1,005 research outputs found
On representation of mechanical behavior and stereological measures of microstructure
Macroscopic homogeneity of a heterogeneous body is defined from various points of view. The applicability of the principle of Delesse to a single macroscopically homogeneous body is discussed. It is then seen that a function derived from a consideration of the area fraction of a phase can serve as a measure of clustering of particles of that phase
Bochdalek hernia with concomitant partial situs inversus in an adult
We report the case of 44-year-old woman with a left-sided Bochdalek hernia
(BH) with concomitant partial situs inversus. The patient was presented from
the outpatient clinic with lower chest discomfort. She had suffered from abdominal
pain for one year, with no history of trauma, previous surgery, or
extreme physical exertion. Chest radiograph revealed a large left-sided BH.
The patient underwent thoracotomy. Intestinal organs, containing bowel,
small intestine, caecum, and appendix were seen in the left hemithorax. Because
of the failure to reduce the intestinal organs into the peritoneal cavity,
laparotomy was performed. The right side of the abdominal cavity was empty.
In conclusion, partial situs inversus was diagnosed. The diaphragmatic
defect was repaired with non-absorbable sutures via laparotomy, and with
a prolene mesh via thoracotomy. Bochdalek hernia with partial situs inversus is
a rare clinical entity with none reported in medical literature. (Folia Morphol
2010; 69, 2: 119-122
One-year regional brain volume changes as potential predictors of cognitive function in multiple sclerosis: a pilot study
BackgroundThe most reliable magnetic resonance imaging (MRI) marker of cognitive dysfunction in multiple sclerosis (MS) is brain atrophy. However, 1-year volumetric changes prior to cognitive assessment were never studied as potential predictors of cognition, which we aim to assess with this pilot work.MethodsTwenty-two MS patients were submitted to a baseline measure of 83 regional brain volumes with MRI and re-evaluated 1 year later; they were also tested with the Brief International Cognitive Assessment for MS (BICAMS): sustained attention and processing speed were examined with the Symbol Digit Modalities Test (SDMT), verbal and visuo-spatial learning and memory with the learning trials from the California Verbal Learning Test-II (CVLT) and the Brief Visuo-spatial Memory Test-revised (BVMT), respectively. Controlling for age, sex, and years of education, a multivariate linear regression model was created for each cognitive score at 1-year follow-up in a backward elimination manner, considering cross-sectional regional volumes and 1-year volume changes as potential predictors.ResultsDecreases in the volumes of the left amygdala and the right lateral orbitofrontal cortex in the year prior to assessment were identified as possible predictors of worse performance in verbal memory (P = 0.009) and visuo-spatial memory (P = 0.001), respectively, independently of cross-sectional brain regional volumes at time of testing.ConclusionOur work reveals novel 1-year regional brain volume changes as potential predictors of cognitive deficits in MS. This suggests a possible role of these regions in such deficits and might contribute to uncover cognitively deteriorating patients, whose detection is still unsatisfying in clinical practice.Open access funding provided by FCT|FCCN (b-on). Biogen, Fundacao para a Ciencia e Tecnologia, UIDB/50026/2020, Fundacao para a ciencia e tecnologia, UIDP/50026/2020, Fundacao para a Ciencia e a Tecnologia, EXPL/MEC-NEU/0888/2021, Torcato Meira
A review of Morgagni and Bochdalek hernias in adults
The incidence of Bochdalek and Morgagni hernias among adults is very rare.
The purpose of this study was to determine retrospectively the prevalence and
characteristics of adult Bochdalek and Morgagni hernias in a decade. Consequently,
we demonstrated 12 patients with Bochdalek and 8 patients with
Morgagni hernias. We presented plain radiography, operation images, and
computed tomography findings of an adult patient with symptoms due to Bochdalek
and Morgagni hernias. In surgical repair, the Morgagni hernia is best
approached via laparotomy, and the Bochdalek hernia can be treated through
thoracotomy or laparotomy. (Folia Morphol 2011; 70, 1: 5-12
PTPN22 gene polymorphism in Takayasu's arteritis
Objective. Takayasu's arteritis (TA) is a chronic, rare granulomatous panarteritis of unknown aetiology involving mainly the aorta and its major branches. In this study, genetic susceptibility to TA has been investigated by screening the functional single nucleotide polymorphism (SNP) of PTPN22 gene encoding the lymphoid-specific protein tyrosine phosphatase. Methods. Totally, 181 patients with TA and 177 healthy controls are genotyped by PCR-RFLP method for the SNP rs2476601 (A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Results. Detected frequencies of heterozygous genotype (AG) were 5.1% (9/177) in control group and 3.8% (7/181) in TA group (P = 0.61, odds ratio: 0.75, 95% CI: 0.3, 2.0). No association with angiographic type, vascular involvement or prognosis of TA was observed either. Conclusion. The distribution of PTPN22 polymorphism did not reveal any association with TA in Turkey. © The Author 2008. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved
100 GHz resonant cavity enhanced Schottky photodiodes
Cataloged from PDF version of article.Resonant cavity enhanced (RCE) photodiodes are promising candidates for applications in optical communications and interconnects where ultrafast high-efficiency detection is desirable. We have designed and fabricated RCE Schottky photodiodes in the (Al, In) GaAs material system for 900-nm wavelength. The observed temporal response with 10-ps pulsewidth was limited
by the measurement setup and a conservative estimation of the bandwidth corresponds to more than 100 GHz. A direct comparison of RCE versus conventional detector performance was performed by high speed measurements under optical excitation at resonant wavelength (895 nm) and at 840 nm where the device functions as a single-pass conventional photodiode. A more than two-fold bandwidth enhancement with the RCE detection scheme was demonstrated
Materials with periodic internal structure: Computation based on homogenization and comparison with experiment
The combination of thermal and mechanical loading expected in practice means that constitutive equations of metal matrix composites must be developed which deal with time-independent and time-dependent irreversible deformation. Also, the internal state of composites is extremely complicated which underlines the need to formulate macroscopic constitutive equations with a limited number of state variables which represent the internal state at the micro level. One available method for calculating the macro properties of composites in terms of the distribution and properties of the constituent materials is the method of homogenization whose formulation is based on the periodicity of the substructure of the composite. A homogenization procedure was developed which lends itself to the use of the finite element procedure. The efficiency of these procedures, to determine the macroscopic properties of a composite system from its constituent properties, was demonstrated utilizing an aluminum plate perforated by directionally oriented slits. The selection of this problem is based on the fact that, extensive experimental results exist, the macroscopic response is highly anisotropic, and that the slits provide very high stress gradients which severely test the effectiveness of the computational procedures. Furthermore, both elastic and plastic properties were investigated so that the application to practical systems with inelastic deformation should be able to proceed without difficulty. The effectiveness of the procedures was rigorously checked against experimental results and with the predictions of approximate calculations. Using the computational results it is illustrated how macroscopic constitutive equations can be expressed in forms of the elastic and limit load behavior
Early postzygotic mutations contribute to de novo variation in a healthy monozygotic twin pair
Cataloged from PDF version of article.Background: Human de novo single-nucleotide variation (SNV) rate is estimated to range between 0.82-1.70×10-8 mutations per base per generation. However, contribution of early postzygotic mutations to the overall human de novo SNV rate is unknown. Methods: We performed deep whole-genome sequencing (more than 30-fold coverage per individual) of the whole-blood-derived DNA samples of a healthy monozygotic twin pair and their parents. We examined the genotypes of each individual simultaneously for each of the SNVs and discovered de novo SNVs regarding the timing of mutagenesis. Putative de novo SNVs were validated using Sanger-based capillary sequencing. Results: We conservatively characterised 23 de novo SNVs shared by the twin pair, 8 de novo SNVs specific to twin I and 1 de novo SNV specific to twin II. Based on the number of de novo SNVs validated by Sanger sequencing and the number of callable bases of each twin, we calculated the overall de novo SNV rate of 1.31×10-8 and 1.01×10-8 for twin I and twin II, respectively. Of these, rates of the early postzygotic de novo SNVs were estimated to be 0.34×10-8 for twin I and 0.04×10-8 for twin II. Conclusions: Early postzygotic mutations constitute a substantial proportion of de novo mutations in humans. Therefore, genome mosaicism resulting from early mitotic events during embryogenesis is common and could substantially contribute to the development of diseases
Design and Optimization of High-Speed Resonant Cavity Enhanced Schottky Photodiodes
Cataloged from PDF version of article.Resonant cavity enhanced (RCE) photodiodes (PD’s)
are promising candidates for applications in optical communications
and interconnects where high-speed high-efficiency photodetection
is desirable. In RCE structures, the electrical properties
of the photodetector remain mostly unchanged; however, the
presence of the microcavity causes wavelength selectivity accompanied
by a drastic increase of the optical field at the resonant
wavelengths. The enhanced optical field allows to maintain a high
efficiency for faster transit-time limited PD’s with thinner absorption
regions. The combination of an RCE detection scheme with
Schottky PD’s allows for the fabrication of high-performance
photodetectors with relatively simple material structures and
fabrication processes. In top-illuminated RCE Schottky PD’s,
a semitransparent Schottky contact can also serve as the top
reflector of the resonant cavity. We present theoretical and
experimental results on spectral and high-speed properties of
GaAs–AlAs–InGaAs RCE Schottky PD’s designed for 900-nm
wavelength
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