Alien Registration- Simpson, Annie E. (South Portland, Cumberland County)

https://digitalmaine.com/alien_docs/20436/thumbnail.jp

The artistic reputation of Raphael

Thesis (Ed.M.)--Boston University, 1937. This item was digitized by the Internet Archive

eulogies in law & soil

Landscape images, no matter how straight forward, are subjective & bound up in cultural memory which shapes narratives that obfuscate the racist violence done upon people within the landscape. This project seeks to show the political and duplicitous landscapes of Northampton County through the context of environmental racism. I will narrate how topography lends itself to formulating one’s conception of self, how this historical micro-chasm of environmental terror fits into the record of racism that is integral to American history, and how the Southern landscape as a cultural construction is, at its heart, deceitful and memorialized through false and a-historical remembering.Bachelor of Art

Eficacia de la Terapia de Aceptación y Compromiso en los Trastornos de la Conducta Alimentaria (TCA): una revisión sistemática

Esta revisión sistemática se ha realizado mediante el modelo Prisma con el propósito de comprobar la eficacia de la Terapia de Aceptación y Compromiso (ACT) de Steven Hayes para el tratamiento de los Trastornos de la Conducta Alimentaria (TCA). Se ha efectuado una búsqueda sistemática de la literatura en las bases de datos electrónicas Psycho-Info, Scopus y PubMed entre los años 2000 y 2022. Se obtuvieron 2540 registros tras eliminar los duplicados y se filtraron los resultados en base a los criterios de inclusión y exclusión. Finalmente, 5 estudios fueron seleccionados. Los resultados obtenidos muestran que la ACT podría ser una opción terapéutica más eficaz para el tratamiento de los TCA que el Tratamiento habitual o la Terapia cognitiva. Sin embargo, las condiciones metodológicas no permiten obtener resultados concluyentes. En consecuencia, se hace necesario replicar dichos hallazgos, con una muestra superior, mayor variabilidad, presencia de un grupo control y más rigor metodológico, entre otros.This systematic review has been carried out using the Prisma model with the aim of testing the efficacy of Steven Hayes’ Acceptance and Commitment Therapy (ACT) for the treatment of eating disorders (ED). A systematic literature search was conducted in the electronic databases Psycho-Info, Scopus and PubMed between the years 2000 and 2022. After eliminating duplicates and filtering the results based on inclusion and exclusion criteria, 2540 records were obtained. Finally, 5 studies were selected. The results suggest that ACT could be a more effective therapeutic option for the treatment of ED than treatment as usual or Cognitive Therapy. However, the methodological conditions do not allow conclusive results to be obtained. Therefore, it is necessary to replicate these findings, with a larger sample, more variability, the inclusion of a control group and more methodological rigor, among others

Tuesday Student Recital

Kemp Recital Hall Tuesday Afternoon October 30, 2001 2:00p.m

Outcomes from an Undergraduate Cadet Women\u27s Backpacking Experience

Women undergraduates at military colleges are likely to experience challenges including heightened stress, isolation, and discrimination. Wilderness-based programs show promising outcomes in an array of areas including stress-coping, fitness motivation, self-efficacy, social support, and improved cognitive functioning. This mixed-methods exploratory study examined outcomes for 17 cadet women (N=17) who participated in a preparatory workshop series and backpacking event. Quantitative data indicated the backpacking workshop series was associated with decreases in perceived stress (p \u3c .05). The backpacking trip was associated with increases in self-efficacy (p \u3c .01). Cadets attributed decreases in perceived stress and increases in self-efficacy to interpersonal/intrapersonal factors and the wilderness/ backpacking experience. These results support the use of wilderness experience to bolster coping and wellness among cadet women

Structural and functional analysis of the Rous Sarcoma virus negative regulator of splicing and demonstration of its activation by the 9G8 SR protein

Retroviruses require both spliced and unspliced RNAs for replication. Accumulation of Rous Sarcoma virus (RSV) unspliced RNA depends upon the negative regulator of splicing (NRS). Its 5′-part is considered as an ESE binding SR proteins. Its 3′-part contains a decoy 5′-splice site (ss), which inhibits splicing at the bona fide 5′-ss. Only the 3D structure of a small NRS fragment had been experimentally studied. Here, by chemical and enzymatic probing, we determine the 2D structure of the entire RSV NRS. Structural analysis of other avian NRSs and comparison with all sequenced avian NRSs is in favour of a phylogenetic conservation of the NRS 2D structure. By combination of approaches: (i) in vitro and in cellulo splicing assays, (ii) footprinting assays and (iii) purification and analysis of reconstituted RNP complex, we define a small NRS element retaining splicing inhibitory property. We also demonstrate the capability of the SR protein 9G8 to increase NRS activity in vitro and in cellulo. Altogether these data bring new insights on how NRS fine tune splicing activity

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

Cathelicidins are CHDP with essential roles in innate host defense but also more recently associated with the pathogenesis of certain chronic diseases. These peptides have microbicidal potential and the capacity to modulate innate immunity and inflammatory processes. PMN are key innate immune effector cells with pivotal roles in defense against infection. The appropriate regulation of PMN function, death, and clearance is critical to innate immunity, and dysregulation is implicated in disease pathogenesis. The efferocytosis of apoptotic PMN, in contrast to necrotic cells, is proposed to promote the resolution of inflammation. We demonstrate that the human cathelicidin LL-37 induced rapid secondary necrosis of apoptotic human PMN and identify an essential minimal region of LL-37 required for this activity. Using these LL-37-induced secondary necrotic PMN, we characterize the consequence for macrophage inflammatory responses. LL-37-induced secondary necrosis did not inhibit PMN ingestion by monocyte-derived macrophages and in contrast to expectation, was not proinflammatory. Furthermore, the anti-inflammatory effects of apoptotic PMN on activated macrophages were retained and even potentiated after LL-37-induced secondary necrosis. However, this process of secondary necrosis did induce the release of potentially harmful PMN granule contents. Thus, we suggest that LL-37 can be a potent inducer of PMN secondary necrosis during inflammation without promoting macrophage inflammation but may mediate host damage through PMN granule content release under chronic or dysregulated conditions

Seven recommendations to make your invasive alien species data more useful

Science-based strategies to tackle biological invasions depend on recent, accurate, well-documented, standardized and openly accessible information on alien species. Currently and historically, biodiversity data are scattered in numerous disconnected data silos that lack interoperability. The situation is no different for alien species data, and this obstructs efficient retrieval, combination, and use of these kinds of information for research and policy-making. Standardization and interoperability are particularly important as many alien species related research and policy activities require pooling data. We describe seven ways that data on alien species can be made more accessible and useful, based on the results of a European Cooperation in Science and Technology (COST) workshop: (1) Create data management plans; (2) Increase interoperability of information sources; (3) Document data through metadata; (4) Format data using existing standards; (5) Adopt controlled vocabularies; (6) Increase data availability; and (7) Ensure long-term data preservation. We identify four properties specific and integral to alien species data (species status, introduction pathway, degree of establishment, and impact mechanism) that are either missing from existing data standards or lack a recommended controlled vocabulary. Improved access to accurate, real-time and historical data will repay the long-term investment in data management infrastructure, by providing more accurate, timely and realistic assessments and analyses. If we improve core biodiversity data standards by developing their relevance to alien species, it will allow the automation of common activities regarding data processing in support of environmental policy. Furthermore, we call for considerable effort to maintain, update, standardize, archive, and aggregate datasets, to ensure proper valorization of alien species data and information before they become obsolete or lost

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

Cationic host defense peptides are key, evolutionarily conserved components of the innate immune system. The human cathelicidin LL-37 is an important cationic host defense peptide up-regulated in infection and inflammation, specifically in the human lung, and was shown to enhance the pulmonary clearance of the opportunistic pathogen Pseudomonas aeruginosa in vivo by as yet undefined mechanisms. In addition to its direct microbicidal potential, LL-37 can modulate inflammation and immune mechanisms in host defense against infection, including the capacity to modulate cell death pathways. We demonstrate that at physiologically relevant concentrations of LL-37, this peptide preferentially promoted the apoptosis of infected airway epithelium, via enhanced LL-37-induced mitochondrial membrane depolarization and release of cytochrome c, with activation of caspase-9 and caspase-3 and induction of apoptosis, which only occurred in the presence of both peptide and bacteria, but not with either stimulus alone. This synergistic induction of apoptosis in infected cells was caspase-dependent, contrasting with the caspase-independent cell death induced by supraphysiologic levels of peptide alone. We demonstrate that the synergistic induction of apoptosis by LL-37 and Pseudomonas aeruginosa required specific bacteria-epithelial cell interactions with whole, live bacteria, and bacterial invasion of the epithelial cell. We propose that the LL-37-mediated apoptosis of infected, compromised airway epithelial cells may represent a novel inflammomodulatory role for this peptide in innate host defense, promoting the clearance of respiratory pathogens