La fuerza de la palabra y la mirada del héroe en el libro VII de la Gesta Danorum

Aproximación a la Gesta Danorum de Saxo Gramático, su transmisión textual y, especialmente el empleo de versos en momentos de gran emoción. Un cambio de registro que implica un mayor cuidado estilístico y que contribuye a profundizar en los aspectos heroicos a lo largo del libro VII y que nos permite atisbar la concepción sagrada de la poesía en la antigua cultura escandinava y su capacidad para transformar la realidad. Un acercamiento al sistema religioso y concepciones sagradas y heroicas en la gesta danorum especialmente la mirada y la voz del héroe.Rapprochement à la Gesta Danorum de Saxo Gramaticus, sa transmission textuelle et, spécialement l’emploi de vers à des moments de grande émotion. Un changement de registre qui implique de plus grands soins stylistique et qui contribue à approfondir dans les aspects héroïques le long du livre VII et qui nous permet percevoir la conception sacrée de la poésie dans l’ancienne culture scandinave et leur capacité pour transformer la réalité. Un rapprochement le système religieux et les conceptions sacrées et héroïques dans la Gesta Danorum spécialement le regard et la voix du héros

Los tejidos de la cortesía medieval

El tacto y la mesura en la sociedad del norte de Francia en el siglo XII y también del conjunto del occidente Medieval a partir de los conceptos de corte y cortesía. El tejido social, sus transformaciones y la dialéctica establecida entre Literatura y realidad a partir del Tristán de Béroul. Sin olvidar cuestiones como noción de juventud, matrimonio, amor y adulterio y la importancia del atuendo como forma de diferenciación social.The tact and the moderation in the society of the north of France in XII century and also of the set of the Medieval West from the concepts of court and courtesy. The social weave, its transformations and the dialectic established between Literature and reality from the Tristán by Beroul. Not forgetting questions like notion youth, marriage, love and adultery and the importance of clothes as form of social differentiation

La fuerza de la palabra y la mirada del héroe en el libro VII de la Gesta Danorum

Aproximación a la Gesta Danorum de Saxo Gramático, su transmisión textual y, especialmente el empleo de versos en momentos de gran emoción. Un cambio de registro que implica un mayor cuidado estilístico y que contribuye a profundizar en los aspectos heroicos a lo largo del libro VII y que nos permite atisbar la concepción sagrada de la poesía en la antigua cultura escandinava y su capacidad para transformar la realidad. Un acercamiento al sistema religioso y concepciones sagradas y heroicas en la gesta danorum especialmente la mirada y la voz del héroe

Los tejidos de la cortesía medieval

El tacto y la mesura en la sociedad del norte de Francia en el siglo XII y también del conjunto del occidente Medieval a partir de los conceptos de corte y cortesía. El tejido social, sus transformaciones y la dialéctica establecida entre Literatura y realidad a partir del Tristán de Béroul. Sin olvidar cuestiones como noción de juventud, matrimonio, amor y adulterio y la importancia del atuendo como forma de diferenciación social

Transcervical carotid stenting with internal carotid artery flow reversal: Feasibility and preliminary results

ObjectiveTransfemoral carotid artery stenting (CAS), with or without distal protection, is associated with risk for cerebral and peripheral embolism and access site complications. To establish cerebral protection before crossing the carotid lesion and to avert transfemoral access complications, the present study was undertaken to evaluate a transcervical approach for CAS with carotid flow reversal for cerebral protection.MethodsFifty patients underwent CAS through a transcervical approach. All patients with symptoms had greater than 60% internal carotid artery (ICA) stenosis, and all patients without symptoms had greater than 80% ICA stenosis. Twenty-one patients (42%) had symptomatic disease or ipsilateral stroke, and 8 patients (16%) had contralateral stroke. Four patients (8%) had recurrent stenosis, 7 patients (14%) had contralateral ICA occlusion, and 1 patient (2%) had undergone previous neck radiation. Twenty-seven procedures (54%) were performed with local anesthesia, and 23 (46%) with general anesthesia. Using a cervical cutdown, flow was reversed in the ICA by occluding the common carotid artery and establishing a carotid–jugular vein fistula. Pre-dilation was selective, and 8-mm to 10-mm self-expanding stents were deployed and post-dilated with 5-mm to 6-mm balloons in all cases.ResultsThe procedure was technically successful in all patients, without significant residual stenoses. No strokes or deaths occurred. There was 1 wound complication (2%). All patients were discharged within 2 days of surgery. Mean flow reversal time was 21.4 minutes (range, 9-50 minutes). Carotid flow reversal was not tolerated in 2 patients (4%). Early in the experience, carotid flow reversal was not possible in 1 patient, and there were 1 major and 3 minor common carotid artery dissections, which resolved after stent placement. One intraoperative transient ischemic attack (2%) occurred in 1 patient in whom carotid flow was not reversed, and 1 patient with a contralateral ICA occlusion had a contralateral transient ischemic attack. At 1 to 12 months of follow-up, all patients remained asymptomatic, and all but 1 stent remained patent.ConclusionTranscervical CAS with carotid flow reversal is feasible and safe. It can be done with the patient under local anesthesia, averts the complications of the transfemoral approach, and eliminates the increased complexity and cost of cerebral protection devices. Transcervical CAS is feasible when the transfemoral route is impossible or contraindicated, and may be the procedure of choice in a subset of patients in whom carotid stenting is indicated

Anti-IL-6 Receptor Tocilizumab in Refractory Graves? Orbitopathy: National Multicenter Observational Study of 48 Patients

Graves’ orbitopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease (GD). Our aim was to assess the e cacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were the best-corrected visual acuity (BVCA), Clinical Activity Score (CAS) and intraocular pressure (IOP). These outcome variables were assessed at baseline, 1st, 3rd, 6th and 12th month after TCZ therapy onset. The severity of GO was assessed according to the European Group on Graves’ Orbitopathy (EUGOGO). We studied 48 (38 women and 10 men) patients (95 eyes); mean age standard deviation 51 11.8 years. Before TCZ and besides oral glucocorticoids, they had received IV methylprednisolone (n = 43), or selenium (n = 11). GO disease was moderate (n =29) or severe (n = 19) and dysthyroid optic neuropathy (DON) (n = 7). TCZ was used in monotherapy (n = 45) or combined (n = 3) at a dose of 8 mg/kg IV every four weeks (n = 43) or 162 mg/s.c. every week (n = 5). TCZ yielded a significant improvement in all of the main outcomes at the 1st month that was maintained at one year. Comparing the baseline with data at 1 year all of the variables improved; BCVA (0.78 0.25 vs. 0.9 0.16; p = 0.0001), CAS (4.64 1.5 vs. 1.05 1.27; p = 0.0001) and intraocular pressure (IOP) (19.05 4.1 vs. 16.73 3.4 mmHg; p = 0.007). After a mean follow-up of 16.1 2.1 months, low disease activity (CAS 3), was achieved in 88 eyes (92.6%) and TCZ was withdrawn in 29 cases due to low disease activity (n = 25) or ine cacy (n = 4). No serious adverse events were observed. In conclusion, TCZ is a useful and safe therapeutic option in refractory GO treatment.This work was also partially supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from “Instituto de Salud Carlos III” (ISCIII) (Spain)

A Bayesian assessment of an approximate model for unconfined water flow in sloping layered porous media

The prediction of water table height in unconfined layered porous media is a difficult modelling problem that typically requires numerical simulation. This paper proposes an analytical model to approximate the exact solution based on a steady-state Dupuit–Forchheimer analysis. The key contribution in relation to a similar model in the literature relies in the ability of the proposed model to consider more than two layers with different thicknesses and slopes, so that the existing model becomes a special case of the proposed model herein. In addition, a model assessment methodology based on the Bayesian inverse problem is proposed to efficiently identify the values of the physical parameters for which the proposed model is accurate when compared against a reference model given by MODFLOW-NWT, the open-source finite-difference code by the U.S. Geological Survey. Based on numerical results for a representative case study, the ratio of vertical recharge rate to hydraulic conductivity emerges as a key parameter in terms of model accuracy so that, when appropriately bounded, both the proposed model and MODFLOW-NWT provide almost identical results

Evolución de Studium. Despliegue de la plataforma moodle 2.x

Memoria ID-2012.001. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2012-2013

Precariedad, exclusión social y modelo de sociedad: lógicas y efectos subjetivos del sufrimiento social contemporáneo (IV). Innovación docente en Filosofía

El PIMCD “Precariedad, exclusión social y modelo de sociedad: lógicas y efectos subjetivos del sufrimiento social contemporáneo (IV). Innovación docente en Filosofía” constituye la cuarta edición de un PIMCD que ha recibido financiación en las últimas convocatorias de PIMCD UCM, de los que se han derivado actividades de formación para estudiantes de Grado, Máster y Doctorado y al menos 3 publicaciones colectivas publicadas por Ediciones Complutense, Siglo XXI y Palgrave McMillan

Precariedad, exclusión social y diversidad funcional (discapacidad): lógicas y efectos subjetivos del sufrimiento social contemporáneo (III). Innovación docente en Filosofía

El PIMCD Precariedad, exclusión social y diversidad funcional (discapacidad): lógicas y efectos subjetivos del sufrimiento social contemporáneo (III). Innovación docente en Filosofía se ocupa de conceptos que generalmente han tendido a ser eludidos en la enseñanza académica de filosofía. Se trata de la tercera edición de un PIMCD que ha venido recibiendo financiación en las últimas convocatorias PIMCD UCM, de los que se han derivado publicaciones colectivas publicadas por Ediciones Complutense y Siglo XXI