Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis

Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells leads to significant enhancer reorganizations with prominent emergence of leukemia-specific de novo enhancers. Alterations in the enhancer landscape lead to activation of an ectopic embryonic gene program. We show that HOXA9 functions as a pioneer factor at de novo enhancers and recruits CEBPα and the MLL3/MLL4 complex. Genetic deletion of MLL3/MLL4 blocks histone H3K4 methylation at de novo enhancers and inhibits HOXA9/MEIS1-mediated leukemogenesis in vivo. These results suggest that therapeutic targeting of HOXA9-dependent enhancer reorganization can be an effective therapeutic strategy in acute leukemia with HOXA9 overexpressio

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

Regulatory B cells (Breg) have attracted increasing attention for their roles in maintaining peripheral tolerance. Interleukin 33 (IL-33) is a recently identified IL-1 family member, which leads a double-life with both pro- and anti-inflammatory properties. We report here that peritoneal injection of IL-33 exacerbated inflammatory bowel disease in IL-10-deficient (IL-10-/-) mice, whereas IL-33-treated IL-10-sufficient (wild type) mice were protected from the disease induction. A phenotypically unconventional subset(s) (CD19+CD25+CD1dhiIgMhiCD5-CD23-Tim-1-) of IL-10 producing Breg-like cells (BregIL-33) was identified responsible for the protection. We demonstrated further that BregIL-33 isolated from these mice could suppress immune effector cell expansion and functions and, upon adoptive transfer, effectively blocked the development of spontaneous colitis in IL-10-/- mice. Our findings indicate an essential protective role, hence therapeutic potential, of BregIL-33 against mucosal inflammatory disorders in thegut. © 2014.link_to_subscribed_fulltex

predictionofremnantvolatilematterinthesemicokesfromcoalpartialgasification

The semicokes from different coals were prepared under various temperatures by partial gasification method in a fixed bed. According to the analysis of the V (daf) in the coals and semicokes, a new method is presented to predict the content of remnant volatile matter in the semicokes from coal partial gasification. The two fuel character indexes FV and FC were introduced to symbolize the second volatilized temperature and the fully volatilized temperature respectively. Then according to the proximate and ultimate analysis data of raw coal, the content of V (daf) in the semicokes prepared under various temperatures can be predicted

Numerical Simulation of Fluid Flow and Heat Transfer in a DC Non-Transferred Arc Plasma Torch Operating Under Laminar and Turbulent Conditions

In this work, a magnetic fluid dynamics (MHD) model is used to simulate the electromagnetic field, heat transfer and fluid flow in a DC non-transferred arc plasma torch under laminar and turbulent conditions. The electric current density, temperature and velocity distributions in the torch are obtained through the coupled iterative calculation about the electromagnetic equations described in a magnetic vector potential format and the modified fluid dynamics equations. The fluid-solid coupled calculation method is applied to guarantee the continuity of the electric current and heat transfer at the interface between the electrodes and fluid. The predicted location of the anodic arc root attachment and the arc voltage of the torch are consistent with corresponding experimental results. Through a specific analysis of the influence of mass flow rates and electric current on the torch outlet parameters, the total thermal efficiency, thermal loss of each part, and the laws of the variation of outlet parameters with the variation of mass flow rates and electric current was obtained. It is found that operation under a laminar condition with a limited area of the anode could increase the total thermal efficiency of the torch

Numerical simulation of NOx formation in coal combustion with inlet natural gas burning

A full two-fluid model of reacting gas-particle flows and coal combustion is used to simulate coal combustion with and without inlet natural gas added in the inlet. The simulation results for the case without natural gas burning is in fair agreement with the experimental results reported in references. The simulation results of different natural gas adding positions indicate that the natural gas burning can form lean oxygen combustion environment at the combustor inlet region and the NOx concentration is reduced. The same result can be obtained from chemical equilibrium analysis

Studies of the effect of a coal concentrator on NO formation in swirling coal combustion

To develop low-pollution burners, the effect of a coal concentrator on NO formation in swirling coal combustion is studied using both numerical simulation and experiments. The isothermal gas–particle two-phase velocities and particle concentration in a cold model of swirl burners with and without coal concentrators were measured using the phase Doppler particle anemometer (PDPA). A full two-fluid model of reacting gas–particle flows and coal combustion with an algebraic unified second-order moment (AUSM) turbulence-chemistry model for the turbulent reaction rate of NO formation are used to simulate swirling coal combustion and NO formation with different coal concentrators. The results give the turbulent kinetic energy, particle concentration, temperature and NO concentration in cases of with and without coal concentrators. The predicted results for cold two-phase flows are in good agreement with the PDPA measurement results, showing that the coal concentrator increases the turbulence and particle concentration in the recirculation zone. The combustion modeling results indicate that although the coal concentrator increases the turbulence and combustion temperature, but still can remarkably reduce the NO formation due to creating high coal concentration in the recirculation zone

Numerical Simulation of NOx Formation in Coal Combustion with Inlet Natural Gas Burning

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