Rotating gravity currents: small-scale and large-scale laboratory experiments and a geostrophic model

Laboratory experiments simulating gravity-driven coastal surface currents produced by estuarine fresh-water discharges into the ocean are discussed. The currents are generated inside a rotating tank filled with salt water by the continuous release of buoyant fresh water from a small source at the fluid surface. The height, the width and the length of the currents are studied as a function of the background rotation rate, the volumetric discharge rate and the density difference at the source. Two complementary experimental data sets are discussed and compared with each other. One set of experiments was carried out in a tank of diameter 1 m on a small-scale rotating turntable. The second set of experiments was conducted at the large-scale Coriolis Facility (LEGI, Grenoble) which has a tank of diameter 13 m. A simple geostrophic model predicting the current height, width and propagation velocity is developed. The experiments and the model are compared with each other in terms of a set of non-dimensional parameters identified in the theoretical analysis of the problem. These parameters enable the corresponding data of the large-scale and the small-scale experiments to be collapsed onto a single line. Good agreement between the model and the experiments is found

Reading Requirements and Basic Secondary Teacher Certification: An Update

Being involved with pre-service training of content teachers in a state which requires by law courses in reading method, we raised the following question: Since only two such studies appear in the widely circulated professional literature, were the findings reported by Bader truly representative of a positive trend toward a commitment to reading, or had the earlier comments of Estes and Piercey proven to be more prophetic

The effect of metapopulation processes on the spatial scale of adaptation across an environmental gradient

We show that the butterfly Aricia agestis (Lycaenidae) is adapted to its thermal environment in via integer changes in the numbers of generations per year (voltinism): it has two generations per year in warm habitats and one generation per year in cool habitats in north Wales (UK). Voltinism is an “adaptive peak” since individuals having an intermediate number of generations per year would fail to survive the winter, and indeed no populations showed both voltinism types in nature. In spite of this general pattern, 11% of populations apparently possess the “wrong” voltinism for their local environment, and population densities were lower in thermally intermediate habitat patches. Population dynamic data and patterns of genetic differentiation suggest that adaptation occurs at the metapopulation level, with local populations possessing the voltinism type appropriate for the commonest habitat type within each population network. When populations and groups of populations go extinct, they tend to be replaced by colonists from the commonest thermal environment nearby, even if this is the locally incorrect adaptation. Our results illustrate how stochastic population turnover can impose a limit on local adaptation over distances many times larger than predicted on the basis of normal dispersal movements

GIS mapping of anthropogenic soils in Scotland: investigating the location and vulnerability of Scottish plagen-type soils

Research has demonstrated that «plaggen» soils – anthropogenic deposits, sometimes over 1 m thick, resulting from sustained manuring over long periods – retain significant archaeological information from which early arable land management practices can be interpreted. However, as areas of enhanced fertility, plaggen-type soils attract intensive modernday agricultural activity. This paper presents the first phase of a project which aims to a. investigate the distribution of plaggen-type topsoils throughout Scotland and b. establish the impact of present-day land management, and the diversity of modern land cover, on the retention of this soil-based cultural record. An ArcView GIS database has collated relevant historical, geographical and archaeological information, creating a map indicating areas with a strong likelihood of anthropogenic deep topsoil deposits. Survey through these areas has identified sample sites for modern impact study, while this unique database explores the historic, economic and geographical factors influencing the formation of these soils in Scotland

Faraday rotation maps of disk galaxies

Faraday rotation is one of the most widely used observables to infer the strength and configuration of the magnetic field in the ionised gas of the Milky Way and nearby spiral galaxies. Here we compute synthetic Faraday rotation maps at $z=0$ for a set of disk galaxies from the Auriga high-resolution cosmological simulations, for different observer positions within and outside the galaxy. We find that the strength of the Faraday rotation of our simulated galaxies for a hypothetic observer at the solar circle is broadly consistent with the Faraday rotation seen for the Milky Way. The same holds for an observer outside the galaxy and the observed signal of the nearby spiral galaxy M51. However, we also find that the structure and angular power spectra of the synthetic all-sky Faraday rotation maps vary strongly with azimuthal position along the solar circle. We argue that this variation is a result of the structure of the magnetic field of the galaxy that is dominated by an azimuthal magnetic field ordered scales of several kpc, but has radial and vertical magnetic field components that are only ordered on scales of 1-2 kpc. Because the magnetic field strength decreases exponentially with height above the disk, the Faraday rotation for an observer at the solar circle is dominated by the local environment. This represents a severe obstacle for attempts to reconstruct the global magnetic field of the Milky Way from Faraday rotation maps alone without including additional observables.Comment: 10 pages, 10 figures, accepted by MNRA

Unproceedings of the Fourth .Astronomy Conference (.Astronomy 4), Heidelberg, Germany, July 9-11 2012

The goal of the .Astronomy conference series is to bring together astronomers, educators, developers and others interested in using the Internet as a medium for astronomy. Attendance at the event is limited to approximately 50 participants, and days are split into mornings of scheduled talks, followed by 'unconference' afternoons, where sessions are defined by participants during the course of the event. Participants in unconference sessions are discouraged from formal presentations, with discussion, workshop-style formats or informal practical tutorials encouraged. The conference also designates one day as a 'hack day', in which attendees collaborate in groups on day-long projects for presentation the following morning. These hacks are often a way of concentrating effort, learning new skills, and exploring ideas in a practical fashion. The emphasis on informal, focused interaction makes recording proceedings more difficult than for a normal meeting. While the first .Astronomy conference is preserved formally in a book, more recent iterations are not documented. We therefore, in the spirit of .Astronomy, report 'unproceedings' from .Astronomy 4, which was held in Heidelberg in July 2012.Comment: 11 pages, 1 figure, .Astronomy 4, #dotastr

THE EFFECTS OF CLEAT LOCATION ON MUSCLE RECRUITMENT STRATEGIES OF CYCLING

Foot placement may play an important role in muscle recruitment patterns and affect cycling performance. The purpose of this study was to determine if magnitude of activation increased in more proximal muscles when a more posterior compared to standard cleat location is used. Surface electromyography (8 muscles) and kinematics were collected from 11 experienced cyclists pedalling at 80 rpm rate during standard and posterior cleat location conditions. Root mean square (RMS) EMG were analyzed using paired t-tests. Peak RMS magnitude and crank angle of peak RMS were affected by cleat conditions. Posterior cleat locations alter the magnitude and muscular recruitment strategies of seated cycling when compared to neutral cleat placement

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic

Background Understanding how complex antibiotics are synthesised by their producer bacteria is essential for creation of new families of bioactive compounds. Thiomarinols, produced by marine bacteria belonging to the genus Pseudoalteromonas, are hybrids of two independently active species: the pseudomonic acid mixture, mupirocin, which is used clinically against MRSA, and the pyrrothine core of holomycin. Methodology/Principal Findings High throughput DNA sequencing of the complete genome of the producer bacterium revealed a novel 97 kb plasmid, pTML1, consisting almost entirely of two distinct gene clusters. Targeted gene knockouts confirmed the role of these clusters in biosynthesis of the two separate components, pseudomonic acid and the pyrrothine, and identified a putative amide synthetase that joins them together. Feeding mupirocin to a mutant unable to make the endogenous pseudomonic acid created a novel hybrid with the pyrrothine via “mutasynthesis” that allows inhibition of mupirocin-resistant isoleucyl-tRNA synthetase, the mupirocin target. A mutant defective in pyrrothine biosynthesis was also able to incorporate alternative amine substrates. Conclusions/Significance Plasmid pTML1 provides a paradigm for combining independent antibiotic biosynthetic pathways or using mutasynthesis to develop a new family of hybrid derivatives that may extend the effective use of mupirocin against MRSA

Prevalence, distribution, and severity of cerebral amyloid angiopathy differ between Lewy body diseases and Alzheimer’s disease

\ua9 The Author(s) 2024.Dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and Parkinson’s disease (PD) collectively known as Lewy body diseases (LBDs) are neuropathologically characterised by α-synuclein deposits (Lewy bodies and Lewy neurites). However, LBDs also exhibit pathology associated with Alzheimer’s disease (AD) (i.e. hyperphosphorylated tau and amyloid β (Aβ). Aβ can be deposited in the walls of blood vessels in the brains of individuals with AD, termed cerebral amyloid angiopathy (CAA). The aim of this study was to investigate the type and distribution of CAA in DLB, PDD, and PD and determine if this differs from AD. CAA type, severity, and topographical distribution was assessed in 94 AD, 30 DLB, 17 PDD, and 11 PD cases, and APOE genotype evaluated in a subset of cases where available. 96.3% AD cases, 70% DLB cases and 82.4% PDD cases exhibited CAA (type 1 or type 2). However only 45.5% PD cases had CAA. Type 1 CAA accounted for 37.2% of AD cases, 10% of DLB cases, and 5.9% of PDD cases, and was not observed in PD cases. There was a hierarchical topographical distribution in regions affected by CAA where AD and DLB displayed the same distribution pattern that differed from PDD and PD. APOE ε4 was associated with severity of CAA in AD cases. Topographical patterns and severity of CAA in DLB more closely resembled AD rather than PDD, and as type 1 CAA is associated with clinical dementia in AD, further investigations are warranted into whether the increased presence of type 1 CAA in DLB compared to PDD are related to the onset of cognitive symptoms and is a distinguishing factor between LBDs. Possible alignment of the the topographical distribution of CAA and microbleeds in DLB warrants further investigation. CAA in DLB more closely resembles AD rather than PDD or PD, and should be taken into consideration when stratifying patients for clinical trials or designing disease modifying therapies

Evidence for the Evolution of Young Early-Type Galaxies in the GOODS/CDF-S Field

We have developed an efficient photometric technique for identifying young early-type galaxy candidates using a combination of photometric redshifts, spectral-type classification, and optical/near-infrared colors. Applying our technique to the GOODS HST/ACS and VLT/ISAAC data we have selected a complete and homogeneous sample of young elliptical candidates among early-type field galaxies. The distribution of structural parameters for these candidates shows that their selection, which is based on early spectral types, is fully consistent with early morphological types. We investigate the evolution of their luminosities and colors as a function of redshift and galaxy mass and find evidence for an increasing starburst mass fraction in these young early-type galaxy candidates at higher redshifts, which we interpret in terms of massive field galaxies experiencing more massive/intense starbursts at higher redshifts. Moreover, we find indications for a systematically larger young elliptical fraction among sub-L*/2 early-type galaxies compared to their brighter counterparts. The total fraction among the field early-type galaxies increases with redshift, irrespective of galaxy luminosity. Our results are most consistent with galaxy formation scenarios in which stars in massive early-type field galaxies are assembled earlier than in their low-mass counterparts.Comment: 11 pages, 10 figures, accepted for publication in A