La inmigración extranjera en el mapa social de la ciudad de Málaga

A lo largo de los últimos años, la ciudad de Málaga ha mantenido un saldo negativo en la movilidad residencial con el espacio de su corona. Ello supone pérdida de hogares, jóvenes sobre todo, que incide en el envejecimiento y declive de sectores de la ciudad consolidada. Recientemente, sin embargo, la inmigración extranjera ha relanzado el crecimiento demográfico de Málaga. El objeto de este trabajo consiste en analizar el efecto de “repoblación” que este colectivo está iniciando en la ciudad y su reflejo en el mapa de áreas sociales urbanas.Surroundings of Málaga city has supported a negative balance in the residential mobility in the last years. It supposes to lose inhabitants, mainly younger, that affects to the aging and declivity of some urban areas. Recently, nevertheless, population of Málaga has been increase by foreign immigration. The object of this papeer is to analyse the effect of repopulation in the town due to this immigrarion and its consequences in the map of social urban areas

Hogares y viviendas en la prospección demográfica de la planificación urbanística

La proyección demográfica es una herramienta habitual en la planificación urbanística. Con frecuencia sus resultados se manejan como una variable independiente con la que se justifican nuevos desarrollos urbanos. En la realidad, las relaciones entre crecimiento demográfico y urbano, son mucho más complejas, y existen claras interconexiones en ambos sentidos. El trabajo analiza dos aspectos concretos que deben considerarse en la prospección demográfica para la planificación urbanística. En primer lugar, la importancia que debe concederse a la proyección de los hogares. En segundo lugar, se considera como la propia urbanización, más concretamente del mercado de la vivienda, puede afectar la evolución demográfica.The demographic projection is a habitual tool in the urban planning. Frequently their results are handled as an independent variable with which new urban developments are justified. Actually, the relations between population and urban growth are much more complex, existing clear interconnections in both senses. This work analyzes two concrete aspects that must be considered in the demographic prospecting for the city planning. First, the importance that must be granted to the households projection. Second, it is considered how the own urbanization and more concretely the house market can affect the demographic evolution

Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?

Resumen de la comunicaciónMetabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as retinopathies, diabetes and cancer. Glycolysis, among other metabolic routes, has been found to be essential for triggering the angiogenic switch. Additionally, it has been seen that endothelial cells are able to take up lactate from the extracellular media, for example in the case of the tumor microenvironment, where cancer cells would have secreted high amounts of this metabolite. Endothelial cells would oxidize this lactate for obtaining energy, but lactate can also act as a signaling molecule for the angiogenic process. However, experiments to determine the molecular fate of lactate have been performed using only macrovascular endothelial cells. The aim of the present work is to prove whether microvascular endothelial cells are also able to take up and oxidize lactate. For this purpose, fluorimetry, isotopic labeling and Seahorse experiments were used to study the metabolism of a human microvascular endothelial cell line (HMEC). The expression levels of transcripts and proteins of different enzymes and transporters related to lactate metabolism were estimated by qPCR and Western blotting. The results obtained indicate that these cells rely on glycolysis for their metabolism, while the oxidation of glucose and glutamine seems to be considerably low. On the other hand, no lactate oxidation could be detected. We then checked the mRNA expression of the two isoenzymes of lactate dehydrogenase (LDH) and the two main lactate transporters, MCT1 and MCT4, and found that levels of LDH-B and MCT1 were undetectable. We failed to measure any MCT1 mRNA or protein expression either in normoxia or hypoxia. Hence, we can conclude that at least this microvascular endothelial cell line cannot use extracellular lactate as a metabolic fuel.Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). This communicaction has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"

Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention

The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the hallmarks of cancer. However, cancers grow in tight contact with non-tumoral accompanying cells and the surrounding extracellular matrix, as underlined by the concept of tumor microenvironment. Endothelial cells are key components of this tumor microenvironment, since they are requested for angiogenesis, another hallmark of cancer. In this complex system, rewiring of metabolism and signaling pathway in cancer, endothelial and other accompanying cell emerges as new potential targets for therapeutic intervention. In this communication, we will present the drug discovery and characterization approach of our group and our more recent results in this field, including new modeling with an evolutionary and ecological point of view.[Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER) and P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communication has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Los cultivos de los secano herbáceos andaluces

El presente trabajo se inscribe dentro de una invesigación más amplia enfocada al reconocimiento de áreas agrarias con relativa homogeneidad dentro del espacio andaluz. Presenta resultados concretos sobre la clasificación de los secanos herbáceos de los municipios andaluces, en atención a los cultivos a los que se dedican. Se toma como fuente los informes de los municipios la Ministerio de Agricultura, durante los años 1985-89, y se ha realizado un análisis de clusters como método de clasificación