35 research outputs found

    The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

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    Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

    Milan Obaidi's Quick Files

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    The Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity

    The psychology of terrorism revisited : an integrated model of radicalization and terrorism

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    Defence date: 23 March 2016Examining Board: Professor Olivier Roy, European University Institute/RSCAS) (Supervisor); Professor Donatella della Porta (formerly EUI/Scuola Normale Superiore, Firenze); Professor Max Taylor, University College London; Professor Farhad Khosrokhavar, (EHESS, Paris).In the media there are two common explanations for terrorist attacks: Those who commit these acts are either described as mentally ill or as religious fundamentalists. For example, when Anders Breivik killed 77 teenagers he was declared insane suffering from paranoid and schizophrenia, whereas the perpetrators of 9/11 attacks were described as religious zealots. Unfortunately, the scientific literature also simplifies radicalization and terrorism in a similar fashion; the field is divided between person and situation explanations of terrorism and radicalization. However, to understand terrorism and radicalization adequately the dichotomy of person-situation needs to be readdressed. This dissertation begins to explore the premises that the potential for participating in asymmetrical collective violence must be understood as interplay between intra-individual, social psychological and external/societal factors. Broadly speaking, this dissertation aims to answer the following question: What are the social and psychological factors and processes that contribute to the motivations behind the radicalization of first, second and third generation of Muslim Europeans? This dissertation first addressees the dichotomy of person and situation and proposes an integrated model of terrorism and radicalization. Second, integrating perspectives from various line of research I demonstrate how factors from the different domains of research relate, and more importantly, complement each other in shaping circumstances, which will make radicalization more or less likely to occur. Finally, I explore the influence of person factors such as personality traits. While previous research on extremism and violent has overlooked the potential role of non-pathological personality differences, it is proposed here that non-pathological personality characteristics would predict both violent and non-violent behavioral intentions and actual behavior among Muslims in defense of their group. Therefore, this work aims to extend knowledge on terrorism beyond existing literature, which tends to focus exclusively on either situational factors or psychopathology

    Cultural Threat Perceptions Predict Violent Extremism via Need for Cognitive Closure

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    Understanding the psychological processes that drive violent extremism is a pressing global issue. Across six studies, we demonstrate that perceived cultural threats lead to violent extremism because they increase people’s need for cognitive closure (NFC). In general population samples (from Denmark, Afghanistan, Pakistan, France, and an international sample) and a sample of former Mujahideen in Afghanistan, single-level and multi-level mediation analyses revealed that NFC mediated the association between perceived cultural threats and violent extremist outcomes. Further, in comparisons between the sample of former Afghan Mujahideen and the general population sample from Afghanistan following the known-group paradigm, the former Mujahideen scored significantly higher on cultural threat, NFC, and violent extremist outcomes. Moreover, the proposed model successfully differentiated former Afghan Mujahideen participants from the general Afghan participants. Next, two pre-registered experiments provided causal support for the model. Experimentally manipulating the predictor (cultural threat) in Pakistan led to higher scores on the mediator (NFC) and dependent variables (violent extremist outcomes). Finally, an experiment conducted in France demonstrated the causal effect of the mediator (NFC) on violent extremist outcomes. Two internal meta-analyses using state-of-the-art methods (i.e., meta-analytic structural equation modelling and pooled indirect effects analyses) further demonstrated the robustness of our results across the different extremist outcomes, designs, populations, and settings. Cultural threat perceptions seem to drive violent extremism by eliciting a need for cognitive closure

    Understanding violent extremism in the 21st century: The (re)emerging role of relative deprivation

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    Recently, the world has experienced a wave of violent protest, and in particular Islamist and right-wing extremism have become increasing challenges for many societies. We argue that especially the experience of relative deprivation, that is the perception that oneself or one’s group is undeservingly worse off than others, can explain various, contemporary forms of violent extremism, including (a) low-power groups’ violent attempts to challenge the unequal status quo, (b) high-power groups’ violent defense of their privileged position, and sometimes even (c) people’s violent attempt to help out-groups in need. In light of recent research and growing social inequalities, we expect relative deprivation to be a key factor driving violent extremism across cultures and contexts in the 21st century
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