668 research outputs found
HeSSOP Health and Social Services for Older People Summary
The views of older people living in the community on the health and social services available to them had not previously been assessed on a large scale in Ireland. The National Council on Ageing and Older People, in partnership with the Western Health Board (WHB) and the Eastern Regional Health Authority (ERHA) which was formerly the Eastern Health Board, has now carried out such an assessment. It is anticipated that this will assist in planning for services for older people. A survey instrument was developed based on both literature review and focus group work. Groups of older people and key health and social service professionals in the two board areas were consulted to identify the most important concerns to be addressed in the study
HeSSOP Health and Social Services for Older People : Survey of service use, evaluation and preceived need by older people in two health board areas. INTERM REPORT II
HeSSOP is a collaboration across the National Council on Ageing and Older People and two health boards: the Eastern Regional Health Authority and the Western Health Board. Information on service use, service evaluation and perceptions of service need of a large community-dwelling group will be reported separately for each board in the first instance; this is to assist service planning for 2000. A combined report will allow further analysis of patterns of use etc., including comparisons across boards to identify common and locationspecific challenges to service delivery. While the project will cover only two of the country’s health boards as constituted at the time of the work, the particular boards involved represent the most urban and one of the most rural of the boards. Thus findings are expected to have value for other health boards. The wider issue of consultation strategies to involve older people will be addressed and will be included in the combined survey report
Nearly optimal solutions for the Chow Parameters Problem and low-weight approximation of halfspaces
The \emph{Chow parameters} of a Boolean function
are its degree-0 and degree-1 Fourier coefficients. It has been known
since 1961 (Chow, Tannenbaum) that the (exact values of the) Chow parameters of
any linear threshold function uniquely specify within the space of all
Boolean functions, but until recently (O'Donnell and Servedio) nothing was
known about efficient algorithms for \emph{reconstructing} (exactly or
approximately) from exact or approximate values of its Chow parameters. We
refer to this reconstruction problem as the \emph{Chow Parameters Problem.}
Our main result is a new algorithm for the Chow Parameters Problem which,
given (sufficiently accurate approximations to) the Chow parameters of any
linear threshold function , runs in time \tilde{O}(n^2)\cdot
(1/\eps)^{O(\log^2(1/\eps))} and with high probability outputs a
representation of an LTF that is \eps-close to . The only previous
algorithm (O'Donnell and Servedio) had running time \poly(n) \cdot
2^{2^{\tilde{O}(1/\eps^2)}}.
As a byproduct of our approach, we show that for any linear threshold
function over , there is a linear threshold function which
is \eps-close to and has all weights that are integers at most \sqrt{n}
\cdot (1/\eps)^{O(\log^2(1/\eps))}. This significantly improves the best
previous result of Diakonikolas and Servedio which gave a \poly(n) \cdot
2^{\tilde{O}(1/\eps^{2/3})} weight bound, and is close to the known lower
bound of (1/\eps)^{\Omega(\log \log (1/\eps))}\} (Goldberg,
Servedio). Our techniques also yield improved algorithms for related problems
in learning theory
Hometronics – accessible production of graphene suspensions for health sensing applications using only household items
Nanoscience at times can seem out of reach to the developing world and the general public, with much of the equipment expensive and knowledge seemingly esoteric to nonexperts. Using only cheap, everyday household items, accessible research with real applications can be shown. Here, graphene suspensions were produced using pencil lead, tap water, kitchen appliances, soaps and coffee filters, with a children’s glue-based graphene nanocomposite for highly sensitive pulse measurements demonstrated
Quantum Dynamics of the Slow Rollover Transition in the Linear Delta Expansion
We apply the linear delta expansion to the quantum mechanical version of the
slow rollover transition which is an important feature of inflationary models
of the early universe. The method, which goes beyond the Gaussian
approximation, gives results which stay close to the exact solution for longer
than previous methods. It provides a promising basis for extension to a full
field theoretic treatment.Comment: 12 pages, including 4 figure
A sparing effect of increased plasma fatty acids on muscle and liver glycogen content in the exercising rat
Aspects of Magnetic Field Configurations in Planar Nonlinear Electrodynamics
In the framework of three-dimensional Born-Infeld Electrodynamics, we pursue
an investigation of the consequences of the space-time dimensionality on the
existence of magnetostatic fields generated by electric charges at rest in an
inertial frame, which are present in its four-dimensional version. Our analysis
reveals interesting features of the model. In fact, a magnetostatic field
associated with an electric charge at rest does not appear in this case.
Interestingly, the addition of the topological term (Chern-Simons) to
Born-Infeld Electrodynamics yields the appearance of the magnetostatic field.
We also contemplate the fields associated to the would-be-magnetic monopole in
three dimensions.Comment: 8 page
Optimizing training adaptations by manipulating glycogen
For decades, glycogen has been recognized as a storage form of glucose within the liver and muscles. Only recently has a greater role for glycogen as a regulator of metabolic signalling been suggested. Glycogen either directly or indirectly regulates a number of signalling proteins, including the adenosine-5\u27-phosphate- (AMP-) activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (MAPK). AMPK and p38 MAPK play a significant role in controlling the expression and activity of the peroxisome proliferator activated receptor γ coactivators (PGCs), respectively. The PGCs can directly increase muscle mitochondrial mass and endurance exercise performance. As low muscle glycogen is generally associated with greater activation of these pathways, the concept of training with low glycogen to maximize the physiological adaptations to endurance exercise is gaining acceptance in the scientific community. In this review, we evaluate the scientific basis for this philosophy and propose some practical applications of this philosophy for the general population as well as elite endurance athletes.<br /
Mercury in Nelson's Sparrow Subspecies at Breeding Sites
Background: Mercury is a persistent, biomagnifying contaminant that can cause negative effects on ecosystems. Marshes are often areas of relatively high mercury methylation and bioaccumulation. Nelson’s Sparrows (Ammodramus nelsoni) use marsh habitats year-round and have been documented to exhibit tissue mercury concentrations that exceed negative effects thresholds. We sought to further characterize the potential risk of Nelson’s Sparrows to mercury exposure by sampling individuals from sites within the range of each of its subspecies
How the central domain of dystrophin acts to bridge F-actin to sarcolemmal lipids
Dystrophin is a large intracellular protein that prevents sarcolemmal ruptures by providing a mechanical link between the intracellular actin cytoskeleton and the transmembrane dystroglycan complex. Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder allelic variant, Becker Muscular Dystrophy (DMD and BMD). Previous work has shown that concomitant interaction of the actin binding domain 2 (ABD2) comprising spectrin like repeats 11 to 15 (R11-15) of the central domain of dystrophin, with both actin and membrane lipids, can greatly increase membrane stiffness. Based on a combination of SAXS and SANS measurements, mass spectrometry analysis of cross-linked complexes and interactive low-resolution simulations, we explored in vitro the molecular properties of dystrophin that allow the formation of ABD2-F-actin and ABD2-membrane model complexes. In dystrophin we identified two subdomains interacting with F-actin, one located in R11 and a neighbouring region in R12 and another one in R15, while a single lipid binding domain was identified at the C-terminal end of R12. Relative orientations of the dystrophin central domain with F-actin and a membrane model were obtained from docking simulation under experimental constraints. SAXS-based models were then built for an extended central subdomain from R4 to R19, including ABD2. Overall results are compatible with a potential F-actin/dystrophin/membrane lipids ternary complex. Our description of this selected part of the dystrophin associated complex bridging muscle cell membrane and cytoskeleton opens the way to a better understanding of how cell muscle scaffolding is maintained through this essential protein
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