Flavour Symmetries and Kahler Operators

Any supersymmetric mechanism to solve the flavour puzzle would generate mixing both in the superpotential Yukawa couplings and in the Kahler potential. In this paper we study, in a model independent way, the impact of the nontrivial structure of the Kahler potential on the physical mixing matrix, after kinetic terms are canonically normalized. We undertake this analysis both for the quark sector and the neutrino sector. For the quark sector, and in view of the experimental values for the masses and mixing angles, we find that the effects of canonical normalization are subdominant. On the other hand, for the leptonic sector we obtain different conclusions depending on the spectrum of neutrinos. In the hierarchical case we obtain similar conclusion as in the quark sector, whereas in the degenerate and inversely hierarchical case, important changes in the mixing angles could be expected.Comment: 22 pages, LaTe

3D UK? 3D History and the Absent British Pioneers

The recent television ‘rediscovery’ of a small cohort of 1950s British 3D films (and the producers who made them) has offered a new route into considering how the historical stories told about 3D film have focused almost exclusively on the American experience, eliding other national contexts. This article challenges both the partiality of existing academic histories of 3D, and the specific popular media narratives that have been constructed around the British 3D pioneers. Offering a rebuttal of those narratives and an expansion of them based around primary archival research, the article considers how the British 3D company Stereo Techniques created a different business and production model based around non-fiction short 3D films that stand in contrast to the accepted view of 3D as an American feature film novelty. Through an exploration of the depiction (and absence) of these 3D pioneers from existing media histories, the article argues for a revision to both 3D studies and British cinema history

Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease

Wide band observations of the new X-ray burster SAX J1747.0-2853 during the March 1998 outburst

We report on our discovery and follow-up observations of the X-ray source SAX J1747.0-2853 detected in outburst on 1998, March 10 with the BeppoSAX Wide Field Cameras in the energy range 2-28 keV. The source is located about half degree off the Galactic Nucleus. A total of 14 type-I X-ray bursts were detected in Spring 1998, thus identifying the object as a likely low-mass X-ray binary harboring a weakly magnetized neutron star. Evidence for photospheric radius expansion is present in at least one of the observed bursts, leading to an estimate of the source distance of about 9 kpc. We performed a follow-up target of opportunity observation with the BeppoSAX Narrow Field Instruments on March 23 for a total elapsed time of 72 ks. The source persistent luminosity was 2.6x10^36 erg/s in the 2-10 keV energy range. The wide band spectral data (1-200 keV) are consistent with a remarkable hard X-ray spectrum detected up to 150 keV, highly absorbed at low energies (Nh of the order of 10^23 cm^-2) and with clear evidence for an absorption edge near 7 keV. A soft thermal component is also observed, which can be described by single temperature blackbody emission at about 0.6 keV.Comment: 11 pages, 3 figures, accepted for publication in ApJ Letter

The Pioneer Transcription Factor Foxa2 Modulates T Helper Differentiation to Reduce Mouse Allergic Airway Disease

Foxa2, a member of the Forkhead box (Fox) family of transcription factors, plays an important role in the regulation of lung function and lung tissue homeostasis. FOXA2 expression is reduced in the lung and airways epithelium of asthmatic patients and in mice absence of Foxa2 from the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Here we demonstrate a novel role for Foxa2 in the regulation of T helper differentiation and investigate its impact on lung inflammation. Conditional deletion of Foxa2 from T-cells led to increased Th2 cytokine secretion and differentiation, but decreased Th1 differentiation and IFN-γ expression in vitro. Induction of mouse allergic airway inflammation resulted in more severe disease in the conditional Foxa2 knockout than in control mice, with increased cellular infiltration to the lung, characterized by the recruitment of eosinophils and basophils, increased mucus production and increased production of Th2 cytokines and serum IgE. Thus, these experiments suggest that Foxa2 expression in T-cells is required to protect against the Th2 inflammatory response in allergic airway inflammation and that Foxa2 is important in T-cells to maintain the balance of effector cell differentiation and function in the lung

Bounds on R-Parity Violating Parameters from Fermion EDM's

We study one-loop contributions to the fermion electric dipole moments in the Minimal Supersymmetric Standard Model with explicit R-parity violating interactions. We obtain new individual bounds on R-parity violating Yukawa couplings and put more stringent limits on certain parameters than those obtained previously.Comment: 16 pages, LaTe

Systemic Pharmacological Smoothened Inhibition Reduces Lung T-Cell Infiltration and Ameliorates Th2 Inflammation in a Mouse Model of Allergic Airway Disease

Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have indicated that Sonic Hedgehog (Shh) and the Hedgehog (Hh) signaling pathway are involved in allergic asthma and that Shh is upregulated in the lung on disease induction. We used a papain-induced mouse model of allergic airway inflammation to investigate the impact of systemic pharmacological inhibition of the Hh signal transduction molecule smoothened on allergic airway disease induction and severity. Smoothened-inhibitor treatment reduced the induction of Shh, IL-4, and IL-13 in the lung and decreased serum IgE, as well as the expression of Smo, Il4, Il13, and the mucin gene Muc5ac in lung tissue. Smoothened inhibitor treatment reduced cellular infiltration of eosinophils, mast cells, basophils, and CD4+ T-cells to the lung, and eosinophils and CD4+ T-cells in the bronchoalveolar lavage. In the mediastinal lymph nodes, smoothened inhibitor treatment reduced the number of CD4+ T-cells, and the cell surface expression of Th2 markers ST2 and IL-4rα and expression of Th2 cytokines. Thus, overall pharmacological smoothened inhibition attenuated T-cell infiltration to the lung and Th2 function and reduced disease severity and inflammation in the airway