Fotografía J. Porta: 50 años de retratos de estudio en Lérida

Actas de las Cuartas Jornadas Imagen, Cultura y Tecnología celebradas el 4, 5 y 6 de julio de 2005 en la Universidad Carlos III de MadridPublicad

El fondo fotográfico de Lluís Terrés: la ciudad de Lleida a mediados del siglo XX

Actas de las Quintas Jornadas Imagen, Cultura y Tecnología celebradas del 3 al 5 de julio de 2006 en la Universidad Carlos III de Madri

La fiel infantería: un discurso social

Actas del Segundo Congreso Internacional de Historia y Cine organizado por el Instituto de Cultura y Tecnología Miguel de Unamuno y celebrado del 9 al 11 de septiembre de 2010 en la Universidad Carlos III de MadridEsta comunicación pretende describir el impacto social que supuso en la ciudad de Lleida la filmación de la película La fiel infantería. Con guión de Rafael García Serrano y José Luis Dibildos, el film describe la historia coral de unos soldados que pasan unos días de permiso en la retaguardia descansando antes de una acción bélica que supone para muchos de ellos una muerte heroica en el cumplimiento del deber, como corresponde al infante español. La película fue filmada, excepto algunas breves escenas de interior, en su totalidad en la ciudad de Lleida en el año 1959. Desde el punto de vista histórico, las circunstancias del rodaje representan una fuente inapreciable para el estudio de la sociedad leridana del momento. Desde el punto de vista sociológico, la película significó un hito en el imaginario popular hasta el punto que aún hoy día está presente en la memoria ciudadana.This paper expects describe the social impact in the city of Lleida with the filming of the movie “La Fiel Infantería”. The screen play belongs to Rafael García Serrano and José Luis Dibildos. It is a choral story about a group of soldiers who spend two days of license in rearguard in the eve of an attack which can suppose for some of them a heroic death in the line of duty, as it corresponds to a Spanish soldier. The movie was totally filmed, except some scenes inside, in the town of Lleida in 1959. From the point of historic view the shooting circumstances represent a very important source for Lleida society; from the point of sociologic view the movie meant a remarkable point in the popular imaginary so important that nowadays it is still present in the citizen memory.Publicad

El jaciment de l'edat del ferro de la cova de Geguins (les Avellanes i Santa Linya, la Noguera)

El present estudi és el resultat fi nal d'una labor de recuperació de materials arqueològics portada a terme des de la Secció d'Arqueologia de l'Institut d'Estudis Ilerdencs entre 1980 i 1986, període en què es gestionà la reunió de diverses col·leccions particulars procedents d'una única cavitat del Pre-pirineu lleidatà, aleshores inèdita. També inclou els resultats d'una breu intervenció arqueològica efectuada en la mateixa cova en 1982. L'anàlisi dels objectes i el repàs de les condicions físiques del lloc que els acollia constitueixen la base d'unes refl exions sobre dues problemàtiques històriques: una, la possible naturalesa de l'activitat humana desenvolupada en aquell indret, l'altra, la contribució de la cavitat al coneixement del moment cronològic més tardà de la presència humana durant la Prehistòria en les coves del Montse

Protohistoric mining in the Extremadura: The case of in the Cerro de San Cristóbal de Logrosán (Cáceres)

Este artículo resume los trabajos realizados en el Cerro de San Cristóbal (Logrosán, Cáceres) entre  1998  y 2002.  Dichos  trabajos,  impulsados  por  el Dr.  Craig  Merideth  hasta  su muerte en 2005,  permitieron  reconocer  un asentamiento  minero-metalúrgico especializado  en el be- nef icio de la casiterita. Pese a estar muy alterado por las explotaciones de los años cincuenta del siglo XX, se pudieron  documentar  restos de cabañas,  trazas de labores  antiguas  y ciertos aspectos de la “cadena operativa” de la explotación y uso del estaño en este enclave. Todo ello  se enmarca  en un contexto  crono-cultural  de los  siglos  IX/VIII-VII/VI  a.C.,  durante  el cual el actual territorio extremeño se conformó como periferia tartésica. Por otra parte, se avanzan los resultados metalúrgicos preliminares de las nuevas actuaciones llevadas a cabo en 2013 en el Cerro de San Cristóbal  tras su declaración  como “geositio”  dentro del Geoparque “Villuercas-Ibores-Jara”.In this paper the archaeological work carried out in Cerro de San Cristóbal (Logrosán, Cáceres) during the period 1998 to 2002 is summarized. The work, led by Dr. Craig Merideth until his  death  in 2005, allowed  to document  what was interpreted  as a mining-metallurgical site specialized  in the  treatment  of cassiterite.  Despite  being  the prehistoric  layers  disturbed by  contemporary,  1950´s,  mining  works,  it  was  possible  to  document  traces  of  prehistoric mining,  remains  of  elliptical  huts  and  some  of  the  steps  of  the  proposed  operational  chain for the mining and processing of tin in the site. The chronological/cultural context for the archaeological register was placed between the 9th-8th/7th-6th  centuries B.C., during which the present-day Extremadura territory was conformed as a Tartesian periphery. Also, the preliminary metallurgical results of the recent (summer 2013, after its declaration as a “Geosite” within the “Villuercas-Ibores-Jara” Geopark) archaeological  excavation in Cerro de San Cristóbal are presented

Increased risk of MAFLD and liver fibrosis in inflammatory bowel disease independent of classic metabolic risk factors

ackground & Aims There is conflicting evidence regarding the prevalence of and risk factors for metabolic-associated fatty liver disease (MAFLD) in patients with inflammatory bowel disease (IBD). We aimed to determine MAFLD prevalence and risk factors in IBD patients. Methods Cross-sectional, case-control study included all consecutive IBD patients treated at 2 different university hospitals. Controls were subjects randomly selected from the general population and matched by age, sex, type 2 diabetes status, and body mass index in a 1:2 ratio. MAFLD was confirmed by controlled attenuation parameter. Liver biopsies were collected when MAFLD with significant liver fibrosis was suspected. In addition, age- and fibrosis stage-paired non-IBD patients with biopsy-proven MAFLD served as a secondary control group. Results Eight hundred thirty-one IBD patients and 1718 controls were included. The prevalence of MAFLD and advanced liver fibrosis (transient elastography ≥9.7 kPa) was 42.00% and 9.50%, respectively, in IBD patients and 32.77% and 2.31%, respectively, in the general population (P < .001). A diagnosis of IBD was an independent predictor of MAFLD (adjusted odds ratio, 1.99; P < .001) and an independent risk factor for advanced liver fibrosis (adjusted odds ratio, 5.55; P < .001). Liver biopsies were obtained from 40 IBD patients; MAFLD was confirmed in all cases, and fibrosis of any degree was confirmed in 25 of 40 cases (62.5%). Body mass index and type 2 diabetes prevalence were significantly lower in IBD-MAFLD patients than in severity-paired patients with biopsy-proven MAFLD. Conclusions MAFLD and liver fibrosis are particularly prevalent in IBD patients, regardless of the influence of classic metabolic risk factors.Acknowledgements: The authors report funding support from the Spanish Instituto de Salud Carlos III-FEDER Grant (FIS - PI18/01304) related to this manuscript

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases

Altres ajuts: Generalitat de Catalunya, Departament de Salut; Generalitat de Catalunya, Departament d'Empresa i Coneixement i CERCA Program; Ministerio de Ciencia e Innovación; Instituto Nacional de Bioinformática; ELIXIR Implementation Studies (CNAG-CRG); Centro de Investigaciones Biomédicas en Red de Enfermedades Raras; Centro de Excelencia Severo Ochoa; European Regional Development Fund (FEDER).Many patients experiencing a rare disease remain undiagnosed even after genomic testing. Reanalysis of existing genomic data has shown to increase diagnostic yield, although there are few systematic and comprehensive reanalysis efforts that enable collaborative interpretation and future reinterpretation. The Undiagnosed Rare Disease Program of Catalonia project collated previously inconclusive good quality genomic data (panels, exomes, and genomes) and standardized phenotypic profiles from 323 families (543 individuals) with a neurologic rare disease. The data were reanalyzed systematically to identify relatedness, runs of homozygosity, consanguinity, single-nucleotide variants, insertions and deletions, and copy number variants. Data were shared and collaboratively interpreted within the consortium through a customized Genome-Phenome Analysis Platform, which also enables future data reinterpretation. Reanalysis of existing genomic data provided a diagnosis for 20.7% of the patients, including 1.8% diagnosed after the generation of additional genomic data to identify a second pathogenic heterozygous variant. Diagnostic rate was significantly higher for family-based exome/genome reanalysis compared with singleton panels. Most new diagnoses were attributable to recent gene-disease associations (50.8%), additional or improved bioinformatic analysis (19.7%), and standardized phenotyping data integrated within the Undiagnosed Rare Disease Program of Catalonia Genome-Phenome Analysis Platform functionalities (18%)