Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life

Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years. This study therefore aimed to determine if withdrawing from BZDs leads to changes in patients' cognitive function, quality of life, mood and sleep. Method: One hundred and ninety-two long-term users of BZD hypnotics, aged [gt-or-equal, slanted]65 years, were identified in 25 general practices. One hundred and four who wished to withdraw were randomly allocated to one of two groups under double-blind, placebo controlled conditions: group A's BZD dose was tapered from week 1 of the trial; group B were given their usual dose for 12 weeks and then it was tapered. An additional group (C) of 35 patients who did not wish to withdraw from BZDs participated as ‘continuers’. All patients were assessed at 0, 12 and 24 weeks and 50% were re-assessed at 52 weeks. Results: Sixty per cent of patients had taken BZDs continuously for >10 years; 27% for >20 years. Of all patients beginning the trial, 80% had successfully withdrawn 6 months later. There was little difference between groups A and B, but these groups differed from continuers (C) in that the performance of the withdrawers on several cognitive/psychomotor tasks showed relative improvements at 24 or 52 weeks. Withdrawers and continuers did not differ in sleep or BZD withdrawal symptoms. Conclusions: These results have clear implications for clinical practice. Withdrawal from BZDs produces some subtle cognitive advantages for older people, yet little in the way of withdrawal symptoms or emergent sleep difficulties. These findings also suggest that, taken long-term, BZDs do not aid sleep

The radio-infrared correlation in galaxies

The radio-infrared correlation was explained as a direct and linear relationship between star formation and IR emission. However, one fact making the IR-star formation linkage less obvious is that the IR emission consists of at least two emission components, cold dust and warm dust. The cold dust emission may not be directly linked to the young stellar population. Furthermore, understanding the origin of the radio-IR correlation requires to discriminate between the two main components of the radio continuum emission, free-free and synchrotron emission. Here, we present a multi-scale study of the correlation of IR with both the thermal and non-thermal (synchrotron) components of the radio continuum emission from the nearby galaxies M33 and M31.Comment: To appear in Highlights of Astronomy, Volume 15, XXVIIth IAU General Assembly, August 200

TOTAL ECONOMIC VALUATION OF STREAM RESTORATION USING INTERNET AND MAIL SURVEYS

The economic value of restoring Deckers Creek in Monongalia and Preston Counties of West Virginia was determined from mail, internet and personal interview surveys. Multi-attribute, choice experiments were conducted and nested logit models were estimated to derive the economic values of full restoration for three attributes of this creek: aquatic life, swimming, and scenic quality. The relative economic values of attributes were: aquatic life > scenic quality ~ swimming. These economic values imply that respondents had the highest value for aquatic life when fully restoring Deckers Creek to a sustainable fishery rather than "put and take" fishery that can not sustain a fish population (defined as moderate restoration for aquatic life). The consumer surplus estimates for full restoration of all three attributes ranged between $12 and$16 per month per household. Potential stream users (anglers) had the largest consumer surplus gain from restoration while non-angler respondents had the lowest. When the consumer surplus estimates were aggregated up to the entire watershed population, the benefit from restoration of Deckers Creek was estimated to be about $1.9 million annually. This benefit does not account for any economic values from partial stream restoration. Based upon log likelihood tests of the nested logit models, two sub-samples of the survey population (the general population and stream users) were found to be from the same population. Thus, restoration choices by stream users may be representative of the watershed population, although the sample size of stream users was small in this study.Resource /Energy Economics and Policy,

Spin Exchange Rates in Electron-Hydrogen Collisions

The spin temperature of neutral hydrogen, which determines the 21 cm optical depth and brightness temperature, is set by the competition between radiative and collisional processes. In the high-redshift intergalactic medium, the dominant collisions are typically those between hydrogen atoms. However, collisions with electrons couple much more efficiently to the spin state of hydrogen than do collisions with other hydrogen atoms and thus become important once the ionized fraction exceeds ~1%. Here we compute the rate at which electron-hydrogen collisions change the hydrogen spin. Previous calculations included only S-wave scattering and ignored resonances near the n=2 threshold. We provide accurate results, including all partial wave terms through the F-wave, for the de-excitation rate at temperatures T_K < 15,000 K; beyond that point, excitation to n>=2 hydrogen levels becomes significant. Accurate electron-hydrogen collision rates at higher temperatures are not necessary, because collisional excitation in this regime inevitably produces Lyman-alpha photons, which in turn dominate spin exchange when T_K > 6200 K even in the absence of radiative sources. Our rates differ from previous calculations by several percent over the temperature range of interest. We also consider some simple astrophysical examples where our spin de-excitation rates are useful.Comment: submitted to MNRAS, 9 pages, 5 figure

Attorney General v X: Commentary and Feminist Judgment

The commentary considers the feminist judgment as a exercise in progressive constitutionalism addressing gendered harms. The feminist judgment, an imagined Supreme Court judgment in Attorney General v X and others [1992] 1 IR 1 (IESC),.addresses the question of abortion’s permissibility under the Irish Constitution through a feminist approach to constitutional rights, legal method and socio-legal knowledge. The legal test adopted for determining when an abortion is constitutionally permissible is when carrying a pregnancy is an impracticable burden on a woman’s life. This test is substantially different from the one adopted in the actual X case, that a woman may terminate a pregnancy when there is a real and substantial risk to her life, as distinct from her health. Among other things, it avoids the bright line distinctions between life and health which have been problematic for pregnant women since X, including Ms A, Ms B, Ms C, Ms D1, Ms D2, Savita Halappanavar, Michelle Harte and Ms Y, and their health care providers

Using Three-Body Recombination to Extract Electron Temperatures of Ultracold Plasmas

Three-body recombination, an important collisional process in plasmas, increases dramatically at low electron temperatures, with an accepted scaling of T_e^-9/2. We measure three-body recombination in an ultracold neutral xenon plasma by detecting recombination-created Rydberg atoms using a microwave-ionization technique. With the accepted theory (expected to be applicable for weakly-coupled plasmas) and our measured rates we extract the plasma temperatures, which are in reasonable agreement with previous measurements early in the plasma lifetime. The resulting electron temperatures indicate that the plasma continues to cool to temperatures below 1 K.Comment: 5 pages, 3 figure

A genome-wide investigation of the worldwide invader Sargassum muticum shows high success albeit (almost) no genetic diversity

Twenty years of genetic studies of marine invaders have shown that successful invaders are often characterized by native and introduced populations displaying similar levels of genetic diversity. This pattern is presumably due to high propagule pressure and repeated introductions. The opposite pattern is reported in this study of the brown seaweed, Sargassum muticum, an emblematic species for circumglobal invasions. Albeit demonstrating polymorphism in the native range, microsatellites failed to detect any genetic variation over 1,269 individuals sampled from 46 locations over the Pacific-Atlantic introduction range. Single-nucleotide polymorphisms (SNPs) obtained from ddRAD sequencing revealed some genetic variation, but confirmed severe founder events in both the Pacific and Atlantic introduction ranges. Our study thus exemplifies the need for extreme caution in interpreting neutral genetic diversity as a proxy for invasive potential. Our results confirm a previously hypothesized transoceanic secondary introduction from NE Pacific to Europe. However, the SNP panel unexpectedly revealed two additional distinct genetic origins of introductions. Also, conversely to scenarios based on historical records, southern rather than northern NE Pacific populations could have seeded most of the European populations. Finally, the most recently introduced populations showed the lowest selfing rates, suggesting higher levels of recombination might be beneficial at the early stage of the introduction process (i.e., facilitating evolutionary novelties), whereas uniparental reproduction might be favored later in sustainably established populations (i.e., sustaining local adaptation).Agence Nationale de la Recherche - ANR-10-BTBR-04; European Regional Development Fund; Fundacao para a Ciencia e a Tecnologia - SFRH/BPD/107878/2015, UID/Multi/04326/2016, UID/Multi/04326/2019; Brittany Region;info:eu-repo/semantics/publishedVersio

A new efficient method for determining weighted power spectra: detection of low-frequency solar p-modes by analysis of BiSON data

We present a new and highly efficient algorithm for computing a power spectrum made from evenly spaced data which combines the noise-reducing advantages of the weighted fit with the computational advantages of the Fast Fourier Transform (FFT). We apply this method to a 10-year data set of the solar p-mode oscillations obtained by the Birmingham Solar Oscillations Network (BiSON) and thereby uncover three new low-frequency modes. These are the l=2, n=5 and n=7 modes and the l=3, n=7 mode. In the case of the l=2, n=5 modes, this is believed to be the first such identification of this mode in the literature. The statistical weights needed for the method are derived from a combination of the real data and a sophisticated simulation of the instrument performance. Variations in the weights are due mainly to the differences in the noise characteristics of the various BiSON instruments, the change in those characteristics over time and the changing line-of-sight velocity between the stations and the Sun. It should be noted that a weighted data set will have a more time-dependent signal than an unweighted set and that, consequently, its frequency spectrum will be more susceptible to aliasing.Comment: 11 pages, 7 Figures, accepted for publication in MNRAS, Figure 6 had to be reduced in size to upload and so may be difficult to view on screen in .ps versio

Broadband Records of Earthquakes in Deep Gold Mines and a Comparison with Results from SAFOD, California

For one week during September 2007, we deployed a temporary network of field recorders and accelerometers at four sites within two deep, seismically active mines. The ground-motion data, recorded at 200 samples/sec, are well suited to determining source and ground-motion parameters for the mining-induced earthquakes within and adjacent to our network. Four earthquakes with magnitudes close to 2 were recorded with high signal/noise at all four sites. Analysis of seismic moments and peak velocities, in conjunction with the results of laboratory stick-slip friction experiments, were used to estimate source processes that are key to understanding source physics and to assessing underground seismic hazard. The maximum displacements on the rupture surfaces can be estimated from the parameter Rv, where v is the peak ground velocity at a given recording site, and R is the hypocentral distance. For each earthquake, the maximum slip and seismic moment can be combined with results from laboratory friction experiments to estimate the maximum slip rate within the rupture zone. Analysis of the four M 2 earthquakes recorded during our deployment and one of special interest recorded by the in-mine seismic network in 2004 revealed maximum slips ranging from 4 to 27 mm and maximum slip rates from 1.1 to 6:3 m=sec. Applying the same analyses to an M 2.1 earthquake within a cluster of repeating earthquakes near the San Andreas Fault Observatory at Depth site, California, yielded similar results for maximum slip and slip rate, 14 mm and 4:0 m=sec