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The structural organization and protein composition of lens fiber junctions.
The structural organization and protein composition of lens fiber junctions isolated from adult bovine and calf lenses were studied using combined electron microscopy, immunolocalization with monoclonal and polyclonal anti-MIP and anti-MP70 (two putative gap junction-forming proteins), and freeze-fracture and label-fracture methods. The major intrinsic protein of lens plasma membranes (MIP) was localized in single membranes and in an extensive network of junctions having flat and undulating surface topologies. In wavy junctions, polyclonal and monoclonal anti-MIPs labeled only the cytoplasmic surface of the convex membrane of the junction. Label-fracture experiments demonstrated that the convex membrane contained MIP arranged in tetragonal arrays 6-7 nm in unit cell dimension. The apposing concave membrane of the junction displayed fracture faces without intramembrane particles or pits. Therefore, wavy junctions are asymmetric structures composed of MIP crystals abutted against particle-free membranes. In thin junctions, anti-MIP labeled the cytoplasmic surfaces of both apposing membranes with varying degrees of asymmetry. In thin junctions, MIP was found organized in both small clusters and single membranes. These small clusters also abut against particle-free apposing membranes, probably in a staggered or checkerboard pattern. Thus, the structure of thin and wavy junctions differed only in the extent of crystallization of MIP, a property that can explain why this protein can produce two different antibody-labeling patterns. A conclusion of this study is that wavy and thin junctions do not contain coaxially aligned channels, and, in these junctions, MIP is unlikely to form gap junction-like channels. We suggest MIP may behave as an intercellular adhesion protein which can also act as a volume-regulating channel to collapse the lens extracellular space. Junctions constructed of MP70 have a wider overall thickness (18-20 nm) and are abundant in the cortical regions of the lens. A monoclonal antibody raised against this protein labeled these thicker junctions on the cytoplasmic surfaces of both apposing membranes. Thick junctions also contained isolated clusters of MIP inside the plaques of MP70. The role of thick junctions in lens physiology remains to be determined
Plasticity facilitates sustainable growth in the commons
In the commons, communities whose growth depends on public goods, individuals
often rely on surprisingly simple strategies, or heuristics, to decide whether
to contribute to the common good (at risk of exploitation by free-riders).
Although this appears a limitation, here we show how four heuristics lead to
sustainable growth by exploiting specific environmental constraints. The two
simplest ones --contribute permanently or switch stochastically between
contributing or not-- are first shown to bring sustainability when the public
good efficiently promotes growth. If efficiency declines and the commons is
structured in small groups, the most effective strategy resides in contributing
only when a majority of individuals are also contributors. In contrast, when
group size becomes large, the most effective behavior follows a minimal-effort
rule: contribute only when it is strictly necessary. Both plastic strategies
are observed in natural systems what presents them as fundamental social motifs
to successfully manage sustainability
Drugs-related death soon after hospital discharge among drug treatment clients in Scotland:record linkage, validation and investigation of risk factors.
We validate that the 28 days after hospital-discharge are high-risk for drugs-related death (DRD) among drug users in Scotland and investigate key risk-factors for DRDs soon after hospital-discharge. Using data from an anonymous linkage of hospitalisation and death records to the Scottish Drugs Misuse Database (SDMD), including over 98,000 individuals registered for drug treatment during 1 April 1996 to 31 March 2010 with 705,538 person-years, 173,107 hospital-stays, and 2,523 DRDs. Time-at-risk of DRD was categorised as: during hospitalization, within 28 days, 29-90 days, 91 days-1 year, >1 year since most recent hospital discharge versus 'never admitted'. Factors of interest were: having ever injected, misuse of alcohol, length of hospital-stay (0-1 versus 2+ days), and main discharge-diagnosis. We confirm SDMD clients' high DRD-rate soon after hospital-discharge in 2006-2010. DRD-rate in the 28 days after hospital-discharge did not vary by length of hospital-stay but was significantly higher for clients who had ever-injected versus otherwise. Three leading discharge-diagnoses accounted for only 150/290 DRDs in the 28 days after hospital-discharge, but ever-injectors for 222/290. Hospital-discharge remains a period of increased DRD-vulnerability in 2006-2010, as in 1996-2006, especially for those with a history of injecting
Numerical Study of the Two Color Attoworld
We consider QCD at very low temperatures and non-zero quark chemical
potential from lattice Monte Carlo simulations of the two-color theory in a
very small spatial volume (the attoscale). In this regime the quark number
rises in discrete levels in qualitative agreement with what is found
analytically at one loop on S3xS1 with radius R_S3 << 1/{\Lambda}_QCD. The
detailed level degeneracy, however, cannot be accounted for using weak coupling
arguments. At each rise in the quark number there is a corresponding spike in
the Polyakov line, also in agreement with the perturbative results. In addition
the quark number susceptibility shows a similar behaviour to the Polyakov line
and appears to be a good indicator of a confinement-deconfinement type of
transition.Comment: 18 pages, 10 figure
A soliton menagerie in AdS
We explore the behaviour of charged scalar solitons in asymptotically global
AdS4 spacetimes. This is motivated in part by attempting to identify under what
circumstances such objects can become large relative to the AdS length scale.
We demonstrate that such solitons generically do get large and in fact in the
planar limit smoothly connect up with the zero temperature limit of planar
scalar hair black holes. In particular, for given Lagrangian parameters we
encounter multiple branches of solitons: some which are perturbatively
connected to the AdS vacuum and surprisingly, some which are not. We explore
the phase space of solutions by tuning the charge of the scalar field and
changing scalar boundary conditions at AdS asymptopia, finding intriguing
critical behaviour as a function of these parameters. We demonstrate these
features not only for phenomenologically motivated gravitational Abelian-Higgs
models, but also for models that can be consistently embedded into eleven
dimensional supergravity.Comment: 62 pages, 21 figures. v2: added refs and comments and updated
appendice
A solid state light-matter interface at the single photon level
Coherent and reversible mapping of quantum information between light and
matter is an important experimental challenge in quantum information science.
In particular, it is a decisive milestone for the implementation of quantum
networks and quantum repeaters. So far, quantum interfaces between light and
atoms have been demonstrated with atomic gases, and with single trapped atoms
in cavities. Here we demonstrate the coherent and reversible mapping of a light
field with less than one photon per pulse onto an ensemble of 10 millions atoms
naturally trapped in a solid. This is achieved by coherently absorbing the
light field in a suitably prepared solid state atomic medium. The state of the
light is mapped onto collective atomic excitations on an optical transition and
stored for a pre-programmed time up of to 1 mu s before being released in a
well defined spatio-temporal mode as a result of a collective interference. The
coherence of the process is verified by performing an interference experiment
with two stored weak pulses with a variable phase relation. Visibilities of
more than 95% are obtained, which demonstrates the high coherence of the
mapping process at the single photon level. In addition, we show experimentally
that our interface allows one to store and retrieve light fields in multiple
temporal modes. Our results represent the first observation of collective
enhancement at the single photon level in a solid and open the way to multimode
solid state quantum memories as a promising alternative to atomic gases.Comment: 5 pages, 5 figures, version submitted on June 27 200
Collective Excitations of Holographic Quantum Liquids in a Magnetic Field
We use holography to study N=4 supersymmetric SU(Nc) Yang-Mills theory in the
large-Nc and large-coupling limits coupled to a number Nf << Nc of
(n+1)-dimensional massless supersymmetric hypermultiplets in the Nc
representation of SU(Nc), with n=2,3. We introduce a temperature T, a baryon
number chemical potential mu, and a baryon number magnetic field B, and work in
a regime with mu >> T,\sqrt{B}. We study the collective excitations of these
holographic quantum liquids by computing the poles in the retarded Green's
function of the baryon number charge density operator and the associated peaks
in the spectral function. We focus on the evolution of the collective
excitations as we increase the frequency relative to T, i.e. the
hydrodynamic/collisionless crossover. We find that for all B, at low
frequencies the tallest peak in the spectral function is associated with
hydrodynamic charge diffusion. At high frequencies the tallest peak is
associated with a sound mode similar to the zero sound mode in the
collisionless regime of a Landau Fermi liquid. The sound mode has a gap
proportional to B, and as a result for intermediate frequencies and for B
sufficiently large compared to T the spectral function is strongly suppressed.
We find that the hydrodynamic/collisionless crossover occurs at a frequency
that is approximately B-independent.Comment: 45 pages, 8 png and 47 pdf images in 22 figure
Behavioral implications of shortlisting procedures
We consider two-stage “shortlisting procedures” in which the menu of alternatives is first pruned by some process or criterion and then a binary relation is maximized. Given a particular first-stage process, our main result supplies a necessary and sufficient condition for choice data to be consistent with a procedure in the designated class. This result applies to any class of procedures with a certain lattice structure, including the cases of “consideration filters,” “satisficing with salience effects,” and “rational shortlist methods.” The theory avoids background assumptions made for mathematical convenience; in this and other respects following Richter’s classical analysis of preference-maximizing choice in the absence of shortlisting
Abelian-Higgs and Vortices from ABJM: towards a string realization of AdS/CMT
We present ans\"{a}tze that reduce the mass-deformed ABJM model to gauged
Abelian scalar theories, using the fuzzy sphere matrices . One such
reduction gives a Toda system, for which we find a new type of nonabelian
vortex. Another gives the standard Abelian-Higgs model, thereby allowing us to
embed all the usual (multi-)vortex solutions of the latter into the ABJM model.
By turning off the mass deformation at the level of the reduced model, we can
also continuously deform to the massive theory in the massless ABJM
case. In this way we can embed the Landau-Ginzburg model into the AdS/CFT
correspondence as a consistent truncation of ABJM. In this context, the mass
deformation parameter and a field VEV act as and
respectively, leading to a well-motivated AdS/CMT construction from string
theory. To further this particular point, we propose a simple model for the
condensed matter field theory that leads to an approximate description for the
ABJM abelianization. Finally, we also find some BPS solutions to the
mass-deformed ABJM model with a spacetime interpretation as an M2-brane ending
on a spherical M5-brane.Comment: 43 pages, latex, explanations added in the introduction, end of
section 4, and on page 2
Recognition of cancer warning signs and anticipated time to help-seeking in a population sample of adults in the UK
Background: Not recognising a symptom as suspicious is a common reason given by cancer patients for delayed help-seeking; but inevitably this is retrospective. We therefore investigated associations between recognition of warning signs for breast, colorectal and lung cancer and anticipated time to help-seeking for symptoms of each cancer.
Methods: Computer-assisted telephone interviews were conducted with a population-representative sample (N=6965) of UK adults age greater than or equal to50 years, using the Awareness and Beliefs about Cancer scale. Anticipated time to help-seeking for persistent cough, rectal bleeding and breast changes was categorised as >2 vs less than or equal to2 weeks. Recognition of persistent cough, unexplained bleeding and unexplained lump as cancer warning signs was assessed (yes/no). Associations between recognition and help-seeking were examined for each symptom controlling for demographics and perceived ease of health-care access.
Results: For each symptom, the odds of waiting for >2 weeks were significantly increased in those who did not recognise the related warning sign: breast changes: OR=2.45, 95% CI 1.47–4.08; rectal bleeding: OR=1.77, 1.36–2.30; persistent cough: OR=1.30, 1.17–1.46, independent of demographics and health-care access.
Conclusion: Recognition of warning signs was associated with anticipating faster help-seeking for potential symptoms of cancer. Strategies to improve recognition are likely to facilitate earlier diagnosis
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