2,518 research outputs found
Identification and cost of adverse events in metastatic breast cancer in taxane and capecitabine based regimens.
PurposeWe sought to compare the economic impact of treatment-related adverse events (AEs) in patients with metastatic breast cancer (mBC) using taxane- or capecitabine-based treatment regimens as either first- or second-line (FL or SL) therapy in the US.MethodsWe used healthcare claims data from the Truven Health Analytics MarketScan® Commercial Databases to conduct a retrospective cohort study comparing the economic impact of AEs amongst taxane- and capecitabine-treated mBC patients in the US. We selected women diagnosed with mBC between 2008-2010 who received a taxane or capecitabine as first- or second-line (FL or SL) chemotherapy. Costs related to hospitalization, outpatient services, emergency department visits, chemotherapy and other medications were tabulated and combined to determine total healthcare costs. The incremental monthly costs associated with the presence of AEs compared to no AEs were estimated using generalized linear models, controlling for age and Charlson Comorbidity Index.ResultsWe identified 15,443 mBC patients meeting inclusion criteria. Adjusted total monthly costs were significantly higher in those who experienced AEs than in those without AEs in both lines of treatment (FL incremental cost: taxanes 1,817; SL incremental cost: taxanes 4,437). Total costs increased with the number of AEs and were primarily driven by increased hospitalization amongst those with AEs.ConclusionsAdverse events in taxane- or capecitabine-treated mBC patients are associated with significant increases in costs. Selecting treatment options associated with fewer AEs may reduce costs and improve outcomes in these patients
Quadrupole moments of rotating neutron stars
Numerical models of rotating neutron stars are constructed for four equations
of state using the computer code RNS written by Stergioulas. For five selected
values of the star's gravitational mass (in the interval between 1.0 and 1.8
solar masses) and for each equation of state, the star's angular momentum is
varied from J=0 to the Keplerian limit J=J_{max}. For each neutron-star
configuration we compute Q, the quadrupole moment of the mass distribution. We
show that for given values of M and J, |Q| increases with the stiffness of the
equation of state. For fixed mass and equation of state, the dependence on J is
well reproduced with a simple quadratic fit, Q \simeq - aJ^2/M c^2, where c is
the speed of light, and a is a parameter of order unity depending on the mass
and the equation of state.Comment: ReVTeX, 7 pages, 5 figures, additional material, and references adde
Stochastic Assembly of Bacteria in Microwell Arrays Reveals the Importance of Confinement in Community Development
Citation: Hansen, R. H., Timm, A. C., Timm, C. M., Bible, A. N., Morrell-Falvey, J. L., Pelletier, D. A., . . . Retterer, S. T. (2016). Stochastic Assembly of Bacteria in Microwell Arrays Reveals the Importance of Confinement in Community Development. Plos One, 11(5), 18. doi:10.1371/journal.pone.0155080The structure and function of microbial communities is deeply influenced by the physical and chemical architecture of the local microenvironment and the abundance of its community members. The complexity of this natural parameter space has made characterization of the key drivers of community development difficult. In order to facilitate these characterizations, we have developed a microwell platform designed to screen microbial growth and interactions across a wide variety of physical and initial conditions. Assembly of microbial communities into microwells was achieved using a novel biofabrication method that exploits well feature sizes for control of innoculum levels. Wells with incrementally smaller size features created populations with increasingly larger variations in inoculum levels. This allowed for reproducible growth measurement in large (20 mu m diameter) wells, and screening for favorable growth conditions in small (5, 10 mu m diameter) wells. We demonstrate the utility of this approach for screening and discovery using 5 mu m wells to assemble P. aeruginosa colonies across a broad distribution of innoculum levels, and identify those conditions that promote the highest probability of survivial and growth under spatial confinement. Multi-member community assembly was also characterized to demonstrate the broad potential of this platform for studying the role of member abundance on microbial competition, mutualism and community succession
Mapping spacetimes with LISA: inspiral of a test-body in a `quasi-Kerr' field
The future LISA detector will constitute the prime instrument for
high-precision gravitational wave observations.LISA is expected to provide
information for the properties of spacetime in the vicinity of massive black
holes which reside in galactic nuclei.Such black holes can capture stellar-mass
compact objects, which afterwards slowly inspiral,radiating gravitational
waves.The body's orbital motion and the associated waveform carry information
about the spacetime metric of the massive black hole,and it is possible to
extract this information and experimentally identify (or not!) a Kerr black
hole.In this paper we lay the foundations for a practical `spacetime-mapping'
framework. Our work is based on the assumption that the massive body is not
necessarily a Kerr black hole, and that the vacuum exterior spacetime is
stationary axisymmetric,described by a metric which deviates slightly from the
Kerr metric. We first provide a simple recipe for building such a `quasi-Kerr'
metric by adding to the Kerr metric the deviation in the value of the
quadrupole moment. We then study geodesic motion in this metric,focusing on
equatorial orbits. We proceed by computing `kludge' waveforms which we compare
with their Kerr counterparts. We find that a modest deviation from the Kerr
metric is sufficient for producing a significant mismatch between the
waveforms, provided we fix the orbital parameters. This result suggests that an
attempt to use Kerr waveform templates for studying EMRIs around a non-Kerr
object might result in serious loss of signal-to-noise ratio and total number
of detected events. The waveform comparisons also unveil a `confusion' problem,
that is the possibility of matching a true non-Kerr waveform with a Kerr
template of different orbital parameters.Comment: 19 pages, 6 figure
Erratum to: Comparative Analysis of Length of Stay and Inpatient Costs for Orthopedic Surgery Patients Treated with IV Acetaminophen and IV Opioids vs. IV Opioids Alone for Post-Operative Pain
Early-universe constraints on a time-varying fine structure constant
Higher-dimensional theories have the remarkable feature of predicting a time
(and hence redshift) dependence of the `fundamental' four dimensional constants
on cosmological timescales. In this paper we update the bounds on a possible
variation of the fine structure constant alpha at the time of BBN (z =10^10)
and CMB (z=10^3). Using the recently-released high-resolution CMB anisotropy
data and the latest estimates of primordial abundances of 4He and D, we do not
find evidence for a varying alpha at more than one-sigma level at either epoch.Comment: 5 pages, 1 figure, minor misprints corrected, references added. The
analysis has been updated using new BOOMERanG and DASI data on CMB anisotrop
Energy Release During Disk Accretion onto a Rapidly Rotating Neutron Star
The energy release L_s on the surface of a neutron star (NS) with a weak
magnetic field and the energy release L_d in the surrounding accretion disk
depend on two independent parameters that determine its state (for example,
mass M and cyclic rotation frequency f) and is proportional to the accretion
rate. We derive simple approximation formulas illustrating the dependence of
the efficiency of energy release in an extended disk and in a boundary layer
near the NS surface on the frequency and sense of rotation for various NS
equations of state. Such formulas are obtained for the quadrupole moment of a
NS, for a gap between its surface and a marginally stable orbit, for the
rotation frequency in an equatorial Keplerian orbit and in the marginally
stable circular orbit, and for the rate of NS spinup via disk accretion. In the
case of NS and disk counterrotation, the energy release during accretion can
reach . The sense of NS rotation is a factor that strongly
affects the observed ratio of nuclear energy release during bursts to
gravitational energy release between bursts in X-ray bursters. The possible
existence of binary systems with NS and disk counterrotation in the Galaxy is
discussed. Based on the static criterion for stability, we present a method of
constructing the dependence of gravitational mass M on Kerr rotation parameter
j and on total baryon mass (rest mass) m for a rigidly rotating neutron star.
We show that all global NS characteristics can be expressed in terms of the
function M(j, m) and its derivatives.Comment: 42 pages, 12 figures, to appear in Astronomy Letters, 2000, v.26,
p.69
The social value of a QALY : raising the bar or barring the raise?
Background: Since the inception of the National Institute for Health and Clinical Excellence (NICE) in England,
there have been questions about the empirical basis for the cost-per-QALY threshold used by NICE and whether
QALYs gained by different beneficiaries of health care should be weighted equally. The Social Value of a QALY
(SVQ) project, reported in this paper, was commissioned to address these two questions. The results of SVQ were
released during a time of considerable debate about the NICE threshold, and authors with differing perspectives
have drawn on the SVQ results to support their cases. As these discussions continue, and given the selective use of
results by those involved, it is important, therefore, not only to present a summary overview of SVQ, but also for
those who conducted the research to contribute to the debate as to its implications for NICE.
Discussion: The issue of the threshold was addressed in two ways: first, by combining, via a set of models, the
current UK Value of a Prevented Fatality (used in transport policy) with data on fatality age, life expectancy and
age-related quality of life; and, second, via a survey designed to test the feasibility of combining respondents’
answers to willingness to pay and health state utility questions to arrive at values of a QALY. Modelling resulted in
values of £10,000-£70,000 per QALY. Via survey research, most methods of aggregating the data resulted in values
of a QALY of £18,000-£40,000, although others resulted in implausibly high values. An additional survey, addressing
the issue of weighting QALYs, used two methods, one indicating that QALYs should not be weighted and the
other that greater weight could be given to QALYs gained by some groups.
Summary: Although we conducted only a feasibility study and a modelling exercise, neither present compelling
evidence for moving the NICE threshold up or down. Some preliminary evidence would indicate it could be
moved up for some types of QALY and down for others. While many members of the public appear to be open to
the possibility of using somewhat different QALY weights for different groups of beneficiaries, we do not yet have
any secure evidence base for introducing such a system
Evidence for Quantum Interference in SAMs of Arylethynylene Thiolates in Tunneling Junctions with Eutectic Ga-In (EGaIn) Top-Contacts
This paper compares the current density (J) versus applied bias (V) of self-assembled monolayers (SAMs) of three different ethynylthiophenol-functionalized anthracene derivatives of approximately the same thickness with linear-conjugation (AC), cross-conjugation (AQ), and broken-conjugation (AH) using liquid eutectic Ga-In (EGaIn) supporting a native skin (~1 nm thick) of Ga2O3 as a nondamaging, conformal top-contact. This skin imparts non-Newtonian rheological properties that distinguish EGaIn from other top-contacts; however, it may also have limited the maximum values of J observed for AC. The measured values of J for AH and AQ are not significantly different (J ≈ 10-1 A/cm2 at V = 0.4 V). For AC, however, J is 1 (using log averages) or 2 (using Gaussian fits) orders of magnitude higher than for AH and AQ. These values are in good qualitative agreement with gDFTB calculations on single AC, AQ, and AH molecules chemisorbed between Au contacts that predict currents, I, that are 2 orders of magnitude higher for AC than for AH at 0 < |V| < 0.4 V. The calculations predict a higher value of I for AQ than for AH; however, the magnitude is highly dependent on the position of the Fermi energy, which cannot be calculated precisely. In this sense, the theoretical predictions and experimental conclusions agree that linearly conjugated AC is significantly more conductive than either cross-conjugated AQ or broken conjugate AH and that AQ and AH cannot necessarily be easily differentiated from each other. These observations are ascribed to quantum interference effects. The agreement between the theoretical predictions on single molecules and the measurements on SAMs suggest that molecule-molecule interactions do not play a significant role in the transport properties of AC, AQ, and AH.
Quantitative evaluation of oligonucleotide surface concentrations using polymerization-based amplification
Quantitative evaluation of minimal polynucleotide concentrations has become a critical analysis among a myriad of applications found in molecular diagnostic technology. Development of high-throughput, nonenzymatic assays that are sensitive, quantitative and yet feasible for point-of-care testing are thus beneficial for routine implementation. Here, we develop a nonenzymatic method for quantifying surface concentrations of labeled DNA targets by coupling regulated amounts of polymer growth to complementary biomolecular binding on array-based biochips. Polymer film thickness measurements in the 20–220 nm range vary logarithmically with labeled DNA surface concentrations over two orders of magnitude with a lower limit of quantitation at 60 molecules/μm2 (∼106 target molecules). In an effort to develop this amplification method towards compatibility with fluorescence-based methods of characterization, incorporation of fluorescent nanoparticles into the polymer films is also evaluated. The resulting gains in fluorescent signal enable quantification using detection instrumentation amenable to point-of-care settings
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