Assessing the Value of Coordinated Sire Genetics in a Synchronized AI Program

Synchronized artificial insemination was used to inseminate cows using different types of sire genetics, including low-accuracy, calving-ease, and high-accuracy. These three calf sire groups were compared to calves born to cows bred using natural service. We found substantial production efficiency grains, carcass merit improvement, and economic value to calves born to cows following a synchronized artificial insemination program with high-accuracy semen included. The economic advantage to the high-accuracy calf sire group was computed to be in the neighborhood of $40 to$80/head, relative to the natural service calf sire group.artificial insemination, beef, cow, carcass, feed-out, genetics, pre-conditioning, sire synchronization., Agricultural Finance,

PEGASUS: A multi-megawatt nuclear electric propulsion system

A propulsion system (PEGASUS) consisting of an electric thruster driven by a multimegawatt nuclear power system is proposed for a manned Mars mission. Magnetoplasmadynamic and mercury-ion thrusters are considered, based on a mission profile containing a 510-day burn time (for a mission time of approximately 1000 days). Both thrusters are capable of meeting the mission parameters. Electric propulsion systems have significant advantages over chemical systems, because of high specific impulse, lower propellant requirements, and lower system mass. The power for the PEGASUS system is supplied by a boiling liquid-metal fast reactor. The power system consists of the reactor, reactor shielding, power conditioning subsystems, and heat rejection subsystems. It is capable of providing a maximum of 8.5 megawatts of electrical power of which 6 megawatts is needed for the thruster system, leaving 1.5 megawatts available for inflight mission applications

Equipment management trial : final report

Executive Summary The Equipment Management (EM) trial was one of the practical initiatives conceived and implemented by members of The Application Home Initiative (TAHI) to demonstrate the feasibility of interoperability between white and brown goods, and other domestic equipment. The trial ran from October 2002 to June 2005, over which period it achieved its core objectives through the deployment in early 2005 of an integrated system in trials in 15 occupied homes. Prior to roll out into the field, the work was underpinned by soak testing, validation, laboratory experiments, case studies, user questionnaires, simulations and other research, conducted in a single demonstration home in Loughborough, as well as in Universities in the East Midlands and Scotland. Throughout its life, the trial faced significant membership changes, which had a far greater impact than the technical issues that were tackled. Two blue chip companies withdrew at the point of signing the collaborative agreement; another made a major change in strategic direction half way through and withdrew the major portion of its backing; another corporate left at this point, a second one later; one corporate was a late entrant; the technical leader made a boardroom decision not to do the engineering work that it had promised; one company went into liquidation; another went up for sale whilst others reorganised. The trial was conducted against this backdrop of continual commercial change. Despite this difficult operating environment, the trial met its objectives, although not entirely as envisaged initially – a tribute to the determination of the trial’s membership, the strength of its formal governance and management processes, and especially, the financial support of the dti. The equipment on trial featured a central heating/hot water boiler, washing machine, security system, gas alarm and utility meters, all connected to a home gateway, integrated functionally and presented to the users via a single interface. The trial met its principal objective to show that by connecting appliances to each other and to a support system, benefits in remote condition monitoring, maintenance, appliance & home controls optimisation and convenience to the customer & service supplier could be provided. This is one of two main reports that form the trial output (the other, the Multi Home Trial Report, is available to EM Trial members only as it contains commercially sensitive information). A supporting library of documents is also available and is held in the virtual office hosted by Loughborough University Centre for the Integrated Home Environment

Equipment management trial : TAHI summary

The Equipment Management (EM) trial was one of the practical initiatives conceived and implemented by members of The Application Home Initiative (TAHI) with strong support from the DTI, to demonstrate the feasibility of interoperability between white and brown goods, and other domestic equipment. The trial ran from October 2002 to June 2005, over which period it achieved its core objectives through the deployment in early 2005 of an integrated system in trials in 15 occupied homes. Prior to roll out into the field, the work was underpinned by soak testing, validation, laboratory experiments, case studies, user questionnaires, simulations and other research, conducted in a single demonstration home in Loughborough, as well as in Universities in the East Midlands and Scotland. The trial was conducted against a backdrop of continual commercial change. Despite this difficult operating environment, the trial met its objectives, although not entirely as envisaged initially – a tribute to the determination of the trial’s membership, the strength of its formal governance and management processes, and especially, the financial support of the dti. The equipment on trial featured a central heating/hot water boiler, washing machine, security system, gas alarm and utility meters, all connected to a home gateway, integrated functionally and presented to the users via a single interface. The trial met its principal objective to show that by connecting appliances to each other and to a support system, benefits in remote condition monitoring, maintenance, appliance & home controls optimisation and convenience to the customer & service supplier could be provided. The EM trial identified exciting opportunities for the UK’s domestic white and brown goods manufacturing sector. Despite the relative immaturity of some of the enabling technologies people seem interested in the use of smart home devices to improve their quality of life or just generally make things easier at home in their busy schedules. Whilst the enabling technology behind future smart homes is being developed at a rapid pace, it is the intelligent application and integration of this technology that will make the difference to the home consumer. Just because the technology provider can make a ‘useful’ device it does not necessarily mean that the consumer actually wants to buy the ‘new’ invention. The EM trial has successfully shown where certain technology can be deployed successfully and also identified areas where further work is required

The impact of an intervention to increase uptake to structured self-management education for people with type 2 diabetes mellitus in primary care (the embedding package), compared to usual care, on glycaemic control: study protocol for a mixed methods study incorporating a wait-list cluster randomised controlled trial

Abstract: Background: Approximately 425 million people globally have diabetes, with ~ 90% of these having Type 2 Diabetes Mellitus (T2DM). This is a condition that leads to a poor quality of life and increased risk of serious health complications. Structured self-management education (SSME) has been shown to be effective in improving glycaemic control and patient related outcome measures and to be cost-effective. However, despite the demonstrated benefits, attendance at SSME remains low. An intervention has been developed to embed SSME called the ‘Embedding Package’. The intervention aims to address barriers and enhance enablers to uptake of SSME at patient, healthcare professional and organisational levels. It comprises a marketing strategy, user friendly and effective referral pathways, new roles to champion SSME and a toolkit of resources. Methods: A mixed methods study incorporating a wait-list cluster randomised trial and ethnographic study, including 66 UK general practices, will be conducted with two intervention start times (at 0 and 9 months), each followed by an active delivery phase. At 18 months, the intervention will cease to be actively delivered and a 12 month observational follow-up phase will begin. The intervention, the Embedding Package, aims to increase SSME uptake and subsequent improvements in health outcomes, through a clear marketing strategy, user friendly and effective referral pathways, a local clinical champion and an ‘Embedder’ and a toolkit of resources for patients, healthcare professionals and other key stakeholders. The primary aim is, through increasing uptake to and attendance at SSME, to reduce HbA1c in people with T2DM compared with usual care. Secondary objectives include: assessing whether there is an increase in referral to and uptake of SSME and improvements in biomedical and psychosocial outcomes; an assessment of the sustainability of the Embedding Package; contextualising the process of implementation, sustainability of change and the ‘fit’ of the Embedding Package; and an assessment of the cost-effectiveness of the Embedding Package. Discussion: This study will assess the effectiveness, cost-effectiveness and sustainability of the Embedding Package, an intervention which aims to improve biomedical and psychosocial outcomes of people with T2DM, through increased referral to and uptake of SSME. Trial registration: International Standard Randomised Controlled Trials Number ISRCTN23474120. Assigned 05/04/2018. The study was prospectively registered. On submission of this manuscript practice recruitment is complete, participant recruitment is ongoing and expected to be completed by the end of 2019

The MATISSE study: a randomised trial of group art therapy for people with schizophrenia.

RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: Art Therapy has been promoted as a means of helping people who may find it difficult to express themselves verbally engage in psychological treatment. Group Art Therapy has been widely used as an adjunctive treatment for people with schizophrenia but there have been few attempts to examine its effects and cost effectiveness has not been examined. The MATISSE study aims to evaluate the clinical and cost effectiveness of group Art Therapy for people with schizophrenia. METHOD/DESIGN: The MATISSE study is a three-arm, parallel group, pragmatic, randomised, controlled trial of referral to group Art Therapy plus standard care, referral to an attention control 'activity' group plus standard care, or standard care alone. Study participants were recruited from inpatient and community-based mental health and social care services at four centres in England and Northern Ireland. Participants were aged over 18 years with a clinical diagnosis of schizophrenia, confirmed by an examination of case notes using operationalised criteria. Participants were then randomised via an independent and remote telephone randomisation service using permuted stacked blocks, stratified by site. Art Therapy and activity groups were made available to participants once a week for up to 12 months. Outcome measures were assessed by researchers masked to allocation status at 12 and 24 months after randomisation. Participants and care givers were aware which arm of the trial participants were allocated to. The primary outcomes for the study are global functioning (measured using the Global Assessment of Functioning scale) and mental health symptoms (measured using the Positive and Negative Syndrome Scale) assessed at 24 months. Secondary outcomes were assessed at 12 and 24 months and comprise levels of group attendance, social function, satisfaction with care, mental wellbeing, and costs. DISCUSSION: We believe that this is the first large scale pragmatic trial of Art Therapy for people with schizophrenia. TRIAL REGISTRATION: Current Controlled Trials ISRCTN46150447.Published versio

Group art therapy as an adjunctive treatment for people with schizophrenia: multicentre pragmatic randomised trial

Objectives To evaluate the clinical effectiveness of group art therapy for people with schizophrenia and to test whether any benefits exceed those of an active control treatment