Geocapitalism

En el contexto de una obra mucho más amplia, que propone como único sistema plenamente legítimo aquél cuyo cuerpo político viene constituido por la totalidad de habitantes del planeta, es conveniente reflexionar acerca del sistema capitalista y su reforma. Parece obvio que, desde la caída del muro de Berlín, el mundo no ha sabido vivir sin el capitalismo y que su óbito no parece cercano. Su necesidad de reforma sí se ha mostrado necesaria, y más en un contexto de globalización creciente. La relación entre democracia y capitalismo, sin embargo, no siempre es perceptible. Cómo transformar el sistema capitalista es una tarea tan ardua como necesaria. Existen múltiples posibilidades y nuevas técnicas para una mejor gestión del capitalismo, también como forma de alcanzar el Geunismo, y en medio de una crisis financiera que algunos (pocos) supieron explicar a tiempo, y de la que debemos aprender algunas lecciones en el contexto de una vigente plutocleptocracia bancomunista.Within the context of a much wider piece, that proposes as only fully legitimate system the one whose political body is composed of all the inhabitants on the planet, it is convenient to reflect on the capitalist system and its reform. It seems obvious that after the fall of the Berlin Wall the World has not learned to live without capitalism, and its demise does not seem to be close. The need of its reform has indeed been showcased even more within a context of growing globalization. The relation between democracy and capitalism has nevertheless not always been a fact. How to transform the capitalist system is a difficult, as well as a necessary task. There are multiple possibilities and new techniques in order to improve the management of capitalism, also as a path towards Geunismo, and in the midst of a financial crisis that some (few) could explain on time, and of which we shall learn many lessons within the context of a current bankommunist cleptoplutocracy

Sorismo en el contexto del geunismo

Within the context of a much wider and developing piece proposing as only fully legitimate system the one the body politic of which is composed of the totality of inhabitants on the planet, it is convenient to bring to us the political and economic philosophy of George Soros for it adds a very different vision to that applied by the deified economists who could not in advance see the global Great Recession in which we keep on living. The relation between reality and thought is key within Sorism, as it is the distinction amongst the several kinds of sciences. The Efficient Markets Hypothesis is also put into question side by side with the concept of equilibrium in Economics, uncertainty, and fallibility. The critique of market fundamentalism is also implemented as well as the regulatory proposals. And all of it taking place within the context of a scarcely political but very economic globalisation. En el contexto de una obra mucho más amplia y en ciernes, que propone como único sistema plenamente legítimo aquél cuyo cuerpo político viene constituido por la totalidad de habitantes del planeta, es conveniente traer a colación la filosofía política y económica de George Soros, porque aporta una visión muy diferente a la aplicada por los endiosados economistas que no supieron ver con antelación la Gran Recesión global en la que seguimos inmersos. La relación entre la realidad y el pensamiento es clave en el sorismo, como también lo es la distinción entre los diversos tipos de ciencias. La hipótesis de la eficiencia en los mercados también es cuestionada, junto con el concepto de equilibrio en economía, la incertidumbre y la falibilidad. También se acomete la crítica del fundamentalismo de mercado y a las propuestas regulatorias. Y todo en el contexto de una globalización económica poco política.Within the context of a much wider and developing piece proposing as only fully legitimate system the one the body politic of which is composed of the totality of inhabitants on the planet, it is convenient to bring to us the political and economic philosophy of George Soros for it adds a very different vision to that applied by the deified economists who could not in advance see the global Great Recession in which we keep on living. The relation between reality and thought is key within Sorism, as it is the distinction amongst the several kinds of sciences. The Efficient Markets Hypothesis is also put into question side by side with the concept of equilibrium in Economics, uncertainty, and fallibility. The critique of market fundamentalism is also implemented as well as the regulatory proposals. And all of it taking place within the context of a scarcely political but very economic globalisation

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

A randomized, double-blind study on the efficacy of oral domperidone versus placebo for reducing SARS-CoV-2 viral load in mild-to-moderate COVID-19 patients in primary health care

15 p.-3 fig.-3 tab.Introduction:The clinical effect of domperidone against COVID-19 has been investigated in a double-blind phase III clinical trial (EudraCT number 2021-001228-17). Domperidone has shown in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential immudolatory properties through the stimulation of prolactin secretion.Patients and methods:The efficacy of oral domperidone plus standard of care (SOC; n = 87) versus placebo plus SOC (n = 86) was evaluated in a 28-day randomized double-blind multicentre study in primary health care centres. A total of 173 outpatients with mild-to-moderate COVID-19 were included. Three daily doses of 10 mg (30 mg/day) of domperidone or placebo were administered for 7 days. Reduction of viral load on day 4 was the primary efficay endpoint. It was estimated in saliva samples by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), as the cycle thresholds detected ORF1ab, N Protein and S Protein genes.Results:A significant reduction in the viral load was observed (p < 0.001) from baseline to days 4, 7 and 14 of the three genes studied with non-significant differences between domperidone and placebo groups. Twenty-three patients (13.3%) experienced adverse events, 14 patients in the domperidone group (16.1%) and 9 patients in the placebo group (10.5%). No patients needed to be hospitalized.Conclusion: Results do not prove the use of domperidone as antiviral in patients with COVID-19.This research was funded by CSIC (grant no. PIE 201980E024) and by the European Commission: NextGeneration EU (Regulation EU 2020/2094) through CSIC’s Global Health Platform (PTI Salud Global). The study sponsor was Agencia Estatal Consejo Superior de Investigaciones Científicas, M.P. (CSIC), Madrid, Spain. The sponsor was involved in the design, data interpretation, manuscript review and the decision to submit the article for publication.Peer reviewe

How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort

CatedresBackground: To estimate the prevalence and severity of menopausal symptoms and anxiety/depression and to assess the differences according to menopausal status among women living with HIV aged 45-60 years from the cohort of Spanish HIV/AIDS Research Network (CoRIS). Methods: Women were interviewed by phone between September 2017 and December 2018 to determine whether they had experienced menopausal symptoms and anxiety/depression. The Menopause Rating Scale was used to evaluate the prevalence and severity of symptoms related to menopause in three subscales: somatic, psychologic and urogenital; and the 4-item Patient Health Questionnaire was used for anxiety/depression. Logistic regression models were used to estimate odds ratios (ORs) of association between menopausal status, and other potential risk factors, the presence and severity of somatic, psychological and urogenital symptoms and of anxiety/depression. Results: Of 251 women included, 137 (54.6%) were post-, 70 (27.9%) peri- and 44 (17.5%) pre-menopausal, respectively. Median age of onset menopause was 48 years (IQR 45-50). The proportions of pre-, peri- and post-menopausal women who had experienced any menopausal symptoms were 45.5%, 60.0% and 66.4%, respectively. Both peri- and post-menopause were associated with a higher likelihood of having somatic symptoms (aOR 3.01; 95% CI 1.38-6.55 and 2.63; 1.44-4.81, respectively), while post-menopause increased the likelihood of having psychological (2.16; 1.13-4.14) and urogenital symptoms (2.54; 1.42-4.85). By other hand, post-menopausal women had a statistically significant five-fold increase in the likelihood of presenting severe urogenital symptoms than pre-menopausal women (4.90; 1.74-13.84). No significant differences by menopausal status were found for anxiety/depression. Joint/muscle problems, exhaustion and sleeping disorders were the most commonly reported symptoms among all women. Differences in the prevalences of vaginal dryness (p = 0.002), joint/muscle complaints (p = 0.032), and sweating/flush (p = 0.032) were found among the three groups. Conclusions: Women living with HIV experienced a wide variety of menopausal symptoms, some of them initiated before women had any menstrual irregularity. We found a higher likelihood of somatic symptoms in peri- and post-menopausal women, while a higher likelihood of psychological and urogenital symptoms was found in post-menopausal women. Most somatic symptoms were of low or moderate severity, probably due to the good clinical and immunological situation of these women