A mortalidade em tempos de ventura e desventura: o Brás na virada do século XIX para o século XX.

Este estudo analisa a mortalidade – suas características e condicionantes – no distrito do Brás, um bairro tipicamente de imigrantes e operários da cidade de São Paulo, nos anos finais do século XIX e primeiros anos do século XX. A partir das estatísticas de óbitos produzidas e publicadas pela Repartição de Estatística e Arquivo do Estado de São Paulo, pode-se verificar que, naquele momento, a população desse bairro vivenciou um padrão de mortalidade característico de sociedade em pré-transição demográfica – alta mortalidade geral e alta mortalidade infantil – impactado pelo movimento imigratório, pelo ambiente, pelas condições de vida e trabalho e pela precariedade das políticas públicas de saúde.  

Jack of all trades: thymosin α1 and its pleiotropy

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A MICROFILMAGEM DE DOCUMENTOS DA UNIVERSIDADE FEDERAL DE SANTA CATARINA: UMA ANÁLISE SOBRE PRÁTICAS E NORMATIVAS ARQUIVÍSTICAS

Este trabalho visa analisar o processo de microfilmagem de documentos e sua aplicabilidade no Setor de Microfilmagem da Universidade Federal de Santa Catarina. Para tanto, se propõe a identificar as diferenças e semelhanças existentes entre a teoria e as práticas exigidas no processo de microfilmagem. Esta pesquisa teve abordagem qualitativa, e o procedimento investigativo utilizado é o “estudo de caso”. Com ele, procura-se elucidar o intrincado mosaico existente em situações cotidianas complexas e, nesse intento, utiliza-se, como passos metodológicos constitutivos da pesquisa, experimentos e/ou levantamento de dados. Por meio da aplicação do questionário ficou evidente a necessidade de um Termo de Eliminação e, também, de um Sistema de Arquivo. Nesta pesquisa foram apresentados os procedimentos adotados durante o processo de microfilmagem, desde a seleção dos documentos a serem microfilmados até o armazenamento, destacando-se também a comparação entre o sistema híbrido e a microfilmagem expondo a legalidade dos dois sistemas, suas vantagens e desvantagens. Conclui-se, contudo, que é mister a implantação de um Sistema de Arquivos como condição de viabilidade para o gerenciamento total dos arquivos em todos os seus suportes

Incremento de las precipitaciones (1921/1998) en el centro este de la provincia de La Pampa (Argentina)

p.193-196El corrimiento hacia el oeste de la frontera agropecuaria de la Región Pampeana Argentina, debido a una combinación de innovaciones tecnológicas y un incremento de las precipitaciones ha sido puesto en evidencia por diversos trabajos de investigación. La serie de precipitaciones mensuales, agrupadas por campaña agrícola 1921-22- 1997-98, de la localidad de Anguil (Pcia de La Pampa) fue tomada como representativa del margen occidental de la región pampeana de cultivo en secano. Las precipitaciones por campaña presentaron una tendencia positiva estadísticamente significativa al nivel del 1 por ciento, causada principalmente por el aumento de las lluvias durante el trimestre noviembre -diciembre- enero. El restante incremento de las precipitaciones se encuentra repartido en los otros meses, pero ninguno de los mismos, ni su suma presentan tendencias significativas

Exploring energy performance certificates through visualization

Energy Performance Certificates (EPCs) provide interesting information on the standard-based calculation of energy performance, thermo-physical and geometrical related properties of a building. Because of the volume of available data (issued as open data) and the heterogeneity of the attributes, the exploration of these energy-related data collections is challenging. This paper presents INDICE (INformative DynamiC dashboard Engine), a new data visualization framework able to automatically explore large collections of EPCs. INDICE explores EPCs through both querying and analytics tasks, and intuitively presents the output through informative dashboards. The latter include dynamic and interactive maps along with different informative charts allowing different stakeholders (e.g., domain and non-domain expert users) to explore and interpret the extracted knowledge at different spatial granularity levels. The objective of INDICE is to create energy maps useful for the characterization of the energy performance of buildings located in different areas. The experimental evaluation, performed on a real set of EPCs related to a major Italian region in the North West of Italy, demonstrates the effectiveness of INDICE in exploring an EPC dataset through different data and knowledge visualization techniques

Effect of the Nano-Ca(OH)2 addition on the Portland clinker cooking efficiency

A new technology was tested to improve the cooking efficiency of the raw mixture for Portland clinker production by the use of nano-Ca(OH)2. A decrease in the free lime concentration after the firing of approximately 35% and 55% in the nano-added clinkers burned at 1350 °C and 1450 °C, respectively, with respect to the standard Portland clinkers was observed. Moreover, in the nano-added clinkers, a slight decrease in alite (C3S), of approximately 2-4 wt%, and increase in belite (C2S), of approximately 5-6 wt%, were observed. Despite these variations, the C2S and C3S abundance lies within the ranges for standard Portland clinkers. The results showed that the nano-addition leads to an increase of the raw mixtures' cooking efficiency. The relatively low energy required for the clinker firing could be used to increase the plant productivity and decrease the CO2 emissions during clinker burning. The decrease of the work index of the clinkers produced by the use of the nano-Ca(OH)2 also contributes to the energy saving during clinker grinding. Differences were also found in the pore size distribution among nano-added clinkers and the standard Portland clinker. The smallest porosities with the modal volume lying in the class of 3 × 10-6 mm3 were found to increase by the use of nano-Ca(OH)2. However, the pore volumes higher than 2.0 × 10-5 mm3 decreased in the nano-added clinkers. © 2019 by the authors

Quinoa burger formulation

Se eligió la quínoa para realizar desarrollo de productos porque esta semilla posee un elevado porcentaje de proteínas entre 16 a 23 g/% con un buen equilibrio de aminoácidos. Contiene entre 4 a 9% de grasas poliinsaturadas y un importante aporte de fibras. Por ello el objetivo del presente trabajo fue formular hamburguesas con mejor perfil nutricional

α-Synuclein is a Novel Microtubule Dynamase.

α-Synuclein is a presynaptic protein associated to Parkinson's disease, which is unstructured when free in the cytoplasm and adopts α helical conformation when bound to vesicles. After decades of intense studies, α-Synuclein physiology is still difficult to clear up due to its interaction with multiple partners and its involvement in a pletora of neuronal functions. Here, we looked at the remarkably neglected interplay between α-Synuclein and microtubules, which potentially impacts on synaptic functionality. In order to identify the mechanisms underlying these actions, we investigated the interaction between purified α-Synuclein and tubulin. We demonstrated that α-Synuclein binds to microtubules and tubulin α2β2 tetramer; the latter interaction inducing the formation of helical segment(s) in the α-Synuclein polypeptide. This structural change seems to enable α-Synuclein to promote microtubule nucleation and to enhance microtubule growth rate and catastrophe frequency, both in vitro and in cell. We also showed that Parkinson's disease-linked α-Synuclein variants do not undergo tubulin-induced folding and cause tubulin aggregation rather than polymerization. Our data enable us to propose α-Synuclein as a novel, foldable, microtubule-dynamase, which influences microtubule organisation through its binding to tubulin and its regulating effects on microtubule nucleation and dynamics

Stellar Astrophysics and Exoplanet Science with the Maunakea Spectroscopic Explorer (MSE)

The Maunakea Spectroscopic Explorer (MSE) is a planned 11.25-m aperture facility with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy. A rebirth of the 3.6m Canada-France-Hawaii Telescope on Maunakea, MSE will use 4332 fibers operating at three different resolving powers (R ~ 2500, 6000, 40000) across a wavelength range of 0.36-1.8mum, with dynamical fiber positioning that allows fibers to match the exposure times of individual objects. MSE will enable spectroscopic surveys with unprecedented scale and sensitivity by collecting millions of spectra per year down to limiting magnitudes of g ~ 20-24 mag, with a nominal velocity precision of ~100 m/s in high-resolution mode. This white paper describes science cases for stellar astrophysics and exoplanet science using MSE, including the discovery and atmospheric characterization of exoplanets and substellar objects, stellar physics with star clusters, asteroseismology of solar-like oscillators and opacity-driven pulsators, studies of stellar rotation, activity, and multiplicity, as well as the chemical characterization of AGB and extremely metal-poor stars.Comment: 31 pages, 11 figures; To appear as a chapter for the Detailed Science Case of the Maunakea Spectroscopic Explore