La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamento Santander

El diplomado de profundización “Acompañamiento Psicosocial en Escenarios de Violencia ” en su fase final a través de la revisión de las fuentes bibliográficas sugeridas permitió que como psicólogos en formación próximos a desempeñarnos en el ámbito laboral lográramos realizar un análisis argumentativo, crítico e interpretativo sobre el abordaje de contextos desde los enfoques narrativos y los eventos psicosociales traumáticos desde una perspectiva psicológica y partiendo de un respaldo teórico tener una postura clara y coherente sobre la técnica análisis del relato en un escenario. El relato que según Kullenberg, L. (2009). Pertenece a “José Ignacio Medina”, expresa la experiencia de una persona desmovilizada que vivió el flagelo de la violencia desde dos escenarios, el primero al ser un servidor de la patria en el ejército nacional y la segunda por pertenecer a un grupo armado al margen de la ley. Desde ambos contextos fue testigo de hechos de injusticia, exclusión social, desigualdad, hostigamiento, abusos, y otros actos que se catalogan como violación de los derechos humanos. Pero a su vez se hace hincapié en la capacidad de Resiliencia de este individuo en el afrontamiento de las consecuencias a nivel económico, psicológico y familiar que implicaba el haber pertenecido a estos grupos subversivos, rescatando sus ideales de forjar un futuro junto a su familia a través del arduo trabajo y el compromiso consigo mismo y con la comunidad. El proceso de reintegración a la vida civil se lleva a cabo por medio de la reconciliación desde lo individual hasta lo colectivo donde es expresado según Kullenberg, L. (2009). Como “verdad, justicia, pacto y memoria” los garantes para que estos episodios de violencia no se vuelvan a repetir en sus comunidades. Para finalizar, se analiza los aspectos psicosociales del Caso; donde se evidencia el flagelo y las consecuencias emergentes de la violencia, una vez identificados los factores más relevantes de la problemática, realizando una propuesta de abordaje psicosocial que permite implementar estrategias de acompañamiento psicosocial que ayuden a mitigar las consecuencias adversas de la violencia y disminuya la probabilidad de hechos repetitivos violentos similares.The graduate of deepening " Accompaniment Psicosocial in Scenes of Violence " in his final phase across the review of the bibliographical suggested sources allowed that as psychologists in formation close to get out of a jam ourselves in the labor area we should manage to realize an argumentative, critical and interpretive analysis on the boarding context from the narrative approaches and the events psicosociales traumatic from a psychological perspective and departing from a theoretical support having a clear and coherent position on the technology analysis of the statement in a scene. The statement that according to Kullenberg, L. (2009). It belongs to "Jose Ignacio Medina", expresses the experience of a demobilized person that a servant of the mother land lived through the scourge of the violence from two scenes, the first one to the being in the national army and the second one for belonging to a group armed to the margin of the law. From both contexts he was a witness of facts of injustice, social exclusion, inequality, harassment, abuses, and other acts that are catalogued as violation of the human rights. But in turn it is emphasized in Resiliencia's capacity of this individual in the confrontation of the consequences to economic, psychological and familiar level that was implying the credit belonged to these subversive groups, rescuing his ideal ones of forging a future close to his family across the arduous work and the commitment with it itself and with the community. The process of reimbursement to the civil life is carried out by means of the reconciliation from the individual thing up to the collective thing where it is expressed according to Kullenberg, L. (2009). As " truth, justice, agreement and memory " the guarantors in order that these episodes of violence do not return to repeat in his communities. To finish, the aspects are analyzed psychosocials of the Case; where there are demonstrated the scourge and the emergent consequences of the violence, once identified the most relevant factors of the problematic, realizing an offer of boarding psychosocial that allows to implement strategies of accompaniment psychosocial that they help to mitigate the adverse consequences of the violence and diminish the probability of repetitive violent similar facts

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Atlas de las praderas marinas de España

Knowledge of the distribution and extent of seagrass habitats is currently the basis of management and conservation policies of the coastal zones in most European countries. This basic information is being requested through European directives for the establishment of monitoring programmes and the implementation of specific actions to preserve the marine environment. In addition, this information is crucial for the quantification of the ecological importance usually attributed to seagrass habitats due to, for instance, their involvement in biogeochemical cycles, marine biodiversity and quality of coastal waters or global carbon budgets. The seagrass atlas of Spain represents a huge collective effort performed by 84 authors across 30 Spanish institutions largely involved in the scientific research, management and conservation of seagrass habitats during the last three decades. They have contributed to the availability of the most precise and realistic seagrass maps for each region of the Spanish coast which have been integrated in a GIS to obtain the distribution and area of each seagrass species. Most of this information has independently originated at a regional level by regional governments, universities and public research organisations, which explain the elevated heterogeneity in criteria, scales, methods and objectives of the available information. On this basis, seagrass habitats in Spain occupy a total surface of 1,541,63 km2, 89% of which is concentrated in the Mediterranean regions; the rest is present in sheltered estuarine areas of the Atlantic peninsular regions and in the open coastal waters of the Canary Islands, which represents 50% of the Atlantic meadows. Of this surface, 71.5% corresponds to Posidonia oceanica, 19.5% to Cymodocea nodosa, 3.1% to Zostera noltii (=Nanozostera noltii), 0.3% to Zostera marina and 1.2% to Halophila decipiens. Species distribution maps are presented (including Ruppia spp.), together with maps of the main impacts and pressures that has affected or threatened their conservation status, as well as the management tools established for their protection and conservation. Despite this considerable effort, and the fact that Spain has mapped wide shelf areas, the information available is still incomplete and with weak precision in many regions, which will require an investment of major effort in the near future to complete the whole picture and respond to demands of EU directives

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues