Oral Signs and HLA-DQB1 1702 Haplotypes in the Celiac Paediatric Patient: A Preliminary Study.

Celiac disease (CD) diagnosis can be extremely challenging in the case of atypical patterns. In this context, oral signs seem to play a decisive role in arousing suspicion of these forms of the disease. At the same time, the different expressions of the HLA-DQB1 1702 allele apparently seem to facilitate the interpretation of signs and highlighted symptoms. The aim of this work was to verify whether it is possible to identify a correlation between the development of oral signs and different DQ2 haplotypes in celiac pediatric patients. 44 celiac patients with a medium age of 9.9 were studied. Oral examinations were performed in order to identify recurrent aphthous stomatitis (RAS) and dental enamel defects (DED). The diagnosis of DED resulted as being related to allele expression (P value = 0.042) while it was impossible to find a similar correlation with RAS. When both oral signs were considered, there was an increase in correlation with HLA-DQB1 1702 expression (P value = 0.018). The obtained results identified both the fundamental role that dentists can play in early diagnosis of CD, as well as the possible role of HLA haplotype analysis in arousing suspicion of atypical forms of the disease

Effects of physical rehabilitation integrated with rhythmic auditory stimulation on spatio-temporal and kinematic parameters of gait in parkinsons's disease

Movement rehabilitation by means of physical therapy represents an essential tool in the management of gait disturbances induced by Parkinson’s disease (PD). In this context, the use of Rhythmic Auditory Stimulation (RAS) has been proven useful in improving several spatio-temporal parameters, but concerning its effect on gait patterns scarce information is available from a kinematic viewpoint. In this study we used three-dimensional gait analysis based on optoelectronic stereophotogrammetry to investigate the effects of 5 weeks of intensive rehabilitation, which included gait training integrated with RAS on 26 individuals affected by PD (age 70.4±11.1, Hoehn & Yahr 1-3). Gait kinematics was assessed before and at the end of the rehabilitation period and after a three-month follow-up, using concise measures (Gait Profile Score and Gait Variable Score, GPS and GVS, respectively), which are able to describe the deviation from a physiologic gait pattern. The results confirm the effectiveness of gait training assisted by RAS in increasing speed and stride length, in regularizing cadence and correctly reweighting swing/stance phase duration. Moreover, an overall improvement of gait quality was observed, as demonstrated by the significant reduction of the GPS value, which was created mainly through significant decreases in the GVS score associated with the hip flexion-extension movement. Future research should focus on investigating kinematic details to better understand the mechanisms underlying gait disturbances in people with PD and the effects of RAS, with the aim of finding new or improving current rehabilitative treatments

The control system of the 3 mm band SIS receiver for the Sardinia Radio Telescope

We present the control system of the 84-116 GHz (3 mm band) Superconductor-Insulator-Superconductor (SIS) heterodyne receiver to be installed at the Gregorian focus of the Sardinia Radio Telescope (SRT). The control system is based on a single-board computer from Raspberry, on microcontrollers from Arduino, and on a Python program for communication between the receiver and the SRT antenna control software, which remotely controls the backshorttuned SIS mixer, the receiver calibration system and the Local Oscillator (LO) system

Clinical Effectiveness of Transversus Abdominis Plane (TAP) Block versus Local Anesthesia Wound Infiltration for Postoperative Pain Relief After Laparoscopic Appendicectomy in Children: A Study Protocol for a Multicenter Double-Blind Randomized Controlled Phase III Trial

Geoffrey Bloy,1 Amelie Jurine,1 Yann Chaussy,2 Frederic Auber,2 Pierre-Gregoire Guinot,3 Belaid Bouhemad,3 Michel Francois,4 Lucie Vettoretti,1 Sebastien Pili-Floury,5 Maxime Nguyen,3 Guillaume Besch5 1CHU Besançon, Département d’Anesthésie Réanimation Chirurgicale, Besançon, F-25000, France; 2Université de Franche-Comté, CHU Besançon, SINERGIES, Service de Chirurgie Pédiatrique, Besançon, F-25000, France; 3University of Burgundy and Franche-Comté, Dijon University Hospital, INSERM LNC UMR1231, FCS Bourgogne Franche-Comté LipSTIC LabEx, Dijon, F-21000, France; 4Université de Bourgogne, CHU Dijon, Service de Chirurgie Pédiatrique, Dijon, F-21000, France; 5Université de Franche-Comté, CHU Besançon, SINERGIES, Département d’Anesthésie Réanimation Chirurgicale, Besançon, F-25000, FranceCorrespondence: Guillaume Besch, Département d’Anesthésie Réanimation Chirurgicale, CHU Besançon, 3 bvd Alexandre Fleming, Besançon, 25030, France, Tel +3381218958, Fax +3381669331, Email [email protected]: Postoperative pain relief after laparoscopic appendicectomy is a key determinant of early rehabilitation in children. Recent guidelines recommend performing either a transversus abdominis plane (TAP) block or local anesthesia (LA) wound infiltration as part of multimodal postoperative analgesia after appendectomy. To date, the clinical effectiveness of TAP block versus LA wound infiltration has never been compared. The hypothesis of this study is that the TAP block may provide a greater opioid-sparing effect after laparoscopic appendicectomy in children than LA wound infiltration.Study Design and Methods: We designed a multicenter double-blind randomized controlled phase III trial and aim to include 110 children who undergo laparoscopic appendicectomy. Children are randomized to receive either TAP block (TAP group) or LA wound infiltration (infiltration group). Multimodal analgesia is standardized in the two groups using the same protocol, which includes the stepwise prescription of paracetamol, phloroglucinol, ketoprofene, and nalbuphine according to the hetero-evaluation of pain performed by the nurses who were blinded to the treatment allocated using the validated FLACC scale. The primary outcome is the total dose of nalbuphine administered within 24 hours after surgery.Discussion: No study has specifically compared the clinical effectiveness of TAP block versus LA wound infiltration for postoperative pain relief after laparoscopic appendectomy in children. This paper describes the protocol for a randomized trial that addresses this issue. The results of this trial will be useful for editing guidelines with a higher level of evidence on this topic.Keywords: laparoscopic appendectomy, TAP block, wound infiltration, analgesia, childre

Multi-wavelength observations of the lensed quasar PKS 1830−-211 during the 2019 γ\gamma-ray flare

PKS 1830$-$211 is a $\gamma$-ray emitting, high-redshift (z $= 2.507 \pm 0.002$), lensed flat-spectrum radio quasar. During the period mid-February to mid-April 2019, this source underwent a series of strong $\gamma$-ray flares that were detected by both AGILE-GRID and Fermi-LAT, reaching a maximum $\gamma$-ray flux of $F_{\rm E>100 MeV}\approx 2.3\times10^{-5}$ ph cm$^{-2}$ s$^{-1}$. Here we report on a coordinated campaign from both on-ground (Medicina, OVRO, REM, SRT) and orbiting facilities (AGILE, Fermi, INTEGRAL, NuSTAR, Swift, Chandra), with the aim of investigating the multi-wavelength properties of PKS 1830$-$211 through nearly simultaneous observations presented here for the first time. We find a possible break in the radio spectra in different epochs above 15 GHz, and a clear maximum of the 15 GHz data approximately 110 days after the $\gamma$-ray main activity periods. The spectral energy distribution shows a very pronounced Compton dominance (> 200) which challenges the canonical one-component emission model. Therefore we propose that the cooled electrons of the first component are re-accelerated to a second component by, e.g., kink or tearing instability during the $\gamma$-ray flaring periods. We also note that PKS 1830$-$211 could be a promising candidate for future observations with both Compton satellites (e.g., e-ASTROGAM) and Cherenkov arrays (CTAO) which will help, thanks to their improved sensitivity, in extending the data availability in energy bands currently uncovered.Comment: Accepted for publication in MNRAS. 16 pages, 18 figures, 12 table

Study of solar brightness profiles in the 18-26 GHz frequency range with INAF radio telescopes I: solar radius

The Sun is an extraordinary workbench, from which several fundamental astronomical parameters can be measured with high precision. Among these parameters, the solar radius $R_{\odot}$ plays an important role in several aspects, such as in evolutionary models. Despite the efforts in obtaining accurate measurements of $R_{\odot}$, the subject is still debated and measurements are puzzling and/or lacking in many frequency ranges. We aimed to determine the mean, equatorial, and polar radii of the Sun ($R_c$, $R_{eq}$, and $R_{pol}$) in the frequency range 18.1 - 26.1 GHz. We employed single-dish observations from the newly-appointed Medicina "Gavril Grueff" Radio Telescope and the Sardinia Radio Telescope (SRT) throughout 5 years, from 2018 to mid-2023, in the framework of the SunDish project for solar monitoring. Two methods to calculate the radius at radio frequencies are considered and compared. To assess the quality of our radius determinations, we also analysed the possible degrading effects of the antenna beam pattern on our solar maps, using two 2D-models. We carried out a correlation analysis with the evolution of the solar cycle through the calculation of Pearson's correlation coefficient $\rho$. We obtained several values for the solar radius - ranging between 959 and 994 arcsec - and $\rho$, with typical errors of a few arcsec. Our $R_{\odot}$ measurements, consistent with values reported in literature, suggest a weak prolatness of the solar limb ($R_{eq}$ > $R_{pol}$), although $R_{eq}$ and $R_{pol}$ are statistically compatible within 3$\sigma$ errors. The correlation analysis using the solar images from Grueff shows (1) a positive correlation between the solar activity and the temporal variation of $R_c$ (and $R_{eq}$) at all observing frequencies, and (2) a weak anti-correlation between the temporal variation of $R_{pol}$ and the solar activity at 25.8 GHz.Comment: 18 pages, 12 figures, 6 tables, accepted by A&A; v

Observation of an Excited Bc+ State

Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc∗(2S31)+ state reconstructed without the low-energy photon from the Bc∗(1S31)+→Bc+γ decay following Bc∗(2S31)+→Bc∗(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date

Randomized, Double-Blind, Placebo-Controlled Phase III Study of Tasquinimod in Men With Metastatic Castration-Resistant Prostate Cancer

PURPOSE: Tasquinimod, a novel oral therapy targeting the tumor microenvironment, significantly improved progression-free survival (PFS) in a randomized, placebo-controlled phase II trial in men with metastatic castration-resistant prostate cancer (mCRPC). This phase III study was conducted to confirm the phase II results and to detect an overall survival (OS) benefit. PATIENTS AND METHODS: Men with chemotherapy-naïve mCRPC and evidence of bone metastases were assigned (2:1) to receive tasquinimod once per day or placebo until progression or toxicity. The primary end point was radiographic PFS (rPFS; time from random assignment to radiologic progression or death) per Prostate Cancer Working Group 2 criteria and RECIST 1.1. The study had 99.9% power to detect an rPFS hazard ratio (HR) of 0.6 with a two-sided alpha error of .05 and 80% power to detect a target HR of 0.8 for OS, the key secondary end point. RESULTS: In all, 1,245 patients were randomly assigned to either tasquinimod (n = 832) or placebo (n = 413) between March 2011 and December 2012 at 241 sites in 37 countries. Baseline characteristics were balanced between groups: median age, 71 years; Karnofsky performance status ≥ 90%, 77.3%; and visceral metastases, 21.1%. Estimated median rPFS by central review was 7.0 months (95% CI, 5.8 to 8.2 months) with tasquinimod and 4.4 months (95% CI, 3.5 to 5.5 months) with placebo (HR, 0.64; 95% CI, 0.54 to 0.75; P < .001). Median OS was 21.3 months (95% CI, 19.5 to 23.0 months) with tasquinimod and 24.0 months (95% CI, 21.4 to 26.9 months) with placebo (HR, 1.10; 95% CI, 0.94 to 1.28; P = .25). Grade ≥ 3 adverse events were more frequent with tasquinimod (42.8% v 33.6%), the most common being anemia, fatigue, and cancer pain. CONCLUSION: In chemotherapy-naïve men with mCRPC, tasquinimod significantly improved rPFS compared with placebo. However, no OS benefit was observed