ICT alone is not enough, the whole village is needed. A community-based and dialogic approach to technology in schools

The socio-cultural context shapes learning and development. Thus, schools cannot ignore neither the transformations shaping their surrounding societies, but be an active part of them, nor what those transformations mean for school learning. In this regard, technology has changed the way we think and learn, and learning has been shown to be deeply linked to the community of which we are part. However, benefits of involving the community in the ICT use in schools are barely explored in the literature; this article is aimed to shed some light on that aspect. We draw from a successful case, the Ariño school, and based on the dialogic learning theoretical framework, different strategies that promote a dialogic use of ICT are presented: community involvement in self-sufficient classrooms, community involvement outside the school settings, and community digital literacy. This analysis leads to the proposal of a community-based and dialogic approach to technology in schools.peer-reviewe

DRec:Multidomain Recommendation System for Social Community

The Recommendation System is the software engines and the approaches for consideration proposal to the user which might be most probably matched with the liking of users. Usually, Recommendations system recommends on various fields like what items to buy, which movies to watch even the job recommendations, depending upon the users profile. Instinctively if the domains of users are captured and filtered out accordingly to recommend them will be a very useful idea. In this paper we will be discussing about the research done by us and the limitation of the system.We design a system for recommending domains in social network, using an explicit / offline data. We have tested it on two popular dataset namely Epinions and Ciao. The ratings of items are studied and performance measures are calculated with three different ways 1) MAP (Mean Average Precision) 2)F-measure and 3) nDCG (Normalized Discounted Cumulative Gain) . As well we have compared the results with 5 comparisons methods.All the techniques and methods are explained in paper. DOI: 10.17762/ijritcc2321-8169.15081

Adult Education and The Scientific Community

In this paper, we analyzed the recent developments of the AE Scientific Community in Spain. Particularly, we focus in which factors have made possible to overcome its isolated initial situation towards a high quality one. Finally, we identified current works and future trends in order to characterized its main aspects such as its dialogic approach as a result of their interdisciplinary and interinstitutional efforts

La Tertulia: A Dialogic Model of Adult Basic Education in the New Information Age

In the new information age dialogue and dialogic projects are increasingly becoming a social requirement. La Tertulia Literaria is a learning experience in which adults with non-academic background read Joyce, among other classics, crossing cultural barriers and transforming the horizons of their lives and environments

Social Impact of Psychological Research on Well-Being Shared in Social Media

The purpose of this article is to demonstrate how the Social Impact in Social Media (SISM, hereinafter) methodology applied in psychological research provides evidence for the visibility of the social impact of the research. This article helps researchers become aware of whether and how their improvements are capturing the interest of citizens and how citizens are applying such evidence and obtaining better outcomes, in this case, in relation to well-being. In addition, citizens can access the latest evidence on social media and act as channels of communication between science and social or personal networks and, in doing so, they can improve the living conditions of others. This methodology is also useful for agencies that support researchers in psychology with financial assistance, which can use it to evaluate the social impact of the funds that they invest in research. In this article, the 10 studies on well-being were selected for analysis using the following criteria: their research results led to demonstrable improvement in well-being, and these improvements are presented on social media. We applied the social impact coverage ratio to identify the percentage of the social impact shared in social media in relation to the total amount of social media data collected. Finally, examples of quantitative and qualitative evidence of the social impact of the research on well-being are presented

Determining Protease Substrate Selectivity and Inhibition by Label-Free Supramolecular Tandem Enzyme Assays

An analytical method has been developed for the continuous monitoring of protease activity on unlabeled peptides in real time by fluorescence spectroscopy. The assay is enabled by a reporter pair comprising the macrocycle cucurbit[7]uril (CB7) and the fluorescent dye acridine orange (AO). CB7 functions by selectively recognizing N-terminal phenylalanine residues as they are produced during the enzymatic cleavage of enkephalin-type peptides by the metalloendopeptidase thermolysin. The substrate peptides (e.g., Thr-Gly-Ala-Phe-Met-NH2) bind to CB7 with moderately high affinity (K ≈ 104 M–1), while their cleavage products (e.g., Phe-Met-NH2) bind very tightly (K \u3e 106 M–1). AO signals the reaction upon its selective displacement from the macrocycle by the high affinity product of proteolysis. The resulting supramolecular tandem enzyme assay effectively measures the kinetics of thermolysin, including the accurate determination of sequence specificity (Ser and Gly instead of Ala), stereospecificity (d-Ala instead of l-Ala), endo- versus exopeptidase activity (indicated by differences in absolute fluorescence response), and sensitivity to terminal charges (−CONH2 vs −COOH). The capability of the tandem assay to measure protease inhibition constants was demonstrated on phosphoramidon as a known inhibitor to afford an inhibition constant of (17.8 ± 0.4) nM. This robust and label-free approach to the study of protease activity and inhibition should be transferable to other endo- and exopeptidases that afford products with N-terminal aromatic amino acids

Rigid-rod β-barrel pores as enzyme sensors

Ce travail présente le design et la synthèse d'une baguette formée d'un octiphényle portant sur chaque phényle: le pentapeptide -Leu-Arg-Leu-His-Leu. L'auto-assemblage de cette baguette forme une barrique β qui agit comme un pore dans les doubles couches lipidiques, perméable au passage d'anions. Les études de blocage avec l'acide poly-glutamique ont mis en évidence la formation d'un complexe entre le polymère et la barrique transmembranaire ainsi qu'une coopérativité dipôle-potentiel. La mise au point et l'utilisation de la structure supramoléculaire comme senseur d'enzymes ont été largement illustrées sur des biopolymères ou des enzymes intervenant dans différents processus biologiques. L'utilisation d'un seul pore permet la détection d'une large variété d'enzymes et de substrats à intérêt biologiques, sans requérir aucune modification chimique des composés impliqués. Des applications telles que la recherche d'inhibiteurs d'enzymes ou la quantification du sucre dans les boissons ont découlé de cette recherche

Does Natural Gas Utilisation Improve Economic Wellbeing? Empirical Evidence from Nigeria

This study examined the effects of natural gas utilised on per capita income measured in term of purchasing power parity (economic wellbeing) in Nigeria from 2010 to 2020 using quarterly data sourced from International Energy Agency and the Central Bank of Nigeria. The Autoregressive and Distributed Lag (ARDL) technique was used to analyse the data after conducting descriptive statistics, trend analysis and unit roots test on the data. The result shows that in the long run, gas demanded for power and transport sectors as well as its cost contributed to a decline in per capita income which ultimately hampered economic wellbeing in Nigeria. On the other side, households and industrial sector demand for gas improved per capita income and, over time promoted long run economic wellbeing in Nigeria. The study also found an insignificant nexus between demand for gas by the various sectors and economic wellbeing in the long run. In the short run, gas utilised for power generation and the industrial sector had negative and significant impact on economic wellbeing while households demand for natural gas significantly improve economic wellbeing by increasing per capita income in Nigeria. Based on these results, the study concludes that gas demand had serious implication on economic wellbeing in the short run than long run. Also gas demand utilised by households had positive effect on economic wellbeing both in the long and short runs.  Consequent upon the findings, the study recommends, increase in gas demand for household and industrial use by enhancing a competitive price for natural gas in order to enhance sustainable economic wellbeing in Nigeria.&nbsp

α-Helix Recognition by Rigid-Rod β-Barrel Ion Channels with Internal Arginine-Histidine Dyads in Polarized Bilayer Membranes

The objective of this study was to exploit multifunctional rigid-rod ß-barrel ion channels for a-helix recognition by dipole-potential interactions in polarized membranes. Synthesis and evaluation of artificial ß-barrel 1 characterized by p-octiphenyl ‘staves,' leucine residues at the outer and histidine as well as, for the first time, arginine residues at the inner barrel surface are described. Internal arginines were introduced to recognize organic ions such as a-helical poly-Image -glutamic acid (a-PLGA) passing through pores formed by barrel 1 at nanomolar concentrations. In unpolarized spherical bilayers (EYPC-LUVs), P-helical a-PLGA blocked pore 1 with a KD=150 nM at pH=4.5. As expected for a highly symmetric supramolecular host, a KD=100 nM determined for M-helical a-PDGA at pH=4.5 did not support substantial chiral guest recognition. Decreasing KD's with increasing pH indicated that, in unpolarized bilayers, pore 1 recognizes anions (rather than a-helices). In polarized spherical membranes, the KD for a-PLGA at pH=4.5 dropped substantially to 13 nM at V ˜-150 mV. This experimental support for operational dipole-potential interactions indicates that a-PLGAs bind within active pores in transmembrane orientation with intravesicular N- and extravesicular C-termini. Independence on bilayer polarization for binding of random-coil PLGA at pH=5.5 corroborated that dipole–potential interactions account for a-helix recognition in polarized membranes

On selectivity and sensitivity of synthetic multifunctional pores as enzyme sensors: Discrimination between ATP and ADP and comparison with biological pores

This report delineates scope and limitation of the selectivity of synthetic multifunctional pores as enzyme sensors using glycolytic enzymes as example (G. Das, P. Talukdar, and S. Matile, Science, 2002, Vol. 298, pp. 1600-1602). Unproblematic detectability of hexokinase and phosphofructokinase demonstrates that the selectivity of synthetic multifunctional pore (SMPs) sensors suffices to sense ATP in mixed analytes containing ADP, whereas detection of the isomerization of glucose 6-phosphate into fructose 6-phosphate by phosphoglucose isomerase is not possible with confidence. The sensitivity of SMP sensors is sufficient for end-point detection of one picomole poly-L-glutamate hydrolyzed by papain in unoptimized assay format; the sensitivity of melittin as representative biological pore of similar charge and aggregation number to detect the same reaction is more than four orders of magnitude inferior