10 research outputs found
Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2/ERIC-PPCI): a single-blind randomised controlled trial.
BACKGROUND: Remote ischaemic conditioning with transient ischaemia and reperfusion applied to the arm has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). We investigated whether remote ischaemic conditioning could reduce the incidence of cardiac death and hospitalisation for heart failure at 12 months. METHODS: We did an international investigator-initiated, prospective, single-blind, randomised controlled trial (CONDI-2/ERIC-PPCI) at 33 centres across the UK, Denmark, Spain, and Serbia. Patients (age >18 years) with suspected STEMI and who were eligible for PPCI were randomly allocated (1:1, stratified by centre with a permuted block method) to receive standard treatment (including a sham simulated remote ischaemic conditioning intervention at UK sites only) or remote ischaemic conditioning treatment (intermittent ischaemia and reperfusion applied to the arm through four cycles of 5-min inflation and 5-min deflation of an automated cuff device) before PPCI. Investigators responsible for data collection and outcome assessment were masked to treatment allocation. The primary combined endpoint was cardiac death or hospitalisation for heart failure at 12 months in the intention-to-treat population. This trial is registered with ClinicalTrials.gov (NCT02342522) and is completed. FINDINGS: Between Nov 6, 2013, and March 31, 2018, 5401 patients were randomly allocated to either the control group (n=2701) or the remote ischaemic conditioning group (n=2700). After exclusion of patients upon hospital arrival or loss to follow-up, 2569 patients in the control group and 2546 in the intervention group were included in the intention-to-treat analysis. At 12 months post-PPCI, the Kaplan-Meier-estimated frequencies of cardiac death or hospitalisation for heart failure (the primary endpoint) were 220 (8·6%) patients in the control group and 239 (9·4%) in the remote ischaemic conditioning group (hazard ratio 1·10 [95% CI 0·91-1·32], p=0·32 for intervention versus control). No important unexpected adverse events or side effects of remote ischaemic conditioning were observed. INTERPRETATION: Remote ischaemic conditioning does not improve clinical outcomes (cardiac death or hospitalisation for heart failure) at 12 months in patients with STEMI undergoing PPCI. FUNDING: British Heart Foundation, University College London Hospitals/University College London Biomedical Research Centre, Danish Innovation Foundation, Novo Nordisk Foundation, TrygFonden
Why Good People Do Bad Things At Work
[...]the Sarbanes-Oxley Act of 2002 (SOX) requires that external auditors assess a company\u27s tone at the top as part of its audit of the organization\u27s internal control over financial reporting. In 2019, PPG Industries, Inc., a global supplier of paints and specialty coatings and materials, reached a settlement with the U.S. Securities & Exchange Commission (SEC) over charges that it intentionally manipulated its financial accounting multiple times to improve reported performance. Both of these examples point to the importance of practicing management accountants and other financial professionals, companies, auditors, and regulators focusing on the tune in the middle and the tone at the top when assessing the likelihood of unethical behavior. According to this theory, individuals faced with an ethical dilemma where they need to choose whether to gain a benefit by behaving unethically or to maintain a positive self-image by doing the right thing will find a balance between these two competing motivations
New Laws, New Challenges: Implications of Sarbanes-Oxley
https://nsuworks.nova.edu/hcbe_facbooks/1161/thumbnail.jp
Bloggers: Separating the Wheat from the Chaff
This one-of-a-kind collection consists of actual cases written by fraud examiners out in the field. These cases were hand selected from hundreds of submissions and together form a comprehensive picture of the many types of computer fraud how they are investigated, across industries and throughout the world. Topics included are email fraud, on-line auction fraud, security breaches, counterfeiting, and others.https://nsuworks.nova.edu/hcbe_facbooks/1158/thumbnail.jp
Richard Scrushy: The Rise and Fall of the King of Health Care
It has been said that scammers and swindlers often display characteristics commonly attributed to good leadership. These include setting a vision, communicating it clearly, and motivating others to follow their lead. But when these skills are used by unconscionable people to satisfy greed, how can the average person recognize that foul play is afoot?
Providing a unique account of frauds throughout modern history, Handbook of Frauds, Scams, and Swindles: Failures of Ethics in Leadership compiles narratives from around the world, including a number of highly-publicized cases. Leading financial and investigative experts have authored the individual chapters, yet the book maintains a reader-friendly style.
The result is a text that is highly engaging and most importantly, provides regulators and investigators with an understanding of the motivations and behavior common to the individuals behind these life-damaging crimes.
The book includes a wealth of stories, including famous cases such as Ponzi, ZZZZ Best, Enron, Parmalat, and Vivendi, along with lesser-known scandals involving both corporations and individuals. There is also a section on frauds perpetrated for motives other than financial rewards, including instances when the government performed experiments on humans without their knowledge or consent, as well as stories on frauds involving science and religion.
A section detailing the Arthur Anderson debacle discusses the compounding of a fraud when the supposed watchdogplays a complicit role. And recognizing that not every issue is black or white, the book also explores whether a hoax perpetrated in the name of a noble cause can ever be justified.
By reviewing the tactics used by swindlers and the motivations that turned good people crooked, investigators and others will come to recognize the red flags that accompany unscrupulous behavior. In doing so, they may well learn how to head off potential disaster.https://nsuworks.nova.edu/hcbe_facbooks/1159/thumbnail.jp
See No Evil; Hear No Evil; Speak No Evil: Ernst & Young\u27s Ethical Responsibility for the HealthSouth Fraud
It has been said that scammers and swindlers often display characteristics commonly attributed to good leadership. These include setting a vision, communicating it clearly, and motivating others to follow their lead. But when these skills are used by unconscionable people to satisfy greed, how can the average person recognize that foul play is afoot?
Providing a unique account of frauds throughout modern history, Handbook of Frauds, Scams, and Swindles: Failures of Ethics in Leadership compiles narratives from around the world, including a number of highly-publicized cases. Leading financial and investigative experts have authored the individual chapters, yet the book maintains a reader-friendly style.
The result is a text that is highly engaging and most importantly, provides regulators and investigators with an understanding of the motivations and behavior common to the individuals behind these life-damaging crimes.
The book includes a wealth of stories, including famous cases such as Ponzi, ZZZZ Best, Enron, Parmalat, and Vivendi, along with lesser-known scandals involving both corporations and individuals. There is also a section on frauds perpetrated for motives other than financial rewards, including instances when the government performed experiments on humans without their knowledge or consent, as well as stories on frauds involving science and religion.
A section detailing the Arthur Anderson debacle discusses the compounding of a fraud when the supposed watchdogplays a complicit role. And recognizing that not every issue is black or white, the book also explores whether a hoax perpetrated in the name of a noble cause can ever be justified.
By reviewing the tactics used by swindlers and the motivations that turned good people crooked, investigators and others will come to recognize the red flags that accompany unscrupulous behavior. In doing so, they may well learn how to head off potential disaster.https://nsuworks.nova.edu/hcbe_facbooks/1160/thumbnail.jp