[In processu procuratoris astricti contra Iuan y Isabel de Roda : por ellos]

Enc. per. con correillas.Tít. tomado de p. 1 y menc. de resp. de p. 15.En p. 1 consta el año 1631.Sign.: A-D2.Inic. grab. xil.Sello: "Instituto y Provª de Huesca. Biblioteca

[En los processos fraganciae contra Iuan y Isabel de Roda y procuratoris astricti, contra los mismos : informacion en derecho contra los acusados]

Enc. per. con correillas.Tít. tomado de p. 1 y menc. de resp. de p. 16.Precede al tít. "Iesus, Maria, Ioseph"En p. 14 consta el año 1629.Sign.: A-D2.Inic. grab. xil.Sello: "Instituto y Provª de Huesca. Biblioteca

Determination of density, viscosity and vapor pressures of mixtures of dimethyl sulfoxide + 1-allyl-3-methylimidazolium chloride at atmospheric pressure

Producción CientíficaIn this work, densities, viscosities and vapor pressures of dimethyl sulfoxide (DMSO) + 1-allyl-3-methylimidazolium chloride (AmimCl) mixtures have been experimentally determined. Densities and viscosities were measured at temperatures T = [293.15, 373.15] K and molar fractions of dimethyl sulfoxide xDMSO = 0, 0.05, 0.1, 0.15, 0.25, 0.5, 0.75, 0.9 and 1 at atmospheric pressure with a Stabinger densimeter-viscosimeter. Viscosities and densities were found to decrease with increasing temperature and DMSO concentrations. Correlation of viscosity was made as a function of temperature and concentration with two modifications of the Seddon and Grunberg-Nissan equation, one with an average relative deviation of 6.8% and the second one of 16.3%. Vapor pressures of the mixtures were measured at T = [353.1, 433.1] K. and were correlated with Non-Random-Two-Liquid (NRTL) model, obtaining ARD% between 5 and 12%.Junta de Castilla y León, proyecto VA295U14MINECO proyecto ENE2014-53459-RMINECO Prorama Ramón y Cajal RYC-2013-1397

Implementation of the frequency scatter index in clinical commercially available double-pass systems

A previous work has reported a methodology to quantify intraocular scattering using a high sensitivity double-pass instrument with a robust index, the frequency scatter index. The purpose of our study was to evaluate an adaptation of the frequency scatter index for use in clinical double-pass systems. A prospective observational study was carried out in a group of patients with nuclear cataracts (n = 52) and in a control group (n = 11) using conventional double-pass systems. The frequency scatter index and the objective scatter index were used to assess the scattering. The Spearman coefficient was calculated to assess the correlation between both indexes, obtained from the double-pass images. Simultaneous measurements were performed with a double-pass and with a Hartmann-Shack wavefront sensor in the control group. The root-mean-square wavefront error and the full width at half maximum of the double-pass image were used to quantify the residual aberrations introduced by the variations in pupil size and retinal eccentricity. Measurement in eyes with different grades of cataracts shows a strong correlation (¿ = 0.929, p .05). We have introduced and evaluated an adaptation of a methodology proposed recently for the measurement of intraocular scattering using the double-pass technique with a robust index, which is less affected by ocular aberrations. The frequency scatter index can be applied to conventional double-pass instruments available in clinical environments.Peer ReviewedPostprint (updated version

Influence of water concentration in the viscosities and densities of cellulose dissolving ionic liquids. Correlation of viscosity data

Producción CientíficaThe densities and viscosities of aqueous mixtures of two cellulose dissolving ionic liquids: 1-allyl-3-methylimidazolium chloride and 1-ethyl-3-methyl imidazolium acetate ionic liquids have been experimentally determined for water concentration up to approx. 35% water at atmospheric pressure and temperature range from (298.15 to 373.15) K. Molar excess volumes were calculated, resulting in negative values. Literature viscosity correlations were modified in order to describe the viscosity as a function of temperature and water concentration for both water concentrations lower than xH2O = 0.4 and for all the water concentration range. These modified equations were applied to correlate viscosity of (water + ionic liquid) viscosity data for other 1-alkyl-3-methylimidazolium chloride ionic liquids as well as for (ethanol + 1-ethyl-3-methyl imidazolium acetate) from literature obtaining a good reproducibility of the data.Junta de Castilla y León VA295U14MINECO proyecto CTQ 2011 – 14825 – E (Program Explora)MINECO contrato FPI BES-2011-046496MINECO programa Ramon y Cajal RYC-2013-1397

Avaluació de l'ús d'esferes vaginals conjuntament amb els exercicis musculars del sòl pelvià en el tractament primari de la incontinència urinària femenina

Introducció La incontinència urinària (IU) en la dona és un problema freqüent que té un elevat impacte en la qualitat de vida. La rehabilitació muscular del sòl pelvià (RMSP) forma part del tractament de primera línia per a qualsevol tipus d'IU. Els exercicis de RMSP es poden fer amb o sense l'ajuda d'algun dispositiu vaginal. L'objectiu d'aquesta tesi doctoral és donar resposta a dues preguntes de recerca: 1- Les esferes vaginals, són eficaces i segures com a part d'un programa de RMSP per a la IU femenina? I, 2- Les esferes vaginals, potencien l'adherència a la RMSP? Quins són els determinants i les barreres de l'adherència al tractament? Material i Mètode Es va realitzar un assaig clínic controlat, prospectiu, multicèntric, aleatoritzat i de grups paral·lels. Les participants, dones amb IU clínica, van ser assignades de forma aleatòria per rebre un programa supervisat d'exercicis de RMSP dues vegades al dia, 5 dies a la setmana, durant 6 mesos amb esferes vaginals (grup estudi) o per rebre el mateix programa però sense les esferes vaginals (grup control). La variable de resultat principal va ser la puntuació de la prova International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI-SF) als 6 mesos. Les variables secundàries van ser els resultats de la Prova de la Compresa d'1 hora (1-hour Pad-test), del King's Health Questionnaire (KHQ) i els d'una escala tipus Likert de 5 ítems per a l'avaluació subjectiva del resultat. L'adherència es va mesurar amb el qüestionari de Morisky-Green. Es va realitzar una anàlisi secundària dels resultats d'adherència per tal d'investigar els determinants i barreres de l'adherència i la seva influència en els resultats del tractament. Resultats Es van incloure 70 pacients, 37 aleatoritzades al grup tractament (Kegel + esferes) i 33 al grup control (Kegel). Es van poder analitzar les dades de 65 participants (35 grup tractament i 30 controls). Els resultats de l'ICIQ-UI-SF van millorar de manera significativa al cap d'1 mes de seguiment al grup esferes respecte al grup control (p 0.01) i en ambdós grups als 6 mesos. Al final del seguiment (6 mesos), la prova de la compresa d'1 hora va millorar en el grup esferes i, en canvi, no en el grup control. No hi va haver diferències significatives entre ambdós grups pel que fa als resultats del KHQ ni en la valoració subjectiva d'eficàcia i seguretat en aquest període de seguiment. Els efectes adversos observats van ser lleus i transitoris (4 en el grup esferes i 1 en el grup control). No hi va haver diferències significatives en l'adherència al tractament al final del seguiment (33% d'adherència en els controls, 42.9% en el grup tractat). En ambdós grups, el motiu principal per la no-adherència va ser que les participants simplement van oblidar realitzar els exercicis. Els resultats de l'ICIQ-UI-SF entre pacients que es van adherir i les que no ho van fer no va diferir significativament (p=0.143). No es va observar una diferència significativa en l'adherència entre aquelles participants que van obtenir més millora en la IU i les que en van obtenir menys al final del seguiment (p=0.140). Conclusions La incontinència urinària va millorar en els dos grups, però les participants que van utilitzar les esferes van començar a millorar de forma més ràpida. Les esferes van ser ben tolerades i no van causar efectes adversos. Les esferes no van actuar com a facilitador de l'adherència. La manca d'adherència va ser deguda a que les participants van oblidar la realització dels exercicis amb independència de l'eficàcia del tractament i de la gravetat de la incontinència.Introduction Urinary incontinence (UI) is a highly prevalent condition in women and significantly impairs quality of life. Pelvic floor muscle training (PFMT) is a first-line therapy for all types of UI. Pelvic floor rehabilitation exercises can be done through exercises alone or in combination with intravaginal devices (spheres or cones). It is the objective of this thesis to provide meaningful answers to two main research questions: 1- Are vaginal spheres safe and efficacious as part of PFMT treatment programs for female UI? And, 2- Do vaginal spheres enhance adherence to PFMT therapy? Which are the determinants and barriers of adherence to PFMT treatment? Materials and Methods We conducted a randomized, controlled, multicentre, parallel-group, prospective pilot study. Participants were women with UI. Women assigned to the treatment group were asked to use vaginal spheres while they performed PFMT at home. The control group performed the same domiciliary training program without this or any other device. In both groups, PFMT consisted of Kegel exercises for 15min, twice daily, at least 5 days a week for a period of 6 months. The primary endpoint for this study was the International Consultation on Incontinence Questionnaire Short Form (ICIQ-UI-SF) score. Secondary endpoints were the 1-hour pad-test, the Kings' Health Questionnaire (KHQ), subjective efficacy and tolerance, and Morisky-Green questionnaire score to assess adherence to treatment. We performed a secondary analysis of data to investigate the determinants and barriers of adherence and their association with treatment outcome. Results A total of 70 women were included and randomized to receive treatment, 37 to PFMT with vaginal spheres and 33 to PFMT alone. Data from 65 patients (35 treated patients and 30 controls) were finally suitable for analysis. ICIQ-UI-SF results improved significantly at 1-month follow-up in the spheres group (p 0.01) and at 6 months in the controls. At the end of follow-up (6 months), the 1-hour pad-test improved in the spheres group but not in the control group. No significant differences were found in the KHQ results or in the subjective evaluation of efficacy and safety. Mild transient side effects were reported in four patients in the spheres group and one in the control group. There were no significant differences in adherence to treatment between groups at the end of follow-up (33.3% adherence in controls and 42.9% in spheres group). The largest group of non-adherent women in both arms were those who mainly forgot to do the exercises. ICIQ-UI-SF results between adherent and non-adherent women did not differ significantly (p=0.143). No significant difference was observed in adherence between women who attained greater improvements and those who had poorer improvements in urinary incontinence after treatment (p=0.140). Conclusions Both treatments improved urinary incontinence but women who performed the exercises with vaginal spheres showed an earlier improvement. Vaginal spheres were well tolerated and safe. In patients with urinary incontinence, vaginal spheres as an adjunct to PFMT did not increase adherence to pelvic muscle exercises. Lack of persistence appeared to be due to forgetfulness and did not seem to be influenced by the efficacy of PFMT

Determination of density and excess molar volume of dimethyl sulfoxide+1-allyl-3-methylimidazolium chloride mixtures at high pressure

Producción CientíficaIn this work, densities of dimethyl sulfoxide + 1-allyl-3-methylimidazolium chloride mixtures have been experimentally determined with a vibrating tube densimeter. Densities were measured at temperatures between 293.15 and 373.15 K and molar fractions of dimethyl sulfoxide xDMSO = 0, 0.05, 0.1, 0.15, 0.25, 0.5, 0.75, 0.9 and 1 at pressures in the range P = [0.1, 35] MPa. It was found that density increases with ionic liquid concentration and with pressure and decrease with temperature. Excess molar volumes were calculated resulting in negative values with a maximum of non-ideality at DMSO concentration of xDMSO = 0.5. The excess molar values were less negative at high pressures. At T = 330 K a maximum in the excess molar values was observed at several concentrations. Density was correlated as a function of temperature, pressure and concentration with an average relative deviation of 0.12%.2019-08-012019-08-01Junta de Castilla y León VA295U14Ministerio de Economía. Programa Ramon y Cajal, RyC RYC-2013-1397

Comparison of a human acellular dermal matrix and a polypropylene mesh for pelvic floor reconstruction : a randomized trial study in a rabbit model

Non-absorbable polypropylene (PP) meshes have been widely used in surgical reconstruction of the pelvic floor disorders. However, they are associated with serious complications. Human acellular dermal matrices (hADM) have demonstrated safety and efficacy in reconstructive medicine, but their suitability and efficacy at vaginal level is not known. This study compares the biological performance of PP mesh and a newly developed hADM. 20 rabbits were randomized to receive the hADM graft or the PP mesh. Grafts were surgically implanted in the abdominal wall and vagina. After 180 days, grafts were explanted and evaluated. The vaginal mesh extrusion rate was higher in the PP group (33% vs. 0%, p = 0.015). Full integration of the vaginal grafts was more frequent in the hADM group, where 35% of the grafts were difficult to recognize. In the PP group, the vaginal mesh was identified in 100% of the animals (p = 0.014). In PP group, the infiltrates had a focal distribution and were mostly located in the internal part of the epithelium, while in the hADM group, the infiltrates had a diffuse distribution. Additionally, the hADM group also presented more B-lymphocytes and less T-lymphocytes. Biomechanical analysis showed that hADM had lower resistance to stress. Moreover, PP mesh stiffness and elasticity were higher. Then, hADM is associated with fewer clinical complications, as well as better tissue integration. However, it shows greater incorporation into the surrounding native tissue, especially in the vaginal location, undergoing a reduction in its biomechanical properties 6 months after implantation

Breeding biology and conservation of the Marsh Seedeater Sporophila palustris

El Capuchino Pecho Blanco Sporophila palustris es uno de los capuchinos menos conocidos y uno de los más amenazados. Sus poblaciones reproductivas son locales, fragmentadas y ocurren en el nordeste de Argentina, sudeste de Brasil y en Uruguay. Presentamos datos reproductivos describiendo nidos y huevos, comportamiento (incluyendo cortejo, nidificación, incubación y cuidado parental), sitios de anidación y datos sobre alimentación. El Capuchino Pecho Blanco nidifica en pastizales altos y húmedos en buen estado de conservación. Estos hábitats en general se han convertido en áreas ganaderas. Las principales amenazas son sobrepastoreo, uso generalizado del fuego, drenaje de humedales, reemplazo total del hábitat por pasturas y forestaciones y captura ilegal. La mayoría de los sitios se localizan en AICAs, pero sólo uno en Brasil y otro en Argentina se encuentran protegidos. Finalmente, proponemos una serie de medidas que contribuyen a la preservación del Capuchino Pecho Blanco y de otras aves amenazadas que conviven con este.The Marsh Seedeater Sporophila palustris is one of the most endangered and least known of the capuchino seedeaters. Breeding populations are patchy, occurring in north-east Argentina,southern Brazil, and Uruguay. We present data on the breeding biology of the species, and describe nests and eggs, behaviour (including courtship, nesting, incubation and parental care), breeding sites and food items. Marsh Seedeaters breed in well-preserved grasslands with wet soils and tall vegetation. In general, these habitats are used for extensive livestock ranching. Main threats are overgrazing, widespread use of fire, conversion of grasslands to pastures of exotic grasses and rice fields, afforestation, and illegal trapping. Most breeding sites are located in Important Bird Areas, but only one in Brazil and one in Argentina are protected. We propose a series of actions to promote the conservation of Marsh Seedeaters and other endangered birds that coexist in grassland habitats.Fil: Vizentin Bugoni, Jefferson. Universidade Estadual de Campinas; Brasil;Fil: Areta, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Salta. Instituto de Bio y Geociencias del Noroeste Argentino; Argentina;Fil: Di Giacomo, Alejandro G.. Asociación Ornitológica del Plata. Aves Argentinas. Departamento de Conservación; Argentina;Fil: Di Giacomo, Adrian Santiago. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ecología, Genética y Evolución. Laboratorio de Ecología y Comportamiento Animal; Argentina;Fil: Jacobs, Fernando. Universidade Federal de Pelotas. Instituto de Biologia. Departamento de Zoologia e Genética; Brasil;Fil: Afonso Coimbra, Marco A.. Universidade Federal de Pelotas. Instituto de Biologia. Núcleo de Reabilitação da Fauna Silvestre e Centro de Triagem de Animais Silvestres; Brasil;Fil: Dias, Rafael A.. Universidade Católica de Pelotas. Laboratório de Biologia e Ecologia de Cordados. Setor de Ornitologia; Brasil

Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in Adults Consensus Guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CIBERES)

Prevention, Diagnosis and Management of Post-Surgical Mediastinitis in Adults Consensus Guidelines of the Spanish Society of Cardiovascular Infections (SEICAV), the Spanish Society of Thoracic and Cardiovascular Surgery (SECTCV) and the Biomedical Research Centre Network for Respiratory Diseases (CIBERES) doctors and radiologists. Despite the clinical and economic consequences of sternal wound infections, to date, there are no specific guidelines for the prevention, diagnosis and management of mediastinitis based on a multidisciplinary consensus. The purpose of the present document is to provide evidencebased guidance on the most effective diagnosis and management of patients who have experienced or are at risk of developing a post-surgical mediastinitis infection in order to optimise patient outcomes and the process of care. The intended users of the document are health care providers who help patients make decisions regarding their treatment, aiming to optimise the benefits and minimise any harm as well as the workload.Funding: J.M. Miró was a recipient of a personal 80:20 research grant from IDIBAPS during the period 2017–2021