In the Right Ballpark? Assessing the Accuracy of Net Price Calculators

Large differences often exist between a college’s sticker price and net price after accounting for financial aid. Net price calculators (NPCs) were designed to help students more accurately estimate their actual costs to attend a given college. This study assesses the accuracy of information provided by net price calculators. Specifically, we compare NPC estimates of financial aid to actual aid packages for a sample of low-income, first-time college students at seven postsecondary institutions which all utilize the federal template NPC. We find that NPC estimates of grant aid correlate highly with actual grant aid on average, but variation in individual financial aid packages among socioeconomically similar students can be substantial. We offer four recommendations. First, NPC aid estimates should include information on variability, and potentially, on sources of that variability. Second, a basic metric of academic merit such as SAT/ACT scores and GPA should be an optional addition to the federal template NPC. Third, institutions should update the data underlying their NPCs annually. Finally, we recommend that institutions use the “Explanations and Caveats” options on the federal NPC template to include additional information that may be helpful for students and families in anticipating their likely college aid and expenses. Our findings have implications for federal policy related to NPCs

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Sex Trafficking in State-Authorized Massage Schools: A Case Study

This brief is the first research paper on sex trafficking at vocational schools in the United States, which a set of state authorizers and massage education experts believe to be a widespread problem in higher education. We explore a recent Minnesota case where a state authorizer ordered the closure of an institution due to an explicit suspicion of sex trafficking, and the subsequent processes that enabled that school to continue operations without losing Title IV eligibility. In this case, the regulatory triad functioned exactly as designed: an exemplary state authorizer identified areas of non-compliance, notified the accreditor and the U.S. Department of Education, and ordered the closure of the school. The majority of the 57 state agencies that responded to our outreach were unaware of the issue or claimed that it was not a problem in their state. We contend that many state authorizers of postsecondary education may be ill-equipped to address this issue – and unprepared to notice the red flags that may indicate that a school is engaged in behaviors connected to sex trafficking. State governments must take immediate steps to investigate the scale of trafficking in their states and to strengthen their regulatory framework to ensure that they only authorize schools – not sex trafficking operations. Moreover, the ease with which a school disciplined for suspected sex trafficking can continue to operate raises serious concerns about whether the triad can protect students from more mundane fraud, poor education quality, and insufficient earnings outcomes at for-profit institutions within their jurisdictions

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis.

BACKGROUND & AIMS: Genome-wide association studies in primary biliary cholangitis (PBC) have failed to find X chromosome (chrX) variants associated with the disease. Here, we specifically explore the chrX contribution to PBC, a sexually dimorphic complex autoimmune disease. METHODS: We performed a chrX-wide association study, including genotype data from 5 genome-wide association studies (from Italy, United Kingdom, Canada, China, and Japan; 5244 case patients and 11,875 control individuals). RESULTS: Single-marker association analyses found approximately 100 loci displaying P < 5 × 10(-4), with the most significant being a signal within the OTUD5 gene (rs3027490; P = 4.80 × 10(-6); odds ratio [OR], 1.39; 95% confidence interval [CI], 1.028-1.88; Japanese cohort). Although the transethnic meta-analysis evidenced only a suggestive signal (rs2239452, mapping within the PIM2 gene; OR, 1.17; 95% CI, 1.09-1.26; P = 9.93 × 10(-8)), the population-specific meta-analysis showed a genome-wide significant locus in East Asian individuals pointing to the same region (rs7059064, mapping within the GRIPAP1 gene; P = 6.2 × 10(-9); OR, 1.33; 95% CI, 1.21-1.46). Indeed, rs7059064 tags a unique linkage disequilibrium block including 7 genes: TIMM17B, PQBP1, PIM2, SLC35A2, OTUD5, KCND1, and GRIPAP1, as well as a superenhancer (GH0XJ048933 within OTUD5) targeting all these genes. GH0XJ048933 is also predicted to target FOXP3, the main T-regulatory cell lineage specification factor. Consistently, OTUD5 and FOXP3 RNA levels were up-regulated in PBC case patients (1.75- and 1.64-fold, respectively). CONCLUSIONS: This work represents the first comprehensive study, to our knowledge, of the chrX contribution to the genetics of an autoimmune liver disease and shows a novel PBC-related genome-wide significant locus.The article is available via Open Access. Click on the 'Additional link' above to access the full-text.Published version, accepted versio