The Right Match: A Strong Principal in Every Public School

This report has one central premise: Keeping great principals starts with hiring the right principal. Even as Chicago fights to retain principals long enough to make student learning and school culture gains more permanent, we must recognize some principal attrition is inevitable.More than 70,000 students started the 2016-17 school year with a new principal, and at least 60 schools will need a new principal each year for the foreseeable future. The stakes are high: No great public school exists without great leadership. In fact, variation in principal quality accounts for about 25 percent of a school's total impact on student learning. Yet, more than four out of every 10 public school principals in Chicago leave before they begin their fifth year. To keep great principals, we have to make the right match from the start

Managing Fatigue with Technology for Individuals with Multiple Sclerosis

OBJECTIVE: The purpose of this study was to investigate whether a mobile health application (mHealth app) will result in a decrease in fatigue and an increase in adherence to energy conservation techniques for adults with multiple sclerosis (MS). METHOD: Using a quantitative, exploratory, pretest and post-test design, we examined the use of the mHealth app, Pace My Day (PMD), by seven participants during one chosen task while incorporating energy conservation strategies for two weeks. Main outcome measures included Modified Fatigue Impact Scale (MFIS) and Canadian Occupational Performance Measure (COPM). RESULTS: There was a significant decrease in the MFIS scores indicating a decrease in fatigue over the two-week period t(6)=5.75, p=0.001. CONCLUSION: Use of mHealth apps and energy conservation strategies were found to significantly reduce levels of fatigue and increase self-perceived performance and satisfaction of task execution.https://scholar.dominican.edu/ug-student-posters/1060/thumbnail.jp

Managing Fatigue with Technology for Individuals with Multiple Sclerosis

OBJECTIVE: The purpose of this study was to investigate whether the use of a mobile health application (mHealth app) in conjunction with energy conservation management techniques will result in a decrease in fatigue for adults with multiple sclerosis. METHOD: Using a quantitative, exploratory, pre-posttest design, we examined outcomes associated with the use of the mHealth app, Pace My Day, by seven participants during one chosen task over two weeks. The app reinforced the use of energy conservation management techniques during the chosen task. Outcome measures included Modified Fatigue Impact Scale (MFIS) and Canadian Occupational Performance Measure (COPM). RESULTS: There was a significant decrease in the MFIS scores indicating a decrease in fatigue over the two-week period t (6) =5.75, p=0.001. Additionally, there was a significant increase in satisfaction with performance of the chosen task as measured by the COPM over the two-week period t (6) =-3.359, p=0.015. CONCLUSION: The use of a mHealth app to support energy conservation management education was found to significantly reduce levels of fatigue and increase self-perceived performance and satisfaction with task execution

Sphincter damage during fistulotomy for perianal fistulae and its relationship with faecal incontinence

Background The length of sphincter which can be divided during fistulotomy for perianal fistula is unclear. The aim was to quantify sphincter damage during fistulotomy and determine the relationship between such damage with symptoms and severity of faecal incontinence and long-term quality of life (QOL). Methods A prospective cohort study was performed over a 2-year period. Patients with intersphincteric and mid to low transsphincteric perianal fistulas without risk factors for faecal incontinence were scheduled for fistulotomy. All patients underwent 3D endoanal ultrasound (3D-EAUS) pre-operatively and 8 weeks postoperatively. Measurements were taken of pre- and postoperative anal sphincter involvement and division. Anal continence was assessed using the Jorge-Wexner scale and QOL scores pre, 6 and 12 months postoperatively. Results Forty-nine patients were selected. A strong correlation between pre- and postoperative measurements was found p < 0.001. A median length of 41% of the external anal sphincter and 32% of the internal anal sphincter was divided during fistulotomy. Significant differences in mild symptoms of anal continence were found with increasing length of external anal sphincter division. But there was no significant deterioration in continence, soiling, or quality of life scores at the 1-year follow-up. Division of over two-thirds of the external anal sphincter was associated with the highest incontinence rates. Conclusions 3D-EAUS is a valuable tool for quantifying the extent of sphincter involvement pre- and postoperatively. Post-fistulotomy faecal incontinence is mild and increases with increasing length of sphincter division but does not affect long-term quality of life

Extracellular Vesicles from Different Pneumococcal Serotypes Are Internalized by Macrophages and Induce Host Immune Responses

Bacterial extracellular vesicles are membranous ultrastructures released from the cell surface. They play important roles in the interaction between the host and the bacteria. In this work, we show how extracellular vesicles produced by four different serotypes of the important human pathogen, Streptococcus pneumoniae, are internalized by murine J774A.1 macrophages via fusion with the membrane of the host cells. We also evaluated the capacity of pneumococcal extracellular vesicles to elicit an immune response by macrophages. Macrophages treated with the vesicles underwent a serotype-dependent transient loss of viability, which was further reverted. The vesicles induced the production of proinflammatory cytokines, which was higher for serotype 1 and serotype 8-derived vesicles. These results demonstrate the biological activity of extracellular vesicles of clinically important pneumococcal serotypes

Relation Between Oceanic Plate Structure, Patterns of Interplate Locking and Microseismicity in the 1922 Atacama Seismic Gap

We deployed a dense geodetic and seismological network in the Atacama seismic gap in Chile. We derive a microseismicity catalog of >30,000 events, time series from 70 GNSS stations, and utilize a transdimensional Bayesian inversion to estimate interplate locking. We identify two highly locked regions of different sizes whose geometries appear to control seismicity patterns. Interface seismicity concentrates beneath the coastline, just downdip of the highest locking. A region with lower locking (27.5°S–27.7°S) coincides with higher seismicity levels, a high number of repeating earthquakes and events extending toward the trench. This area is situated where the Copiapó Ridge is subducted and has shown previous indications of both seismic and aseismic slip, including an earthquake sequence in 2020. While these findings suggest that the structure of the downgoing oceanic plate prescribes patterns of interplate locking and seismicity, we note that the Taltal Ridge further north lacks a similar signature

Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin.

Leucinostatins are antimicrobial peptides with a broad range of activities against infectious agents as well as mammalian cells. The leucinostatin-derivative peptide ZHAWOC_6027 (peptide 6027) was tested in vitro and in vivo for activity against the intracellular apicomplexan parasite Toxoplasma gondii. While highly efficacious in vitro (EC50 = 2 nM), subcutaneous application of peptide 6027 (3 mg/kg/day for 5 days) in mice experimentally infected with T. gondii oocysts exacerbated the infection, caused mild clinical signs and elevated cerebral parasite load. Peptide 6027 also impaired the proliferation and viability of mouse splenocytes, most notably LPS-stimulated B cells, in vitro. To identify common potential targets in Toxoplasma and murine splenocytes, we performed differential affinity chromatography (DAC) with cell-free extracts from T. gondii tachyzoites and mouse spleens using peptide 6027 or an ineffective analogue (peptide 21,358) coupled to N-hydroxy-succinimide sepharose, followed by mass spectrometry. Proteins specifically binding to peptide 6027 were identified in eluates from the peptide 6027 column but not in peptide 21,358 nor the mock column eluates. In T. gondii eluates, 269 proteins binding specifically to peptide 6027 were identified, while in eluates from mouse spleen extracts 645 proteins specifically binding to this peptide were detected. Both datasets contained proteins involved in mitochondrial energy metabolism and in protein processing and secretion. These results suggest that peptide 6027 interacts with common targets in eukaryotes involved in essential pathways. Since this methodology can be applied to various compounds as well as target cell lines or organs, DAC combined with mass spectrometry and proteomic analysis should be considered a smart and 3R-relevant way to identify drug targets in pathogens and hosts, thereby eliminating compounds with potential side effects before performing tedious and costly safety and efficacy assessments in animals or humans

Ocular surface analysis and automatic non-invasive assessment of tear film breakup location, extension and progression in patients with glaucoma

Background: Tear film stability is the key event in ocular surface diseases. The purpose of this study is to evaluate spatial and temporal progression of the tear film breakup using an automatic non-invasive device. Methods: Non-invasive tear breakup time (NITBUT) parameters, such as First NITBUT (F-NITBUT) and Average NITBUT (A-NITBUT), were evaluated in 132 glaucoma and 87 control eyes with the Keratograph 5 M device. Further analysis of this data was used to determine size, location and progression of tear film breakup with automatically identified breakup areas (BUA). The progression from First BUA (F-BUA) to total BUA (T-BUA) was expressed as Dry Area Growth Rate (DAGR). Differences between both groups were analysed using Student t-test for parametric data and Mann-Whitney U test for non-parametric data. Pearson’s correlation coefficient was used to assess the relationship between parametric variables and Spearman in the case of non-parametric variables. Results: F-NITBUT was 11.43 ± 7.83 s in the control group and 8.17 ± 5.73 in the glaucoma group (P = 0.010). A-NITBUT was 14.04 ± 7.21 and 11.82 ± 6.09 s in control and glaucoma groups, respectively (P = 0.028). F-BUA was higher in the glaucoma group than in the control group (2.73 and 2.28; P = 0.022) and was more frequently located at the centre of the cornea in the glaucoma group (P = 0.039). T-BUA was also higher in the glaucoma group than in the control group (13.24 and 9.76%; P = 0.012) and the DAGR was steeper in the glaucoma group than in the control group (34.38° and 27.15°; P = 0.009). Conclusions: Shorter NITBUT values and bigger, more central tear film breakup locations were observed in the glaucoma group than in the control group. The DAGR indicates that tear film rupture is bigger and increases faster in glaucomatous eyes than in normal eyes

The West Midland Space Sector Strengths, Underpinning Assets, and Market

This report outlines the key findings from the West Midlands Space Cluster project. The project has:• mapped regional space activities in industry, academia and beyond • developed a vision for how the region could become a major player in space industry – identified the regional specialisms and networking opportunities• assessed the opportunities for the regional supply chain to join these developments and hence the realise growth potential for the regionThere have been four key stages of research, these are:• Phase 1 – Secondary Data Analysis of Space Sector Firms in the Region • Phase 2 – Secondary Data Analysis of Underlying Assets in the Region • Phase 3: Interviews with Key Stakeholders • Phase 4: Local Space Leadership GroupThe project was led by WMREDI/City-REDI and supported by Professor Kai Bongs (Director of Innovation – College for Engineering and Physical Sciences) and Tariq Ali (Deputy Pro-Vice Chancellor for Strategic Partnerships, University of Birmingham, and Vice-Provost for Research &amp; Innovation).This report developed in partnership with the West Midlands Combined Authority, Greater Birmingham and Solihull Local Enterprise Partnership (GBSLEP), the Black Country LEP and Coventry and Warwickshire LEP, under the UKSA Local Space Sector Cluster and Supply Chain Development Funding Call

In Vitro Assessment of Acute Neuro-inflammation in a Model of the Blood Brain Barrier

Cassandra Phillips ’20 Major: Biology and Psychology Dak Ojuka \u2720Major: Biology Minor: Business and Innovation Anne-Deyssa Victor \u2721Major: Biology Ramon G. Ortega-Alvarez ’20Major: Biology Kathryn Fama ’21 Major: Biology Faculty Mentor: Dr. Charles Toth, Biology The purpose of this experiment was to develop an in vitro model of the blood brain barrier that incorporated brain endothelial microvascular cells (BMEC) and co-cultures composed of neurons, astrocytes, and macrophages. All cell types were derived from human induced pluripotent stem cells. A transendothelial electrical resistance (TEER) assay and immunofluorescence were used to evaluate barrier function. In addition, the model was used to investigate acute neuro-inflammatory responses. An in vitro model of the blood brain barrier could be a valuable tool to observe and assess neuro-inflammation because a human stem cell model is more physiologically relevant