levels were increased in a concentration-dependent manner, and kinetic analysis revealed a rapid onset of mRNA expression, indicating that CD69 is a primary TGF-β/1α,25(OH)2D3 target gene. PCR analysis of different regions of the CD69 mRNA revealed that de novo transcription was initiated and proximal and distal parts were induced concomitantly. In common with 5-lipoxygenase, no activation of 0.7 kb or ~2.3 kb promoter fragments by TGF-β and 1α,25(OH)2D3 could be observed in transient reporter assays for CD69. Analysis of mRNA stability using a transcription inhibitor and a 3′UTR reporter construct showed that TGF-β and 1α,25(OH)2D3 do not influence CD69 mRNA stability. Functional knockdown of Smad3 clearly demonstrated that upregulation of CD69 mRNA, in contrast to 5-LO, depends on Smad3. Comparative studies with different inhibitors for mitogen activated protein kinases (MAPKs) revealed that MAPK signalling is involved in CD69 gene regulation, whereas 5-lipoxygenase gene expression was only partly affected. Mechanistically, we found evidence that CD69 gene upregulation depends on TAK1-mediated p38 activation. In summary, our data indicate that CD69 gene expression, conforming with 5-lipoxygenase, is regulated monocyte-specifically by the physiologic stimuli TGF-β and 1α,25(OH)2D3 on mRNA level, although different mechanisms account for the upregulation of each gene

Malignant insulinoma with multiple liver metastases and hypercalcitoninemia in a patient with type 2 diabetes mellitus presenting as recurrent episodes of diaphoresis due to severe hypoglycemia

Insulinoma is an insulin-producing pancreatic neuroendocrine tumor that can be malignant in about 10% of cases. Locoregional invasion, lymph node metastases, or remote metastases are the main criteria of malignant insulinoma. Its incidence in patients with pre-existing diabetes mellitus (DM) is exceptionally rare. In this report, we describe a 66-year-old man with long-standing type 2 DM who presented with recurrent episodes of diaphoresis due to severe hypoglycemia despite the withdrawal of insulin therapy, hypercalcitoninemia, and biochemical and radiological findings suggestive of metastatic malignant insulinoma. Unfortunately, after few days of diazoxide treatment, edema, hypotension, oliguria, and water retention were observed, patient's clinical status deteriorated rapidly, and he died in our department from acute renal failure

Leading order analysis of neutrino induced dimuon events in the CHORUS experiment

We present a leading order QCD analysis of a sample of neutrino induced charged-current events with two muons in the final state originating in the lead-scintillating fibre calorimeter of the CHORUS detector. The results are based on a sample of 8910 neutrino and 430 antineutrino induced opposite-sign dimuon events collected during the exposure of the detector to the CERN Wide Band Neutrino Beam between 1995 and 1998. % with $E_{\mu 1},E_{\mu 2} > 5$ GeV and $Q^2 > 3$ GeV$^2$ collected %between 1995 and 1998. The analysis yields a value of the charm quark mass of \mc = (1.26\pm 0.16 \pm 0.09) \GeVcc and a value of the ratio of the strange to non-strange sea in the nucleon of $\kappa = 0.33 \pm 0.05 \pm 0.05$, improving the results obtained in similar analyses by previous experiments.Comment: Submitted to Nuclear Physics