Analysis of cyclic delay diversity on DVB-H systems over spatially correlated channel

The objective of this work is to research and analyze the performance of Cyclic Delay Diversity (CDD) with two transmit antenna on DVB-H systems operating in spatially correlated channel. It is shown in this paper that CDD can achieve desirable transmit diversity gain over uncorrelated channel with or without receiver diversity. However, in reality, the respective signal paths between spatially separated antennas and the mobile receiver is likely to be correlated because of insufficient antenna separation at the transmitter and the lack of scattering effect of the channel. Under this spatially correlated channel, it is apparent that CDD cannot achieve the same diversity gain as obtained under the uncorrelated channel. In this paper, a new upper bound on the pairwise error probability (PEP) of the CDD with spatial correlation of two transmit antennas is derived. The upper bound is used to study the CDD theoretical error performance and diversity gain losses over a generalized spatially correlated Rayleigh channel. This theoretical analysis is validated by the simulation of DVB-H systems with two transmit antennas and the CDD scheme. Both the theoretical and simulated results give the valuable insight that the CDD ability to perform well with a certain amount of channel correlation

Analysis of DVB-H network coverage with the application of transmit diversity

This paper investigates the effects of the Cyclic Delay Diversity (CDD) transmit diversity scheme on DVB-H networks. Transmit diversity improves reception and Quality of Service (QoS) in areas of poor coverage such as sparsely populated or obscured locations. The technique not only povides robust reception in mobile environments thus improving QoS, but it also reduces network costs in terms of the transmit power, number of infrastructure elements, antenna height and the frequency reuse factor over indoor and outdoor environments. In this paper, the benefit and effectiveness of CDD transmit diversity is tackled through simulation results for comparison in several scenarios of coverage in DVB-H networks. The channel model used in the simulations is based on COST207 and a basic radio planning technique is used to illustrate the main principles developed in this paper. The work reported in this paper was supported by the European Commission IST project—PLUTO (Physical Layer DVB Transmission Optimization)

Zigzag-shaped nickel nanowires via organometallic template-free route

In this manuscript, the formation of nickel nanowires (average size: several tens to hundreds of μm long and 1.0-1.5 μm wide) at low temperature is found to be driven by dewetting of liquid organometallic precursors during spin coating process and by self-assembly of Ni clusters. Elaboration of metallic thin films by low temperature deposition technique makes the preparation process compatible with most of the substrates. The use of iron and cobalt precursor shows that the process could be extended to other metallic systems. In this work, AFM and SEM are used to follow the assembly of Ni clusters into straight or zigzag lines. The formation of zigzag structure is specific to the Ni precursor at appropriate preparation parameters. This template free process allows a control of anisotropic structures with homogeneous sizes and angles on standard Si/SiO2 surface

Ionic liquids for energy, materials, and medicine.

As highlighted by the recent ChemComm web themed issue on ionic liquids, this field continues to develop beyond the concept of interesting new solvents for application in the greening of the chemical industry. Here some current research trends in the field will be discussed which show that ionic liquids research is still aimed squarely at solving major societal issues by taking advantage of new fundamental understanding of the nature of these salts in their low temperature liquid state. This article discusses current research trends in applications of ionic liquids to energy, materials, and medicines to provide some insight into the directions, motivations, challenges, and successes being achieved with ionic liquids today

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

Deletion of exon 9 from Cullin‐3 (CUL3, residues 403–459: CUL3Δ403–459) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 and various substrate adaptors to form Cullin‐RING‐ubiquitin‐ligase complexes. Bound to KLHL3, CUL3‐RBX1 ubiquitylates WNK kinases, promoting their ubiquitin‐mediated proteasomal degradation. Since WNK kinases activate Na/Cl co‐transporters to promote salt retention, CUL3 regulates blood pressure. Mutations in both KLHL3 and WNK kinases cause PHA2 by disrupting Cullin‐RING‐ligase formation. We report here that the PHA2E mutant, CUL3Δ403–459, is severely compromised in its ability to ubiquitylate WNKs, possibly due to altered structural flexibility. Instead, CUL3Δ403–459 auto‐ubiquitylates and loses interaction with two important Cullin regulators: the COP9‐signalosome and CAND1. A novel knock‐in mouse model of CUL3WT/Δ403–459 closely recapitulates the human PHA2E phenotype. These mice also show changes in the arterial pulse waveform, suggesting a vascular contribution to their hypertension not reported in previous FHHt models. These findings may explain the severity of the FHHt phenotype caused by CUL3 mutations compared to those reported in KLHL3 or WNK kinases

Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals.

BackgroundThe SCID-hu Thy/Liv mouse model of HIV-1 infection is a useful platform for the preclinical evaluation of antiviral efficacy in vivo. We performed this study to validate the model with representatives of all four classes of licensed antiretrovirals.Methodology/principal findingsEndpoint analyses for quantification of Thy/Liv implant viral load included ELISA for cell-associated p24, branched DNA assay for HIV-1 RNA, and detection of infected thymocytes by intracellular staining for Gag-p24. Antiviral protection from HIV-1-mediated thymocyte depletion was assessed by multicolor flow cytometric analysis of thymocyte subpopulations based on surface expression of CD3, CD4, and CD8. These mice can be productively infected with molecular clones of HIV-1 (e.g., the X4 clone NL4-3) as well as with primary R5 and R5X4 isolates. To determine whether results in this model are concordant with those found in humans, we performed direct comparisons of two drugs in the same class, each of which has known potency and dosing levels in humans. Here we show that second-generation antiretrovirals were, as expected, more potent than their first-generation predecessors: emtricitabine was more potent than lamivudine, efavirenz was more potent than nevirapine, and atazanavir was more potent than indinavir. After interspecies pharmacodynamic scaling, the dose ranges found to inhibit viral replication in the SCID-hu Thy/Liv mouse were similar to those used in humans. Moreover, HIV-1 replication in these mice was genetically stable; treatment of the mice with lamivudine did not result in the M184V substitution in reverse transcriptase, and the multidrug-resistant NY index case HIV-1 retained its drug-resistance substitutions.ConclusionGiven the fidelity of such comparisons, we conclude that this highly reproducible mouse model is likely to predict clinical antiviral efficacy in humans

An epidemiologic study of early biologic effects of benzene in Chinese workers.

Benzene is a recognized hematotoxin and leukemogen, but its mechanisms of action in humans are still uncertain. To provide insight into these processes, we carried out a cross-sectional study of 44 healthy workers currently exposed to benzene (median 8-hr time-weighted average; 31 ppm), and unexposed controls in Shanghai, China. Here we provide an overview of the study results on peripheral blood cells levels and somatic cell mutation frequency measured by the glycophorin A (GPA) gene loss assay and report on peripheral cytokine levels. All peripheral blood cells levels (i.e., total white blood cells, absolute lymphocyte count, platelets, red blood cells, and hemoglobin) were decreased among exposed workers compared to controls, with the exception of the red blood cell mean corpuscular volume, which was higher among exposed subjects. In contrast, peripheral cytokine levels (interleukin-3, interleukin-6, erythropoietin, granulocyte colony-stimulating factor, tissue necrosis factor-alpha) in a subset of the most highly exposed workers (n = 11) were similar to values in controls (n = 11), suggesting that benzene does not affect these growth factor levels in peripheral blood. The GPA assay measures stem cell or precursor erythroid cell mutations expressed in peripheral red blood cells of MN heterozygous subjects, identifying NN variants, which result from loss of the GPA M allele and duplication of the N allele, and N phi variants, which arise from gene inactivation. The NN (but not N phi) GPA variant cell frequency was elevated in the exposed workers compared with controls (mean +/- SD, 13.9 +/- 8.4 mutants per million cells versus 7.4 +/- 5.2 per million cells, (respectively; p = 0.0002), suggesting that benzene produces gene-duplicating but not gene-inactivating mutations at the GPA locus in bone marrow cells of exposed humans. These findings, combined with ongoing analyses of benzene macromolecular adducts and chromosomal aberrations, will provide an opportunity to comprehensively evaluate a wide range of early biologic effects associated with benzene exposure in humans

Magnetic inhomogeneities in the quadruple perovskite manganite [Y_{2-x}Mn_{x}] Mn_{6}O_{12}

A combination of competing exchange interactions and substitutional disorder gives rise to magnetic inhomogeneities in the [Y_{2-x}Mn_{x}]Mn_{6}O-{12}x = 0.23 and 0.16 quadruple perovskite manganites. Our neutron powder scattering measurements show that both the x=0.23 and 0.16 samples separate into two distinct magnetic phases; below T_{1} = 120 ± 10 K the system undergoes a transition from a paramagnetic phase to a phase characterized by short-range antiferromagnetic clusters contained in a paramagnetic matrix, and below T2≈65 K the system is composed of well-correlated long-range collinear ferrimagnetic order, punctuated by short-range antiferromagnetic clusters. A sharp increase in the antiferromagnetic phase fraction is observed below ≈33 K, concomitant with a decrease in the ferrimagnetic phase fraction. Our results demonstrate that the theoretically proposed antiferromagnetic phase is stabilized in the [Y_{2-x}Mn_{x}] Mn_{6}O_{12} manganites in the presence of dominant B-B exchange interactions, as predicted