Myxofibrosarcoma of the maxillary sinus: a case report

[ES] El mixofibrosarcoma, también denominado variante mixoide del histiocitoma fibroso maligno, se localiza predominantemente en extremidades y retroperitoneo de varones de edad adulta. Su incidencia en el área ORL es muy baja, por lo que su diagnóstico es a menudo complicado. Presenta alto índice de recidivas, aunque menor de metástasis a distancia. El único tratamiento efectivo es la resección quirúrgica completa, con escasa respuesta a quimio y radioterapia, Presentamos el caso de un mixofibrosarcoma de alto grado de seno maxilar y fosa nasal izquierdos, tratado con cirugía y quimioradioterapia con mala evolución clínica. [EN] Myxofibrosarcoma, also known as myxoid variant of malignant fibrosis histiocytoma, is often located in the extremities and retroperitoneum of adult males. Its incidence in the ENT area is very low, therefore its diagnosis is often complicated. It has a high rate of local recurrence, although it has low rate of distant metastases. The only effective treatment is complete surgical resection, with little response to chemotherapy and radiotherapy. We present the case of a high-grade myxofibrosarcoma of the left maxillary sinus and nasal cavity, wich we treated with surgery and chemoradiation, but with bad clinical evolution

Assessing Outcomes of Patients Subject to Intensive Care to Facilitate Organ Donation: A Spanish Multicenter Prospective Study

Intensive Care to facilitate Organ Donation (ICOD) consists of the initiation or continuation of intensive care measures in patients with a devastating brain injury (DBI) in whom curative treatment is deemed futile and death by neurological criteria (DNC) is foreseen, to incorporate organ donation into their end-of-life plans. In this study we evaluate the outcomes of patients subject to ICOD and identify radiological and clinical factors associated with progression to DNC. In this first prospective multicenter study we tested by multivariate regression the association of clinical and radiological severity features with progression to DNC. Of the 194 patients, 144 (74.2%) patients fulfilled DNC after a median of 25 h (95% IQR: 17–44) from ICOD onset. Two patients (1%) shifted from ICOD to curative treatment, both were alive at discharge. Factors associated with progression to DNC included: age below 70 years, clinical score consistent with severe brain injury, instability, intracranial hemorrhage, midline shift ≥5 mm and certain types of brain herniation. Overall 151 (77.8%) patients progressed to organ donation. Based on these results, we conclude that ICOD is a beneficial and efficient practice that can contribute to the pool of deceased donors

Electrocatalytic urea mineralization in aqueous alkaline medium using NiIIcyclam-modified nanoparticulate TiO2 anodes and its relationship with the simultaneous electrogeneration of H2 on Pt counterelectrodes

NiIIcyclam-modified nanoparticulate TiO2-coated ITO electrodes (ITO/TiO2//NiIIcyclam) were prepared by electropolymerization of NiIIcyclam monomers to TiO2-coated ITO electrodes (ITO/TiO2) to improve electrocatalytic urea CO(NH2)2 oxidation in alkaline aqueous solutions. A high value adding secondary effect was the collection of electrons at Pt cathodes, to simultaneously generate H2 from water reduction. NiIIcyclam-modified ITO electrodes (ITO//NiIIcyclam) were also prepared by electropolymerization of NiIIcyclam monomers to bare ITO electrodes (ITO) for comparison purposes. In the presence of the TiO2 nanoparticles, the urea mineralization on NiIIcyclam coatings was doubled (23.95% – organic carbon removal at 120 min of electrolysis) compared to those without TiO2 nanoparticles (13.02% – organic carbon removal at 120 min of electrolysis). In agreement, the faradaic efficiency for H2 generation at the Pt cathode, electrically connected to an anode having TiO2 nanoparticles (0.99 at 120 min of electrolysis), was also twice as effective than that observed when the same Pt cathode was electrically connected to an anode without TiO2 nanoparticles (0.46 at 120 min of electrolysis). The experimental results indicated that the poisoning of NiII centers (which is caused by an excessive production of CO intermediates during the urea oxidation on both NiIIcyclam-modified anodes) was strongly inhibited in the presence of the nanoparticulate TiO2|NiIIcyclam junction. A final comparison between our results and those reported in selected publications revealed that the NiIIcyclam-modified nanoparticulate TiO2-coated ITO anodes here developed, constitutes a promising electrocatalytic system for performing direct urea mineralization at a relative short electrolysis time. Furthermore, the combination of the following phenomena: (a) effective charge separation on the semiconducting ITO|nanoparticulate TiO2 junctions, (b) remarkable capabilities of the nanoporous TiO2 films for tuning the load of OH� anions demanded by the urea oxidation and, (c) outstanding capabilities of the TiO2 nanoparticles for capturing CO intermediates (at Ti3+ donor sites), successfully promoted the enhancement of the electron external transport to Pt cathodes, and consequently improved the faradaic efficiency associated to the cathodic generation of H2

Relationship between Mid-Upper Arm Circumference and Body Mass Index in Inpatients.

Nutritional screening is a fundamental aspect of the initial evaluation of the hospitalised patient. Body Mass Index (BMI) in association with other parameters is a good marker of malnutrition (<18.5 kg/m2), but it presents the handicap that the great majority of patients cannot be weighed and measured. For this reason it is necessary to find other indicators that can be measured in these patients.1) Analyse the relationship between BMI and Mid-Upper Arm Circumference (MUAC); 2) establish a cut-off point of MUAC equivalent to BMI <18.5 kg/m2.The anthropometric data of patients hospitalised over the period 2004-2013 were retrospectively revised. The following variables were collected: weight, height, BMI, MUAC, sex and age.1373 patients were evaluated, who presented a mean weight of: 65.04±15.51 kg; height: 1.66±0.09 m; BMI: 23.48±5.03 kg/m2; MUAC: 26.95±4.50 cm; age: 56.24±16.77. MUAC correlates suitably to BMI by means of the following equation (simple linear regression): BMI = - 0.042 + 0.873 x MUAC (cm) (R2 = 0.609), with a Pearson r value of 0.78 (p<0.001). The area under the curve of MUAC for the diagnosis of malnutrition was 0.92 (95% CI: 0.90-0.94; p<0.001). The MUAC value ≤22.5 cm presented a sensitivity of 67.7%, specificity of 94.5%, and a correct classification of 90%. No significant statistical differences were found in the cut-off point of MUAC for the diagnosis of malnutrition based on sex (p = 0.115) and age (p = 0.694).1) MUAC correlates positively and significantly with BMI. 2) MUAC ≤ 22.5 cm correlates properly with a BMI of <18.5 kg/m2, independent of the age or sex of the patient, although there are other alternatives. MUAC constitutes a useful tool as a marker of malnutrition, fundamentally in patients for whom weight and height cannot be determined

Functional insights into the cellular response triggered by a bile-acid platinum compound conjugated to biocompatible ferric nanoparticles using quantitative proteomic approaches

At present, bioferrofluids are employed as powerful multifunctional tools for biomedical applications such as drug delivery, among others. The present study explores the cellular response evoked when bile-acid platinum derivatives are conjugated with bioferrofluids by testing the biological activity in osteosarcoma (MG-63) and T-cell leukemia (Jurkat) cells. The aim of this work is to evaluate the biocompatibility of a bile-acid platinum derivative conjugated with multi-functional polymer coated bioferrofluids by observing the effects on the protein expression profiles and in intracellular pathways of nanoparticle-stimulated cells. To this end, a mass spectrometry-based approach termed SILAC has been applied to determine in a high-throughput manner the key proteins involved in the cellular response process (including specific quantitatively identified proteins related to the vesicular transport, cellular structure, cell cycle, biosynthetic process, apoptosis and regulation of the cell cycle). Finally, biocompatibility was evaluated and validated by conventional strategies also (such as flow cytometry, MTT, etc.).We gratefully acknowledge financial support from the Spanish Health Institute Carlos III (ISCIII) for the grants: FIS PI11/02114 and FIS PI14/01538. We also acknowledge Fondos FEDER (EU) and Junta Castilla-León (grant BIO/SA07/15). The Proteomics Unit belongs to ProteoRed, PRB2-ISCIII, supported by grant PT13/0001, of the PE I + D + I 2013–2016, funded by ISCIII and FEDER. P. D. is supported by a JCYL-EDU/346/2013 Ph.D. scholarship. This work was partially supported by the Spanish Ministry of Science and Innovation (MAT2014-54975-R).Peer Reviewe

Anthropometric characteristics of the sample.

<p>Anthropometric characteristics of the sample.</p

Diagnostic validity of Mid-Upper Arm Circunference for the detection of malnutricion (Body Mass Index <18,5 kg/m²).

<p>Diagnostic validity of Mid-Upper Arm Circunference for the detection of malnutricion (Body Mass Index <18,5 kg/m²).</p

Box plot of Body Mass Index (kg/m²) in women and men.

<p>Box plot of Body Mass Index (kg/m²) in women and men.</p

Relationship between Mid-Upper Arm Circumference and Body Mass Index in women and men.

<p>Relationship between Mid-Upper Arm Circumference and Body Mass Index in women and men.</p

Area Under the Curve of Mid-Upper Arm Circunference for the detection of malnutrition in the whole sample and stratified by sex.

<p>Area Under the Curve of Mid-Upper Arm Circunference for the detection of malnutrition in the whole sample and stratified by sex.</p