Preterm Infants With Biliary Atresia:A Nationwide Cohort Analysis From The Netherlands

Objectives: Biliary atresia (BA) occurs in 0.54 of 10.000 of overall live births in the Netherlands. BAhas an unfavorable prognosis: Methods: Retrospective study including Dutch preterm infants treated for BA. Parameters included gestational age, congenital anomalies, age at KPE, days between first symptoms, and KPE and referral interval (first hospital to KPE). Outcome parameters were clearance of jaundice (COJ) and (transplant-free) survival. Data are presented as medians (ranges). Results: Included 28 preterm infants (13 boys/15 girls) between March 1988 and December 2015. The incidence of BA was 1.06 of 10.000 preterm live births. Gestational age was 34.8 (27.3-36.9) weeks. Congenital anomalies were present in 11 of 28 (39%) infants. Time between first symptoms and KPE was 57 (9-138) days. Referral interval was 28 (8-86) days. Age at KPE was 70 (35-145) days. COJ was achieved in 23% of cases. Four-year transplant-free survival rate was 21%. Four-year overall survival was 61%. Conclusions: BA has a higher incidence in the preterm population compared to the overall BA population. The outcome of BA in preterm infants is poor, regarding COJ and (transplant-free) survival. We speculate that timely recognition of BA-related signs and symptoms in preterm infants will improve prognosis

Epstein–Barr virus and post-transplant lymphoproliferative disease

There is convincing evidence that Epstein–Barr virus (EBV) is associated with post-transplant lymphoproliferative disease (PTLD). Primary EBV infection following transplantation occurs in as many as 90% of cases of PTLD in children and pretransplant EBV seronegativity is a recognized risk factor for developing PTLD. Other risk factors include young age at the time of transplant, the type of transplant that the recipient receives and the type and intensity of immunosuppression. The clinical presentation is often nonspecific and tissue biopsy is necessary to establish the diagnosis. There appears to be a correlation between PTLD and EBV viral load measured by polymerase chain reaction (PCR) of the peripheral blood and quantitative PCR may be a useful guide in the management of PTLD. Antiviral drugs and cytomegalovirus-immunoglobulin G may have a role in preventing PTLD. Because PTLD results from functional over-immunosuppression, the initial treatment is reduction of immunosuppression. Antiviral agents, interferon, immuno-based monoclonal therapy, cell-based therapy and chemotherapy also have a potential role in treating this disorder. At the present time there is no standardized approach to the evaluation and treatment of PTLD.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72483/1/j.1399-3046.2002.02043.x.pd

Délit de discrédit – Thémis au pilori : la répression des atteintes au respect dû à la justice

International audienc

Lien hypertexte et prescription de l'action en diffamation

International audienceNon renseign

L'enfant, le tee-shirt et l'attentat du World Trade Center : action publique et action civile pour apologie

International audienc

L'enfant, le tee-shirt et l'attentat du World Trade Center : action publique et action civile pour apologie

International audienc

Jugement dernier dans l'affaire Lacan

International audienc

Lien hypertexte et prescription de l'action en diffamation

International audienceNon renseign

L'enfant, le tee-shirt et l'attentat du World Trade Center : action publique et action civile pour apologie

International audienc

The part of disaster : the practice of assemblage as a resistance ritual

Cette thèse interroge une expérience individuelle de pratiques artistiques effectuées dans le contexte géographique de l'île de la Martinique. Pour celui qui le vit, l'exil offre la possibilité d'adopter des points de vue distanciés tout en conservant l'implication dans les problématiques les plus actuelles et les plus universelles. Ce travail questionne les relations entre la création artistique et ce qui semble la nier, à savoir tous les phénomènes désastreux. En art, la mise en œuvre peut être comprise comme le montage d'un assemblage. L'artiste relie des fragments entre eux pour composer des objets qui ne constituent ni une unité ni un enchevêtrement hasardeux, mais plutôt des structures ouvertes et instables cultivant l'indétermination. Adoptant cette conception que l'art et la vie sont indissociables, l'approche développée dans ce texte explore les liens entre l'idée d'assemblage d'éléments disparates et les questions soulevées par les relations entre l'individu et les contextes ou encore entre les singularités et les communautés. Le désir de créer persiste malgré la perspective incontournable du désastre. Envisagée sous cet angle, la pratique artistique peut se concevoir comme un rituel de résistance.This thesis examines a personal experience of artistic practices realised in the geographical context of the island of Martinique. For the one who lives it, the exile offers the possibility of adopting viewpoints distanced while retaining involvement in the most current and most universal problems. This work questions the relationship between artistic creation and what seems to deny it, namely all the disastrous phenomena. In art, the implementation can be understood as the setting of an assembly. The artist connects fragments together to compose objects that are neither a unit nor a hazardous entanglement, but rather an open and unstable structure cultivating indeterminacy. Adopting this conception that art and life are inseparable, this work explores the links between the idea of assembly of disparate elements and issues raised by the relationship between the individual and the contexts or between singularities and communities. The desire to create persists despite the unavoidable prospect of disaster. Seen from this angle, the artistic practice can be understood as a resistance ritual