A reply to Gallagher, O'Donnell, Minescu, & Muldoon's commentary on 'The effects of identification with a support group on the mental health of people with multiple sclerosis'

We wish to thank Gallagher and his colleagues for their kind words and insightful comments regarding our recent paper on the effects of identification with a support group on the mental health of people with multiple sclerosis. We too agree that this is an important area of research that is worthy of much future study. Below we provide a brief discussion of each of the three comments that Gallagher and colleagues made about our paper

Detection of Faint BLR Components in the Starburst/Seyfert Galaxy NGC 6221 and Measure of the Central BH Mass

In the last decade, using single epoch virial based techniques in the optical band, it has been possible to measure the central black hole mass on large AGN1 samples. However these measurements use the width of the broad line region as a proxy of the virial velocities and are therefore difficult to be carried out on those obscured (type 2) or low luminosity AGN where the nuclear component does not dominate in the optical. Here we present the optical and near infrared spectrum of the starburst/Seyfert galaxy NGC 6221, observed with X-shooter/VLT. Previous observations of NGC 6221 in the X-ray band show an absorbed (N_H=8.5 +/- 0.4 x 10^21 cm^-2) spectrum typical of a type 2 AGN with luminosity log(L_14-195 keV) = 42.05 erg/s, while in the optical band its spectrum is typical of a reddened (A_V=3) starburst. Our deep X-shooter/VLT observations have allowed us to detect faint broad emission in the H_alpha, HeI and Pa_beta lines (FWHM ~1400-2300 km/s) confirming previous studies indicating that NGC 6221 is a reddened starburst galaxy which hosts an AGN. We use the measure of the broad components to provide a first estimate of its central black hole mass (M_BH = 10^(6.6 +/- 0.3) Msol, lambda_Edd=0.01-0.03), obtained using recently calibrated virial relations suitable for moderately obscured (N_H<10^24 cm^-2) AGN.Comment: 13 pages, 3 figures, 1 table. Published in Frontiers in Astronomy and Space Science

Turning weak emitters into outstanding luminescent materials using rigid host media

The incorporation into rigid silica host structures leads successfully to a significant luminescence enhancement of two zinc(II) dipyrrins, known to be weak emitters in solution. One of these complexes shows a fluorescence efficiency of 55% and prolonged photo-stability once entrapped in silica, demonstrating high potential for applications in energy conversion

The Psychological Emptiness Scale:a psychometric evaluation

BACKGROUND: Feelings of emptiness are commonly reported as deeply distressing experiences. Despite established relationships between emptiness and many mental health difficulties, alongside self-harm and suicide, further study into this phenomenon has been restricted by vague definition and clinical measures with limited utility. Recently the first definition validated by individuals with lived experience of emptiness has been conceptualised, providing an opportunity to create a new measure of emptiness.AIMS: This study aimed to psychometrically evaluate the 31-item Psychological Emptiness Scale (PES), identifying redundancy, and thus creating a psychometrically robust scale with optimised clinical utility.METHOD: Utilising an online survey design, 768 participants completed the 31 items of the initial PES alongside other measures of mental health. Exploratory factor analysis was conducted, and item response theory employed to identify item redundancy and reduce test burden. Expert clinicians provided ratings of each item's clinical relevance and, combined with the psychometric analysis, led to the removal of a number of items. Confirmatory factor analysis was then undertaken. Reliability including test-retest, validity and sensitivity of the measure were evaluated.RESULTS: A two-factor structure encompassing 'nothingness' and 'detachment' was identified, and found to have acceptable fit. The resulting 19-item PES was found to have internal consistency (α = 0.95), convergent validity and test-retest reliability.CONCLUSIONS: This study demonstrated strong psychometric properties of the PES. The PES has potential to support research into the role of emptiness in psychological distress and treatment in clinical practice.</p

‘It was like coming back from the clouds’:a qualitative analysis of the lived experience of overdose consequent to drug use among a cohort of people who use drugs in Scotland

Background: Globally, non-fatal overdose (NFOD) rates consequent to drug use, typically opioids, continue increasing at a startling rate. Existing quantitative research has revealed myriad factors and characteristics linked to experiencing NFOD, but it is critically important to explore the lived context underlying these associations. In this qualitative study, we sought to understand the experiences of NFOD among people who use drugs in a Scottish region in order to: enhance public policy responses; inform potential intervention development to mitigate risk; and contribute to the literature documenting the lived experience of NFOD.Methods: From June to July 2021, two peer researchers conducted face-to-face semi-structured interviews with people who use drugs who had experienced recent NFOD attending harm reduction services in Tayside, Scotland. These were transcribed verbatim and evaluated using thematic analysis with an inductive approach which had an experiential and essentialist orientation.Results: Twenty people were interviewed across two sites. Of those, 15 (75%) were male and mean age was 38.2 (7.7) years. All had experienced at least one NFOD in the prior six months, and all reported polydrug use. Five themes were identified, within which 12 subthemes were situated. The themes were: social context; personal risk-taking triggers; planned and impulsive consumption; risk perception; and overdose reversal. The results spoke to the environmental, behavioural, cognitive, economic, and marketplace, factors which influence the context of NFOD in the region.Conclusions: A complex interplay of behavioural, psychological, and situational factors were found to impact the likelihood of experiencing NFOD. Structural inequities which policy professionals and civic leaders should seek to remedy were identified, while service providers may seek to reconfigure healthcare provision for people who use drugs to account for the interpersonal, psychological, and social factors identified, which appear to precipitate NFOD.Trial registration: Not applicable

Psychosocial factors associated with overdose subsequent to Illicit Drug use:a systematic review and narrative synthesis

Background and aims: Psychological and social status, and environmental context, may mediate the likelihood of experiencing overdose subsequent to illicit drug use. The aim of this systematic review was to identify and synthesise psychosocial factors associated with overdose among people who use drugs.Methods: This review was registered on Prospero (CRD42021242495). Systematic record searches were undertaken in databases of peer-reviewed literature (Medline, Embase, PsycINFO, and Cinahl) and grey literature sources (Google Scholar) for work published up to and including 14 February 2023. Reference lists of selected full-text papers were searched for additional records. Studies were eligible if they included people who use drugs with a focus on relationships between psychosocial factors and overdose subsequent to illicit drug use. Results were tabulated and narratively synthesised.Results: Twenty-six studies were included in the review, with 150,625 participants: of those 3,383–4072 (3%) experienced overdose. Twenty-one (81%) studies were conducted in North America and 23 (89%) reported polydrug use. Psychosocial factors associated with risk of overdose (n = 103) were identified and thematically organised into ten groups. These were: income; housing instability; incarceration; traumatic experiences; overdose risk perception and past experience; healthcare experiences; perception of own drug use and injecting skills; injecting setting; conditions with physical environment; and social network traits.Conclusions: Global rates of overdose continue to increase, and many guidelines recommend psychosocial interventions for dependent drug use. The factors identified here provide useful targets for practitioners to focus on at the individual level, but many identified will require wider policy changes to affect positive change. Future research should seek to develop and trial interventions targeting factors identified, whilst advocacy for key policy reforms to reduce harm must continue

Psychosocial factors associated with overdose subsequent to Illicit Drug use:a systematic review and narrative synthesis

Background and aims: Psychological and social status, and environmental context, may mediate the likelihood of experiencing overdose subsequent to illicit drug use. The aim of this systematic review was to identify and synthesise psychosocial factors associated with overdose among people who use drugs.Methods: This review was registered on Prospero (CRD42021242495). Systematic record searches were undertaken in databases of peer-reviewed literature (Medline, Embase, PsycINFO, and Cinahl) and grey literature sources (Google Scholar) for work published up to and including 14 February 2023. Reference lists of selected full-text papers were searched for additional records. Studies were eligible if they included people who use drugs with a focus on relationships between psychosocial factors and overdose subsequent to illicit drug use. Results were tabulated and narratively synthesised.Results: Twenty-six studies were included in the review, with 150,625 participants: of those 3,383–4072 (3%) experienced overdose. Twenty-one (81%) studies were conducted in North America and 23 (89%) reported polydrug use. Psychosocial factors associated with risk of overdose (n = 103) were identified and thematically organised into ten groups. These were: income; housing instability; incarceration; traumatic experiences; overdose risk perception and past experience; healthcare experiences; perception of own drug use and injecting skills; injecting setting; conditions with physical environment; and social network traits.Conclusions: Global rates of overdose continue to increase, and many guidelines recommend psychosocial interventions for dependent drug use. The factors identified here provide useful targets for practitioners to focus on at the individual level, but many identified will require wider policy changes to affect positive change. Future research should seek to develop and trial interventions targeting factors identified, whilst advocacy for key policy reforms to reduce harm must continue

Extending Virial Black Hole Mass Estimates to Low-Luminosity or Obscured AGN: the cases of NGC 4395 and MCG -01-24-012

In the last decade, using single epoch (SE) virial based spectroscopic optical observations, it has been possible to measure the black hole (BH) mass on large type 1 Active Galactic Nuclei (AGN) samples. However this kind of measurements can not be applied on those obscured type 2 and/or low luminosity AGN where the nuclear component does not dominate in the optical. We have derived new SE relationships, based on the FWHM and luminosity of the broad line region component of the Pabeta emission line and/or the hard X-ray luminosity in the 14-195 keV band, which have the prospect of better working with low luminosity or obscured AGN. The SE relationships have been calibrated in the 10^5-10^9 M_sol mass range, using a sample of AGN whose BH masses have been previously measured using reverberation mapping techniques. Our tightest relationship between the reverberation-based BH mass and the SE virial product has an intrinsic spread of 0.20 dex. Thanks to these SE relations, in agreement with previous estimates, we have measured a BH mass of M_BH =1.7^+1.3_-0.7 X 10^5 M_sol for the low luminosity, type 1, AGN NGC 4395 (one of the smallest active galactic BH known). We also measured, for the first time, a BH mass of M_BH = 1.5^+1.1_-0.6 X 10^7 M_sol for the Seyfert 2 galaxy MCG -01-24-012.Comment: 10 pages, 7 figures. Accepted by MNRA

The effects of identification with a support group on the mental health of people with multiple sclerosis

Objective: Multiple Sclerosis (MS) is associated with various psychological problems, including depression and anxiety. Whilst MS support groups are intended to improve mental health, this goal is not always achieved. Taking a social identity approach, we hypothesise that it is the level of subjective identification with a support group (rather than simply support group membership per se) that positively affects the mental health of people with MS. Methods: 152 individuals with MS were recruited via UK MS support groups and completed a questionnaire. This included measures of support group identification, depression, anxiety and satisfaction with life, as well as control variables (education level and age). Results: Analyses revealed that, as hypothesised, support group identification was significantly linked to depression, anxiety and satisfaction with life. Moreover, group identification explained a significant amount of variance in addition to that explained by education and age on each health outcome. Repeating the analysis to compare each of the three main sub-types of MS revealed these effects to be present for individuals with Relapsing-Remitting (RR) and Primary Progressive (PP) MS, but not for those with Secondary Progressive (SP) MS. Conclusions: We suggest that identifying highly with an MS support group has important positive outcomes for MS patients’ mental health. This has implications for practicing clinicians: people with MS (particularly RRMS and PPMS) should be encouraged to engage with support groups, but more must be done to ensure they subjectively identify with these groups, rather than merely attend them