Sulle tracce delle radici comuni

Abstract not availableUn\u27esperienza di scambio interculturale per la valorizzazione del patrimonio del Mediterrane

Dietro l’immagine. Approcci metodologici allo studio dell’iconografia funeraria

A qualunque epoca o latitudine appartengano, le immagini sono il segno tangibile sia dei processi naturali, storici e sociali che le hanno prodotte, sia delle idee, dei gusti e delle inclinazioni delle comunità che in esse si riconoscevano. Per tale motivo il loro studio in rapporto alle società antiche, se condotto in considerazione del potenziale di significati che esse assommano, rappresenta una delle chiavi di lettura più proficue per la comprensione di realtà e sistemi di valori distanti nel tempo e nello spazio. Whatever age or place they belong to, images are the concrete sign of the natural, historical and social processes that pro­duce them, but also the evidence of the ideas, tastes and inclinations of the communities they identify with. Therefore the analysis of the images that the ancient societies produced – if accomplished in consideration of the potential meanings they can express – can be one of the most profitable keys to understand realities and systems of values far from our time and place. DOI: 10.4429/j.arart.2011.suppl.21

Sardinian Landscape and Lighthouses

Lighthouses are commonly perceived as extraordinary places on the edge between land and sea, with such a strong connection with the landscape to be considered as true landmarks. Remained for long time assigned to the exclusive use of the Italian Navy, most of lighthouses are now abandoned and vulnerable pieces of architectures, exposed to erosion, salt water and the unavoidable decay. This article analyses the Integrated Conservation Program (ICP) of public lighthouses developed by the public agency Conservatoria delle coste della Sardegna. The ICP is based on the Protocol of Integrated Coastal Zone Management and on the concept of conservation, intended as measures to preserve the historical heritage and enhance the architectures quality in relation with the Sardinian cultural landscape

Nuraghe project: Strategies for the creation of a digital environment for international coexistence

[EN] The Nuraghe Project is an international archaeological research and training project in the southwest of Sardinia: the Nuraghe Candelargiu, in San Giovanni Suergiu(SU). As the work progressed, the need to create a common window in which to further develop the project and make the site accessible was highlighted, especially after the COVID pandemic that prevented the archaeology workshop from being held for the last two years, in order to allow a continuous transfer of knowledge based on the activities that characterize it: training, research, cultural exchange and coexistence. From this need was born "Virtual Candelargiu" as an interactive space integrated within the Nuraghe Project website and with the aim of becoming a place of learning and coexistence where the values that distinguish the project are combined, being its fundamental pillar the protection of archaeological heritage from collaborative work.[ES] El Proyecto Nuraghe es un proyecto internacional de investigación y formación arqueológica de uno de los yacimientos más importantes del suroeste de Cerdeña: el Nuraghe Candelargiu, en San Giovanni Suergiu (SU). Con el avance de los trabajos se puso de relieve la necesidad de crear una ventana común en la que poder seguir desarrollando el proyecto y hacer accesible el yacimiento, especialmente tras la pandemia del COVID que impidió la realización del curso de arqueología los dos últimos años, para así permitir una continua transferencia del conocimiento a partir de las actividades que lo caracterizan: la formación, la investigación, el intercambio cultural y la convivencia. De dicha necesidad nace “Candelargiu Virtual” como espacio interactivo integrado dentro de la web del Proyecto Nuraghe y con el objetivo de convertirse en un lugar de aprendizaje y convivencia donde se aúnen los valores que singularizan al proyecto, siendo su pilar fundamental la protección del patrimonio arqueológico a partir del trabajo colaborativo. Rodríguez Azogue, A.; Carranza Peco, LM.; Gómez Díaz, A.; Puddu, M.; Rodríguez Gutiérrez, O.; Fernández Flores, Á. (2022). Proyecto Nuraghe: Estrategias para la creación de un entorno digital de convivencia internacional. En CIMED22 - II Congreso internacional de museos y estrategias digitales. Editorial Universitat Politècnica de València. 353-368. https://doi.org/10.4995/CIMED22.2022.1558535336

Bovine lactoferrin-induced CCL1 expression involves distinct receptors in monocyte-derived dendritic cells and their monocyte precursors

Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation of cytokine and chemokine secretion. In this study, we demonstrate that bovine LF (bLF) up-modulates, in a concentration- and time-dependent manner, CCL1 secretion in monocytes (Mo) at the early stage of differentiation toward dendritic cells (DCs), and in fully differentiated immature Mo-derived DCs (MoDCs). In both cell types, up-modulation of CCL1 secretion is an early event following bLF-mediated enhanced accumulation of CCL1 transcripts. Notably, bLF-mediated up-regulation of CCL1 involves the engagement of distinct surface receptors in MoDCs and their Mo precursors. We show that bLF-mediated engagement of CD36 contributes to CCL1 induction in differentiating Mo. Conversely, toll-like receptor (TLR)2 blocking markedly reduces bLF-induced CCL1 production in MoDCs. These findings add further evidence for cell-specific differential responses elicited by bLF through the engagement of distinct TLRs and surface receptors. Furthermore, the different responses observed at early and late stages of Mo differentiation towards DCs may be relevant in mediating bLF effects in specific body districts, where these cell types may be differently represented in physiopathological conditions

RNAi Screening Implicates a SKN-1-Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

Caenorhabditis elegans SKN-1 (ortholog of mammalian Nrf1/2/3) is critical for oxidative stress resistance and promotes longevity under reduced insulin/IGF-1-like signaling (IIS), dietary restriction (DR), and normal conditions. SKN-1 inducibly activates genes involved in detoxification, protein homeostasis, and other functions in response to stress. Here we used genome-scale RNA interference (RNAi) screening to identify mechanisms that prevent inappropriate SKN-1 target gene expression under non-stressed conditions. We identified 41 genes for which knockdown leads to activation of a SKN-1 target gene (gcs-1) through skn-1-dependent or other mechanisms. These genes correspond to multiple cellular processes, including mRNA translation. Inhibition of translation is known to increase longevity and stress resistance and may be important for DR-induced lifespan extension. One model postulates that these effects derive from reduced energy needs, but various observations suggest that specific longevity pathways are involved. Here we show that translation initiation factor RNAi robustly induces SKN-1 target gene transcription and confers skn-1-dependent oxidative stress resistance. The accompanying increases in longevity are mediated largely through the activities of SKN-1 and the transcription factor DAF-16 (FOXO), which is required for longevity that derives from reduced IIS. Our results indicate that the SKN-1 detoxification gene network monitors various metabolic and regulatory processes. Interference with one of these processes, translation initiation, leads to a transcriptional response whereby SKN-1 promotes stress resistance and functions together with DAF-16 to extend lifespan. This stress response may be beneficial for coping with situations that are associated with reduced protein synthesis