Androgen deprivation therapy (castration therapy) and pedophilia: What's new

Andrology is a constantly evolving discipline, embracing social problems like pedophilia and its pharmacological treatment. With regard to chemical castration, the andrologist may perform an important role as part of a team of specialists. At present, no knowledge is available regarding hormonal, chromosomal or genetic alterations involved in pedophilia. International legislation primarily aims to defend childhood, but does not provide for compulsory treatment. We reviewed international literature that, at present, only comprises a few reports on research concerning androgen deprivation. Most of these refer to the use of leuprolide acetate, rather than medroxyprogesterone and cyproterone acetate, which present a larger number of side effects. Current opinions on chemical castration for pedophilia are discordant. Some surveys confirm that therapy reduces sexual thoughts and fantasies, especially in recidivism. On the other hand, some authors report that chemical castration does not modify the pedophile's personality. In our opinion, once existing legislation has changed, andrologists could play a significant role in the selection of patients to receive androgen deprivation therapy, due in part to their knowledge about its action and side effects

Commentary: Coordinated infraslow neural and cardiac oscillations mark fragility and offline periods in mammalian sleep.

We read with interest the paper by Lecci et al. (2017), who showed oscillations of the electroencephalographic (EEG) spectral power in the sigma band (10\u201315 Hz) during non-rapid-eye-movement (NREM) sleep at frequencies in the infra-slow range (ISO = 0.001\u20130.1 Hz). The occurrence of this rhythm (sigma-ISO) in human subjects and mice, and its correlation with autonomic and behavioral components suggest that it reflects a fundamental physiological mechanism

Implementasi Kontrol Pid pada Pergerakan Laras Mortir 81mm Sesuai dengan Hasil Perhitungan Koreksi Tembakan

Pergerakan Laras Mortir 81mm ini secara umum masih menggunakan manual atau dengan tenaga personil. Dalam pengoperasian Mortir dibutuhkan kecepatan pembidikan agar tembakan mengenai sasaran secara tepat dan cepat. Oleh karena itu perancangan alat ini bertujuan untuk mempercepat pergerakan yang sesuai dengan pembidikan terhadap sasaran yang akan dituju. Perencanaan dan pembuatan alat dibangun dengan meggunakan alat perangkat keras dan perangkat lunak. Perangkat keras yang digunakan yaitu motor DC, mikrokontroler Arduino Uno, driver ULN2003, sensor Compass GY271, sensor Accelerometer. Sedangkan perangkat lunak yang digunakan yaitu Software IDE sebagai alat pengendali pada mikrokontroler Arduino. Dalam pembuatan alat yang dimaksud supaya dapat berfungsi dengan baik, maka diperlukan pemahaman yang mendalam tentang karakteristik dan cara kerja komponen-komponen yang digunakan. Hal ini perlu dikuasa sebaik-baiknya untuk menghindari kesalan penggunaan komponen yang mengakibatkan kegagalan dalam pembuatan alat.Pada perencanaan hardware akan meliputi seluruh perihal yang digunakan pada sistem. Pada perencanaan software merupakan piranti lunak meliputi flowchart dan software secara umum. Perangkat tersebut saling terintegrasi sehingga dalam kerjanya akan maksimum sesuai apa yang diharapkan. Software ini diharapkan mampu memenuhi tugas pokok TNI AD khususnya keahlian menembak agar lebih efektif, akurat dan tepat dalam melaksanakan latihan menembak di satuan TNI AD

Monitoring alkylphenols in water using the polar organic chemical integrative sampler (POCIS): determining sampling rates via the extraction of PES membranes and Oasis beads

Polar organic chemical integrative samplers (POCIS) have previously been used to monitor alkylphenol (AP) contamination in water and produced water. However, only the sorbent receiving phase of the POCIS (Oasis beads) is traditionally analyzed, thus limiting the use of POCIS for monitoring a range of APs with varying hydrophobicity. Here a “pharmaceutical” POCIS was calibrated in the laboratory using a static renewal setup for APs (from 2-ethylphenol to 4-n-nonylphenol) with varying hydrophobicity (log Kow between 2.47 and 5.76). The POCIS sampler was calibrated over its 28 day integrative regime and sampling rates (Rs) were determined. Uptake was shown to be a function of AP hydrophobicity where compounds with log Kow < 4 were preferentially accumulated in Oasis beads, and compounds with log Kow > 5 were preferentially accumulated in the PES membranes. A lag phase (over a 24 h period) before uptake in to the PES membranes occurred was evident. This work demonstrates that the analysis of both POCIS phases is vital in order to correctly determine environmentally relevant concentrations owing to the fact that for APs with log Kow ≤ 4 uptake, to the PES membranes and the Oasis beads, involves different processes compared to APs with log Kow ≥ 4. The extraction of both the POCIS matrices is thus recommended in order to assess the concentration of hydrophobic APs (log Kow ≥ 4), as well as hydrophilic APs, most effectively. © 2017 Elsevier Lt

Highly diastereoselective entry into chiral spirooxindole-based 4-methyleneazetidines via formal [2+2] annulation reaction

We describe here a diastereoselective, DABCO-catalyzed reaction of allenoates with chiral N-tert-butanesulfinyl ketimines derived from isatin

Post-sigh sleep apneas in mice: Systematic review and data-driven definition

Sleep apneas can be categorized as post-sigh (prevailing in non-rapid eye movement sleep) or spontaneous (prevailing in rapid eye movement sleep) according to whether or not they are preceded by an augmented breath (sigh). Notably, the occurrence of these apnea subtypes changes differently in hypoxic/hypercapnic environments and in some genetic diseases, highlighting the importance of an objective discrimination. We aim to: (a) systematically review the literature comparing the criteria used in categorizing mouse sleep apneas; and (b) provide data-driven criteria for this categorization, with the final goal of reducing experimental variability in future studies. Twenty-two wild-type mice, instrumented with electroencephalographic/electromyographic electrodes, were placed inside a whole-body plethysmographic chamber to quantify sleep apneas and sighs. Wake\u2013sleep states were scored on 4-s epochs based on electroencephalographic/electromyographic signals. Literature revision showed that highly different criteria were used for post-sigh apnea definition, the intervals for apnea occurrence after sigh ranging from 1 breath up to 20 s. In our data, the apnea occurrence rate during non-rapid eye movement sleep was significantly higher than that calculated before the sigh only in the 1st and 2nd 4-s epochs following a sigh. These data suggest that, in mice, apneas should be categorized as post-sigh only if they start within 8 s from a sigh; the choice of shorter or longer time windows might underestimate or slightly overestimate their occurrence rate, respectively

The spiropiperidine-3,3 '-oxindole scaffold : a type II beta-turn peptide isostere

An unprecedented chiral spiropiperidine oxindole system quaternary 3-aminooxindole and relying on a ring closing acts as an highly constrained Freidinger gamma-lactam, adopting assessed by modelling and spectroscopical studies. was synthesized starting from enantiopure metathesis as the key step. This compound a type II beta-turn conformation in solution, as (C) 2010 Elsevier Ltd. All rights reserved