Dación en pago : análisis actual de la institución y antecedentes romanísticos

Treball Final de Grau en Dret. Codi: DR1052 Curs acadèmic: 2013-201

Análisis de los constructos de autoconcepto y resiliencia, en jugadoras de baloncesto de categoría cadete

El presente estudio tuvo como objeto determinar y analizar las propiedades psicométricas de los instrumentos Autoconcepto Forma-5 (AF- 5) y CD-RISC así como describir y analizar las relaciones existentes entre ambas y especificar el efecto que tienen las horas de entrenamiento regular y la posición en baloncesto sobre las dimensiones psicosociales (autoconcepto y resiliencia), en jugadoras de baloncesto adolescentes españoles, considerando de manera simultánea variables personales y físico deportivas. Las participantes fueron 74 jugadoras cadetes, con edades comprendidas entre los 12 y 16 años, para el análisis estadística se llevó a cabo un análisis factorial exploratorio y análisis de regresión, donde se exploraba el efecto que tenían las horas de entrenamiento y posicionamiento, sobre las dimensiones de los cuestionarios Autoconcepto Forma-5 (AF-5) de García y Musitu (1999) y de la resiliencia (CD-RISC) de Connor y Davidson (2003). Los resultados, señalan que los cuestionarios CD RISC y AF-5 son aplicables a la población de jugadoras adolescentes de baloncesto, que estas presentan un desafío de la conducta orientada a la acción y autoconcepto familiar elevado en relación al resto de dimensiones. El posicionamiento en el terreno de juego no ejerce ninguna influencia en los aspectos psicosociales y el análisis de regresión establece que a mayor tiempo de entrenamiento se produce un incremento en el autoconcepto.The present study was to determine and analyze the psychometric properties of self-concept (AF-5) and resilience (CD-RISC). The aims of this study as to describe and analyze the relationships between them and specify the effect of hours of regular training and position in basketball on the psychosocial dimensions (self-concept and resilience) in Spanish adolescents basketball players, considering simultaneously personal and physical sports variables. Participants were 74 youth players, aged between 12 and 16 years. It conducted an exploratory factor analysis and regression analysis and the effect they had training hours, positioning, on the dimensions of the test Autoconcepto Form-5 (AF-5) García and Musitu (1999) and explores resilience (CD-RISC), Connor and Davidson (2003). The results indicate that the questionnaires CD-RISC and AF-5 are applicable to the population of youth basketball players. These are challenging the action-oriented behavior and familiar self-concept is high in relation to the other dimensions. Positioning in the field has no influence on the psychosocial aspects and the regression analysis establishes that longer training arean increase in self-concept

PET/TC en Patología No Oncológica (indicaciones en patología infecciosa e inflamatoria)

Revisar y analizar la bibliografía actual disponible sobre la utilidad de la PET/TC en el estudio de la patología inflamatoria/infecciosa, sus principales indicaciones y rentabilidad diagnóstica en el estudio de la fiebre de origen desconocido (FOD), infecciones (infecciones musculoesqueléticas, de prótesis, endocarditis), la sarcoidosis y las vasculitis. Se revisan las principales técnicas de medicina nuclear utilizadas en cada patología, comparándolas entre ellas, así como los principales radiotrazadores empleados, mostrando la evidencia científica que existe hoy en día para su empleo en términos de sensibilidad, especificidad y rentabilidad diagnóstica, siendo la 18F-FDG PET/TC la técnica que mejores resultados ha mostrado.<br /

Random effects modelling versus logistic regression for the inclusion of cluster-level covariates in propensity score estimation: a Monte Carlo simulation and registry cohort analysis

Purpose: Surgeon and hospital-related features, such as volume, can be associated with treatment choices and outcomes. Accounting for these covariates with propensity score (PS) analysis can be challenging due to the clustered nature of the data. We studied six different PS estimation strategies for clustered data using random effects modelling (REM) compared with logistic regression. Methods: Monte Carlo simulations were used to generate variable cluster-level confounding intensity [odds ratio (OR) = 1.01–2.5] and cluster size (20–1,000 patients per cluster). The following PS estimation strategies were compared: i) logistic regression omitting cluster-level confounders; ii) logistic regression including cluster-level confounders; iii) the same as ii) but including cross-level interactions; iv), v), and vi), similar to i), ii), and iii), respectively, but using REM instead of logistic regression. The same strategies were tested in a trial emulation of partial versus total knee replacement (TKR) surgery, where observational versus trial-based estimates were compared as a proxy for bias. Performance metrics included bias and mean square error (MSE). Results: In most simulated scenarios, logistic regression, including cluster-level confounders, led to the lowest bias and MSE, for example, with 50 clusters × 200 individuals and confounding intensity OR = 1.5, a relative bias of 10%, and MSE of 0.003 for (i) compared to 32% and 0.010 for (iv). The results from the trial emulation also gave similar trends. Conclusion: Logistic regression, including patient and surgeon-/hospital-level confounders, appears to be the preferred strategy for PS estimation

Analysis of the levels of self-concept and resilience, in the high school basketball players

The present study was to determine and analyze the psychometric properties of self-concept (AF-5) and resilience (CD-RISC). The aims of this study as to describe and analyze the relationships between them and specify the effect of hours of regular training and position in basketball on the psychosocial dimensions (self-concept and resilience) in Spanish adolescents basketball players, considering simultaneously personal and physical sports variables. Participants were 74 youth players, aged between 12 and 16 years. It conducted an exploratory factor analysis and regression analysis and the effect they had training hours, positioning, on the dimensions of the test Autoconcepto Form-5 (AF-5) García and Musitu (1999) and explores resilience (CD-RISC), Connor and Davidson (2003). The results indicate that the questionnaires CD-RISC and AF-5 are applicable to the population of youth basketball players. These are challenging the action-oriented behavior and familiar self-concept is high in relation to the other dimensions. Positioning in the field has no influence on the psychosocial aspects and the regression analysis establishes that longer training arean increase in self-concept

An expert consensus report on the clinical use of the Vycross® hyaluronic acid VYC-25 L filler.

Background: The portfolio of hyaluronic acid (HA) fillers and the techniques of administration have evolved in recent years. The latest innovation in the Vycross® range was the introduction of VYC-25L (Juvéderm Volux®; Allergan plc), a first-in- class filler effective for chin and facial lower third remodeling. The aim here was to provide clinicians who are starting to use VYC-25L with key advice, and to standardize procedures so that optimal and predictable outcomes can be obtained. Methods: A multidisciplinary group of experts in esthetic medicine from Spain and Portugal reviewed the properties, treatment paradigms, administration techniques, and potential complications of VYC-25L, on the basis of which they drafted consensus recommendations for its clinical use. Results: The consensus panel provided specific recommendations focusing on the patient profile, dose, administration techniques, and the complications of VYC-25L and their management. The panel identified five different profiles of patients who may benefit from VYC-25L, and they drafted recommendations aimed to facilitate the treatment of these patients, namely, microgenia (women/men), masculinization (men), rejuvenation (women/men), facial laxity (women/men), and submental convexity (women/men). In terms of their safety, no specific recommendations were made beyond those established for other HA fillers. Conclusions: The evolution of esthetic medicine makes it necessary to update the clinical recommendations that guide patient assessment and treatment with the new HA fillers developed. The current consensus document addresses relevant issues related to the use of VYC-25L on different types of patient, in an attempt to standardize procedures and help specialists obtain predictable results.post-print806 K

Caracterización de las intrusiones de polvo en Canarias

En el capítulo 1 de esta nota técnica se exponen generalidades y conceptos básicos del polvo mineral atmosférico. En el capítulo 2 se desarrolla la metodología utilizada y se describen la red de observación y las series históricas de PM10, a la vez que se explica detalladamente el procedimiento para determinar si ha tenido lugar o no una intrusión de polvo desértico sobre el archipiélago canario. En el capítulo 3 se presentan los resultados de la caracterización de las intrusiones de polvo desértico en Canarias que incluyen datos relevantes sobre la duración de los eventos, el efecto de las intrusiones en la calidad del aire y la caracterización de los valores PM10 de fondo. En el capítulo 4 se exponen varios casos de estudio que muestran distintos tipos de eventos de intrusión de polvo en Canarias. El capítulo 5 recoge las conclusiones principales de este trabajo. El capítulo 6 incluye una guía básica que pretende servir de ayuda a la hora de afrontar un posible evento de intrusión de polvo desértico. La nota técnica concluye con dos anexos: el primero, con información adicional sobre las estaciones de la Red de Calidad del Aire del Gobierno de Canarias; y el segundo con una relación de los episodios de intrusión destacados y utilizados en los cálculos del capítulo 2

First reported double drug–drug interaction in a cancer renal patient under everolimus treatment: therapeutic drug monitoring and review of literature

Everolimus is an inhibitor of mammalian target of rapamycin (mTOR) used in both transplantation and cancer treatment (breast, renal and neuroendocrine). In transplantation, therapeutic drug monitoring (TDM) is recommended due to the potential drug-drug interactions with chronic medications, which can affect everolimus pharmacokinetics. In cancer treatment, everolimus is used at higher doses than in transplantation and without a systematic drug monitoring.We present a case report of a 72-year-old woman with epilepsy history to whom everolimus 10 mg QD was prescribed as third line of treatment for renal cell carcinoma (RCC). The potential drug interactions between everolimus and the patient's chronic medications, carbamazepine and phenytoin, are significant as both are known as strong inducers CYP3A4 metabolism, potentially leading to underexposure to everolimus.TDM of everolimus was recommended by the pharmacist. The literature suggests that a minimum plasma concentration (Cminss) of everolimus over 10 ng/ml is associated with better response to treatment and progression-free survival (PFS). The patient's everolimus dose had to be increased until 10 mg BID, and regular monitoring of everolimus levels showed an increase in Cminss from 3.7 ng/ml to 10.8 ng/ml.This case highlights the importance of checking for potential drug interactions and monitoring everolimus levels in patients on chronic medication, especially those with several inducers or inhibitors of CYP3A4 metabolism. TDM can help to ensure that patients are treated with their optimal dose, which can improve the effectiveness of the treatment or minimize the risk of toxicities

Mathematical modeling of SARS-CoV-2 variant substitutions in European countries: transmission dynamics and epidemiological insights

Background: Countries across Europe have faced similar evolutions of SARS-CoV-2 variants of concern, including the Alpha, Delta, and Omicron variants. Materials and methods: We used data from GISAID and applied a robust, automated mathematical substitution model to study the dynamics of COVID-19 variants in Europe over a period of more than 2 years, from late 2020 to early 2023. This model identifies variant substitution patterns and distinguishes between residual and dominant behavior. We used weekly sequencing data from 19 European countries to estimate the increase in transmissibility (Δβ) between consecutive SARS-CoV-2 variants. In addition, we focused on large countries with separate regional outbreaks and complex scenarios of multiple competing variants. Results: Our model accurately reproduced the observed substitution patterns between the Alpha, Delta, and Omicron major variants. We estimated the daily variant prevalence and calculated Δβ between variants, revealing that: (i) Δβ increased progressively from the Alpha to the Omicron variant; (ii) Δβ showed a high degree of variability within Omicron variants; (iii) a higher Δβ was associated with a later emergence of the variant within a country; (iv) a higher degree of immunization of the population against previous variants was associated with a higher Δβ for the Delta variant; (v) larger countries exhibited smaller Δβ, suggesting regionally diverse outbreaks within the same country; and finally (vi) the model reliably captures the dynamics of competing variants, even in complex scenarios. Conclusion: The use of mathematical models allows for precise and reliable estimation of daily cases of each variant. By quantifying Δβ, we have tracked the spread of the different variants across Europe, highlighting a robust increase in transmissibility trend from Alpha to Omicron. Additionally, we have shown that the geographical characteristics of a country, as well as the timing of new variant entrances, can explain some of the observed differences in variant substitution dynamics across countries