A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia

[EN] To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (TFT) and overall survival (OS), 2,493 patients with CLL were studied. 242 patients (9.7%) had 11q-. Fluorescence in situ hybridization (FISH) studies showed a threshold of 40% of deleted cells to be optimal for showing that clinical differences in terms of TFT and OS within 11q-CLLs. In patients with >= 40% of losses in 11q (11q-H) (74%), the median TFT was 19 months compared with 44 months in CLL patients with <40% del(11q) (11q-L) (P<0.0001). In the multivariate analysis, only the presence of 11q-L, mutated IGHV status, early Binet stage and absence of extended lymphadenopathy were associated with longer TFT. Patients with 11q-H had an OS of 90 months, while in the 11q-L group the OS was not reached (P = 0.008). The absence of splenomegaly (P = 0.02), low LDH (P = 0.018) or beta 2M (P = 0.006), and the presence of 11q-L (P = 0.003) were associated with a longer OS. In addition, to detect the presence of mutations in the ATM, TP53, NOTCH1, SF3B1, MYD88, FBXW7, XPO1 and BIRC3 genes, a select cohort of CLL patients with losses in 11q was sequenced by next-generation sequencing of amplicons. Eighty % of CLLs with 11q-showed mutations and fewer patients with low frequencies of 11q-had mutations among genes examined (50% vs 94.1%, P = 0.023). In summary, CLL patients with <40% of 11q-had a long TFT and OS that could be associated with the presence of fewer mutated genes.European Commision (EC). Funding FP7/SP1/HEALTH. Project Code: 30624

Interacción sedimentaria del polvo sahariano, y los flujos biogénicos y litogénicos en la cuenca oceánica de Canarias

Saharan dust events are currently the predominant source of lithogenic particles in the Canary Basin. In order to quantify this input and its relationship with the biogenic fluxes, a sediment trap was deployed in a free-drifting system at 150 m depth, 50 km off the north coast of Gran Canaria (Canary Islands). The mineralogy of the lithogenic particles included illite, calcite, hematite quartz, barite and kaolinite. The biogenic matter was composed of chitin, transparent exopolymer particles, and carbonates from foraminifera and gastropod shells. The average Saharan dust flux over the ocean surface was approximately 5±4 mg m–2 day-1. The lithogenic, carbonate and chitin fluxes were 0.8±0.6, 6.0±7.4 and 154±386 mg m–2 day-1, respectively. A fairly strong Saharan dust event during sampling was observed in the trap, with a delay of three days in the peaks of lithogenic and biogenic fluxes. The theoretical settling velocity of the lithogenic particles associated with Saharan dust events at 150 m depth was vStokes=275 m day-1, and the experimental settling was about 50 m day-1. The associated sinking behaviour of particulate organic carbon and biogenic and lithogenic fluxes observed in this study may contribute to a more realistic prediction of these fluxes in carbon biological pump models.En la actualidad los eventos de polvo Sahariano son la fuente principal de partículas litogénicas en la cuenca oceánica de Canarias. Con el objetivo de cuantificar su entrada y la interacción con los flujos biogénicos, se instaló una trampa de sedimento a la deriva, a 150 m de profundidad, 50 km al norte de la costa de Gran Canaria (Islas Canarias). Las partículas litogénicas detectadas fueron de illita, calcita, hematites, cuarzo, barita y caolinita. El material biogénico estaba compuesto por quitina, partículas de exopolímeros transparentes (TEP) y carbonatos procedentes de foraminíferos y conchas de gasterópodos. La media del flujo de polvo sahariano sobre la superficie oceánica fue aproximadamente 5±4 mg m-2 dia-1. Las medias de flujos litogénico, carbonato y quitina respectivamente fueron 0.8±0.6 mg m-2 dia–1, 6.0±7.4 mg m–2 dia-1 y 154±386 mg m-2 dia-1. Durante el muestreo se registró un intenso evento de polvo sahariano seguido, a los tres días, de picos en los flujos litogénicos y biogénicos en la trampa de sedimento a 150 m de profundidad. La velocidad teórica de sedimentación de las partículas litogénicas asociadas a los eventos de polvo sahariano a 150 m de profundidad calculada fue de vStokes=275 m dia-1, siendo la velocidad de sedimentación experimental obtenida tras el análisis de los flujos fue de 50 m dia-1. El comportamiento de los procesos de sedimentación asociados al POC, el flujo biogénico y el flujo litogénico observados en este estudio podría contribuir a modelos más realistas de la bomba biológica de carbono en los océanos

Diseño de políticas de escala salarial y de remuneraciones para mejorar la motivación del personal de la Empresa Grupo Global Legions, ubicada en el municipio de San Salvador.

Grupo Global Legions, es una organización dedicada a prestar servicios de seguridad tanto nacional como internacional, le conocimos por medio de uno de sus colabores, quien nos expuso como se había visto afectada la empresa y sus empleados asignados a la seguridad AVSEC en El Aeropuerto Internacional de El Salvador San Óscar Arnulfo Romero y Galdámez, permitiéndonos así realizar nuestra investigación dado que en la actualidad muchos colaboradores se encuentran desmotivados debido a las medidas que el gobierno del país tomó para enfrentar la pandemia Covid-19, ya que dentro de las medidas estuvo el cierre de operaciones en el aeropuerto, limitando los vuelos para usos de carga y humanitarios, la mayoría de sus subalternos se vieron afectados porque sus jornadas laborales fueron suspendidas o en el mejor de los casos recortadas. En ello como equipo decidimos aplicar los conocimientos adquiridos en la especialización en Gestión de Talento humano y elaborar un estudio y presentar una propuesta en ayuda de la organización. De acuerdo a la circunstancia antes mencionada, se consideró elaborar un plan sobre el diseño de políticas de escala salarial y remuneraciones que ayude a mejorar la motivación de los empleados de Grupo Global Legions, para lo cual se desarrolló una investigación de tipo exploratorio, de igual forma se utilizaron la encuesta y la entrevista como instrumentos para facilitar la recolección, tabulación e interpretación de los datos, logrando proporcionar un diagnóstico de la situación actual en la que se encuentra la empresa. Podemos destacar que la entidad cuenta con un sistema de evaluación de desempeño a los empleados, sin embargo, no es considerado como base en la asignación de aumentos salariales sino solo para medir el cumplimiento de actividades, además identificamos que la entidad carece de comunican interna con los subalternos, por tales motivos los colaboradores transmiten estar inconformes con estos temas, por lo que se recomienda diseñar un sistema de evaluación en el que se incluyan a todos los empleados y que su resultado sea utilizado correctamente, además comunicar de forma oportuna los lineamientos que se deban cumplir para obtener beneficios, ya que ellos consideran que la elaboración de políticas es un incentivo que les ayudaría a desempeñar de una mejor manera sus funciones

DNA delivery via cationic solid lipid nanoparticles (SLNs)

In recent years the use of solid lipid nanoparticles (SLNs) as transport systems for the delivery of drugs and biomolecules has become particularly important. The use of cationic SLNs developed by the technique of microemulsion, which are complexed with DNA in order to study their application as non-viral vectors in gene therapy, is reported. The nanoparticles are characterized by scanning electron microscopy and transmission electron microscopy (SEM and TEM), atomic force microscopy (AFM) and differential scanning calorimetry (DSC). Furthermore, the process of lyophilization of the samples and their stability was studied. The nanoparticles obtained presented a particle size of 340 nm with a positive surface charge of 44 mV and the capability of forming lipoplexes with DNA plasmids was stated

MODELACIÓN PEDAGÓGICA DE LA ATENCIÓN EDUCATIVA INTEGRAL POR LA PERMANENCIA ESTUDIANTIL EN EL CONTEXTO UNIVERSITARIO

RESUMEN El artículo que se presenta tiene como objetivo socializar los principales resultados teóricos de una investigación realizada en respuesta a las insuficiencias en las estrategias educativas en la educación superior en relación con las posibilidades de éxito y la satisfacción de los estudiantes en el proceso formativo, que limitan su permanencia en el contexto universitario. La investigación aporta un modelo pedagógico de atención educativa integral para la permanencia estudiantil en el contexto universitario que tiene como fundamento el principio de la educabilidad para la participación estudiantil por la permanencia. La propuesta de atención educativa integral se distingue por propiciar el logro de una necesaria integración académica y social en la formación, connotando la relación dialéctica que tiene el rendimiento académico y el desarrollo intelectual de los estudiantes, con el desarrollo y la frecuencia de las interacciones positivas con pares y docentes, así como la participación en las actividades curriculares y extracurriculares que tributen a su formación integral. La triangulación metodológica de la información obtenida durante el proceso de validación, corrobora la pertinencia y factibilidad de los resultados que se aportan en la investigación. PALABRAS CLAVE: formación universitaria; permanencia estudiantil; atención educativa; contexto universitario; participación estudiantil. PEDAGOGICAL MODELING OF COMPREHENSIVE EDUCATIONAL ATTENTION FOR STUDENT PERMANENCE IN THE UNIVERSITY CONTEXT ABSTRACT This paper aims to socialize the main theoretical results of a research carried out in response to the inadequacies in educational strategies in higher education, in relation to the possibilities of success and the satisfaction of students in the training process, which limit their permanence in the university context. The research contributes a pedagogical model of integral educational assistance for the student permanence in the university context that is based on the educative principle of educability for the student participation for the permanence. The proposal of integral educational assistance is distinguished by favoring the achievement of a necessary academic and social integration in the formation, highlighting the dialectic relation that the academic performance and the intellectual development of the students have with the development and the frequency of the positive interactions with peers and teachers, as well as the participation in the curricular and extracurricular activities that support their integral formation. The methodological triangulation of the information obtained during the validation process, corroborates the pertinence and feasibility of the results that are contributed in the research. KEYWORDS: university education; student stay; educational attention; university context; student participation

Correction: A feasible pathway to stabilize monoclinic and tetragonal phase coexistence in barium titanate-based ceramics

Depto. de Física de MaterialesFac. de Ciencias FísicasTRUEpu

Impact of a simplified treatment protocol for moderate acute malnutrition with a decentralized treatment approach in emergency settings of Niger

IntroductionOf the 45.4 million children under five affected by acute malnutrition in the world, the majority (31.8 million) are affected by moderate acute malnutrition (MAM). Its treatment is particularly complex in emergency settings such as the Diffa region in Niger. This study aims to evaluate the effectiveness and coverage of a simplified treatment protocol with Community Health Workers (CHWs) as treatment providers.MethodsThis study is a non-randomized controlled trial. The control group (n = 181) received the standard protocol currently used in country, delivered by nursing staff only in health centres and health posts, while the intervention group (n = 483) received the simplified protocol which included nursing at health centres and CHWs at health post as treatment providers.ResultsThe recovery rate was higher in the simplified protocol group (99.6% vs. 79.56%, p &lt; 0.001) recording lower time to recover and higher anthropometric gain. Treatment coverage in the intervention group increased from 28.8% to 84.9% and reduced in the control group (25.3% to 13.6%). No differences were found in the recovery rate of children treated by CHWs and nursing staff.ConclusionThe outcomes using the simplified protocol exceeded humanitarian requirements and demonstrated improvements compared to the standard protocol showing that the simplified protocol could be safely provided by CHWs in an emergency context. Further research in other contexts is needed to scale up this intervention

Unexpected reactivity of “GaI” towards N,N′-diaryl-β-diketiminate tin(II) chloride: Synthesis, X-ray diffraction analysis and DFT studies

Reaction of the [HC(CMeNAr)2]SnCl (Ar = 2,4,6-Me3C6H2) with ‘‘GaI” in THF provided an unexpected transhalogenation reaction product [HC(CMeNAr)2]SnI. The crystal structure shows a tin(II) ion with a distorted tetrahedral pyramidal geometry. Theoretical calculations, using density functional theory (B3LYP), suggest the probable reaction mechanism for transhalogenation. The activation energy for moving from reactant ([HC(CMeNAr)2]SnCl to product [HC (CMeNAr)2]SnI) is only 10.2 kcal/mol. The chloride ion is displaced by the iodine ion, probably by the help of the gallium atom when it is coordinated to the chlorine atom

Tenemos cita con el arte: a pilot project of visits and workshops with people affected by Alzheimer's disease in the Prado Museum, the Centro de Arte Reina Sofía Museum and the Faculty of Fine Arts at the Complutense University of Madrid

GIMUPAI is a research group comprising teachers and researchers from the Faculty of Fine Arts (University Complutense of Madrid) and the Department of Social Psychology and Anthropology (Salamanca University) who have been working in art and health projects over the last thirteen years. Recently, we have carried out Tenemos cita con el arte, part of a national research project entitled "Art education in museums and other cultural institutions as a tool for increasing the wellbeing of people affected with Alzheimer" (Ministry of the Economy and Competitiveness-EDU2013-43253-R). The main objective of the program is to make the museum‘s artworks available to people with Alzheimer‘s and their caregivers, at the same time encouraging them to participate in artistic activities and artistic creation through art workshops. Tenemos cita con el arte has been designed as a program of visits of the Prado Museum and the Centro de Arte Reina Sofia Museum. The program also has included participation in workshops on visual arts and artistic creativity in the Faculty of Fine Arts. The program was undertaken between October and December 2015 with a group of 15 participants (Alzheimer‘s patients, caregivers, and other health and social workers)