8 research outputs found
Improved Survival of HIV-1-Infected Patients with Progressive Multifocal Leukoencephalopathy Receiving Early 5-Drug Combination Antiretroviral Therapy
- Author
- A Antinori
- A d'Arminio Monforte
- A De Luca
- A De Luca
- A Mocroft
- A Vendrely
- Anne Dulioust
- Anne-Aurélie Mazet
- Anne-Sophie Lascaux
- CL Day
- DB Clifford
- Dominique Costagliola
- F Raffi
- F Sallusto
- FN Engsig
- H Tada
- Houria Hendel-Chavez
- IJ Koralnik
- J Gasnault
- J Gasnault
- J Gasnault
- J Herman
- J Molto
- J Reynes
- Jacques Gasnault
- JC van Swieten
- Jean-François Delfraissy
- JR Berger
- K Tan
- Lydie Porte
- MA Lima
- MA Williams
- Marie-Ghislaine de Goer de Herve
- MG de Goer de Herve
- P Cinque
- P Cinque
- P Cinque
- RA Du Pasquier
- Rupert Kaul
- Rémi Lancar
- S Grabar
- SA Younes
- SL Letendre
- Sophie Pakianather
- T Brott
- V Falco
- Y Levy
- Y Taoufik
- Yassine Taoufik
- Publication venue
- Public Library of Science
- Publication date
- 30/06/2011
- Field of study
Progressive multifocal leukoencephalopathy (PML), a rare devastating demyelinating disease caused by the polyomavirus JC (JCV), occurs in severely immunocompromised patients, most of whom have advanced-stage HIV infection. Despite combination antiretroviral therapy (cART), 50% of patients die within 6 months of PML onset. We conducted a multicenter, open-label pilot trial evaluating the survival benefit of a five-drug cART designed to accelerate HIV replication decay and JCV-specific immune recovery.All the patients received an optimized cART with three or more drugs for 12 months, plus the fusion inhibitor enfuvirtide during the first 6 months. The main endpoint was the one-year survival rate. A total of 28 patients were enrolled. At entry, median CD4+ T-cell count was 53 per microliter and 86% of patients had detectable plasma HIV RNA and CSF JCV DNA levels. Seven patients died, all before month 4. The one-year survival estimate was 0.75 (95% confidence interval, 0.61 to 0.93). At month 6, JCV DNA was undetectable in the CSF of 81% of survivors. At month 12, 81% of patients had undetectable plasma HIV RNA, and the median CD4+ T-cell increment was 105 per microliter. In univariate analysis, higher total and naive CD4+ T-cell counts and lower CSF JCV DNA level at baseline were associated with better survival. JCV-specific functional memory CD4+ T-cell responses, based on a proliferation assay, were detected in 4% of patients at baseline and 43% at M12 (P = 0.008).The early use of five-drug cART after PML diagnosis appears to improve survival. This is associated with recovery of anti-JCV T-cell responses and JCV clearance from CSF. A low CD4+ T-cell count (particularly naive subset) and high JCV DNA copies in CSF at PML diagnosis appear to be risk factors for death.ClinicalTrials.gov NCT00120367
Connaissances et pratiques des migrants africains en matière de prévention du paludisme
- Author
- Publication venue
- Publication date
- 01/01/2010
- Field of study
Deux-tiers des cas de paludisme en France concernent des migrants africains. Deux études d'évaluation des connaissances et pratiques des migrants en matière de prévention du paludisme ont été menées afin de dégager les facteurs de mauvaise prévention. La première, auprès de patients hospitalisés pour paludisme, comparait les pratiques de prévention des migrants et des non-migrants. La seconde était une analyse descriptive des connaissances et opinions d'une population de migrants sur la prévention du paludisme. Au total, les migrants s'informaient moins sur le paludisme avant un séjour dans leur pays d'origine. Les raisons principales étaient la mésestimation du risque, la contrainte de prendre un traitement pendant les vacances et le coût. Il faudrait développer des messages de prévention spécifiques à cette population à risque, prenant en compte leurs représentations culturelles. Le médecin généraliste a un rôle essentiel à jouer de part sa connaissance du patient dans sa globalité.TOULOUSE3-BU Santé-Centrale (315552105) / SudocSudocFranceF
One pot synthesis of fluorescent p-conjugated materials: immobilization of phenylene-ethynylene polyelectrolytes in silica confined ionogels
- Author
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 25/06/2011
- Field of study
International audienc
Favorable outcome of severe human herpes virus-6 encephalitis in an HIV-infected patient
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2016
- Field of study
Quinine unbound concentration is the best marker for therapeutic drug monitoring
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Infective endocarditis in pregnant women without intravenous drug use: a multicentre retrospective case series
- Author
- Almirante Benito
- Barranco Francisco José
- Bouiller Kevin
- Declerck Charles
- Dubée Vincent
- Duval Xavier
- Escolà-Vergé Laura
- Fernández-Hidalgo Nuria
- Goehringer François
- Habib Gilbert
- Hammoudi Nadjib
- Issa Nahema
- Lamas Cristiane da Cruz
- Lavie-Badie Yoan
- Martin-Blondel Guillaume
- Nacinovich Francisco
- Porte Lydie
- Rello Pau
- Richaud Clémence
- Rouleau Fréderic
- Selton-Suty Christine
- Tattevin Pierre
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 13/08/2022
- Field of study
International audienceObjectives: To describe the clinical features and outcomes of infective endocarditis (IE) in pregnant women who do not inject drugs.Methods: A multinational retrospective study was performed at 14 hospitals. All definite IE episodes between January 2000 and April 2021 were included. The main outcomes were maternal mortality and pregnancy-related complications.Results: Twenty-five episodes of IE were included. Median age at IE diagnosis was 33.2 years (IQR 28.3-36.6) and median gestational age was 30 weeks (IQR 16-32). Thirteen (52%) patients had no previously known heart disease. Sixteen (64%) were native IE, 7 (28%) prosthetic and 2 (8%) cardiac implantable electronic device IE. The most common aetiologies were streptococci (n = 10, 40%), staphylococci (n = 5, 20%), HACEK group (n = 3, 12%) and Enterococcus faecalis (n = 3, 12%). Twenty (80%) patients presented at least one IE complication; the most common were heart failure (n = 13, 52%) and symptomatic embolism other than stroke (n = 4, 16%). Twenty-one (84%) patients had surgery indication and surgery was performed when indicated in 19 (90%). There was one maternal death and 16 (64%) patients presented pregnancy-related complications (11 patients ≥1 complication): 3 pregnancy losses, 9 urgent Caesarean sections, 2 emergency Caesarean sections, 1 fetal death, and 11 preterm births. Two patients presented a relapse during a median follow-up of 3.1 years (IQR 0.6-7.4).Conclusions: Strict medical surveillance of pregnant women with IE is required and must involve a multidisciplinary team including obstetricians and neonatologists. Furthermore, the potential risk of IE during pregnancy should never be underestimated in women with previously known underlying heart disease
A highly virulent variant of HIV-1 circulating in the Netherlands
- Author
- Aarsman K
- Abel Sylvie
- Abeler-Dörner Lucie
- Abgrall Sophie
- Abgueguen Pierre
- Abraham Bruno
- Ackens R P
- Adam Axel
- Adams A
- Agher Nouara
- Ahmad S
- Ainsworth J
- Aissi Emmanuelle
- Ajana Faïza
- Al Moujahid A
- Alagna Laura
- Albers M
- Albert Jan
- Alberto A
- Alcaraz Isabelle
- Allavena Clotilde
- Allegre Thierry
- Allen S
- Allienne Christophe
- Alvarez Muriel
- Alvarez-Huve Sandrine
- Amirat Naouel
- Ammerlaan H S M
- Anderson J
- Andrady U
- Andre Marie
- Ang C W
- Antoniotti Odile
- Antonucci S
- Aquilina Christian
- Arastéh Keikawus
- Arbter Peter
- Arends J E
- Arumainayyagam J
- Arvieux Cédric
- Aslan Alexandre
- Assi Assi
- Atoui Nadine
- Aubert V
- Audebert Franz
- Aumaitre Hugues
- Autar R S
- Avettand Fenoel Véronique
- Baas S
- Babiker Abdel
- Back N K T
- Baclet Véronique
- Baillat Vincent
- Bakker M
- Bakker Margreet
- Bakker Y
- Balausine Stéphanie
- Balsarin Florence
- Bannert Norbert
- Bannert Norbert
- Bansaal D
- Bantsimba Jonas
- Barbe Frédérique
- Barbuat Claudine
- Barin Francis
- Barth R E
- Bassant N
- Bastides Frédéric
- Batala Anne-Sophie
- Batard Marie-Laure
- Batisse Dominique
- Battegay M
- Baudry Thomas
- Baumgarten Axel
- Bax H I
- Bazin Christine
- Beck Charles
- Beck-Wirth Geneviève
- Belan Alix Greder
- Belarbi Linda
- Bellenger Katharine
- Ben Abdallah Saadia
- Benomar Meryem
- Berger Jean-Luc
- Bergsma D
- Berkhout B
- Berkhout Ben
- Bermon N
- Bernard Louis
- Bernard Noëlle
- Bernard-Henry Claudine
- Bernasconi E
- Berrebi Valérie
- Berrevoets M A H
- Berthe Huguette
- Berzow Dirk
- Besnier Michel
- Bevan M
- Bevan Margaret-Ann
- Bezemer D O
- Bezemer Daniela
- Bezemer M
- Biekre Raphael
- Bieniek Bernhard
- Bierman W F W
- Biezunski Noemie
- Billaud Eric
- Blaauw H
- Blackman H
- Blackman Helen
- Blanc Arnaud
- Blanquart François
- Bloch Martine
- Blok W L
- Bodard Loïc
- Bogner Johannes
- Bollens Diane
- Bolliot Claudine
- Bomers M
- Bonmarchand Manuela
- Bonnet Bénédicte
- Bonnet Fabrice
- Bonsall David
- Bont L J
- Boonstra A
- Bor P C J
- Bornarel Dominique
- Bottero Julie
- Bouchaud Olivier
- Boucher C A B
- Bouchez Sabelline
- Boue François
- Bourgeois Christine
- Boussard Jean-Luc
- Boutoille David
- Bouwhuis J W
- Bowman C
- Boyd A C
- Branger J
- Braun D L
- Brewer C
- Bridgwood A
- Brinkman K
- Brochier Corinne
- Brockmeyer Norbert
- Brokking W
- Brosseau Delphine
- Brouwer A E
- Brouwer A E
- Browing M
- Brunel-Dalmas Florence
- Brunet Cecile
- Bruns A H W
- Brétin N
- Bucher H C
- Buisson Marielle
- Buisson Martin
- Buiting A
- Buiting A G M
- Burger D
- Burgers K
- Burton-Jeangros C
- Bushby S
- Byrne P
- Böni J
- Cabie André
- Cabras Ornella
- Caby Fabienne
- Cahitte Isabelle
- Calderwood J
- Calin Ruxandra
- Calmy A
- Caltado Sabrina
- Campa Pauline
- Campbell L
- Cardon Fanny
- Care C
- Care Christine
- Carganico Andreas
- Carrick G
- Castel Philippe
- Cavassini M
- Cazanave Charles
- Cazenave Benoit
- Cents-Bosma A S
- Cerland Christophe
- Chabrol Amélie
- Chaigne de Lalande Severin
- Chaix Fabrice
- Chaix Marie-Laure
- Chambrin Véronique
- Champagne Hélène
- Chandramani S
- Chantalat Christelle
- Chapplain Jean-Marc
- Chardon Patricia
- Chas Julie
- Chavanet Pascal
- Cheneau Christine
- Chennebault Jean Marie
- Cheret Antoine
- Chevojon Pierre
- Chiarello Pierre
- Chirouze Catherine
- Christl Andreas
- Claas E C J
- Claassen M
- Clarke Mindy
- Claus Bernd
- Claus Jörg
- Clavel François
- Cloarec Nicolas
- Cohen Stuart J W T
- Colin de Verdiere Nathalie
- Collias Lio
- Connolly L
- Conort Guillaume
- Consigny Paul Henri
- Cordes Christiane
- Cordonnier François
- Cornavin Pauline
- Cornelissen M T E
- Cornelissen Marion
- Coupard Mélissa
- Croisier Delphine
- Cros Agnes
- Cua Eric
- Curlier Elodie
- Currie J
- Cuzin Lise
- Daneluzzi Vincent
- Daniel Corinne
- Dauchy Frédéric
- David L
- Davido Benjamin
- Davids-Veldhuis S
- de Boer C
- de Boer M G J
- De Castro Nathalie
- de Cesare Mariateresa
- de Groot J
- de Groot L
- de Groot-de Jonge H
- de Haan M
- de Jong A
- de Jong-Peltenburg N C
- de Kroon I
- de Kruijf-van de Wiel B A F M
- de la Blanchardiere Arnaud
- de Mendonç A Melo M
- de Munnik E S
- de Regt M
- de Tejada B Martinez
- De Truchis Pierre
- de Vries-Sluijs T E M S
- de Weerd D A
- Dean G
- Debab Yasmine
- Debard Alexa
- Debast S B
- Dehn Günther
- Deiman B
- Delacroix Isabelle
- Delestan Mikael
- Delfraissy Jean François
- Delgado Jeannine
- Delllion Sophie
- Delobel Pierre
- Delpech Valerie
- Delsing C E
- den Hollander J G
- Denes Éric
- Depond Audrey
- Derouineau Jean
- DeSouza C
- Detering-Hübner Barbara
- Devendra S V
- Devidas Alain
- Diab Georges
- Diemer Myriam
- Dinh Aurélien
- Djoechro E
- Dofferhoff A S M
- Dollenmaier G
- Dondia Denis
- Donnelly C
- Donsesco Régine
- Dorama W
- Douma R A
- Drake S
- Drobacheff-Thiebaut Christine
- Ducroix Sophie
- Duffau Pierre
- Duijf-van de Ven C J H M
- Dulucq Marie Josée
- Dumont Cécile
- Dunais Brigitte
- Duong Michel
- Dupke Stephan
- Dupont Matthieu
- Dupont Michel
- Duracinsky Martin
- Durant Jacques
- Durox Hélène
- Dutronc Hervé
- Duvivier Claudine
- Eden Aurélia
- Egger M
- El Berkaoui A
- El Moussaoui R
- Elharrar Brigitte
- Eliazevitch Murielle
- Ellerbroek P M
- Elsenburg L J M
- Elzi L
- Esnault Jean-Luc
- Essat Asma
- Esser Stefan
- Estreich S
- Evans M
- Faber S
- Fabre Isabelle
- Fairbrother Keith
- Fairley I
- Faucher Jean-François
- Faucher Olivia
- Faulkner S
- Faulkner Sue
- Faure Isabelle
- Faville R
- Faville Rebecca
- Fehr J
- Fellay J
- Fellay Jacques
- Fenske Stefan
- Feret Philippe
- Ferret Samuel
- Ferretti Luca
- Ferreyra Milagros
- Fialaire Pascale
- Fidler S
- Fidler S
- Fily Fabien
- Fischer Hugues
- Fischer Klaus
- Fischer Patricia
- Fitzgerald M
- Flegg P
- Foltzer Adeline
- Fonquernie Laurent
- Fox J
- Fox Julie
- Fraaij P L A
- Fraser Christophe
- Fraser P
- Freiwald Matthias
- Frietsch Bernhard
- Froguel Eric
- Fröschl Monika
- Furrer H
- Fux C A
- Gall Astrid
- Galle Peter
- Garipuy Daniel
- Garrait Valérie
- Gatey Caroline
- Gaud Catherine
- Gazaigne Sandrine
- Geelen S P M
- Geerders G F
- Geerlings S E
- Geffray Loïk
- Gehring Peter
- Geilings J
- Gelinck L B S
- Gellen-Dautremer Justine
- Genet Claire
- Genet Philippe
- Gerard Laurence
- Gerbe Juliette
- Ghosn Jade
- Gibert Sylvie
- Gilleran G
- Gilquin Jacques
- Gilson R
- Gilson R
- Girard Jean-Jacques
- Girard Pierre-Marie
- Gisolf E H
- Glaunsinger Tobias
- Godin Collet Claire
- Godinot Mathieu
- Gohier Sandrine
- Goldberg David
- Golubchik Tanya
- Gomez M
- Gompels M
- Goorhuis A
- Goorney B
- Gorgievski M
- Goujard Cécile
- Gourdon Florence
- Goussef Marie
- Grabowski M Kate
- Graefe Katrin
- Green P
- Green Pippa
- Green S
- Greenhough D
- Griffioen-van Santen B M G
- Grintjes-Huisman K J T
- Groeneveld P H P
- Grossi Olivier
- Groters M
- Guillevin Loïc
- Guimard Thomas
- Gunsenheimer-Bartmeyer Barbara
- Gunsenheimer-Bartmeyer Barbara
- Güler Cengiz
- Günthard H
- Günthard Huldrych F
- Hadacek Blanka
- Haerry D
- Haffner-Mauvais Cécile
- Hage de Looff L
- Halaby T
- Hall Matthew
- Hall Nolwenn
- Halna Jean-Michel
- Hansen Stefan
- Harding J
- Haret Sophie
- Harindra V
- Hasse B
- Hassing R J
- Havenith T R A
- Hawkins D
- Hawkins David
- Hazenberg A
- Heikens E
- Heitmuller M
- Henriet S S V
- Herman S
- Herman Sandra
- Herpers B L
- Hertling Sandra
- Hessamfar Mojgan
- Higgs C
- Hillebregt M
- Hillenbrand Heribert
- Hintsche Bettina
- Hiraux Emmanuel
- Hirsch H H
- Hittinger Gilles
- Hoen Bruno
- Hoepelman A I M
- Hoffmann M
- Holtsema H
- Honore Patricia
- Hoogerwerf J
- Hoogewerf M
- Houlbert Dominique
- Hovius J W
- Howard L
- Hower Martin
- Hue Hervé
- Huleux Thomas
- Hustache Mathieu Mathieu
- Häussinger Dieter
- Hösli I
- Ingiliz Patrick
- Jacomet Christine
- Jacquet Jean Marc
- Jansen E R
- Jansen R
- Jansz A R
- Jayle Didier
- Jeantils Vincent
- Jebakumar S P R
- Jennings L
- Jerbi Saadia
- Jessen Arne
- Jessen Heiko
- Jeunet Noëlle
- Johnson Anne
- Johnson M
- Johnson Margaret
- Jolink H
- Jonges M
- Joulie Aline
- Jung Corinne
- Jurriaans S
- Jä Gel-Guedes Eva
- Jäger Hans
- Kahlert C
- Kaiser L
- Kampschreur L M
- Kansau Imad
- Karmochine Marina
- Katlama Christine
- Keelan-Phaf S
- Keiser O
- Kellam Paul
- Kellock D
- Kennedy N
- Kern Peter
- Keuter M
- Kirstetter Myriam
- Kivelä Pia
- Klausen Gerd
- Kleene M J
- Kleinnijenhuis J
- Klimkait T
- Kloeze E
- Kmiec Isabelle
- Knapen M
- Knoester M
- Koffi Joseph
- Kok M
- Koopmans M P G
- Kootstra G J
- Kortmann W
- Kousignan Pascale
- Kouyos R
- Kouyos Roger D
- Kovari H
- Kowalczyk Jakub
- Kraan S
- Kreckel Peter
- Kreft Burkhard
- Kroon F P
- Kruijne E
- Kruiper M S M
- Ktorza Nadine
- Kuijpers T W
- Kuldanek K
- Kuldanek Kristin
- Kwa D
- Köppe Siegfried
- Laan L M
- Lacey H
- Lacoste Denis
- Laeyendecker Oliver
- Lafaurie Matthieu
- Lafeuillade Alain
- Lafon Erik
- Lagarrigue Myriam
- Lagneau Jean-Luc
- Lamaury Isabelle
- Lambregts M M C
- Lambry Véronique
- Lammers A J J
- Langebeek N
- Lanternier Fanny
- Lascaux Anne Sophie
- Lascoux-Combe Caroline
- Lauenroth-Mai Elke
- Launay Odile
- Lauw F N
- Lawlor V
- Le Puil Séverine
- Lean C
- Leantez-Nainville Sophie
- Lechiche Catherine
- Lecuroux Camille
- Ledergerber B
- Lefebvre Benedicte
- Lefeuvre Céline
- Lefort Agnès
- Lelievre Jean Daniel
- Lelivelt K J
- Lemercier Yvon
- Lemoing Vincent
- Lempkes B
- Lenagat Sophie
- Leplatois Anne
- Leport Catherine
- Lepretre Annie
- Lerolle Nathalie
- Leroy Helene
- Lettinga K D
- Leureillard Didier
- Levy Yves
- Leyten E M S
- Livrozet Jean-Michel
- Loay D
- Lodewijk C
- Loeffen Y G T
- Lorenzen Thore
- Loulergue Pierre
- Louni Françoise
- Lowe S H
- Lucas E
- Luycx Odile
- Lyavanc Thomas
- Lynn W
- Machado Moise
- MacIntyre-Cockett George
- Magdy A
- Mahy Sophie
- Maignan Aline
- Majerholc Catherine
- Makhloufi Djamila
- Makinson Alain
- Malet Martine
- Malvy Denis
- Manceron Véronique
- Marigot Dhiba
- Markus Rudolf
- Marneef M
- Marquardt Ties
- Martell Cédric
- Martha Benoît
- Martin Anne
- Martin Isabelle Poizot
- Martinetti G
- Martinot Martin
- Marzolini C
- Masse Virginie
- Massip Patrice
- Mauboussin Jean-Marc
- May Thierry
- Mayr Christoph
- Mazhude C
- McCormack S
- McKernan S
- McKernan Sinead
- McLean K
- McLean Ken
- Meaden J
- Medus Marie
- Meijering R
- Meixenberger Karolin
- Melville R
- Mercie Patrick
- Merle Corinne
- Merlet Audrey
- Merrien Dominique
- Mette R
- Metzner K
- Meybeck Agnès
- Meyer Andreas
- Meyer Laurence
- Meyer Laurence
- Mguni S
- Miailhes Patrick
- Michel Catherine
- Michelet Christian
- Middel A
- Minozzi Catherine
- Minton J
- Molina Jean-Michel
- Moll Arend
- Mollema F
- Moreau Philippe
- Morineau-Le Houssine Pascale
- Morlat Philippe
- Morris S
- Mortier Emmanuel
- Mouton-Rioux Virginie
- Moyes A
- Mudrikova T
- Mulder-Seeleman E
- Mullaney S
- Mullaney Scott
- Munier Anne-Lise
- Munjishvili L
- Murck J L
- Murphy C
- Murphy S
- Muthern Lisa
- Müller Marcus
- Müller N
- Nadal D
- Nait-Ighil Lella
- Naqvi Alissa
- Nastouli Eleni
- Natarajan U
- Nau Pascale
- Nauta N
- Neau Didier
- Nellen F J B
- Nellen J
- Neuville Ségolène
- Niault Mathilde
- Nicca D
- Niesters H G M
- Nobel H
- Nouwen J L
- O'Mahony C
- Obadia Martine
- Ong E
- Ong Swee Hoe
- Oosterheert J J
- Orkin C
- Oude Lashof A M L
- Ouissa Rachida
- Paccalin François
- Pachart Anne
- Pailhes Sylvie
- Pajkrt D
- Paling F
- Pantaleo G
- Parcelier François
- Parrinello Maguy
- Partisani Maria
- Patey Olivier
- Patra-Delo Solène
- Pavie Juliette
- Paz Pauline Caraux
- Peacock K
- Peeck B
- Pellegrin Jean-Luc
- Penot Pauline
- Peretti Delphine
- Perre Philippe
- Perrone Véronique
- Perry N
- Pertusa Marie-Carmen
- Peters E J G
- Petrov-Sanchez Ventzislava
- Peyramond Dominique
- Philip Gisèle
- Phillips Andrew
- Phung Bao
- Pialoux Gilles
- Picard Odile
- Pichancourt Gilles
- Pichon François
- Pierre Isabelle
- Pierre-Francois Sandrine
- Pietri Marie-Pierre
- Pijnappel F J J
- Pinet Pauline
- Pintado Claire
- Pinto Adriana
- Piroth Lionel
- Pistone Thierry
- Plettenberg Andreas
- Pogany K
- Poinsignon Yves
- Ponscarme Diane
- Pontesilli O
- Porte Lydie
- Porter Kholoud
- Post F
- Post Frank
- Postel Nils
- Posthouwer D
- Postma D F
- Pradier Christian
- Prevoteau du Clary François
- Priester Michèle
- Prins J M
- Pritchard J
- Pronk M J H
- Proust Aurélie
- Psomas Christina
- Quertainmont Yann
- Quinsat Denis
- Rabier Valérie
- Raffi François
- Rahamat-Langendoen J
- Raho-Moussa Mariem
- Rajamanoharan S
- Rajda N
- Rami Agathe
- Rangom Camille
- Rauch A
- Rausch Michael
- Ravaux Isabelle
- Raymond Isabelle
- Receveur Marie-Catherine
- Ree C
- Regenass S
- Regtop R
- Rehaiem Sami
- Reimann Evelyne
- Reiss P
- Reiss Peter
- Reliquet Véronique
- Renckens R
- Reuter Stefan
- Reuwer A
- Revest Matthieu
- Rey David
- Reynes Jacques
- Ribeiro Emmanuel
- Ricaud Carole
- Richardson C
- Richardson Celia
- Richel O
- Richier Laurent
- Riddell L
- Rijnders B J A
- Ristola Matti
- Roberts M
- Robertson R
- Robineau Olivier
- Robinson T
- Rodet Roland
- Roger-Schmelz Julien
- Rohan Jennifer
- Rokx C
- Rooijakkers E O W
- Rooney G
- Rosenthal Eric
- Rosingh A
- Rosolen Béatrice
- Ross J
- Rouanet Isabelle
- Roukens A H E
- Rouveix Elisabeth
- Rouzioux Christine
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- Rozenbaum Willy
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- Weitner Lutwin
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- Wesselmann Hans
- Wessels E
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- Wicke Thomas
- Wiemer Dorothea
- Wiersinga W J
- Wijnands S
- Wildenbeest G S
- Wilding H
- Wilkins E
- Williams O
- Winter A
- Wintermans B
- Wirth Gaétane
- Wit F W M N
- Wither J
- Witte E C
- Wolfs T F W
- Wolthers K C
- Woodward R
- Woudstra T
- Wouthuyzen-Bakker M
- Wttewaal E
- Wymant Chris
- Yazdanpanah Yazdan
- Yerly S
- Young Carmel
- Young F
- Young S
- Youssef Elaney
- Zaaijer H L
- Zadeh Mahsa Mohseni
- Zaheri S
- Zak Dit Zbar Olivier
- Zeng Ai-Feng
- Zhao Lele
- Zucchetti Antonella
- Zucman David
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 04/02/2022
- Field of study
We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
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- Armstrong-James Darius
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- Backer Jonathan M
- Backues Steven K
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- Eskelinen Eeva-Liisa
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- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field