121 research outputs found
THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage
- Author
- Publication venue
- ScholarWorks @ UTRGV
- Publication date
- 01/12/2016
- Field of study
Background and Purpose A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage (SAH). This study seeks to define a specific gene whose mutation leads to disease. Methods More than 500 IA probands and 100 affected families were enrolled and clinically characterized. Whole exome sequencing was performed on a large family, revealing a segregating THSD1 mutation. THSD1 was sequenced in other probands and controls. Thsd1 loss-of-function studies in zebrafish and mice were used for in vivo analyses, and functional studies performed using an in vitro endothelial cell model. Results A nonsense mutation in THSD1 (thrombospondin type-1 domain-containing protein 1) was identified that segregated with the 9 affected (3 suffered SAH; 6 had unruptured IA) and 13 unaffected family members (LOD score 4.69). Targeted THSD1 sequencing identified mutations in 8 of 507 unrelated IA probands, including 3 who had suffered SAH (1.6% [95% CI, 0.8%–3.1%]). These THSD1 mutations/rare variants were highly enriched in our IA patient cohort relative to 89,040 chromosomes in ExAC database (p\u3c0.0001). In zebrafish and mice, Thsd1 loss-of-function caused cerebral bleeding (which localized to the subarachnoid space in mice) and increased mortality. Mechanistically, THSD1 loss impaired endothelial cell focal adhesion to the basement membrane. These adhesion defects could be rescued by expression of wild-type THSD1 but not THSD1 mutants identified in IA patients. Conclusions This report identifies THSD1 mutations in familial and sporadic IA patients, and shows that THSD1 loss results in cerebral bleeding in two animal models. This finding provides new insight into IA and SAH pathogenesis and provides new understanding of THSD1 function, which includes endothelial cell to extracellular matrix adhesion
Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors
- Author
- Publication venue
- ScholarWorks @ UTRGV
- Publication date
- 19/11/2015
- Field of study
Background
Constitutive and regulated internalization of cell surface proteins has been extensively investigated. The regulated internalization has been characterized as a principal mechanism for removing cell-surface receptors from the plasma membrane, and signaling to downstream targets of receptors. However, so far it is still not known whether the functional properties of remaining (non-internalized) receptor/channels may be regulated by internalization of the same class of receptor/channels. The N-methyl-D-aspartate receptor (NMDAR) is a principal subtype of glutamate-gated ion channel and plays key roles in neuronal plasticity and memory functions. NMDARs are well-known to undergo two types of regulated internalization – homologous and heterologous, which can be induced by high NMDA/glycine and DHPG, respectively. In the present work, we investigated effects of regulated NMDAR internalization on the activity of residual cell-surface NMDARs and neuronal functions. Results
In electrophysiological experiments we discovered that the regulated internalization of NMDARs not only reduced the number of cell surface NMDARs but also caused an inhibition of the activity of remaining (non-internalized) surface NMDARs. In biochemical experiments we identified that this functional inhibition of remaining surface NMDARs was mediated by increased serine phosphorylation of surface NMDARs, resulting from the activation of protein kinase D1 (PKD1). Knockdown of PKD1 did not affect NMDAR internalization but prevented the phosphorylation and inhibition of remaining surface NMDARs and NMDAR-mediated synaptic functions. Conclusion
These data demonstrate a novel concept that regulated internalization of cell surface NMDARs not only reduces the number of NMDARs on the cell surface but also causes an inhibition of the activity of remaining surface NMDARs through intracellular signaling pathway(s). Furthermore, modulating the activity of remaining surface receptors may be an effective approach for treating receptor internalization-induced changes in neuronal functions of the CNS
Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis
- Author
- Abdul Latiff Amir
- Abdullah Baharudin
- Aberer Werner
- Agache Ioana
- Akdis Cezmi
- Akdis Mubeccel
- Al-Ahmad Mona
- Almeida Mário Morais
- Alobid Isam
- Ansotegui Zubeldia Ignacio Javier
- Anto M. J.
- Arshad Syed Hasan
- Asayag Estrella
- Barata Luís Taborda
- Bedbrook Anna
- Bennoor Kazi Saifuddin
- Berghea Elena Camelia
- Bergmann Karl-Christian
- Bernstein D.
- Bewick M.
- Bindslev-Jensen Carsten
- Blain Hubert
- Bonini Matteo
- Bosnic-Anticevich Sinthia
- Bousquet Jean
- Braido Fulvio
- Brightling Chris
- Brussino Luisa
- Buhl Roland
- Bumbacea Roxana Silvia
- Burte Emilie
- Bush Andrew
- Bustamante Mariona
- Bárbara Cristina
- Calderon Moises
- Calvo Mário
- Camargos Paulo
- Canonica Giogio Walter
- Caraballo Luis
- Cardona Victoria
- Carlsen Karin C. Lodrup
- Carr Warner
- Casale Thomas
- Cecchi Lorenzo
- Celedón Juan C
- Cepeda Sarabia Alfonso
- Chandrasekharan Ramanathan
- Charpin Denis
- Chen Y. Z.
- Cherrez Ojeda Ivan
- Chivato Tomás
- Chkhartishvili Ekaterine
- Christoff George
- Chu Derek K
- Cingi C.
- Cordeiro Carlos Manuel Da Silva Robalo
- Corrigan Chris
- Costa Elisio
- Cruz Alvaro
- Custovic Adnan
- Czarlewski Wienczyslawa
- D'Amato G.
- Daniel Aguilar
- De Blay Frédéric
- Devillier Philippe
- Didier Alain
- Dokic Dejan
- Douagui Habib
- Doulaptsi Maria
- Durham Stephen
- Dykewicz Mark
- Eiwegger Thomas
- Erhola Marina
- Filho Nelson Augusto Rosario
- Fiocchi Alessandro
- Florin Mihaltan
- Fokkens Wytske
- Fonseca João P.
- Fyhrquist Nanna Theresia
- Garcia-Aymerich J.
- Gemicioglu Bilun
- Giacco S. Del
- Gomez R Maximiliano
- Gotua Maia
- Guerra Stefano
- Guzman Maria Antonieta
- Haahtela Tari
- Hagemann Jan
- Halken Susanne
- Halpin David M.G.
- Hamamah Samir
- Heinrich Joachim
- Helga Kraxner
- Hofmann Maja Ann
- Hossny Elham
- Hrubiško Martin
- Irani Carla
- Ispayeva Zhanat
- Ivancevich Juan Carlos
- Jares Edgardo
- Jartti Tuomas
- Jassem Ewa
- Julge Kalev
- Just Jocelyne
- Jutel Marek
- Kaidashev Igor
- Kalayci Omer
- Kalyoncu Ali Fuat
- Kardas Przemyslaw
- Keil Thomas
- Kirenga Bruce
- Klimek Ludger
- Koppelman Gerard
- Kull Inger
- Kulus Marek
- Kuna Piotr
- Kupczyk Maciej
- Kvedarienė Violeta
- La Grutta Stefania
- Lau Susanne
- Le Thi Tuyet Lan
- Lemonnier Nathanaël
- Levin Michael
- Linnemann Désirée Larenas
- Lipworth Brian
- Lkhagvaa Battur
- Louis Renaud
- Louis-Philippe Boulet
- Loureiro Cláudia Chaves
- Lourenço Olga
- Mahboub Bassam
- Makris Michael
- Martinez‐Infante E.
- Martins Pedro Carreiro
- Matricardi Paolo Maria
- Maurer Marcus
- Melén Erik
- Miculinic Neven
- Migueres Nicolas
- Mohamed Sayed Zeinab
- Mohammad Yousser
- Momas Isabelle
- Moniuszko Marcin
- Montefort Stephen
- Mullol Joaquim
- Mäkelä Mika J.
- Naclerio Robert
- Nadeau Kari
- Nadif Rachel
- Neffen Hugo
- Nekam Kristof
- Niedoszytko Marek
- Nunes Elizabete
- Nyembue Tshipukane Dieudonne
- O'Hehir Robyn
- Ogulur Ismail
- Ohta Ken
- Okamoto Yoshitaka
- Okubo Kimihiro
- Ollert Markus W.
- Olze Heidi
- Ouedraogo Solange
- Pali Isabella
- Palomares O.
- Palosuo Kati
- Panaitescu Carmen
- Panzner P.
- Papadopoulos Nikolaos
- Park Hae-Sim
- Passalacqua Giovanni
- Patella Vincenzo
- Pawankar Ruby
- Pfaar Oliver
- Pham Thi Nhan
- Pinto Bernardo Sousa
- Pitsios Constantinos
- Plavec Davor
- Popov T. A.
- Puggioni Francesca
- Quirce Santiago
- Recto Marysia
- Regateiro Frederico S.
- Repka-Ramirez María Susana
- Ring Johannes
- Roche Nicolas
- Rodriguez-Gonzalez Monica
- Romantowski Jan
- Rothenberg Marc
- Rottem Menachem
- Rouadi Philip
- Sagara Hironori
- Samoliński Bolesław
- Sastre Joaquin
- Savouré Marine
- Sayah Zineb
- Scheire Sophie
- Schmid-Grendelmeier Peter
- Scichilone Nicola
- Serpa Faradiba
- Shamji Mohamed
- Sheikh Aziz
- Siroux Valérie
- Sisul Juan
- Solé Dirceu
- Soto-Martinez Manuel
- Sousa Jaime Correia de
- Sova Milan
- Sperl Annette
- Spranger Otto
- Standl Marie
- Stelmach Rafael
- Sunyer J.
- Suppli Ulrik Charlotte
- Teixeira Maria Do Céu
- Thomas Mike
- To Teresa
- Todo-Bom Ana
- Togias Alkis
- Tomazic Peter Valentin
- Toppila-Salmi Sanna Katriina
- Torres María Jose
- Tsiligianni Ioanna
- Urrutia-Pereira Marilyn
- Valenta Rudolf
- Valentin Rostan Marylin
- Valiulis Arunas
- Valovirta Erkka
- Van Ganse Eric
- Van Hage Marianne
- Vandenplas O.
- Vasankari Tuula
- Ventura Maria Teresa
- Vichyanond Pakit
- Viegi Giovanni
- Wallace Dana
- Wang De Yun
- Weiss Scott
- Wickman Magnus
- Williams Siân
- Worm Margitta
- Yiallouros Panayiotis
- Yorgancıoglu Arzu
- Yusuf Osman
- Zaitoun Fares
- Zernotti Mario
- Zhang Luo
- Zidarn Mihaela
- Zuberbier Jaron
- Zuberbier Torsten
- Ėmužytė Regina
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2023
- Field of study
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio
Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects
- Author
- Agolini E. (Emanuele)
- Agrawal P.B. (Pankaj B.)
- Alders M. (Mariëlle)
- Bruel A.-L. (Ange-Line)
- Collins S.C. (Stephan C.)
- Dooren M.F. (Marieke) van
- Duncan A.R. (Anna R.)
- Faivre L. (Laurence)
- Genetti C.A. (Casie A.)
- Goizet C. (Cyril)
- Grant P.E. (Patricia E.)
- Guillen Sacoto M.J. (Maria J.)
- Lelliott C.J. (Christopher J.)
- Maas S.M. (Saskia)
- Nizon M. (Mathilde)
- Novelli A. (Antonio)
- Philippe C. (Christophe)
- Prontera P. (Paolo)
- Rodan L. (Lance)
- Santiago-Sim T. (Teresa)
- Seman A.R. (Ann R.)
- Shi J. (Jiahai)
- Sorlin A. (Arthur)
- Stoler J. (Joan)
- Trimouille A. (Aurélien)
- Vancollie V.E. (Valerie E.)
- Vitobello A. (Antonio)
- Wojcik M.H. (Monica H.)
- Yalcin B. (Binnaz)
- Yoon G. (Grace)
- Publication venue
- 'Elsevier BV'
- Publication date
- 03/12/2020
- Field of study
KDM4B is a lysine-specific demethylase with a preferential activity on H3K9 tri/di-methylation (H3K9me3/2)-modified histones. H3K9 tri/di-demethylation is an important epigenetic mechanism responsible for silencing of gene expression in animal development and cancer. However, the role of KDM4B on human development is still poorly characterized. Through international data sharing, we gathered a cohort of nine individuals with mono-allelic de novo or inherited variants in KDM4B. All individuals presented with dysmorphic features and global developmental delay (GDD) with language and motor skills most affected. Three individuals had a history of seizures, and four had anomalies on brain imaging ranging from agenesis of the corpus callosum with hydrocephalus to cystic formations, abnormal hippocampi, and polymicrogyria. In mice, lysine demethylase 4B is expressed during brain development with high levels in the hippocampus, a region important for learning and memory. To understand how KDM4B variants can lead to GDD in humans, we assessed the effect of KDM4B disruption on brain anatomy and behavior through an in vivo heterozygous mouse model (Kdm4b+/-), focusing on neuroanatomical changes. In mutant mice, the total brain volume was significantly reduced with decreased size of the hippocampal dentate gyrus, partial agenesis of the corpus callosum, and ventriculomegaly. This report demonstrates that variants in KDM4B are associated with GDD/ intellectual disability and neuroanatomical defects. Our findings suggest that KDM4B variation leads to a chromatinopathy, broadening the spectrum of this group of Mendelian disorders caused by alterations in epigenetic machinery
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey Mathew B.
- Bajwa Ed
- Balkhi Hicham
- Baltus Thomas
- Banner-Goodspeed Valerie M.
- Barberet Guillaume
- Baron Rebecca M.
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros Filipa M.
- Barros Nelson C.
- Batra Hitesh
- Battle Ceri E.
- Bauer Philippe R.
- Beck Eduardo
- Beck Oliver
- Bedreag Ovidiu H.
- Beegle Scott H.
- Beitler Jeremy R.
- Bellani Giacomo
- Bellani Giacomo
- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman Thomas C.
- Bolon Stefan
- Borello Silvina A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddine
- Boukhazna Messabi
- Bouw Maria J.
- Boyd Owen
- Bramall Jon
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito Vania A.
- Brizuela Matias
- Brochard Laurent
- Brochard Laurent
- Broman Lars M.
- Brown Samuel M.
- Browne Troy S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns Monique M.
- Buensuseso Juan A.
- Bugedo Guillermo
- Buise Marc P.
- Bulpa Pierre A.
- Bumbasierevic Vesna
- Bumbasirevic Vesna
- Burtenshaw Andrew J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz Cecilia
- Cardonnet Luis P.
- Careless Jon P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement Jonathan
- Castro Alejandro G.
- Castro Silvia
- Catorze Nuno T.
- Cazorla-Barranquero Francisca G.
- Ceniceros-Barros Alexandra
- Cereijo Enrique
- Cerny Vladimir
- Cerrato Valeria I.
- Cervantes Mavy Ramirez
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
- Clarkson Kevin P.
- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
- Collins Daniel V.
- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
- Combes Alain
- Cooper Raphael
- Coppadoro Andrea
- Corneci Dan E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo Cristina M.
- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
- de Cima-Iglesias Sara
- de Gordoa Laura Ortiz-Ruiz
- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
- Dean Michael N.
- Declercq Pierre-Louis M.
- Dector Dulce
- Dector Dulce M.
- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
- di Tomasso Nora N.
- di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- Do Vale Fernandes Antero
- Dolva Merete S.
- Donnelly Adrian
- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
- Fan Eddy
- Fartoukh Muriel
- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
- Franco Nieves
- França Ana G.
- Frati Elena
- Frendl Gyorgy
- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yan
- Gao Yuan N.
- Garcia Patricio H.
- Gattinoni Luciano
- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis Sarah
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa Dina
- Gomes Rui M.
- Gomez Pablo E.
- Gomez-Flores Saira S.
- Gonz Á Lez Raquel Montiel
- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
- Goubaux Bernard
- Graziani Romano
- Grelon Fabien
- Griffin Ruth O.
- Grigoriev Evgeny
- Grijalba Carolina Quintana
- Grissom Colin K.
- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
- Gómez Pilar Ricart Aroa
- Hacking Danielle J.
- Haddad Youssef
- Hadfield Dan
- Hagan Samantha J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian S. M.
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Zhenyang
- Hedlund Lars
- Heidari Farshad
- Heines Serge J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne
- Hermosa Cecilia
- Hessell Robert J.
- Heunks Leo M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff Nidhi G.
- Humphreys Sally K.
- Hunt Anna
- Hurtado Javier
- Hutchison Robyn A.
- Hutton Paula J.
- Ibañez-Santacruz Marcos
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
- Imperio María C.
- Insaurralde Carolina S.
- Inskip Deborah M.
- Ioannou Nicholas
- Iotti Giorgio A.
- Irvine Donald A.
- Ismail Dina
- Ismail Mehvish
- Ito Fumihito
- Izawa Masayo
- Jaafar Rola F.
- Jakubowska Karina
- Jamaati Hamidreza
- Jarquin-Badiola Yves D.
- Jassal Mandeep
- Javeed Areej
- Javier-Blanco
- Jhamatthew Thomas Rajeev R.
- Jiang Liangyan
- Jibaja Manuel
- Jimenez Antonio G.
- Jochmans S. bastien
- Jog Sameer A.
- Jovanovic Bojan
- Judy Claine
- Jurado M. . Teresa
- Kadaba Varsha
- Kajtor Istvan
- Kakar Vivek
- Kalaitzis Evangelos
- Kalkoff Michael
- Kamel Ghassan
- Kameyama Yoshinobu
- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
- Kansuke-Koyama
- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir Fayez
- Kheir Fayez M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch Barrett T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Kraßler Jens
- Krstevski Amanda
- Kulkarni Shreedhar
- Kumar Alek
- Kurahashi Kiyoyasu
- Kusumoto Kohei
- Laake Jon H.
- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John
- Laffey John G.
- Laffey John G.
- Lamb Keith D.
- Lanspa Michael J.
- Larsson Anders
- Larsson Niklas
- le Moal Charlene
- Lebbinck Herve
- Lee Jarone
- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus Jordana S.
- Leon Yoshido Hector H.
- Li Bin
- Li Qingdong
- Li Qiong J.
- Li Wenwen
- Li Xiao L.
- Li Xinyu
- Li Yimin
- Li Yuan Y.
- Li-Xin Zhou
- Liew Kong Y.
- Ling Long L.
- Liu Haitao
- Liu Jian
- Liu Jing L.
- Liu Ling
- Llano Miguel
- Llinares Moya David D.
- Lohner Ralph
- Loiacono Flavia A.
- Lombardo Andrea
- Lopez Esther Bermejo
- Lopez-Delgado Juan C.
- Lora Fredy S.
- Lora Pilar
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- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
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- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Abbas Rezaianzadeh
- Abdonas Tamosiunas
- Abdul Basit
- Abdul Hamid Zargar
- Abdullah Alkandari
- Abdullatif Husseini
- Abhijit Sen
- Abla M Sibai
- Abu Am Hanif
- Adela Chirita-Emandi
- Adelheid Weber
- Adetoyeje Y Oyeyemi
- Adewale L Oyeyemi
- Adolfo Rubinstein
- Adoubi Kassi Anicet
- Adroaldo Cesar Araujo Gaya
- Afshin Ostovar
- Agnes L Kadvan
- Agneta Sjöberg
- Agneta Yngve
- Agnès Le Port
- Agustinus Soemantri
- Agustín Perez-Londoño
- Ahmad A Zainuddin
- Ahmad Faudzi Yusoff
- Ahmad Reza Dorosty
- Ahmed A Madar
- Aida Pilav
- Aïcha Soumaré
- Akaninyene Otu
- Akihiro Yoshihara
- Akkumis Salhanova
- Akram Pourshams
- Ala'a Alkerwi
- Alain Morejon
- Alanna G da Silva
- Albertino Damasceno
- Alberto Barceló
- Alberto Palloni
- Albina A Fakhretdinova
- Alejandro Diaz
- Aleksander Giwercman
- Aleksandra Gomula
- Aleksandra Piwonska
- Alessandro Gialluisi
- Aletta E Schutte
- Alexander D Deev
- Alexandra M Cucu
- Alexandre C Pereira
- Alfonso Siani
- Alfonso Sousa-Poza
- Ali Ahmadi
- Ali Akbar Shayesteh
- Ali Esmaeili
- Ali Ghanbari
- Ali Reza Safarpour
- Alice Bonilla-Vargas
- Alicia Matijasevich
- Alina G Platonova
- Alina Kerimkulova
- Aline Meirhaeghe
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- Sajid Soofi
- Salar Rahimikazerooni
- Salim Berkinbayev
- Salim Mohanna
- Salvador Villalpando
- Sameer Narake
- Samuel C Dumith
- San-Lin You
- Sanda M Kolo
- Sandjaja
- Sandra C Fuchs
- Sandra Colorado-Yohar
- Sania Nishtar
- Sanja Musić Milanović
- Sanja Šalaj
- Sanjay Rampal
- Sanjib K Sharma
- Santiago F Gómez
- Santosh K Bhargava
- Sara Magnacca
- Sara Schramm
- Sarah Cuschieri
- Sarah P Garnett
- Sare Safi
- Sareh Eghtesad
- Sari Hantunen
- Saskia Te Velde
- Satoko Sakata
- Sauli Herrala
- Savvas Savva
- Scott B McLean
- Semánová Csilla
- Senthil K Vasan
- Seongjun Ha
- Seppo Koskinen
- Sergej M Ostojic
- Sergio Viana Peixoto
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- Seyed Mohammad Hashemi-Shahri
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- Shahla AlDhukair
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- Sheikh Mohammed Shariful Islam
- Shelly R McFarlane
- Sherali Rakhmatulloev
- Sherilynn Madraisau
- Shina Avi
- Shiqi Zhen
- Shirin Djalalinia
- Shoaib Afzal
- Shoichiro Tsugane
- Shouling Wu
- Shu-Ti Chiou
- Shubash Ganapathy
- Shufa Du
- Shukri F Mohamed
- Shuohua Chen
- Shynar Abdrakhmanova
- Sibel Gogen
- Sigmund A Anderssen
- Silje Steinsbekk
- Silvana P Donoso
- Silvia Bel-Serrat
- Silvije Vuletić
- Simo Pone Larissa
- Simona Bo
- Simona Costanzo
- Simona Giampaoli
- Sinead Brophy
- Sirkka Keinänen-Kiukaanniemi
- Slavica Sovic
- Slawomir Koziel
- Snehalatha Chamukuttan
- Sofia K Malyutina
- Soheir H Ahmed
- Sok King Ong
- Solie Puhakka
- Son Thai Pham
- Songhomitra Panda-Jonas
- Sonya V Galcheva
- Soon-Woo Park
- Sophia J Kiechl
- Sophie Visvikis-Siest
- Sounnia Mediene Benchekor
- Sousana K Papadopoulou
- Srinivasan Kannan
- Stefaan De Henauw
- Stefaan Demarest
- Stefan Adela Gabriela
- Stefan Kiechl
- Stefan Rach
- Stefan Savin
- Stefan Söderberg
- Stefania Maggi
- Stefania Toselli
- Stefano Marventano
- Steinar Krokstad
- Stephen T McGarvey
- Steve Botomba
- Stevo R Popovic
- Stig E Bojesen
- Stine Schramm
- Sudha Ramachandra Rao
- Sudhir Kowlessur
- Suhad Bahijri
- Suhaila Abdul Ghaffar
- Sumit Bharadwaj
- Suntara Klanarong
- Susana C Confortin
- Susana Sans
- Susana Vale
- Susanne Kobel
- Susanne R de Rooij
- Susi Kriemler
- Suyeon Park
- Suzanne C Ho
- Suzanne N Morin
- Svetlana Shalnova
- Sylvain Sebert
- Sylvia Alexius
- Tabara Yasuharu
- Tahir Aris
- Tai Hing Lam
- Tajana Zeljkovic Vrkic
- Takafumi Ishida
- Take Naseri
- Takuro Furusawa
- Tal Shimony
- Tamara R Santos
- Tamás Csányi
- Tamerlan Rajabov
- Tandi E Matsha
- Tania Lopez
- Tania Tello
- Tanja Gm Vrijkotte
- Tara C Coppinger
- Taru Manyanga
- Tasanee Braithwaite
- Tatjana Hejgaard
- Tatyana Slazhnyova
- Tazeen Jafar
- Terence Dwyer
- Terence W O'Neill
- Teresa Haugsgjerd
- Teresa Shamah-Levy
- Terho Lehtimäki
- Thamara Hubler Figueiró
- Thein Thein Htay
- Themistoklis Tzotzas
- Theodora Benedek
- Thet Thet Mu
- Thi Tuyet-Hanh Tran
- Thirunavukkarasu Sathish
- Thomas Ferrao
- Thomas M Dantoft
- Thomas Münzel
- Thomas Waldhör
- Thor Aspelund
- Thorkild Ia Sørensen
- Tien Yin Wong
- Tiffany K Gill
- Tiina Laatikainen
- Tiina Lankila
- Tiina Vlasoff
- Tilema Cama
- Till Ittermann
- Timothy Key
- Tina Harmer Lassen
- Tint Swe Latt
- Tobias F Rinke de Wit
- Tom Wilsgaard
- Tomas Vega
- Tomasz Zdrojewski
- Tomi-Pekka Tuomainen
- Toomas Veidebaum
- Torben Jørgensen
- Toshiharu Ninomiya
- Tran Quoc Bao
- Trevor S Ferguson
- Tuija Jääskeläinen
- Tuyen D Le
- Tze Pin Ng
- Ulf Ekelund
- Ulf Risérus
- Ulla Roggenbuck
- Ulrich Keil
- Ulrike Gehring
- Unjali P Gujral
- Urho M Kujala
- Ursula Kiechl-Kohlendorfer
- Uruwan Yamborisut
- Vaitheeswaran Kulothungan
- Valentina Peterkova
- Valéria Regecová
- Valérie Deschamps
- Valirie N Agbor
- Valter Barbosa Filho
- Vanessa Rouzier
- Vanina Bongard
- Vasiliki Efthymiou
- Vassilis Zafiropulos
- Vayia Rarra
- Vedrana Sember
- Veikko Salomaa
- Vera Lanska
- Vera Musil
- Veronica Mocanu
- Vesna Juresa
- Vesselka L Duleva
- Victor M Herrera
- Victor Matsudo
- Victor Pf Lhoste
- Victoria E Soto-Rojas
- Victoria Farrugia Sant'Angelo
- Vijaya Lingam
- Viktoria Anna Kovacs
- Viktoriya Furdela
- Vilma E Irazola
- Vilma Kriaucioniene
- Vilmundur Gudnason
- Vilnis Dzerve
- Vinay B Nangia
- Vincent Jr DeGennaro
- Vincenzo Capuano
- Vincenzo Solfrizzi
- Violeta Iotova
- Virginija Dulskiene
- Virgílio V Ramires
- Visnja Djordjic
- Viswanathan Mohan
- Viviana Guajardo
- Viviane C Cardoso
- Vladimir Kutsenko
- Wafaie W Fawzi
- Wan Mohamad Wan Bebakar
- Wan Nazaimoon Wan Mohamud
- Wei Zheng
- Wei-Cheng Lo
- Wei-Yen Lim
- Weili Yan
- Wen-Harn Pan
- Wenbin Wei
- Wendy Van Lippevelde
- Wenhua Zhao
- Wichai Aekplakorn
- Willem A Hanekom
- William A Neal
- William R Tebar
- Wilma M Hopman
- Winsome R Parnell
- Wm Monique Verschuren
- Wojciech Drygas
- Wojciech Rusek
- Wolfgang Ahrens
- Wolfgang Kratzer
- Xenophon Theodoridis
- Xiangjun Wang
- Xiaoguang Yang
- Xiaotian Liu
- Ximena Berrios Carrasola
- Xinyi Gwee
- Xiu-Hua Guo
- Xu Lin
- Xu Ma
- Xueling Sim
- Xun Tang
- Ya Xing Wang
- Yadlapalli S Kusuma
- Yajaira Briceño
- Yang Yang
- Yanhui Dong
- Yanina Zocalo
- Yanitsa V Zhecheva
- Yannis Manios
- Yanping Li
- Yemane Berhane
- Yeunsook Rho
- Yeva Movsesyan
- Yi Song
- Yi Zeng
- Yih Chung Tham
- Yiling J Cheng
- Yin Guo
- Ying-Wei Wang
- Yingfeng Zheng
- Yn-Tz Sung
- Yong Tao
- Yonghua Hu
- Yosef Farzi
- Yoto Yotov
- Youcef Laid
- Young-Ho Khang
- Yousef Saleh Khader
- Yu-Ling Yu
- Yuan He
- Yufang Bi
- Yuki Fujita
- Yulia Balanova
- Yuliya V Solovieva
- Yuna He
- Yunjiang Yu
- Yury P Nikitin
- Yves Kameli
- Yves Martin-Prevel
- Yvonne T van der Schouw
- Zahra Mohammadi
- Zbigniew Gaciong
- Zbigniew Kulaga
- Zengchang Pang
- Zhamilya Battakova
- Zhamyila Usupova
- Zhanna Kalmatayeva
- Zhen-Yu Zhang
- Zhengming Chen
- Ziad A Abdeen
- Zivka Dika
- Zlatko Fras
- Zulfiqar A Bhutta
- Zulfiya Abdurrahmonova
- Zumin Shi
- Łukasz Kryst
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We
estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from
1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods We used data from 3663 population-based studies with 222 million participants that measured height and
weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate
trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children
and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the
individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference)
and obesity (BMI >2 SD above the median).
Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in
11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed
changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and
140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of
underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and
countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior
probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse
was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of
thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a
posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%)
with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and
obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for
both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such
as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged
children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls
in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and
42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents,
the increases in double burden were driven by increases in obesity, and decreases in double burden by declining
underweight or thinness.
Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an
increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy
nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of
underweight while curbing and reversing the increase in obesit
stairs and fire
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adair Antony
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Arora Sanjay
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Beernaert Kelly
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belotelov Ivan
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biasotto Massimo
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilinskas Mykolas Jurgis
- Bilki Burak
- Bilmis Selcuk
- Biselli Angela
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Bobrovskyi Sergei
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodin David
- Boimska Bozena
- Boldizsar Laszlo
- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Caebergs Thierry
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Callner Jeremy
- Calvert Brian
- Calvo Enrique
- Campagnari Claudio
- Campbell Alan
- Camporesi Tiziano
- Capiluppi Paolo
- Caponeri Benedetta
- Cappello Gigi
- Cardaci Marco
- Carlin Roberto
- Carlsmith Duncan
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casal Bruno
- Casimiro Linares Edgar
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Castro Elena
- Caudron Julien
- Caulfield Matthew
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerizza Giordano
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Chen Zhiling
- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Cho Yongjin
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Conetti Sergio
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooper William
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cuplov Vesna
- Curé Benoît
- Cushman Priscilla
- Cussans David
- Custódio Analu
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- Da Cunha Marinho Franciole
- Daci Nadir
- Dahmes Bryan
- Dahms Torsten
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Dammann Dirk
- Danielson Thomas
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- Dauncey Paul
- David Tinoco Mendes Andre
- Davids Martina
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Cosa Annapaola
- De Favereau De Jeneret Jerome
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F.
- De Visscher Simon
- De Wolf Eddi A.
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delgado Peris Antonio
- Deliomeroglu Mehmet
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Dermenev Alexander
- Dero Vincent
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
- Di Marco Emanuele
- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dirkes Guido
- Dissertori Günther
- Dittmar Michael
- Djordjevic Milos
- Dobrzynski Ludwik
- Dobson Marc
- Dobur Didar
- Doesburg Robert
- Dogangun Oktay
- Dolen James
- Dominguez Aaron
- Dominik Wojciech
- Domínguez Vázquez Daniel
- Dorigo Tommaso
- Dorney Brian
- Doroba Krzysztof
- Dos Reis Martins Thiago
- Dosselli Umberto
- Dozen Candan
- Draeger Jula
- Dragicevic Marko
- Dragoiu Cosmin
- Drell Brian Robert
- Dremin Igor
- Drouhin Frédéric
- Drozdetskiy Alexey
- Du Pree Tristan
- Duarte Campderros Jordi
- Duarte Javier
- Dubinin Mikhail
- Dudero Phillip Russell
- Dudko Lev
- Dugad Shashikant
- Duggan Daniel
- Dumanoglu Isa
- Dupont-Sagorin Niels
- Duric Senka
- Duris Joseph
- Durkin Lloyd Stanley
- Duru Firdevs
- Dutta Dipanwita
- Dutta Suchandra
- Dutta Valentina
- Dzelalija Mile
- Dünser Marc
- Eads Michael
- Eartly David P.
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
- Edelhoff Matthias
- Edelmaier Christopher
- Eerola Paula
- Efron Jonathan
- Eggert Nicholas
- Ekmedzic Marko
- El Mamouni Houmani
- Elgammal Sherif
- Elliott-Peisert Anna
- Ellison John Anthony
- Ellithi Kamel Ali
- Elmer Peter
- Elvira Victor Daniel
- Enderle Holger
- Engh Daniel
- Eno Sarah Catherine
- Epshteyn Vladimir
- Erbacher Robin
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- Newman-Holmes Catherine
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- Polatoz Ayse
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- Polic Dunja
- Poll Anthony
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- Popov Vladimir
- Pordes Ruth
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- Radburn-Smith Benjamin Charles
- Radi Amr
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- Rander John
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- Ratti Sergio P.
- Raupach Frank Arthur
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- Rebane Liis
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- Reithler Hans
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- Rennefeld Jörg
- Renz Manuel
- Reucroft Steve
- Reyes-Santos Marco A.
- Ribeiro Cipriano Pedro M.
- Ribeiro Pedro Quinaz
- Ribnik Jacob
- Riccardi Cristina
- Richards Alan
- Richman Jeffrey
- Rinkevicius Aurelijus
- Rizzi Andrea
- Ro Sang-Ryul
- Roberts Jay
- Robles Jorge
- Robmann Peter
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- Rodozov Mircho
- Rodrigo Teresa
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- Rodriguez Jorge Luis
- Rodríguez-Marrero Ana Yaiza
- Roe Jeffrey
- Rogan Christopher
- Rogerson Samuel
- Roh Youn
- Rohe Tilman
- Rohlf James
- Rohringer Christine
- Rohringer Herbert
- Roland Benoit
- Roland Christof
- Roland Gunther
- Rolandi Gigi
- Romano Francesco
- Romanowska-Rybinska Katarzyna
- Romeo Francesco
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- Romero Luciano
- Rommerskirchen Tanja
- Rompotis Nikolaos
- Ronchese Paolo
- Ronga Frederic Jean
- Rose Andrew
- Rose Keith
- Rosin Michele
- Rosowsky André
- Ross Ian
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- Rossi Antonio
- Rossin Roberto
- Rossini Marco
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- Rovelli Tiziano
- Rovere Marco
- Ruchti Randy
- Rudolph Matthew
- Ruiz-Jimeno Alberto
- Rumerio Paolo
- Rusack Roger
- Rusakov Sergey V.
- Ruspa Marta
- Russ James
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- Ryan Matthew John
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- Sakumoto Willis
- Sala Leonardo
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- Salerno Roberto
- Salfeld-Nebgen Jakob
- Salur Sevil
- Salvati Emmanuele
- Sammet Jan
- Sanabria Juan Carlos
- Sanchez Ann - Karin
- Sander Christian
- Sanders David A.
- Sanders Stephen
- Sani Matteo
- Santanastasio Francesco
- Santaolalla Javier
- Santocchia Attilio
- Santoro Alberto
- Saoulidou Niki
- Saout Christophe
- Sarkar Subir
- Sarycheva Ludmila
- Sasseville Michael
- Sauerland Philip
- Savin Alexander
- Savrin Viktor
- Sawley Marie-Christine
- Scarborough Tara
- Schael Stefan
- Schettler Hannes
- Scheurer Armin
- Schieferdecker Philipp
- Schilling Frank-Peter
- Schlein Peter
- Schleper Peter
- Schlieckau Eike
- Schmanau Mike
- Schmidt Alexander
- Schmidt Ringo
- Schmitt Michael Henry
- Schmitt Michael Houston
- Schmitz Stefan Antonius
- Schnetzer Steve
- Schoerner-Sadenius Thomas
- Schott Gregory
- Schröder Matthias
- Schul Nicolas
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- Schwarz Thomas
- Schwick Christoph
- Schäfer Christoph
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- Scurlock Bobby
- Searle Matthew
- Seez Christopher
- Segala Michael
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- Seixas Joao
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- Selvaggi Michele
- Semenov Sergey
- Sen Niladri
- Sen Sercan
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- Sengupta Sinjini
- Senkin Sergey
- Seo Eunsung
- Seo Hyunkwan
- Serban Alin Titus
- Serin Meltem
- Sever Ramazan
- Sexton-Kennedy Elizabeth
- Sfiligoi Igor
- Sguazzoni Giacomo
- Shah Mehar Ali
- Sharma Archana
- Sharma Archana
- Sharma Seema
- Sharma Varun
- Sharma Vivek
- Sheldon Paul
- Shepherd-Themistocleous Claire H.
- Shi Xin
- Shipkowski Simon Peter
- Shipsey Ian
- Shiu Jing-Ge
- Shivpuri Ram Krishen
- Shmatov Sergey
- Shoaib Muhammad
- Shrestha Shruti
- Shreyber Irina
- Shukla Prashant
- Shumeiko Nikolai
- Sibille Jennifer
- Siegrist Patrice
- Sigamani Michael
- Sikler Ferenc
- Silkworth Christopher
- Sill Alan
- Sillou Daniel
- Silva Do Amaral Sheila Mara
- Silva Pedro
- Silvers David
- Silverwood Hamish
- Silvestre Catherine
- Silvestris Lucia
- Sim Kwang Souk
- Simon Michal
- Simon Sean
- Simonetto Franco
- Simonis Hans-Jürgen
- Singh Anil
- Singh Gurpreet
- Singh Jasbir
- Singh Supreet Pal
- Singovsky Alexander
- Sinthuprasith Tutanon
- Sirois Yves
- Siroli Gianni
- Sirunyan Albert M.
- Skhirtladze Nikoloz
- Skuja Andris
- Slaunwhite Jason
- Smirnov Igor
- Smirnov Vitaly
- Smith James
- Smith John
- Smith Kenneth
- Smith Vincent J.
- Smith Wesley H.
- Snigirev Alexander
- Snoek Hella
- Snook Benjamin
- Snow Gregory R.
- Snowball Matthew
- Soares Jorge Luana
- Sobol Andrei
- Sobron Sanudo Mar
- Soffi Livia
- Sogut Kenan
- Solano Ada
- Somalwar Sunil
- Son Dong-Chul
- Song Sanghyeon
- Sonmez Nasuf
- Sonnenschein Lars
- Sordini Viola
- Souza Dos Anjos Tiago
- Spagnolo Paolo
- Spalding William J.
- Spanier Stefan
- Sparrow Alex
- Speer Thomas
- Sperka David
- Sphicas Paraskevas
- Spiegel Leonard
- Spiga Daniele
- Spiridonov Alexander
- Spiropulu Maria
- Sprenger Daniel
- Squires Michael
- St John Jason
- Stadie Hartmut
- Stahl Achim
- Staiano Amedeo
- Starodumov Andrei
- Steggemann Jan
- Stein Matthias
- Steinbrück Georg
- Stenson Kevin
- Stephans George
- Stickland David
- Stieger Benjamin
- Stiliaris Efstathios
- Stober Fred-Markus Helmut
- Stolin Viatcheslav
- Stone Robert
- Stoye Markus
- Stoykova Stefka
- Stoynev Stoyan
- Strauss Josef
- Stringer Robert
- Strobbe Nadja
- Strom Derek
- Stuart David
- Sturdy Jared
- Stöckli Fabian
- Suarez Gonzalez Juan
- Suarez Indara
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- Tabarelli de Fatis Tommaso
- Tadel Matevz
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- Tali Bayram
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- Tan Ping
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- Taroni Silvia
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- Taurok Anton
- Tauscher Ludwig
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- Teischinger Florian
- Temple Jeffrey
- Tenchini Roberto
- Teng Haiyun
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- Teyssier Daniel
- Thea Alessandro
- Theofilatos Konstantinos
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- Tomalin Ian R.
- Tomaszewska Justyna
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- Tonelli Guido
- Tonjes Marguerite
- Tonwar Suresh C.
- Topakli Huseyin
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- Triantis Frixos A.
- Tricomi Alessia
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- Trocino Daniele
- Trocsanyi Zoltan Laszlo
- Troendle Daniel
- Troitsky Sergey
- Tropiano Antonio
- Troshin Sergey
- Tsang Ka Vang
- Tschudi Yohann
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- Tully Christopher
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- Uplegger Lorenzo
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- Van Haevermaet Hans
- Van Hove Pierre
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- Van Onsem Gerrit Patrick
- Van Remortel Nick
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- Vander Velde Catherine
- Vanelderen Lukas
- Vanini Sara
- Vanlaer Pascal
- Varela Joao
- Varelas Nikos
- Vartak Adish
- Vasquez Sierra Ricardo
- Vaughan Jennifer
- Vavilov Sergey
- Vazquez Acosta Monica
- Vazquez Valencia Fabiola
- Veelken Christian
- Veeraraghavan Venkatesh
- Velasco Mayda
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- Velkovska Julia
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- Verdier Patrice
- Verdini Piero Giorgio
- Veres Gabor Istvan
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- Vergili Mehmet
- Verwilligen Piet
- Verzetti Mauro
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- Vesztergombi Gyorgy
- Veverka Jan
- Vichoudis Paschalis
- Vidal Marono Miguel
- Vidal Richard
- Vila Ivan
- Vilar Cortabitarte Rocio
- Vilela Pereira Antonio
- Villasenor-Cendejas Luis Manuel
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
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- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Viviani Claudio
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vodopiyanov Igor
- Vogel Helmut
- Volkov Alexey
- Volobouev Igor
- Volodko Anton
- Volpe Roberta
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Philipp
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
- Wallny Rainer
- Walsh Roberval
- Walsh Sinead
- Waltenberger Wolfgang
- Walzel Gerhard
- Wan Zongru
- Wang Dayong
- Wang Jian
- Wang Jian
- Wang Minzu
- Wang Siguang
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wardrope David
- Wasserbaech Steven
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Wehrli Lukas
- Weiler Thomas
- Weinberg Marc
- Wendland Lauri
- Weng Joanna
- Weng Yao
- Wenger Edward Allen
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Whyntie Tom
- Wickens John
- Wickramage Nadeesha
- Widl Edmund
- Wigmans Richard
- Wilken Rachel
- Wilkinson Richard
- Williams Grayson
- Williams Thomas
- Willmott Carlos
- Wimpenny Stephen
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wolf Matthias
- Wolf Roger
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xu Ming
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yildirim Eda
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Marco
- Zang Jingjing
- Zang Shi-Lei
- Zarubin Anatoli
- Zatserklyaniy Andriy
- Zeinali Maryam
- Zeise Manuel
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Zhen
- Zheng Yu
- Zhokin Alexander
- Zhu Bo
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Ziebarth Eva Barbara
- Ziegler Jill
- Zielinski Marek
- Zito Giuseppe
- Zotto Pierluigi
- Zou Wei
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2012
- Field of study
Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Acosta Darin
- Acosta Jhon Gabriel
- Adam Nadia
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Afanasiev Serguei
- Agostino Lorenzo
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Aguilo Ernest
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alexander James
- Aliev Takhmasib
- Almeida Nuno
- Alver Burak
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Jacob
- Anderson Michael
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Anghel Ioana Maria
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Aranyi Attila
- Arce Pedro
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arfaei Hessamaddin
- Argiro Stefano
- Arisaka Katsushi
- Arneodo Michele
- Asaadi Jonathan
- Asghar Muhammad Irfan
- Askew Andrew
- Assran Yasser
- Ata Metin
- Atac Muzaffer
- Atramentov Oleksiy
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avery Paul
- Avetisyan Aram
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Bacchetta Nicola
- Bachtis Michail
- Baden Drew
- Baesso Paolo
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bai Yuting
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Bakken Jon Alan
- Balazs Michael
- Ball Austin
- Ball Gordon
- Ballin Jamie
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Banzuzi Kukka
- Barbagli Giuseppe
- Barberis Emanuela
- Barbone Lucia
- Bardak Cemile
- Barfuss Anne-fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barnes Virgil E.
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Barrett Matthew
- Bartalini Paolo
- Barth Christian
- Basegmez Suzan
- Basso Lorenzo
- Battilana Carlo
- Baty Clement
- Bauer Gerry
- Bauer Julia
- Bauerdick Lothar A. T.
- Baumgartel Darin
- Baur Ulrich
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaupere Nicolas
- Bedjidian Marc
- Behrenhoff Wolf
- Behrens Ulf
- Belforte Stefano
- Beliy Nikita
- Bell Alan James
- Bell Ken W.
- Bellan Paolo
- Bellan Riccardo
- Bellinger James Nugent
- Belyaev Alexander
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Bender Walter
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beretvas Andrew
- Bergauer Thomas
- Bergholz Matthias
- Beri Suman Bala
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Berzano Umberto
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Beuselinck Raymond
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialas Wojciech
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilinskas Mykolas Jurgis
- Bilki Burak
- Bilmis Selcuk
- Biselli Angela
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Ingo
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Bobrovskyi Sergei
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Bodin David
- Boeriu Oana
- Boldizsar Laszlo
- Bolla Gino
- Bolognesi Sara
- Bolton Tim
- Bona Marcella
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bontenackels Michael
- Boos Edouard
- Borcherding Frederick
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bostock Francis
- Botta Cristina
- Boudoul Gaelle
- Boulahouache Chaouki
- Boumediene Djamel
- Bourilkov Dimitri
- Boutemeur Madjid
- Boutle Sarah
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G.
- Breedon Richard
- Breuker Horst
- Brew Christopher
- Brigliadori Luca
- Brigljevic Vuko
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Broutin Clementine
- Brown Robert M.
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Buchmuller Oliver
- Buege Volker
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Cabrera Andrés
- Cabrillo Iban Jose
- Caebergs Thierry
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Callner Jeremy
- Calvo Enrique
- Camanzi Barbara
- Caminada Lea
- Campagnari Claudio
- Campbell Alan
- Camporesi Tiziano
- Capiluppi Paolo
- Caponeri Benedetta
- Cappello Gigi
- Cardaci Marco
- Carlin Roberto
- Carlsmith Duncan
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casimiro Linares Edgar
- Cassel David
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Castro Elena
- Caudron Julien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerizza Giordano
- Cerminara Gianluca
- Ceron Cristobal
- Cerrada Marcos
- Chabert Eric Christian
- Chadwick Matthew
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Matthew
- Chandra Avdhesh
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chang Yuan-Hann
- Chanon Nicolas
- Chao Yuan
- Charaf Otman
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chauhan Sushil
- Checchia Paolo
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Yi
- Chen Zhiling
- Cheng Teh Lee
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chierici Roberto
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C.
- Choudhury Rajani Kant
- Choudhury Somnath
- Christiansen Tim
- Chuang Shan-Huei
- Chung Jin Hyuk
- Chung Yeon Sei
- Chwalek Thorsten
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Cirino Guy
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R.
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David J. A.
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Contardo Didier
- Conte Eric
- Conway John
- Cooper Seth
- Cooper William
- Cortina Gil Eduardo
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Coughlan John A.
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cuplov Vesna
- Curé Benoît
- Cushman Priscilla
- Cussans David
- Cutajar Michael
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- Zotto Pierluigi
- Zou Wei
- Zumerle Gianni
- Zuranski Andrzej
- Zöller Marc Henning
- Publication venue
- Publication date
- 01/01/2011
- Field of study
A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació
Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.
- Author
- Publication venue
- DigitalCommons@TMC
- Publication date
- 01/05/2009
- Field of study
BACKGROUND AND PURPOSE: Familial aggregation of intracranial aneurysms (IA) strongly suggests a genetic contribution to pathogenesis. However, genetic risk factors have yet to be defined. For families affected by aortic aneurysms, specific gene variants have been identified, many affecting the receptors to transforming growth factor-beta (TGF-beta). In recent work, we found that aortic and intracranial aneurysms may share a common genetic basis in some families. We hypothesized, therefore, that mutations in TGF-beta receptors might also play a role in IA pathogenesis.
METHODS: To identify genetic variants in TGF-beta and its receptors, TGFB1, TGFBR1, TGFBR2, ACVR1, TGFBR3, and ENG were directly sequenced in 44 unrelated patients with familial IA. Novel variants were confirmed by restriction digestion analyses, and allele frequencies were analyzed in cases versus individuals without known intracranial disease. Similarly, allele frequencies of a subset of known SNPs in each gene were also analyzed for association with IA.
RESULTS: No mutations were found in TGFB1, TGFBR1, TGFBR2, or ACVR1. Novel variants identified in ENG (p.A60E) and TGFBR3 (p.W112R) were not detected in at least 892 reference chromosomes. ENG p.A60E showed significant association with familial IA in case-control studies (P=0.0080). No association with IA could be found for any of the known polymorphisms tested.
CONCLUSIONS: Mutations in TGF-beta receptor genes are not a major cause of IA. However, we identified rare variants in ENG and TGFBR3 that may be important for IA pathogenesis in a subset of families
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