Isolamento de Candida spp. de estomatite relacionada à prótese no Pará, Brasil.

The aim of this study was to isolate and identify Candida species from the oral cavity of den-ture wearers with denture-related stomatitis who were attended at the University Federalof Pará (Belém City, Pará State, Brazil). A total of 36 denture wearers with denture-relatedstomatitis were included, and type I (50%), type II (33%) and type III (17%) stomatitis wereobserved. Candida spp. were isolated from 89% of the cases and included five differentCandida species. C. albicans was the most frequently recovered species (78% of the cases),followed by C. famata and C. tropicalis. We observed a significant association between Candidaspecies isolation and unsatisfactory denture condition (p = 0.0017). Our results demonstratedthe highly frequency of Candida species isolation in denture wearers with denture-relatedstomatitis and showed the relationship between these species and poor denture maintence.O objetivo deste estudo foi isolar e identificar espécies de Candida da cavidade oral de usuários com estomatite relacionada à dentadura, atendidos na Universidade Federal do Pará (Cidade de Belém, Pará, Brasil). Foram incluídos 36 usuários de protese com estomatite relacionada à prótese, e foram observadas estomatite tipo I (50%), tipo II (33%) e tipo III (17%). Candida spp. foram isolados em 89% dos casos e incluíram cinco espécies diferentes de Candida. C. albicans, frequentemente recuperada (78% dos casos), seguida por C. famata e C. tropicalis. Observamos uma associação significativa entre o isolamento da espécie Candidas e a condição insatisfatória da prótese (p = 0,0017). Nossos resultados demonstraram a alta frequência de isolamento de espécies de Candida em usuários de próteses com estomatite relacionada à prótese e mostraram a relação entre essas espécies e má manutenção da prótese

Doenças cardiovasculares como principal fator de risco para medicina periodontal: revisão de literatura

Background: Periodontal medicine has been growing and the demand for knowledge about the effects of periodontal disease and periodontal therapy in systemic health has increased. This study described a narrative review of the literature on the correlation between cardiovascular diseases (CVDs) and periodontal disease (PD). Materials and Methods: A literature search were performed on the platforms PubMed, SciELO, MEDLINE, LILACS, using the keywords “Chronic Periodontitis” AND/OR “Periodontal Diseases” AND/OR “Cardiovascular Diseases” AND/OR “Periodontal Microbiology” AND/OR “Cardiopathies AND/OR Atherosclerosis” and the inclusion criteria were articles published from 2015 to 2020, in Portuguese and English. Results: Although the connection between CVDs and PD is well documented, evidence for the cause effect of this relationship remains to be clarified. Results: CVDs such as atherosclerosis have pro-inflammatory characteristics, and the continuous adhesion of adipose cells to the inner endothelial walls promotes possible damage to the patient's entire cardiovascular system. Furthermore, it is known that periodontal bacteria when they fall into the bloodstream may have an affinity for atherosclerotic plaques, aggravating the pro-inflammatory systemic state, so understanding how the interaction between these two pathologies works is of great importance to the dental surgeon in order to proceed with his plan of treatment. Conclusions: The focus of the studies captured in this work was on the eti-opathogenesis, mechanism of action and clinical care between PD and CVDs and based on the analyzes we sought to update clinical and scientific evidence and hypotheses for significant associations between these two pathologies.Introducción: Las enfermedades cardiovasculares (ECV) y la enfermedad periodontal (EP) comparten varios factores de riesgo comunes, como la edad, el sexo, la obesidad, el nivel socioeconómico, el tabaquismo y el alcohol. En los últimos años, varios estudios en el campo de la medicina periodontal han proporcionado evidencia de que existe una asociación entre la EP y un mayor riesgo de ECV. Objetivos: Este estudio tiene como objetivo describir una revisión narrativa de la literatura sobre la correlación entre ECV y EP, además de producir un manejo de la atención odontológica para pacientes con enfermedades del corazón. Materiales y métodos: Se realizó una búsqueda bibliográfica en las siguientes bases de datos: Google Scholar, PubMed, EBSCO y Scielo, de manuscritos de 2015 a 2020 utilizando términos de búsqueda y descriptores. Discusión: aunque la conexión entre las ECV y la EP está bien documentada, todavía falta evidencia clara de causa y efecto de esta relación. Las ECV como la aterosclerosis tienen características proinflamatorias y la adhesión continua de las células grasas a las paredes endoteliales internas promueve un posible daño a todo el sistema cardiovascular del paciente. Además, se sabe que las bacterias periodontales, cuando ingresan al torrente sanguíneo, pueden tener afinidad por las placas ateroscleróticas, agravando el estado sistémico proinflamatorio, por lo que comprender cómo funciona la interacción entre estas dos patologías es de gran importancia para el cirujano dentista. para poder continuar con su plan de tratamiento. Conclusión: Por lo tanto, el manejo y tratamiento periodontal exitoso puede disminuir el riesgo o incluso prevenir la aparición y progresión de las ECV.Introdução: Doenças cardiovasculares (DCVs) e a doença periodontal (DP) compartilham variados fatores de riscos em comuns como idade, gênero, obesidade, status socioeconômico, tabagismo e álcool. Nos últimos anos diversos estudos, no campo da medicina periodontal, forneceram evidências de que há uma associação entre DP e risco elevado para DCVs. Objetivos: Este estudo tem como objetivo descrever uma revisão narrativa da literatura sobre a correlação entre DCVs e DP, além de produzir um manejo de atendimento odontológico a pacientes cardiopatas. Materiais e métodos: Foi realizada uma busca na literatura nas bases de dados: Google Acadêmico, PubMed, EBSCO e Scielo, de manuscrito de 2015 até 2020 usando termos de pesquisa e descritores.Discussão: Embora a conexão entre DCVs e DP sejam bem documentadas, ainda faltam esclarecer evidências de causa-efeito desta relação. DCVs como a aterosclerose possuem características pró-inflamatórias, e a contínua adesão das células adiposas nas paredes internas endoteliais promovendo possíveis lesões a todo sistema cardiovascular do paciente. Ademais sabe-se que bactérias periodontais quando caem na corrente sanguínea podem ter afinidade pelas placas ateroscleróticas agravando o estado sistêmico pró-inflamatório, sendo assim entender como funciona a interação entre essas duas patologias de grande importância ao cirurgião dentista poder prosseguir com seu plano de tratamento. Conclusão: Assim, o manejo e tratamento periodontal bem-sucedidos podem diminuir o risco ou mesmo prevenir início e progressão de DCVs

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Influence of composition of the organic matrix, filler content and thermic treatment on different properties of experimental composites

Objetivo: Analisar a influência da matriz orgânica, do conteúdo inorgânico e do tratamento térmico (TT) sobre diferentes propriedades de compósitos experimentais, tais como o grau de conversão (GC), tenacidade à fratura (KIC), resistência à flexão (RF) e módulo de elasticidade (ME). Métodos: Para o experimento foram analisadas seis formulações de compósitos experimentais com proporções molares de Bis-GMA:TEGDMA de 5:5 e 7:3, a carga utilizada foi o vidro de bário, nas concentrações de 30, 50 e 70% em peso, e os fotoiniciadores a amina e canforoquinona. O GC foi analisado através da espectroscopia no infra-vermelho (FTIR) (n=5). A KlC foi avaliada pelo método single-edge notched beam (SENB). As imagens das superfícies de fratura foram capturadas por um estereomicroscópio e a KlC calculada (n=10). A análise da RF e ME foi realizada através do teste dos três pontos (n=10). Para todos os fatores de variação estudados, metade dos espécimes imediatamente após à confecção receberam TT em estufa convencional, a 170º C por 10 minutos e a outra metade não. Após 24 horas, as amostras foram destinadas de acordo com os ensaios realizados. Os dados foram analisados utilizando ANOVA/Tukey para o grau de conversão, tenacidade à fratura e resistência à flexão, e, Kruskal-Wallis para o módulo de elasticidade (=5%). Resultados: Na análise do GC (%) foi observada significância estatística para os três fatores de variação analisados individualmente (monômero, carga e TT), como também, para a interação monômero x TT (p<0,001). Para a KIC e RF, as alterações significantes foram observadas apenas nos três fatores de variação (monômero, carga e TT) analisados individualmente (p<0,001). Para o ME, os fatores individuais (monômero, carga e TT), a interação carga x TT apresentaram significância estatística (p<0,001), bem como a interação monômero x carga (p=0,001). Conclusões: A matriz orgânica e o conteúdo inorgânico dos compósitos experimentais influenciaram o GC, a KIC, a RF e ME, e o TT promoveu melhorias nas propriedades estudadas.Objective: To analyze the influence of organic matrix, the inorganic content and thermic treatment (TT) on different properties of experimental composites, such as the degree of conversion (DC), fracture toughness (KIC), flexural strength (FS) and elastic modulus (EM). Methods: This experiment analyzed six formulations of experimental composites with 5:5 and 7:3 molar proportions of Bis-GMA: TEGDMA. The load used was barium glass at concentrations of 30, 50 and 70% by weight and the photoinitiators, camphorquinone and amine. GC was analyzed by infrared spectroscopy (FTIR) (n=5). The KIC was evaluated by a \"single-edge notched beam\" (SENB). The images of the fracture surfaces were captured by a stereomicroscope and KIC calculated (n=10). The analysis FS and EM were performed by testing three points (n=10). For all the variation factors studied, half of the specimens immediately after the preparation received TT in conventional oven at 170º C for 10 minutes and the other half not. After 24 hours, the samples were designed according to the tests. Data were analyzed using ANOVA/Tukey the degree of conversion, fracture toughness and flexural strength, and Kruskal-Wallis test for the elastic modulus (=5%). Results: Analysis of GC (%) statistical significance was observed for the three variation factors analyzed individually (monomer, filler and TT), as well as for the interaction monomer x TT (p <0.001). For KIC and FS, significant changes were observed only in the three variation factors (monomer, filler and TT) analyzed individually (p<0.001). For EM, the individual factors (monomer, filler and TT) TT x filler interaction showed statistical significance (p <0.001), as well as the monomer x filler interaction (p = 0.001). Conclusions: The organic matrix and inorganic content of experimental composites influenced the GC, KIC, FS and EM, and the TT caused improvements in the properties studied

Relationship among local and functional factors in the development of denture stomatitis in denture wearers in northern Brazil

OBJECTIVE: The aim of this study was to evaluate the relationship among functional and qualitative factors in the development of denture stomatitis (DS) (according to Newton's classification) in acrylic-based denture wearers residents from northern Brazil.MATERIAL AND METHOD: A total of 99 patients who wore partial or total acrylic resin-based upper dentures were included in this study. The subjects completed an epidemiological data form that includes the patient's gender, age, local factors (hygiene habits, remove denture to sleep, use of mouthwash, present condition of the denture, age of the denture) and functional factors (vertical dimension at rest, vertical dimension of occlusion, occlusion, retention, and static and dynamic stability). To detect yeasts, samples were collected from the inner surface of the dentures and from the palatal mucosa in contact with it. Subsequently, the samples were cultured on Sabouraud dextrose agar, observing macro and microscopic characteristics.RESULT: In the present study, we did not find any significant relationship between the gender and disease onset. Based on the Newton classification, 36.3% of the patients presented with DS and 89.0% were colonized by yeasts; of these subjects, 50% had type I lesions, 33.3% had type II lesions, and 16.6% had type III lesions. All of the qualitative and local factors, except the use of mouthwash, were clinically relevant to the development of disease.CONCLUSION: Denture stomatitis in denture users in northern Brazil was multifactorial, involving local, functional and microbiological factors

Isolation of Candida spp. from denture-related stomatitis in Pará, Brazil

The preparation of this manuscript was supported by the Postgraduate Program in Biology ofInfectious and Parasitic Agents, Federal University of Pará (Edital PAPQ/2013-UFPA).Federal University of Pará. Science Health Institute Belém. Odontology College. Belém, PA, Brazil / Federal University of Pará. Science Biologic Institute. Postgraduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Science Health Institute Belém. Odontology College. Belém, PA, BrazilFederal University of Pará. Science Biologic Institute. Postgraduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Science Health Institute Belém. Odontology College. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Micologia. Ananindeua, PA, Brasil.The aim of this study was to isolate and identify Candida species from the oral cavity of denture wearers with denture-related stomatitis who were attended at the University Federal of Pará (Belém City, Pará State, Brazil). A total of 36 denture wearers with denture-related stomatitis were included, and type I (50%), type II (33%) and type III (17%) stomatitis were observed. Candida spp. were isolated from 89% of the cases and included five different Candida species. C. albicans was the most frequently recovered species (78% of the cases), followed by C. famata and C. tropicalis. We observed a significant association between Candida species isolation and unsatisfactory denture condition (p = 0.0017). Our results demonstrated the highly frequency of Candida species isolation in denture wearers with denture-related stomatitis and showed the relationship between these species and poor denture maintenance

Relationship among local and functional factors in the development of denture stomatitis in denture wearers in northern Brazil

OBJECTIVE: The aim of this study was to evaluate the relationship among functional and qualitative factors in the development of denture stomatitis (DS) (according to Newton's classification) in acrylic-based denture wearers residents from northern Brazil.MATERIAL AND METHOD: A total of 99 patients who wore partial or total acrylic resin-based upper dentures were included in this study. The subjects completed an epidemiological data form that includes the patient's gender, age, local factors (hygiene habits, remove denture to sleep, use of mouthwash, present condition of the denture, age of the denture) and functional factors (vertical dimension at rest, vertical dimension of occlusion, occlusion, retention, and static and dynamic stability). To detect yeasts, samples were collected from the inner surface of the dentures and from the palatal mucosa in contact with it. Subsequently, the samples were cultured on Sabouraud dextrose agar, observing macro and microscopic characteristics.RESULT: In the present study, we did not find any significant relationship between the gender and disease onset. Based on the Newton classification, 36.3% of the patients presented with DS and 89.0% were colonized by yeasts; of these subjects, 50% had type I lesions, 33.3% had type II lesions, and 16.6% had type III lesions. All of the qualitative and local factors, except the use of mouthwash, were clinically relevant to the development of disease.CONCLUSION: Denture stomatitis in denture users in northern Brazil was multifactorial, involving local, functional and microbiological factors