Frosted Branch Angiitis Diagnosed as Neuro-Behçet: A Diagnostic and Etiologic Dilemma

Purpose: To report a case of frosted branch angiitis (FBA) secondary to neuro-Behçet. Methods: Description, diagnosis, angiogram imaging and follow-up of a 28-year-old female with FBA. Results: ‘Frosted branch angiitis’ is a clinical term applied to three conditions: infiltration of vessels by malignant cells, and sheathing of vessels either secondary to an active disorder or subsequently to a previous inflammatory disease. Our patient’s history of two optic neuropathies and the lack of demyelinating signs in neuroimaging made us consider FBA in the context of neuro-Behçet. Conclusion: Recognition of the category of FBA from the clinical signs is essential to establish the correct diagnosis and prescribe the appropriate treatment

Landscape dynamics and fire activity since 6740 cal yr BP in the Cantabrian region (La Molina peat bog, Puente Viesgo, Spain)

A lack of paleobotanic studies with adequate resolution and multiproxy approaches has limited proper discussion of vegetation dynamics in Cantabria and of the role of fires in the configuration of the plant landscape during the Holocene in the northwest part of the Iberian peninsula. The pollen diagram of La Molina peat bog in Puente Viesgo (43 ‹15 Œ38 N.3 ‹58 Œ37 W; ETRS89), located at 484 m.a.s.l., and the study of its sedimentary charcoals allowed the acquisition of a continuous and thorough fire sequence for the last 6 700 cal yr BP and an understanding of its relationship to the forest. The results show the importance of human influence on the incidence and characteristics of fire activity during the different phases studied: the Neolithic, Bronze Age, Iron Age, Roman period, and Middle Ages. A synergy seems to exist between dry climate periods (especially during Bond events 3 and 4) and a greater presence of biomass. As the Holocene advances, vegetation coverage clearly tends to decrease. This study provides key elements for understanding the role of fire activity in the forest dynamics of deciduous and evergreen Quercus, Corylus, Pinus, Fagus, and Alnus and demonstrates the strongly artificialized character of the present landscape

Informe: Derecho del trabajo y de la seguridad social en España en 2013. Algunos puntos críticos

Este documento intenta reflejar algunos de los principales cambios y novedades del ordenamiento laboral español en 2013, levantando acta de cómo la mutabilidad de nuestro Derecho del Trabajo es imparable. Este informe, consciente de ello, ofrece una selección de elementos esenciales, a juicio de sus autores, especialistas en cada una de las materias, encuadrados en la Sección Juvenil de la Asociación Española de Derecho del Trabajo y de la Seguridad Social. En él, conforme a la organización de dicha Sección en grupos de trabajo, se abordan las novedades más relevantes en materia de derechos fundamentales inespecíficos, contratación laboral, vicisitudes del contrato de trabajo, Derecho colectivo, conciliación y corresponsabilidad, protección social y prevención de riesgos laborales. This paper tries to show some of the many changes and novelties in Spanish Labour Law during 2013, drawing up a record of the unstoppable character of our Labour legal system. This report offers a selection of essential elements, according to its authors, all of them specialists in each one of the subjects, being part of the Young Scholars’ Section of the Spanish Association for Labour and Social Security Law. According to the organization of the said Section in working groups, we can find novelties concerning unspecific fundamental rights, work contracts, the life of the work contract and collective Labour Law, reconciliation and co responsibility, social protection and occupational risk prevention

Efectos de la terapia no farmacológica en el envejecimiento normal y el deterioro cognitivo: consideraciones sobre los objetivos terapéuticos

Resumen: Introducción: Las terapias no farmacológicas (TNF) en el envejecimiento y las demencias representan un conjunto de intervenciones orientadas a estimular el rendimiento de los procesos cognitivos, mejorar la afectividad, potenciar la independencia en la vida cotidiana y, en última instancia, incrementar la calidad de vida de los pacientes. Métodos: Se aplicó una batería de pruebas que valoraban 4 dominios principales (estado mental general, afectividad, calidad de vida y actividades de la vida diaria) a una muestra de 317 adultos con más de 64 años (240 con envejecimiento normal y 77 con deterioro cognitivo). Posteriormente, fueron asignados a grupos de TNF en función de sus capacidades o a otras actividades no específicas. Se valoró el beneficio tras 9 meses de TNF con la misma batería de pruebas. Resultados: Los resultados evidencian una mejora del estado mental general en el envejecimiento sano y ausencia de progresión en el envejecimiento patológico. En los 2 grupos, la afectividad (ansiedad y depresión) y la calidad de vida autopercibida se vio beneficiada por la TNF. No obstante, no parecen mejorar otros aspectos habitualmente incluidos entre los objetivos terapéuticos, como la independencia en las actividades de la vida diaria. Conclusiones: Este trabajo evidencia los resultados positivos que se obtienen por la aplicación de un programa de TNF en el envejecimiento. Es importante destacar que los individuos con deterioro cognitivo se benefician más del mismo, si bien su aplicación generalizada parece resultar un óptimo programa preventivo primario en estos aspectos cognitivos y emocionales. Abstract: Introduction: Non-pharmacological therapies for normal ageing and dementia are a set of treatment programmes intended to improve the performance of cognitive processes, improve emotional well-being, promote independence in daily life activities, and ultimately increase patients’ quality of life. Methods: We applied a battery of tests assessing four major domains (general mental state, emotional well-being, quality of life, and daily life activities) to a sample of 317 adults older than 64 (240 with normal ageing and 77 with cognitive impairment). They were then assigned either to non-pharmacological therapy groups according to their abilities or to other non-specific activities. Progress was assessed 9 months later using the same test battery. Results: The results show a general improvement in mental state in the group with normal ageing and absence of disease progression in the group with pathological ageing. In both groups, emotional well-being (anxiety and depression) and self-identified quality of life both benefited from non-pharmacological therapy. However, other aspects commonly included among the therapeutic targets did not seem to improve, including independence in daily life activities. Conclusions: This study provides evidence that non-pharmacological therapy in ageing patients can produce positive results. It must be stressed that benefits are greater in individuals with cognitive impairment, although generalising use of this therapy could prove to be an excellent primary programme for preventing cognitive and emotional disorders. Palabras clave: Terapia no farmacológica, Estimulación cognitiva, Intervención neuropsicológica, Envejecimiento, Deterioro cognitivo leve, Demencia, Keywords: Non-pharmacological therapy, Cognitive stimulation, Neuropsychological intervention, Ageing, Mild cognitive impairment, Dementi

Effects of non-pharmacological therapy on normal ageing and on cognitive decline: Reflections on treatment objectives

Introduction: Non-pharmacological therapies for normal ageing and dementia are a set of treatment programmes intended to improve the performance of cognitive processes, improve emotional well-being, promote independence in daily life activities, and ultimately increase patients’ quality of life. Methods: We applied a battery of tests assessing four major domains (general mental state, emotional well-being, quality of life, and daily life activities) to a sample of 317 adults older than 64 (240 with normal ageing and 77 with cognitive impairment). They were then assigned to non-pharmacological therapy groups according to their abilities or other non-specific activities. Progress was assessed 9 months later using the same test battery. Results: The results show a general improvement in mental state in the group with normal ageing and absence of disease progression in the group with pathological ageing. In both groups, emotional well-being (anxiety and depression) and self-identified quality of life both benefited from non-pharmacological therapy. However, other aspects commonly included among the therapeutic targets did not seem to improve, including independence in daily life activities. Conclusions: This study provides evidence that non-pharmacological therapy in ageing patients can produce positive results. It must be stressed that benefits are greater in individuals with cognitive impairment, although generalising use of this therapy could prove to be an excellent primary programme for preventing cognitive and emotional disorders. Resumen: Introducción: Las terapias no farmacológicas (TNF) en el envejecimiento y las demencias representan un conjunto de intervenciones orientadas a estimular el rendimiento de los procesos cognitivos, mejorar la afectividad, potenciar la independencia en la vida cotidiana y, en última instancia, incrementar la calidad de vida de los pacientes. Métodos: Se aplicó una batería de pruebas que valoraban 4 dominios principales (estado mental general, afectividad, calidad de vida y actividades de la vida diaria) a una muestra de 317 adultos con más de 64 años (240 con envejecimiento normal y 77 con deterioro cognitivo). Posteriormente, fueron asignados a grupos de TNF en función de sus capacidades o a otras actividades no específicas. Se valoró el beneficio tras 9 meses de TNF con la misma batería de pruebas. Resultados: Los resultados evidencian una mejora del estado mental general en el envejecimiento sano y ausencia de progresión en el envejecimiento patológico. En los 2 grupos, la afectividad (ansiedad y depresión) y la calidad de vida autopercibida se vio beneficiada por la TNF. No obstante, no parecen mejorar otros aspectos habitualmente incluidos entre los objetivos terapéuticos, como la independencia en las actividades de la vida diaria. Conclusiones: Este trabajo evidencia los resultados positivos que se obtienen por la aplicación de un programa de TNF en el envejecimiento. Es importante destacar que los individuos con deterioro cognitivo se benefician más del mismo, si bien su aplicación generalizada parece resultar un óptimo programa preventivo primario en estos aspectos cognitivos y emocionales. Keywords: Non-pharmacological therapy, Cognitive stimulation, Neuropsychological intervention, Ageing, Mild cognitive impairment, Dementia, Palabras clave: Terapia no farmacológica, Estimulación cognitiva, Intervención neuropsicológica, Envejecimiento, Deterioro cognitivo leve, Demenci

Dissipation and effects of tricyclazole on soil microbial communities and rice growth as affected by amendment with alperujo compost

8 páginas.-- 6 figuras.-- 3 tablas.-- 49 referencias.-- Supplementary data to this article can be found online at http://dx.doi.org/10.1016/j.scitotenv.2016.01.174The presence of pesticides in surface and groundwater has grown considerably in the last decades as a consequence of the intensive farming activity. Several studies have shown the benefits of using organic amendments to prevent losses of pesticides from runoff or leaching. A particular soil from the Guadalquivir valley was placed in open air ponds and amended at 1 or 2% (w/w) with alperujo compost (AC), a byproduct from the olive oil industry. Tricyclazole dissipation, rice growth and microbial diversity were monitored along an entire rice growing season. An increase in the net photosynthetic rate of Oryza sativa plants grown in the ponds with AC was observed. These plants produced between 1100 and 1300 kg ha-1 more rice than plants from the unamended ponds. No significant differences were observed in tricyclazole dissipation, monitored for a month in soil, surface and drainage water, between the amended and unamended ponds. The structure and diversity of bacteria and fungi communities were also studied by the use of the polymerase chain reaction denaturing gel electrophoresis (PCR-DGGE) from DNA extracted directly from soil samples. The banding pattern was similar for all treatments, although the density of bands varied throughout the time. Apparently, tricyclazole did not affect the structure and diversity of bacteria and fungi communities, and this was attributed to its low bioavailability. Rice cultivation under paddy field conditions may be more efficient under the effects of this compost, due to its positive effects on soil properties, rice yield, and soil microbial diversity.This research was supported by the Ministry of Economy and Competitiveness (AGL2010-21421 and AGL2013-48446-C3-1-R) and the Autonomous Government of Andalusia (PAIDI AGR-264). The projects were co-financed with European Funds (FEDER-FSE PO2007-13). M. García-Jaramillo also thanks MEC/FECYT for a doctoral fellowship through AGL2010-21421-CO2-01 project of MICINN. Further, we wish to thank J.L. Fernández, F. Molina and P. Velarde for their help with the soil sampling. Also thanks to the research station IFAPA - Las Torres (Seville) for experimental field facilities and to the IFAPA-Centro Venta del Llano (Jaén) for provide us the alperujo compost.Peer reviewe

Up-to-date Spanish continental Neogene synthesis and paleoclimatic interpretation

A synthesis of the Spanish continental Neogene is presented by designing an integrated correlative chart of the Neo" gen-e "succes"Siuns-ofthe "lberian-PeninsuIa-. -Ninemain-sedimentary-breaks-have-been -distinguished-in-most-of-the "basins. They are considered a valuable criteria for correlation as they occur in similar time intervals from basin to basin. The determined sedimentary breaks occur in the Agenian, Ramblian, Middle Aragonian, Late Aragonian, Late Vallesian, Middle Turolian, Late Turolian, Late Ruscinian-Early Villafranchian, and Villafranchian ages. The larger interior basins (Ebro, Tajo, Duero) show a fairly complete Neogene sedimentary record in which the aboye mentioned sedimentary breaks are usually well recognized. A good correlation may be established from basin to basin. Likewise, there is a fairly good correlation among the Upper Miocene-Pliocene sedimentary record of basins spreading out in Levante and southeastern Spain. However, the correlation is not as c1ear in those basins located within the Iberian and Catalan Coastal Ranges, which usually do not show a similar sedimentary pattern. The comparison between Neogene stratigraphic logs in most of the Spanish continental basins and the pattern of global events from currentIy accepted Cenozoic Cyc1e Charts allows recognition of chronological coincidences, especially with regard to the age of seven major sedimentary ruptures (those developed at about 24.5 Ma, 22 Ma, 16 Ma, 13.5 Ma, 9.5 Ma, 5.5 Ma, 3.3 Ma). Evolutionary sedimentary trends in both offshore Mediterranean areas and inland peripheral zones of the Iberian Peninsula show also striking coincidences regarding the chronology of major sedimentary breaks observed in continental successions. Paleoc1imatic curves for the Spanish continental Neogene display four relative temperature peaks indicative of warm c1imatic conditions (Late Agenian, Early-Middle Aragonian, Vallesian-Turolian, and Late Villafranchian) as well as five relatively dry periods (Early Ramblian, Middle-Late Aragonian, Middle Turolian, Late Ruscinian, and Middle Villafranchian ages)