A Study on Principal Component Analysis over Wireless Channel

Applications in many fields such as the internet of things (IoT), stock market, image compression, food adulteration, wireless physical layer key generation, etc. are becoming progressively complex due to a large number of users and increment in their usage. Data obtained by these applications are in huge amount creating a high computational cost. Further, it is difficult to handle and analyze it. To deal with such problems, dimensionality reduction techniques are used and one of the dimensionality reduction techniques is the Principal Component Analysis (PCA). In this paper, PCA is applied over a wireless Rician channel with AWGN at different SNR. It is concluded that the information content is more in less number of principal components with samples at higher SNR. It is also observed that the different combinations of several groups and elements in the sample space provide a different cumulative percentage of information

Web Application for News Portal

News Portal provides access to all online Information about the Environment and each information source gets its dedicated area on the page for displaying information. Ne ws portal is to provide specific information, selected from newswire sit es on the Internet and also by video clips automatically extracted from TV broadcasts and as per the needs of users . The idea to made this project is to develop such web sites which will be very User friendly. This web site is working for peoples who want to share something interesting, knowledgeable, healthy, and entertainment. The traditional media rooms all around the world are fast adapting to the new age technologies. This marks the beginnin g of news portals by media houses across the globe and such new media channels give them the opportunity to reach the viewers in a shorter span of time than their print media counterparts

Efficacy of different herbicides against weed flora in Onion

ABSTRAC

Alumina-catalysed derivatisation of sesquiterpene lactones

1047-104

Targeted proteomics reveals compositional dynamics of 60S pre‐ribosomes after nuclear export

Construction and intracellular targeting of eukaryotic pre-ribosomal particles involve a multitude of diverse transiently associating trans-acting assembly factors, energy-consuming enzymes, and transport factors. The ability to rapidly and reliably measure co-enrichment of multiple factors with maturing pre-ribosomal particles presents a major biochemical bottleneck towards revealing their function and the precise contribution of >50 energy-consuming steps that drive ribosome assembly. Here, we devised a workflow that combines genetic trapping, affinity-capture, and selected reaction monitoring mass spectrometry (SRM-MS), to overcome this deficiency. We exploited this approach to interrogate the dynamic proteome of pre-60S particles after nuclear export. We uncovered assembly factors that travel with pre-60S particles to the cytoplasm, where they are released before initiating translation. Notably, we identified a novel shuttling factor that facilitates nuclear export of pre-60S particles. Capturing and quantitating protein interaction networks of trapped intermediates of macromolecular complexes by our workflow is a reliable discovery tool to unveil dynamic processes that contribute to their in vivo assembly and transport

Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated Topoisomerase I to promote genome stability

Peer reviewedPublisher PD

The neuromuscular, biochemical, and endocrine responses to a single-session vs. double-session training day in elite athletes

Purpose: The aim of this study was to compare the acute neuromuscular, biochemical, and endocrine responses of a training day consisting of a speed session only to performing a speed and weight training session on the same day. Methods: Fifteen male academy level rugby players completed two protocols in a randomized order. The speed only protocol involved performing 6 maximal effort repetitions of 50m running sprints with 5 minutes recovery between each sprint, while the speed and weights protocol involved the same sprinting session but was followed 2h post by a lower body weights session consisting of 4 sets of 5 back squat and Romanian deadlift at 85% 1RM. Testosterone, cortisol, creatine kinase, lactate, and perceived muscle soreness were determined immediately before, immediately after, 2h post, and 24h post both protocols. Peak power, relative peak power, jump height, and average rate of force development were determined from a counter movement jump (CMJ) at the same time points. Results: At 24h post, muscle soreness was significantly higher following the speed and weights protocol compared to speed only protocol (effect size eta2= .253, F=4.750, p < 0.05). There was no significant difference between any of the CMJ variables at any of the post training time points. Likewise creatine kinase, testosterone, and cortisol were unaffected by the addition of a weight training session. Conclusion: These data indicate that the addition of a weight training session 2h post a speed session, while increasing the perception of fatigue the following day, does not result in a difference in endocrine response or in neuromuscular capability

Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

Vaccines are powerful tools to develop immune memory to infectious diseases and prevent excess mortality. In older adults, however vaccines are generally less efficacious and the molecular mechanisms that underpin this remain largely unknown. Autophagy, a process known to prevent aging, is critical for the maintenance of immune memory in mice. Here, we show that autophagy is specifically induced in vaccine-induced antigen-specific CD8+ T cells in healthy human volunteers. In addition, reduced IFNγ secretion by RSV-induced T cells in older vaccinees correlates with low autophagy levels. We demonstrate that levels of the endogenous autophagy-inducing metabolite spermidine fall in human T cells with age. Spermidine supplementation in T cells from old donors recovers their autophagy level and function, similar to young donors' cells, in which spermidine biosynthesis has been inhibited. Finally, our data show that endogenous spermidine maintains autophagy via the translation factor eIF5A and transcription factor TFEB. In summary, we have provided evidence for the importance of autophagy in vaccine immunogenicity in older humans and uncovered two novel drug targets that may increase vaccination efficiency in the aging context