Wastelands Afforestation in Northern India by Cooperatives: A Socio-Economic Evaluation

India has an estimated area of 129 million ha of wasteland, which can be used for providing sustainable livelihood for millions of rural unemployed. An evaluation of enhancing income and employment generation and environmental externalities due to plantations on wastelands through cooperatives and self-help groups was done. The development process was set up in leased degraded lands in three north Indian states of Madhya Pradesh, Uttar Pradesh and Rajasthan. The capacity building processes like savings and micro-enterprise skills empowered resource-poor farmers. An internal rate of return of 11.5 to 17.0 % in the phase I of the project imply tangible economic benefits at the end of 17 years, which improved to 13.9 to 20.4 % by including environmental benefits like carbon sequestration, soil conservation, soil salinity reclamation, etc. By extrapolating the trend till the end of 30 years, the estimated IRR increased further. The incremental net return due to afforestation of wastelands ranged between Rs. 2283 and 9514 (US $51 -211) ha-1 yr -1 over the pre-developed status. The organization of stakeholders through cooperative societies for developing plantations on degraded lands and managing them for deriving benefits has demonstrated the viability of these models. The model can be replicated by dovetailing the same with the government schemes like food-for work programme and the recently enacted national rural employment guarantee programme.common pool resources, environmental evaluation, farmers, micro enterprises, self-help groups, Land Economics/Use,

Forestry to Support Increased Agricultural Production: Focus on Employment Generation and Rural Development

India possesses several advantages due to its varied ecological range and agro-climates to cultivate several important and diverse commercial food commodities ranging from cereals, fruits and spices to medicinal plants. The country has abundance of human resource comprising skilled, educated, technical and scientific manpower on one hand and unskilled manpower on the other. Forests- and agriculture-based industries are a major source of employment in the primary, secondary and tertiary sectors all over the country. This article has presented a brief overview of the potential of forest and agriculture in generating employment, providing livelihood and environmental services, sequestration of green house gases, carbon trading, rehabilitation of degraded lands, production of fuel wood, etc. There are clear linkages and synergies between agricultural production and sustainable forest management. If the sustainability of the agriculture and forests can be assured, food security and employment generation would go in long-term perpetuity.Community/Rural/Urban Development, Resource /Energy Economics and Policy,

Impact of Shelterbelts on Net Returns from Agricultural Production in Arid Western Rajasthan

This paper has documented the impact of shelterbelt on agricultural returns by collecting primary data from 80 farmers each in shelterbelt and non-shelterbelt areas. To decompose the total change in net returns, separate production functions have been estimated for shelterbelt and non-shelterbelt farms. The study has revealed an increase of 430.8 per cent in net returns due to shelterbelt plantation, in which shelterbelt technology has contributed 399.4 per cent and increase in use of complementary inputs, 31.4 per cent. In the change of 399.4 per cent, shelterbelt has accounted for 305.6 per cent, i.e. shifting from non- shelterbelt to shelterbelt and remaining 93.8 per cent has been due to inputs used by non-shelterbelt, which might be due to improvement in soil health.Agricultural Finance,

Clinical and molecular characterization of HER2 amplified-pancreatic cancer

<p>Background: Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing of therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements in outcome. Although HER2 amplification occurs in pancreatic cancer, it is inadequately characterized to exploit the potential of anti-HER2 therapies.</p> <p>Methods: HER2 amplification was detected and further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined HER2 amplification in a large cohort of patients (n = 469) with pancreatic ductal adenocarcinoma (PDAC).</p> <p>Results: An amplified inversion event (1 MB) was identified at the HER2 locus in a patient with PDAC. Using standardized laboratory assays, we established diagnostic criteria for HER2 amplification in PDAC, and observed a prevalence of 2%. Clinically, HER2- amplified PDAC was characterized by a lack of liver metastases, and a preponderance of lung and brain metastases. Excluding breast and gastric cancer, the incidence of HER2-amplified cancers in the USA is >22,000 per annum.</p> <p>Conclusions: HER2 amplification occurs in 2% of PDAC, and has distinct features with implications for clinical practice. The molecular heterogeneity of PDAC implies that even an incidence of 2% represents an attractive target for anti-HER2 therapies, as options for PDAC are limited. Recruiting patients based on HER2 amplification, rather than organ of origin, could make trials of anti-HER2 therapies feasible in less common cancer types.</p&gt

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies were observed to deplete Treg cells in the periphery, upregulation of the inhibitory Fc gamma receptor (FcγR) IIb at the tumor site prevented intra-tumoral Treg cell depletion, which may underlie the lack of anti-tumor activity previously observed in pre-clinical models. Use of an anti-CD25 antibody with enhanced binding to activating FcγRs led to effective depletion of tumor-infiltrating Treg cells, increased effector to Treg cell ratios, and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies promoted complete tumor rejection, demonstrating the relevance of CD25 as a therapeutic target and promising substrate for future combination approaches in immune-oncology

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor responses and survival. In patients with advanced melanoma, response to ipilimumab was associated with the CD16a-V158F high affinity polymorphism. Such activity only appeared relevant in the context of inflamed tumors, explaining the modest response rates observed in the clinical setting. Our data suggest that the activity of anti-CTLA-4 in inflamed tumors may be improved through enhancement of FcγR binding, whereas poorly infiltrated tumors will likely require combination approaches

Regulation of fat mobilisation in normal subjects in the post-absorptive state Role of hormones

SIGLEAvailable from British Library Document Supply Centre-DSC:D192653 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Not Available

Not AvailableInfiltration characteristics of different landuse systems in class III and class IV lands of shivalik foothills were compared, It was observed that , infiltration rate ,cumulative infiltration and sorptivity rate improved in Eycalyptus+Bhabbar grass based system in comparison to Eucalyptus+Saccharum munja and Eucalyptus+Vertiver agro-forestry systemNot Availabl

Wastelands Afforestation in Northern India by Cooperatives: A Socio-Economic Evaluation

India has an estimated area of 129 million ha of wasteland, which can be used for providing sustainable livelihood for millions of rural unemployed. An evaluation of enhancing income and employment generation and environmental externalities due to plantations on wastelands through cooperatives and self-help groups was done. The development process was set up in leased degraded lands in three north Indian states of Madhya Pradesh, Uttar Pradesh and Rajasthan. The capacity building processes like savings and micro-enterprise skills empowered resource-poor farmers. An internal rate of return of 11.5 to 17.0 % in the phase I of the project imply tangible economic benefits at the end of 17 years, which improved to 13.9 to 20.4 % by including environmental benefits like carbon sequestration, soil conservation, soil salinity reclamation, etc. By extrapolating the trend till the end of 30 years, the estimated IRR increased further. The incremental net return due to afforestation of wastelands ranged between Rs. 2283 and 9514 (US $51 -211) ha-1 yr -1 over the pre-developed status. The organization of stakeholders through cooperative societies for developing plantations on degraded lands and managing them for deriving benefits has demonstrated the viability of these models. The model can be replicated by dovetailing the same with the government schemes like food-for work programme and the recently enacted national rural employment guarantee programme

Systematic review of peri-operative prognostic biomarkers in pancreatic ductal adenocarcinoma

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) continues to be associated with a poor prognosis. This systematic review aimed to summarize the literature regarding potential prognostic biomarkers to facilitate validation studies and clinical application. METHODS: A systematic review was performed (2004-2014) according to PRISMA guidelines. Studies were ranked using REMARK criteria and the following outcomes were examined: overall/disease free survival, nodal involvement, tumour characteristics, metastasis, recurrence and resectability. RESULTS: 256 biomarkers were identified in 158 studies. 171 biomarkers were assessed with respect to overall survival: urokinase-type plasminogen activator receptor, atypical protein kinase C and HSP27 ranked the highest. 33 biomarkers were assessed for disease free survival: CD24 and S100A4 were the highest ranking. 17 biomarkers were identified for lymph node involvement: Smad4/Dpc4 and FOXC1 ranked highest. 13 biomarkers were examined for tumour grade: mesothelin and EGFR were the highest ranking biomarkers. 10 biomarkers were identified for metastasis: p16 and sCD40L were the highest ranking. 4 biomarkers were assessed resectability: sCD40L, s100a2, Ca 19-9, CEA. CONCLUSION: This review has identified and ranked specific biomarkers that should be a primary focus of ongoing validation and clinical translational work in PDAC