Definition, Validation and Comparison of Two Population Models for Austria

In this work we present two structurally different mathematical models for the prognostic simulation of Austria’s population: A time-continuous, macroscopic system dynamics approach and a time-discrete, microscopic agent-based approach. Both models were developed as case studies of a series of population concepts in order to support models for decision-support in Austria’s health care system. In the present work we want to focus on the definition, the parametrisation as well as especially the validation process of both population-models. The latter was of special interest as it included a cross-model validation with Statistics Austria’s own prognostic model SIKURS

Definition, Validation and Comparison of Two Population Models for Austria

In this work we present two structurally different mathematical models for the prognostic simulation of Austria’s population: A time-continuous, macroscopic system dynamics approach and a time-discrete, microscopic agent-based approach. Both models were developed as case studies of a series of population concepts in order to support models for decision-support in Austria’s health care system. In the present work we want to focus on the definition, the parametrisation as well as especially the validation process of both population-models. The latter was of special interest as it included a cross-model validation with Statistics Austria’s own prognostic model SIKURS

Institute Brief: Advancing Parent-Professional Leadership: Effective Strategies for Building the Capacity of Parent Advisory Councils in Special Education

The Individuals with Disabilities Education Act, last amended in 2004 (IDEA 2004), encourages parents and educators to work collaboratively, emphasizing that as a team they are uniquely suited to make decisions that help improve the educational experiences and outcomes of children with disabilities. The Advancing Parent-Professional Leadership in Education (APPLE) Project was funded to develop the leadership skills of parents individually and within their communities. The project took place in Massachusetts, where school districts are required to have a special education parent advisory council (SEPAC)

Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia

Metabolic reprogramming is a hallmark of cancer. Understanding cancer metabolism is instrumental to devise innovative therapeutic approaches. Anabolic metabolism, including the induction of lipogenic enzymes, is a key feature of proliferating cells. Here, we report a novel tumor suppressive function for adipose triglyceride lipase (ATGL), the rate limiting enzyme in the triglyceride hydrolysis cascade. In immunohistochemical analysis, non-small cell lung cancers, pancreatic adenocarcinoma as well as leiomyosarcoma showed significantly reduced levels of ATGL protein compared to corresponding normal tissues. The ATGL gene was frequently deleted in various forms of cancers. Low levels of ATGL mRNA correlated with significantly reduced survival in patients with ovarian, breast, gastric and non-small cell lung cancers. Remarkably, pulmonary neoplasia including invasive adenocarcinoma developed spontaneously in mice lacking ATGL pointing to an important role for this lipase in controlling tumor development. Loss of ATGL, as detected in several forms of human cancer, induces spontaneous development of pulmonary neoplasia in a mouse model. Our results, therefore, suggest a novel tumor suppressor function for ATGL and contribute to the understanding of cancer metabolism. We propose to evaluate loss of ATGL protein expression for the diagnosis of malignant tumors. Finally, modulation of the lipolytic pathway may represent a novel therapeutic approach in the treatment of human cancer

How sick is Austria? – A decision support framework for different evaluations of the burden of disease within the Austrian population based on different data sources

ABSTRACT Objectives In healthcare it is crucial to have a fundamental knowledge of the burden of diseases within the population. Therefore we aimed to develop an Atlas of Epidemiology to gain better insight on the epidemiological situation. Based on primary and secondary health care data, we aimed to present results in interactive charts and maps, comprehensible to experts and the general public. The atlas builds a framework for rapid deployment of new data and results in a reproducible and efficient way. As a first use case three methods based on two different databases for the estimation of diabetes prevalence in Austria are compared. Approach Datasources: (i) reimbursement data 2006/2007 (GAP-DRG); (ii) national routine health survey (ATHIS) for 2006/2007. Methods for diabetes prevalence estimation: 1) ATC-ICD statistically relates pseudonymized data on medications to data on diagnoses from hospitalizations and sick leaves. 2) With the method Experts, medical experts assign specific medications to diabetes diagnoses. Patients with these medications are identified together with hospitalized diabetes diagnosed patients in GAP-DRG. 3) In ATHIS a sample of 15.000 persons was questioned if they a) ever had diabetes and b) were treated against diabetes in the last 12 months. Results are projected onto the Austrian population. Patients are divided by 10-year age-classes, gender and state. For the publicly online framework, implemented in html and javascript, pre-processed data in different granularity is required and used. Results Maps of Austria represent the prevalence of diabetes for each method and granularity level. The difference of the methods can be seen by clicking on the next map. For different age-classes (resp. different gender) the three methods can be compared directly within a bar chart. The technology for a rapid deployment of new data is now developed. For the use case first results have already been presented to decision makers, and feedback has been incorporated. Conclusion Besides depicting disease prevalence, the atlas of epidemiology also allows to visualize health care service data and results of simulation models in a fast and efficient way, which is important for decision makers. Soon the results of the ATC-ICD project on the prevalence of different diseases based on ICD9 diagnoses and medication data will be published in an aggregated form. This project is part of the K-Project dexhelpp in COMET – Competence Centers for Excellent Technologies that is funded by BMVIT, BMWGJ and transacted by FFG

Covid-19: Szenarien für Herbst/Winter 2022 – und darüber hinaus

Die vergangenen Monate haben dynamische Entwicklungen der Pandemie verdeutlicht. Als Folge dessen kam es quasi zeitgleich in Österreich im ersten Quartal des Jahres 2022 neben dem Beschluss äußerst restriktiver Vorgaben wie der Impfpflicht auch wieder zur Aufhebung fast aller Schutzmaßnahmen im Zusammenhang mit der COVID-19-Pandemie. Die letzten beiden Jahre haben gezeigt, wie dynamisch und rasch sich die Situation phasenweise in der Pandemie ändern kann. Jede Phase erfordert – und je länger die Pandemie andauert, umso mehr – verstärkt interdisziplinäre Zugänge und klare Zielsetzungen für Public Health Interventionen. Dies ist einerseits im Sinne einer verständlichen Kommunikation gegenüber der allgemeinen Bevölkerung wichtig, und andererseits im Sinne einer effektiven Bekämpfung der Ausbreitung der Pandemie unbedingt erforderlich

Narcissism and the strategic pursuit of short-term mating : universal links across 11 world regions of the International Sexuality Description Project-2.

Previous studies have documented links between sub-clinical narcissism and the active pursuit of short-term mating strategies (e.g., unrestricted sociosexuality, marital infidelity, mate poaching). Nearly all of these investigations have relied solely on samples from Western cultures. In the current study, responses from a cross-cultural survey of 30,470 people across 53 nations spanning 11 world regions (North America, Central/South America, Northern Europe, Western Europe, Eastern Europe, Southern Europe, Middle East, Africa, Oceania, Southeast Asia, and East Asia) were used to evaluate whether narcissism (as measured by the Narcissistic Personality Inventory; NPI) was universally associated with short-term mating. Results revealed narcissism scores (including two broad factors and seven traditional facets as measured by the NPI) were functionally equivalent across cultures, reliably associating with key sexual outcomes (e.g., more active pursuit of short-term mating, intimate partner violence, and sexual aggression) and sex-related personality traits (e.g., higher extraversion and openness to experience). Whereas some features of personality (e.g., subjective well-being) were universally associated with socially adaptive facets of Narcissism (e.g., self-sufficiency), most indicators of short-term mating (e.g., unrestricted sociosexuality and marital infidelity) were universally associated with the socially maladaptive facets of narcissism (e.g., exploitativeness). Discussion addresses limitations of these cross-culturally universal findings and presents suggestions for future research into revealing the precise psychological features of narcissism that facilitate the strategic pursuit of short-term mating