How to assess technological developments in basic research? Enabling formative interventions regarding sustainability, ethics, and consumer issues at an early stage

In an era of ever faster and more momentous technological development, both technology assessment and transdisciplinary interventions are in danger of structurally lagging behind the speed of innovation. This paper proposes a new tiered approach to technology assessment at low Technology Readiness Levels that enables a both rapid and concerted interdisciplinary science response to this Great Acceleration. Covering sustainability, ethics, and consumer issues, this approach encourages and enables the innovators themselves to conduct assessments embedded in the innovation process as early as possible. Suitable tools for early engagement that help facilitate development-integrated assessments are introduced and described. The design and use of these instruments in the field of basic research is illustrated using the Cluster of Excellence livMatS as an example.In einer Ära immer rascherer und folgenreicherer technologischer Entwicklungen laufen sowohl die Technologiebewertung als auch transdisziplinäre Interventionen Gefahr, strukturell hinter der Dynamik von Innovationen zurückzubleiben. In diesem Beitrag wird ein neuer gestufter Ansatz für die Technikfolgenabschätzung für niedrige Technology Readiness Levels vorgeschlagen, der eine schnelle und konzertierte interdisziplinäre Reaktion der Wissenschaft auf diese "große Beschleunigung" ermöglicht. Dieser Ansatz, der Nachhaltigkeits-, Ethik- und Verbraucherfragen abdeckt, ermutigt und befähigt die Innovatoren, in den Innovationsprozess eingebettete Bewertungen so früh wie möglich selbst durchzuführen. Geeignete Instrumente für entwicklungsintegrierte Bewertungen werden vorgestellt und beschrieben. Die Konzeption und Anwendung dieser Instrumente im Bereich der Grundlagenforschung wird am Beispiel des Exzellenzclusters livMatS veranschaulicht

An Extragalactic 12CO J=3-2 survey with the Heinrich-Hertz-Telescope

We present results of a ^{12}CO J = 3-2 survey of 125 nearby galaxies obtained with the 10-m Heinrich-Hertz-Telescope, with the aim to characterize the properties of warm and dense molecular gas in a large variety of environments. With an angular resolution of 22'', ^{12}CO 3-2 emission was detected in 114 targets. Based on 61 galaxies observed with equal beam sizes the ^{12}CO 3-2/1-0 integrated line intensity ratio R_{31} is found to vary from 0.2 to 1.9, with an average value of 0.81. No correlations are found for R_{31} to Hubble type and far infrared luminosity. Possible indications for a correlation with inclination angle and the 60mum/100mum color temperature of the dust are not significant. Higher R_{31} ratios than in ``normal'' galaxies, hinting at enhanced molecular excitation, may be found in galaxies hosting active galactic nuclei. Even higher average values are determined for galaxies with bars or starbursts, the latter being identified by the ratio of infrared luminosity versus isophotal area, log[(L_{FIR}/L_{SUN})/(D_{25}/kpc)^2)] > 7.25. (U)LIRGs are found to have the highest averaged R_{31} value. This may be a consequence of particularly vigorous star formation activity, triggered by galaxy interaction and merger events. The nuclear CO luminosities are slightly sublinearly correlated with the global FIR luminosity in both the ^{12}CO J = 3-2 and the 1-0 lines. The slope of the log-log plots rises with compactness of the respective galaxy subsample, indicating a higher average density and a larger fraction of thermalized gas in distant luminous galaxies. While linear or sublinear correlations for the ^{12}CO J = 3-2 line can be explained, if the bulk of the observed J = 3-2 emission originates from molecular gas with densities below the critical one, the case of the ^{12}CO J = 1-0 line with its small critical density remains a puzzle.Comment: 26 pages, 9 figures, 4 tables, Accepted for publication in The Astrophysical Journal (Part 1

Grundlagen zur Abschätzung und Bewertung der von Kohlekraftwerken ausgehenden Umweltbelastungen in Entwicklungsländern : Studie im Auftrag des Bundesministeriums für Wirtschaftliche Zusammenarbeit (Nr.: 201-E522-48/78)

Ziel dieses Forschungsberichtes ist es, systematische Bewertungshilfen bereitzustellen, um durch Kohlekraftwerke entstehende Umweltschäden in Entwicklungsländern abzuschätzen. Hierzu müssen von allen denkbaren von Kohlekraftwerken ausgehenden Umweltbelastungen jene ausgesucht werden, die ein hohes Gefährdungspotential besitzen und bei deren Betrieb häufig auftreten. Darüberhinaus sollten aber Ausnahmefälle, bei denen bestimmte Faktorenkombinationen zu für Kohlekraftwerke untypischen Belastungssituationen führen, ebenfalls Berücksichtigung finden. Es besteht also das Problem, Bewertungshilfen zu finden, die sich durch ihre Allgemeingültigkeit und Anwendbarkeit in allen Entwicklungsländern, also in unterschiedlichsten Regionen auszeichnen und die trotzdem im einzelnen Anwendungsfall spezielle Bedingungen beachten

Fluorescence and spin properties of defects in single digit nanodiamonds

International audienceThis article reports stable photoluminescence and high-contrast optically detected electron spin resonance (ODESR) from single nitrogen-vacancy (NV) defect centers created within ultrasmall, disperse nanodiamonds of radius less than 4 nm. Unexpectedly, the efficiency for the production of NV fluorescent defects by electron irradiation is found to be independent of the size of the nanocrystals. Fluorescence lifetime imaging shows lifetimes with a mean value of around 17 ns, only slightly longer than the bulk value of the defects. After proper surface cleaning, the dephasing times of the electron spin resonance in the nanocrystals approach values of some microseconds, which is typical for the type Ib diamond from which the nanoparticle is made. We conclude that despite the tiny size of these nanodiamonds the photoactive nitrogen-vacancy color centers retain their bulk properties to the benefit of numerous exciting potential applications in photonics, biomedical labeling, and imaging

Kartierung der Elementgehalte und Biomarkeranalysen zur Untersuchung des täglichen Lebens in einer frühbyzantinischen Stadt

Bodenchemische Analysen, die über eine einfache Phosphorbestimmung hinausgehen, wurden bisher nur vereinzelt bei Ausgrabungen von Siedlungen durchgeführt. Aufgrund ihrer seltenen Anwendung sind weder großflächige noch detaillierte Bodenuntersuchungen im archäologischen Kontext etabliert.Jahrestagung des Arbeitskreises Geoarchäologie vom 04.05. bis 06.05.2018 in Münche

Artificial Intelligence for the Detection of Focal Cortical Dysplasia: Challenges in Translating Algorithms into Clinical Practice

Focal cortical dysplasias (FCDs) are malformations of cortical development and one of the most common pathologies causing pharmacoresistant focal epilepsy. Resective neurosurgery yields high success rates, especially if the full extent of the lesion is correctly identified and completely removed. The visual assessment of magnetic resonance imaging does not pinpoint the FCD in 30%–50% of cases, and half of all patients with FCD are not amenable to epilepsy surgery, partly because the FCD could not be sufficiently localized. Computational approaches to FCD detection are an active area of research, benefitting from advancements in computer vision. Automatic FCD detection is a significant challenge and one of the first clinical grounds where the application of artificial intelligence may translate into an advance for patients' health. The emergence of new methods from the combination of health and computer sciences creates novel challenges. Imaging data need to be organized into structured, well-annotated datasets and combined with other clinical information, such as histopathological subtypes or neuroimaging characteristics. Algorithmic output, that is, model prediction, requires a technically correct evaluation with adequate metrics that are understandable and usable for clinicians. Publication of code and data is necessary to make research accessible and reproducible. This critical review introduces the field of automatic FCD detection, explaining underlying medical and technical concepts, highlighting its challenges and current limitations, and providing a perspective for a novel research environment

Diseases of the salivary glands in infants and adolescents

<p>Abstract</p> <p>Background</p> <p>Diseases of the salivary glands are rare in infants and children (with the exception of diseases such as parotitis epidemica and cytomegaly) and the therapeutic regimen differs from that in adults. It is therefore all the more important to gain exact and extensive insight into general and special aspects of pathological changes of the salivary glands in these age groups. Etiology and pathogenesis of these entities is still not yet fully known for the age group in question so that general rules for treatment, based on clinical experience, cannot be given, particularly in view of the small number of cases of the different diseases. Swellings of the salivary glands may be caused by acute and chronic inflammatory processes, by autoimmune diseases, by duct translocation due to sialolithiasis, and by tumors of varying dignity. Clinical examination and diagnosis has also to differentiate between salivary gland cysts and inflammation or tumors.</p> <p>Conclusion</p> <p>Salivary gland diseases are rare in childhood and adolescence. Their pattern of incidence differs very much from that of adults. Acute and chronic sialadenitis not responding to conservative treatment requires an appropriate surgical approach. The rareness of salivary gland tumors is particularly true for the malignant parotid tumors which are more frequent in juvenile patients, a fact that has to be considered in diagnosis and therapy.</p