Motor, cognitive and mobility deficits in 1000 geriatric patients : protocol of a quantitative observational study before and after routine clinical geriatric treatment – the ComOn-study

© The Author(s). 2020 Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Motor and cognitive deficits and consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis and for the evaluation of treatment in this vulnerable cohort are limited. The aims of the ComOn (COgnitive and Motor interactions in the Older populatioN) study are (i) to define quantitative markers with clinical relevance for motor and cognitive deficits, (ii) to investigate the interaction between both motor and cognitive deficits and (iii) to assess health status as well as treatment outcome of 1000 geriatric inpatients in hospitals of Kiel (Germany), Brescia (Italy), Porto (Portugal), Curitiba (Brazil) and Bochum (Germany). Methods: This is a prospective, explorative observational multi-center study. In addition to the comprehensive geriatric assessment, quantitative measures of reduced mobility and motor and cognitive deficits are performed before and after a two week's inpatient stay. Components of the assessment are mobile technology-based assessments of gait, balance and transfer performance, neuropsychological tests, frailty, sarcopenia, autonomic dysfunction and sensation, and questionnaires to assess behavioral deficits, activities of daily living, quality of life, fear of falling and dysphagia. Structural MRI and an unsupervised 24/7 home assessment of mobility are performed in a subgroup of participants. The study will also investigate the minimal clinically relevant change of the investigated parameters. Discussion: This study will help form a better understanding of symptoms and their complex interactions and treatment effects in a large geriatric cohort.info:eu-repo/semantics/publishedVersio

Spektroskopie von (HCl)x(H2O)y(HCl)_{x}(H_{2}O)_{y}-Clustern in superflüssigen Heliumtröpfchen

In dieser Arbeit wurden mittels Depletionspektroskopie mehrere $(HCl)_{x}(H_{2}O)_{y}$-Cluster und verwandte Isotope im Frequenzbereich von 2660$cm^{-1}$ bis 2915$cm^{-1}$ spektroskopisch untersucht. Der experimentelle Aufbau bestand aus einem optisch parametrischen Oszillator mit einem Emissionsbereich von 3-4$\mu$m und einer Helium-Cluster-Apparatur. Es konnte der R(0)- Übergang des HCl-Monomers bei einer Frequenz von 2905,15$cm^{-1}$ (fwhm: 1,004$cm^{-1}$) bzw. 2903,03$cm^{-1}$ (fwhm: 0,698$cm^{-1}$) gemessen werden. Es konnte weiterhin die freie $\nu_{1}$ und gebundene $\nu_{2}$ Schwingung des HCl-Dimers gemessen werden. Damit war die Bestimmung der Tunnelaufspaltung des angeregten HCl-Dimer-Komlexes zu 2,698$cm^{-1}$ möglich. Messungen von $(HCl)_{x}(H_{2}O)_{y}$-Clustern im Frequenzbereich um 2670$cm^{-1}$ zeigten, dass vier $H_{2}O$-Moleküle ausreichend sind, um eine Dissoziation des HCl´s zu ermöglichen

SOLVATION OF HCl, AGGREGATION OF H2_2O, HCl AND THEIR DEUTERATED ISOTOPES IN SUPERFLUID He DROPLETS}

this work was supported by FOR 618 of the German Science FoundationAuthor Institution: Department of Physical Chemistry II; Ruhr-University Bochum, Universitatsstr. 150, D-44780We investigate aggregates of HCl, H$_2$O and their deuterated isotopes embedded in superfluid helium using a helium nanodroplet spectrometer combined with a cw infrared OPO set up with an output power of up to 2.7 W and a resolution of better than 0.001 cm$^{-1}$. Depletion spectra of the super cooled aggregates (0.37 K) were recorded between 2650 cm$^{-1}$ and 2720 cm$^{-1}$. We were able to assign the HCl stretch vibration of the HCl-H$_2$O complex. We also observed spectral features of (HCl)$_m$(H$_2$O)$_n$ aggregates and isotopes in the region of the H$_3$O$^+$ stretch vibration. The question of how many H$_2$O molecules are needed to solvate HCl will be addressed

A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy

Classic bladder exstrophy represents the most severe end of all human congenital anomalies of the kidney and urinary tract and is associated with bladder cancer susceptibility. Previous genetic studies identified one locus to be involved in classic bladder exstrophy, but were limited to a restrict number of cohort. Here we show the largest classic bladder exstrophy genome-wide association analysis to date where we identify eight genome-wide significant loci, seven of which are novel. In these regions reside ten coding and four non-coding genes. Among the coding genes is EFNA1, strongly expressed in mouse embryonic genital tubercle, urethra, and primitive bladder. Re-sequence of EFNA1 in the investigated classic bladder exstrophy cohort of our study displays an enrichment of rare protein altering variants. We show that all coding genes are expressed and/or significantly regulated in both mouse and human embryonic developmental bladder stages. Furthermore, nine of the coding genes residing in the regions of genome-wide significance are differentially expressed in bladder cancers. Our data suggest genetic drivers for classic bladder exstrophy, as well as a possible role for these drivers to relevant bladder cancer susceptibility. A genome-wide association study on classic bladder exstrophy reveals eight genome-wide significant loci, most of which contained genes expressed in embryonic developmental bladder stages