156 research outputs found
Student induction experiences: Through the lens of gamification
Student induction serves as the first step of the learning journey, helping students understand the resources, facilities, and supporting infrastructures in the learning environment. A positive induction experience helps improve better learning efficacy and boost performance later on. However, students nowadays complain induction as boring, time-wasting and useless. Given the importance of induction, scholars have called for new research, finding a new way to deliver better-quality and more engaging induction. To respond to this call, the current research aims to investigate whether gamification offers better induction experiences to the students. Gamification is the use of game design techniques, game thinking, and game mechanics in a non-game context. Drawing on the student-centred learning theory, we propose that, through the game-play process, students shall feel less stressed but more confident in learning, leading to a more positive learning experience and outcome. Following the same logic, we hypothesise that gamification is positively correlated with the experiences of induction. That is, gamification-empowered induction brings better experiences to the new students.
To examine the research hypothesis, we plan to recruit 200 students (research participants) through flyers and noticeboards during the university induction period in September 2023 (Ethics Approval Ref: ETH2223-0198). The recruitment is operated on a voluntary basis and participants can drop out at any time. Participant Information Letter, Consent Form, and other participant protection measures are arranged in line with the guidance of institutional ethics committee. The participants will be randomly assigned into two conditions. In Condition A, participants will receive a conventional induction through a regular teaching classroom. All documents and instructions are communicated through paper-based handouts. Participants will receive a campus map, explaining the location of buildings and respective services. The induction will be completed inside the classroom. In Condition B, participants will receive gamification-empowered induction. All documents and instructions are communicated through a gamification APP (to be installed in participants’ mobiles). To complete the induction, participants must visit the designated locations in the campus, exploring the services in person.
To further understand participants' views and experiences of the induction, we plan to collect data through anonymous questionnaires surveys at the end of induction. Condition A will receive questions through web-based surveys, where Condition B will receive questions through APP-based surveys. Both conditions will receive the same survey questions, and Condition B will receive additional questions of APP-user experiences (A copy of the survey questions is enclosed in appendix). The data collected will be analysed and compared through SPSS and Excel software. Research findings will first and foremost examine whether gamification-empowered induction offers better induction experiences to the students. The answers will bring new insights to the gamification-induction literatures. Research findings will be important to the teaching practitioners and policy makers, particularly for those who wish to create better induction programmes through innovative strategies. Implications on induction design and delivery will be clarified. Research limitation and suggestions for future research will also be discussed
Pancreatic endocrine and exocrine function in children following near-total pancreatectomy for diffuse congenital hyperinsulinism.
Published onlineJournal ArticleCONTEXT: Congenital hyperinsulinism (CHI), the commonest cause of persistent hypoglycaemia, has two main histological subtypes: diffuse and focal. Diffuse CHI, if medically unresponsive, is managed with near-total pancreatectomy. Post-pancreatectomy, in addition to persistent hypoglycaemia, there is a very high risk of diabetes mellitus and pancreatic exocrine insufficiency. SETTING: International referral centre for the management of CHI. PATIENTS: Medically unresponsive diffuse CHI patients managed with near-total pancreatectomy between 1994 and 2012. INTERVENTION: Near-total pancreatectomy. MAIN OUTCOME MEASURES: Persistent hypoglycaemia post near-total pancreatectomy, insulin-dependent diabetes mellitus, clinical and biochemical (faecal elastase 1) pancreatic exocrine insufficiency. RESULTS: Of more than 300 patients with CHI managed during this time period, 45 children had medically unresponsive diffuse disease and were managed with near-total pancreatectomy. After near-total pancreatectomy, 60% of children had persistent hypoglycaemia requiring medical interventions. The incidence of insulin dependent diabetes mellitus was 96% at 11 years after surgery. Thirty-two patients (72%) had biochemical evidence of severe pancreatic exocrine insufficiency (Faecal elastase 1<100 µg/g). Clinical exocrine insufficiency was observed in 22 (49%) patients. No statistically significant difference in weight and height standard deviation score (SDS) was found between untreated subclinical pancreatic exocrine insufficiency patients and treated clinical pancreatic exocrine insufficiency patients. CONCLUSIONS: The outcome of diffuse CHI patients after near-total pancreatectomy is very unsatisfactory. The incidence of persistent hypoglycaemia and insulin-dependent diabetes mellitus is very high. The presence of clinical rather than biochemical pancreatic exocrine insufficiency should inform decisions about pancreatic enzyme supplementation
Excitons and rare-earth ions in CsCdBr3
CsCdBr3 has a quasi-linear crystal structure. It consists of covalently bound [CdBr]6 4- chains separated by chains of Cs+ ions. The trivalent rare-earth (RE) ions substitute for divalent Cd ions forming predominantly pair centers of the type RE3+-(Cd vacancy)-RE3+. A minority of RE ions forms "single-ion" centers with more distant charge compensation. The electronic structure around the band gap is determined by the [CdBr]6 4- octahedra. The lowest excitonic states of the lattice are charge-transfer states of these octahedra. At low temperatures they form self-trapped excitons which become mobile around 80 K. In addition we find defect-localized excitons at the RE pairs and single ions with slightly modified spectra. There is a strong energy transfer between the RE ions and the defect-localized excitons in both directions with transition times below 10-8s. For the cooperative fluorescence transition 1D2 × 1G 4 → 3H4 × 3H4 in Pr3+: CsCdBr3 a frequency-modulated vibronic sideband spectrum was found with up to four repetitions of the frequency of the localized optical phonon mode at the ion pair. © 2004 Elsevier B.V. All rights reserved
Clinical characteristics and molecular genetic analysis of 22 patients with neonatal diabetes from the South-Eastern region of Turkey: predominance of non-KATP channel mutations.
PublishedJournal ArticleResearch Support, Non-U.S. Gov'tThis is an open access article available at http://www.eje-online.org/content/172/6/697.BACKGROUND: Neonatal diabetes mellitus (NDM) is a rare form of monogenic diabetes and usually presents in the first 6 months of life. We aimed to describe the clinical characteristics and molecular genetics of a large Turkish cohort of NDM patients from a single centre and estimate an annual incidence rate of NDM in South-Eastern Anatolian region of Turkey. DESIGN AND METHODS: NDM patients presenting to Diyarbakir Children State Hospital between 2010 and 2013, and patients under follow-up with presumed type 1 diabetes mellitus, with onset before 6 months of age were recruited. Molecular genetic analysis was performed. RESULTS: Twenty-two patients (59% males) were diagnosed with NDM (TNDM-5; PNDM-17). Molecular genetic analysis identified a mutation in 20 (95%) patients who had undergone a mutation analysis. In transient neonatal diabetes (TNDM) patients, the genetic cause included chromosome 6q24 abnormalities (n=3), ABCC8 (n=1) and homozygous INS (n=1). In permanent neonatal diabetes (PNDM) patients, homozygous GCK (n=6), EIF2AK3 (n=3), PTF1A (n=3), and INS (n=1) and heterozygous KCNJ11 (n=2) mutations were identified. Pancreatic exocrine dysfunction was observed in patients with mutations in the distal PTF1A enhancer. Both patients with a KCNJ11 mutation responded to oral sulphonylurea. A variable phenotype was associated with the homozygous c.-331C>A INS mutation, which was identified in both a PNDM and TNDM patient. The annual incidence of PNDM in South-East Anatolian region of Turkey was one in 48 000 live births. CONCLUSIONS: Homozygous mutations in GCK, EIF2AK3 and the distal enhancer region of PTF1A were the commonest causes of NDM in our cohort. The high rate of detection of a mutation likely reflects the contribution of new genetic techniques (targeted next-generation sequencing) and increased consanguinity within our cohort.The genetic testing was funded by the Wellcome Trust (Senior Investigator Award to Profs S Ellard and A T Hattersley), and by Diabetes UK (Project funding to Dr D J Mackay). H Demirbilek was funded by European Society for Paediatric Endocrinology (ESPE) and The Scientific and Technological Research Council of Turkey (TUBITAK) for his 1 year clinical fellowship at University College London (UCL), Institute of Child Health, Great Ormond Street Hospital for Children, NHS Trust, Department of Paediatric Endocrinology
Turner syndrome and associated problems in turkish children: A multicenter study
Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology
Spectra and relaxation of electronic excitations in CsCdBr3:Yb3+ and CsCdBr3:Nd3+ monocrystals
Experimental and theoretical studies of the optical and EPR spectra, and the spin-lattice relaxation in CsCdBr3 crystals containing 0.1, 0.3 and 1.0 mol.% of impurity Yb3+ ions have been fulfilled. In the optical excitation spectrum, a broad charge transfer band has been detected in the wave-number range of 25000-35000 cm-1. The hybridization of the excited electron configuration corresponding to the charge transfer from the ligand (Br-) 4p closed shells on the ground 4f13 configuration of the ytterbium ion is considered to interpret the anomalously large crystal field splitting of the 2F5/2 multiplet. The EPR spectra with comparable intensities of the axial single-ion and symmetric dimer centres in the sample containing 0.3 mol.% of impurity Yb3+ ions were observed. Spin-lattice relaxation rates and linewidths in the EPR spectra of the single-ion and dimer centres were measured in the temperature range of 1.5 - 35 K at the frequency of 9.5 GHz at different directions of the applied magnetic field relative to the crystal symmetry axis. Experimental results are analyzed in the framework of the microscopic theory of the electron-phonon interaction with taking into account peculiarities of the phonon spectrum of the impurity CsCdBr3 lattice. High-frequency EPR spectra of dimer centres in CsCdBr3 crystals containing 0.2 and 0.5 mol.% of impurity Nd3+ ions were taken in the range of 205-250 GHz at 4.2 K in the magnetic fields up to 0.8 T parallel to the crystal symmetry axis. The crystal field splitting between the first excited and the ground Kramers doublets, and magnetic splitting factors of these doublets were determined. An estimate of the isotropic ferromagnetic exchange constant A = (2.3±0.3) 10-3 cm-1 in symmetric dimer centres formed by impurity Nd3+ ions was obtained from the zero-field splitting of the EPR signals
What is Good Design in the Eyes of Older Users?
With the population of older consumers increasing and with the recent changes in
legislation and attitudes towards this group, there have been corresponding changes
in product design practice and a growing attempt to adopt an inclusive design
approach. This recognises that people can become excluded from using products,
services or environments if the needs and capabilities of all potential users are not
taken into account. The inclusive design approach has developed from
collaborations between industry, designers and researchers. One major influence
in this area is the i~design project, whose definition is simply that “inclusive
design is better design” (EDC, 2011). The Inclusive Design Toolkit website, a key
output from the i~design project, states that a successful product must be
“functional, usable, desirable and ultimately profitable” and that a key to good
design is to reduce the demand on the user when capabilities decline with age or
disability (EDC, 2011).
It is also important to consider more emotional aspects, such as social
acceptability and whether the potential user would actually want to use or be seen
using the product (Keates and Clarkson, 2003). Other authors also emphasise that
whilst inclusive design research and practice to date have focused primarily on the
physical accessibility and usability of products, a better understanding is required
of people’s emotional needs, such as social acceptability and desirability of
products (Coleman et al, 2007; Lee, 2010). Similar views regarding the required
shift in design focus are reflected in a number of other sources: the need to
consider the less tangible human factors such as identity, emotion, delight and selfexpression
(Cassim et al, 2007); simplicity, aesthetics, pleasure, personality,
conspicuousness and fashion (Pullin, 2009); the product’s visual appearance (Crilly
et al, 2004); creating pleasurable experiences (Demirbilek and Sener, 2003; Jordan,
2000); and the importance of the emotional aspects of design for a successful
product (Norman, 2004), as well as needs related to specific cognitive conditions
(e.g. Baumers and Heylighen, 2010)
Topography and morphometry of intestinal mast cells in children with Hirschsprung's disease.
Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics
Data availability:
The datasets supporting the current study have not been deposited in a public repository due to institutional ethics restrictions but are available from the corresponding author on request.This is the final version. Available from Springer via the DOI in this record. AIMS/HYPOTHESIS: Current clinical guidelines for childhood-onset monogenic diabetes outside infancy are mainly focused on identifying and testing for dominantly inherited, predominantly MODY genes. There are no systematic studies of the recessively inherited causes of monogenic diabetes that are likely to be more common in populations with high rates of consanguinity. We aimed to determine the contribution of recessive causes of monogenic diabetes in paediatric diabetes clinics and to identify clinical criteria by which to select individuals for recessive monogenic diabetes testing. METHODS: We conducted a cross-sectional study of 1093 children from seven paediatric diabetes clinics across Turkey (a population with high rates of consanguinity). We undertook genetic testing of 50 known dominant and recessive causes of monogenic diabetes for 236 children at low risk of type 1 diabetes. As a comparison, we used monogenic diabetes cases from UK paediatric diabetes clinics (a population with low rates of consanguinity). RESULTS: Thirty-four children in the Turkish cohort had monogenic diabetes, equating to a minimal prevalence of 3.1%, similar to that in the UK cohort (p = 0.40). Forty-one per cent (14/34) had autosomal recessive causes in contrast to 1.6% (2/122) in the UK monogenic diabetes cohort (p 10%) assisted the identification of the dominant (all p ≤ 0.0003) but not recessive cases (all p ≥ 0.2) in Turkey. The presence of certain non-autoimmune extra-pancreatic features greatly assisted the identification of recessive (p < 0.0001, OR 66.9) but not dominant cases. CONCLUSIONS/INTERPRETATION: Recessively inherited mutations are a common cause of monogenic diabetes in populations with high rates of consanguinity. Present MODY-focused genetic testing strategies do not identify affected individuals. To detect all cases of monogenic paediatric diabetes, it is crucial that recessive genes are included in genetic panels and that children are selected for testing if they have certain non-autoimmune extra-pancreatic features in addition to current criteria.Wellcome TrustRoyal SocietyNational Institute for Health Researc
Retrospective analysis of individual risk factors for urethrocutaneous fistula after onlay hypospadias repair in pediatric patients
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