Extensions of groups

A study of extensions of groups: given 2 groups G and K, I study the groups E that have K as a normal subgroup such that G = E/K. It is related with exact sequences and group cohomology

Optimal coordinated motions for two square robots

We find the coordinated motion for two square robots that minimizes the sum of the length of the path of every robot, for every initial and final positions of both robots. We study it in an obstacle-free plane, so the unique constraint is that the robots can not collide

Sustainability in Mineral Exploration—Exploring Less Invasive Technologies via Patent Analysis

This paper presents a bibliometric study on patents and scientific publications related to airborne electromagnetic methods used as less invasive technologies in mineral exploration. A statistical analysis of the documents reveals the main players, technology trends, and collaboration patterns via bibliometric techniques. The article aims to analyse the gap between the model of sustainable less invasive innovations and the concrete implementation of the technology pull. Special attention is paid to the enablers of sustainable development and their presence in the technology landscape for less invasive exploration technologies.European Union's Horizon 2020 research and innovation programme 776487Spanish Ministry of Science Innovation and Universities RTI2018-098966-B-I0

Función de excitación de la reacción K+C2H5BrKBr+C2H5 : estudio dinámico por haces moleculares y comparación con reacciones análogas

Tesis - Universidad Complutense de Madrid, 1982.Depto. de Química FísicaFac. de Ciencias QuímicasTRUEProQuestpu

Integration of COSMO-based methodologies into commercial process simulators: Separation and purification of reuterin

The conceptual design of a new process is developed via computer-aided simulation for separating and purifying reuterin, an antimicrobial substance obtained by bacterial fermentation of glycerol, from its mixture with the nonfermented substrate, the main subproduct of the process (1,3-propanediol) and water. The nondatabank components included in the simulations are created by using the structures derived from quantum mechanical calculations and the properties (molecular weight, normal boiling point, and mass density) estimated by COSMO-RS method. The unknown remainder properties are estimated by the methods and models used by default in Aspen Plus (v7.3). The COSMOSAC property model, also implemented in Aspen Plus, is specified with the molecular volumes and sigma profiles obtained by COSMO-RS. The properties (boiling temperatures, densities, VL equilibria, etc.) predicted for glycerol, 1,3-propanediol, water, and their mixtures by COSMO-based methods agree reasonably well with experimental reported values, whereas those obtained for reuterin derivatives are consistent with the behavior of amphoteric compounds having strong capabilities to interact attractively with hydrogen donor and acceptor groups all together. The process consists of a two-stage distillation operation, the first of which removes the water and the second one separates reuterin as a 99.5 wt %-pure bottom product. The second column operates at low pressure (ca. 40 kPa) to avoid thermal decomposition of reuterin (over 280°C) and guaranties 99.9% recovery of the desired product. Water removing offers different heat integration and energy-saving opportunities considering that condenser pressure of the first column can be increased to ∼15 bar preserving the thermal integrity of the reuterin. Dimensions of the equipments as well as capital and operating costs are evaluate

Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice

Osteoarthritis (OA) is a multifactorial joint disease mainly affecting articular cartilage (AC) with a relevant biomechanical component. During endochondral ossification growth plate (GP) chondrocytes arrange in columns. GPs do not ossify in skeletally mature rodents. In neonatal mice, an altered joint loading induces GP chondrocyte disorganization. We aimed to study whether experimental OA involves GP disorganization in adult mice and to assess if it may have additional detrimental effects on AC damage. Knee OA was induced by destabilization of the medial meniscus (DMM) in wild-type (WT) adult mice, and in Tamoxifen-inducible Ellis-van-Creveld syndrome protein (Evc) knockouts (Evc ), used as a model of GP disorganization due to Hedgehog signalling disruption. Chondrocyte column arrangement was assessed in the tibial GP and expressed as Column Index (CI). Both DMM-operated WT mice and non-operated-Evc showed a decreased CI, indicating GP chondrocyte column disarrangement, although in the latter, it was not associated to AC damage. The most severe GP chondrocyte disorganization occurred in DMM-Evc mice, in comparison to the other groups. However, this altered GP structure in DMM-Evc mice did not exacerbate AC damage. Further studies are needed to confirm the lack of interference of GP alterations on the analysis of AC employing OA mice. cKO cKO cKO cKOThis work was financially supported by grants from the Instituto de Salud Carlos III [PI15/00340, PI16/00065, PI18/00261] to RL and GH-B, and Fondo Europeo de Desarrollo Regional (FEDER) by grants SAF-2013–43365-R and SAF2016-75434-R to VL R-P. AL and PG were funded by Fundación Conchita Rábago

Proceso de atemperación de componentes inyectados: análisis del efecto del gap debido a la contracción del polímero

En el conformado de piezas de plástico a través del proceso de inyección, es importante que la temperatura de la pieza al acabar el ciclo sea uniforme para que el perfil de temperaturas a lo largo del grosor de la pieza sea simétrico. De lo contrario, se crean tensiones térmicas que provocan alabeos en las paredes. Para conseguir la uniformidad de temperaturas, se implementa un sistema de atemperación a través de una red de canales dentro del molde por los que circula agua que ayuda a evacuar el calor que cede el componente inyectado al exterior. Durante la fase de atemperación, la pieza contrae un cierto porcentaje a la par que se va enfriando, dando lugar a un gap o hueco de aire entre la superficie externa de la pieza y la superficie de la cavidad del molde. En piezas de gran espesor, el grosor del gap alcanza un tamaño considerable y está presente durante más tiempo que en las piezas de pequeño espesor pues la duración de la fase de atemperación es mayor. La consecuencia que puede acarrear la aparición de este fenómeno es que el gap modifique los flujos de salida del calor del componente inyectado hacia el exterior debido a su carácter aislante, haciendo que la superficie exterior de la pieza tenga una temperatura mayor que la superficie interior, dando lugar a alabeos. El presente Trabajo Fin de Grado tiene como objetivo analizar si realmente la aparición del gap provoca una diferencia de temperaturas considerable entre las paredes de la pieza. Para ello, se simulará el proceso de inyección de la preforma de una botella (geometría cilíndrica) en el software Moldex3D® 2020 y se creará un modelo térmico del sistema de atemperación para resolverlo mediante las ecuaciones de transferencia de calor con la ayuda de un programa de resolución de ecuaciones. Además, para analizar el alabeo debido a la diferencia de temperaturas, se simulará en Moldflow ® el caso de una geometría cúbica. <br /

Relationship between Depressive Symptoms, Personality, and Binge Drinking among University Students in Spain

Binge drinking (BD) is a common practice among college students. Alcohol consumption has been related to depressive symptoms and certain personality factors, although less is known about the relationship of these variables with BD. The aim of this study was to analyze the relationship of BD with depressive symptoms and personality in university students. We performed a cross-sectional study among students (aged 18?30 years) enrolled in the academic year 2018-2019 at the Faculty of Nursing of the University of Cantabria (Spain). Sociodemographic, academic, and alcohol and other drug use information was collected by means of a semi-structured questionnaire. The Beck Depression Inventory-II was used to measure depressive symptomatology and the Neo Five-Factor Inventory was used for personality. A total of 142 participants were included, 88.03% of which were women. Up to 38.03% were classified as BD. Concerning depressive symptoms, 7.41% of BD were at the moderate-severe level compared to 3.41% of non-BD (p = 0.7096). Regarding personality, the median score for extraversion of BD was 35 (Q1 = 29, Q3 = 40), 32 (Q1 = 28, Q3 = 36) in non-BD (p = 0.0062), conscientiousness scored 34 (Q1 = 30.5, Q3 = 38) points in non-BD, 31.50 (Q1 = 27, Q3 = 37) in BD (p = 0.0224). In conclusion, BD students have higher levels of extraversion and lower levels of responsibility than non-BD students. No significant differences were found between the level of depressive symptomatology between BD and non-BD students

Healthcare workers hospitalized due to COVID-19 have no higher risk of death than general population. Data from the Spanish SEMI-COVID-19 Registry

Aim To determine whether healthcare workers (HCW) hospitalized in Spain due to COVID-19 have a worse prognosis than non-healthcare workers (NHCW). Methods Observational cohort study based on the SEMI-COVID-19 Registry, a nationwide registry that collects sociodemographic, clinical, laboratory, and treatment data on patients hospitalised with COVID-19 in Spain. Patients aged 20-65 years were selected. A multivariate logistic regression model was performed to identify factors associated with mortality. Results As of 22 May 2020, 4393 patients were included, of whom 419 (9.5%) were HCW. Median (interquartile range) age of HCW was 52 (15) years and 62.4% were women. Prevalence of comorbidities and severe radiological findings upon admission were less frequent in HCW. There were no difference in need of respiratory support and admission to intensive care unit, but occurrence of sepsis and in-hospital mortality was lower in HCW (1.7% vs. 3.9%; p = 0.024 and 0.7% vs. 4.8%; p<0.001 respectively). Age, male sex and comorbidity, were independently associated with higher in-hospital mortality and healthcare working with lower mortality (OR 0.211, 95%CI 0.067-0.667, p = 0.008). 30-days survival was higher in HCW (0.968 vs. 0.851 p<0.001). Conclusions Hospitalized COVID-19 HCW had fewer comorbidities and a better prognosis than NHCW. Our results suggest that professional exposure to COVID-19 in HCW does not carry more clinical severity nor mortality

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies