Experimental Lagrangian Acceleration Probability Density Function Measurement

We report experimental results on the acceleration component probability distribution function at $R_\lambda = 690$ to probabilities of less than $10^{-7}$. This is an improvement of more than an order of magnitude over past measurements and allows us to conclude that the fourth moment converges and the flatness is approximately 55. We compare our probability distribution to those predicted by several models inspired by non-extensive statistical mechanics. We also look at acceleration component probability distributions conditioned on a velocity component for conditioning velocities as high as 3 times the standard deviation and find them to be highly non-Gaussian.Comment: submitted for the special issue of Physica D: "Anomalous Distributions" 11 pages, 6 figures revised version: light modifications of the figures and the tex

Pathological mechanisms of abnormal iron metabolism and mitochondrial dysfunction in systemic lupus erythematosus

Introduction: Systemic lupus erythematosus [SLE] is a chronic, autoimmune condition characterized by the formation of autoantibodies directed against nuclear components and by oxidative stress. Recently, a number of studies have demonstrated the essential role of iron in the immune response and there is growing evidence that abnormal iron homeostasis can occur in the chronic inflammatory state seen in SLE. Not only is iron vital for hematopoiesis, it is also important for a number of other key physiological processes, in particular in maintaining healthy mitochondrial function. / Areas covered: In this review, we highlight the latest understanding with regards to how patients with SLE may be at risk of cellular iron depletion as a result of both absolute and functional iron deficiency. Furthermore, we aim to explain the latest evidence of mitochondrial dysfunction in the pathogenesis of the disease. / Expert opinion: Growing evidence suggests that both abnormal iron homeostasis and subsequent mitochondrial dysfunction can impair effector immune cell function. Through a greater understanding of these abnormalities, therapeutic options that directly target iron and mitochondria may ultimately represent novel treatment targets that may translate into clinical care of patients with SLE in the near future

The use of a modified Delphi approach to engage stakeholders in zoonotic disease research priority setting

Background After the 2011 cluster of Hendra virus cases in horses in Australia, public health targeted education initiatives at people in the equine industry to reduce human exposure to potentially infected horses. ‘Horse owners and Hendra Virus: A Longitudinal cohort study To Evaluate Risk’ aims to enhance public health measures through improved understanding of Hendra virus risk perception and risk mitigation strategies among horse owners and horse care providers. This paper describes the stakeholder consultation that was undertaken to ensure the cohort study outcomes were relevant to diverse groups who play a role in Hendra virus policy development and implementation. Methods A two-round modified Delphi study with online questionnaires was conducted. In round one, stakeholders identified priority research areas. In round two, stakeholders rated and ranked topics that emerged from thematic analysis of the round one responses. Round two data were analysed using logistic regression. Results Of the 255 stakeholders contacted, 101 responded to round one. Over 450 topics were proposed. These were organized into 18 themes. Approximately two thirds of the round one respondents participated in round two. ‘Hendra virus-related risk awareness and perception’, ‘personal health and safety’, ‘emergency preparedness’, ‘risk prevention, mitigation, and biosecurity’, and ‘Hendra virus vaccination in horses – attitudes/uptake’ were the top five areas identified according to probability of being ranked extremely important. Conclusions In this study, a modified Delphi approach was effective in guiding research into Hendra virus, a zoonotic disease of animal and human health significance. The findings support the notion that stakeholders should be engaged in zoonotic disease research priority setting. Such consultation will help to ensure that research initiatives are relevant and useful to stakeholders in the position to make use of new findings. Keywords Delphi method Stakeholder engagement Zoonotic disease Hendra virus Public health Thematic analysisThis research was funded by the Commonwealth of Australia, the State of New South Wales and the State of Queensland under the National Hendra Virus Research Program

Using the Gene Ontology to Annotate Key Players in Parkinson's Disease

The Gene Ontology (GO) is widely recognised as the gold standard bioinformatics resource for summarizing functional knowledge of gene products in a consistent and computable, information-rich language. GO describes cellular and organismal processes across all species, yet until now there has been a considerable gene annotation deficit within the neurological and immunological domains, both of which are relevant to Parkinson's disease. Here we introduce the Parkinson's disease GO Annotation Project, funded by Parkinson's UK and supported by the GO Consortium, which is addressing this deficit by providing GO annotation to Parkinson's-relevant human gene products, principally through expert literature curation. We discuss the steps taken to prioritise proteins, publications and cellular processes for annotation, examples of how GO annotations capture Parkinson's-relevant information, and the advantages that a topic-focused annotation approach offers to users. Building on the existing GO resource, this project collates a vast amount of Parkinson's-relevant literature into a set of high-quality annotations to be utilized by the research community

Lagrangian Velocity Correlations and Absolute Dispersion in the Midlatitude Troposphere

Employing daily wind data from the ECMWF, we perform passive particle advection to estimate the Lagrangian velocity correlation functions (LVCF) associated with the midlatitude tropospheric flow. In particular we decompose the velocity field into time mean and transient (or eddy) components to better understand the nature of the LVCF's. A closely related quantity, the absolute dispersion (AD) is also examined. Given the anisotropy of the flow, meridional and zonal characteristics are considered separately. The zonal LVCF is seen to be non-exponential. In fact, for intermediate timescales it can either be interpreted as a power law of the form $\tau^{-\alpha}$ with $0<\alpha<1$ or as the sum of exponentials with differing timescales - both interpretations being equivalent. More importantly the long time correlations in the zonal flow result in a superdiffusive zonal AD regime. On the other hand, the meridional LVCF decays rapidly to zero. Before approaching zero the meridional LVCF shows a region of negative correlation - a consequence of the presence of planetary scale Rossby waves. As a result the meridional AD, apart from showing the classical asymptotic ballistic and diffusive regimes, displays transient subdiffusive behaviour.Comment: Revised version. Submitted to JA

Effects of the low frequencies of noise on On-Off intermittency

A bifurcating system subject to multiplicative noise can exhibit on-off intermittency close to the instability threshold. For a canonical system, we discuss the dependence of this intermittency on the Power Spectrum Density (PSD) of the noise. Our study is based on the calculation of the Probability Density Function (PDF) of the unstable variable. We derive analytical results for some particular types of noises and interpret them in the framework of on-off intermittency. Besides, we perform a cumulant expansion for a random noise with arbitrary power spectrum density and show that the intermittent regime is controlled by the ratio between the departure from the threshold and the value of the PSD of the noise at zero frequency. Our results are in agreement with numerical simulations performed with two types of random perturbations: colored Gaussian noise and deterministic fluctuations of a chaotic variable. Extensions of this study to another, more complex, system are presented and the underlying mechanisms are discussed.Comment: 13pages, 13 figure

Stirring up trouble: Multi-scale mixing measures for steady scalar sources

The mixing efficiency of a flow advecting a passive scalar sustained by steady sources and sinks is naturally defined in terms of the suppression of bulk scalar variance in the presence of stirring, relative to the variance in the absence of stirring. These variances can be weighted at various spatial scales, leading to a family of multi-scale mixing measures and efficiencies. We derive a priori estimates on these efficiencies from the advection--diffusion partial differential equation, focusing on a broad class of statistically homogeneous and isotropic incompressible flows. The analysis produces bounds on the mixing efficiencies in terms of the Peclet number, a measure the strength of the stirring relative to molecular diffusion. We show by example that the estimates are sharp for particular source, sink and flow combinations. In general the high-Peclet number behavior of the bounds (scaling exponents as well as prefactors) depends on the structure and smoothness properties of, and length scales in, the scalar source and sink distribution. The fundamental model of the stirring of a monochromatic source/sink combination by the random sine flow is investigated in detail via direct numerical simulation and analysis. The large-scale mixing efficiency follows the upper bound scaling (within a logarithm) at high Peclet number but the intermediate and small-scale efficiencies are qualitatively less than optimal. The Peclet number scaling exponents of the efficiencies observed in the simulations are deduced theoretically from the asymptotic solution of an internal layer problem arising in a quasi-static model.Comment: 37 pages, 7 figures. Latex with RevTeX4. Corrigendum to published version added as appendix

Development and Application of a Framework for Emerging Infectious Disease Intelligence in Lower Resource Settings

Frontline mobile phone-based reporting has the potential to contribute to emerging infectious disease (EID) intelligence as shown by the Infectious Disease Surveillance and Analysis System (IDSAS). This article proposes an EID intelligence framework that can be informed by published literature from the fields of surveillance, epidemic intelligence, and military intelligence. The underlying premise is the need for a framework which reflects the notion that a change in health of animal populations could indicate an impending EID event of human health significance, and functions separately from the Centers for Disease Control and Prevention (CDC) Guidelines for Evaluating Public Health Surveillance Systems