Framing the Israeli-Palestinian conflict : a case-study analysis of the Irish national 'opinion leader' press - July 2000 to July 2004

This case study analyses how four Irish "opinion leader" newspapers - The Irish Times, the Irish Independent, the Sunday Independent and the Sunday Tribune - constructed the issue of the Israeli-Palestinian conflict during the four-year period from July 2000 to July 2004. A primary objective of this case study is to overcome some of the more prominent theoretical inadequacies that have characterised existing research in this area to date. Principally, because existing research has been mostly limited to analysing the American media context and to a lesser extent, the British and other core European contexts, very few analyses have been undertaken on the framing of foreign conflicts by media outlets that operate within entirely different national environments, such as the Irish media environment. Chapter I argues that already existing research has mostly been confined to "testing" propaganda, indexing, hegemonic and political control hypotheses regarding media roles in covering foreign conflicts. These hypotheses are based on assumptions that foreign conflict coverage is mostly influenced by extrinsic structural factors and that, therefore, the media's role is largely restricted to that of acting as conduits for government propaganda and elite perspectives. Consequently, research guided by these hypotheses neglects to investigate fully the influences exerted by the surrounding politico-cultural and media contexts on the various roles adopted by the media when reporting on different types of foreign conflicts. William A. Gamson and his colleagues' model of social constructivist media analysis was chosen as the most appropriate model for fulfilling the objectives of this research. This model analyses media coverage trends as outcomes of contested news construction processes that are potentially influenced by a range of different extrinsic environmental factors and intrinsic media, or news factors. This case study consisted of four different, yet interrelated, stages of research. The first stage consisted of a literature-based contextual analysis of the historical and political environments characterising the arena of the Israeli- Palestinian conflict, as well as the arenas of Irish-Israeli and Irish-Palestinian relations. The second research stage involved a longitudinal and descriptive analysis of a representative sampling of coverage of the Israeli-Palestinian conflict by The Irish Times, the Irish Independent, the Sunday Independent and the Sunday Tribune during the period from July 2000 to July 2004. The third stage consisted of qualitative frame analysis of news discourses. The fourth and final stage of research involved the undertaking of a series of exploratory, qualitative interviews with key media, political/diplomatic and NGO actors. Chapter 3 briefly outlines how the Israeli-Palestinian conflict has been historically manifested as a highly unequal, contested and multi-dimensional conflict. Chapter 4 analyses the potential contextual influences exerted by Irish political culture and foreign policy-makin(I-1t1ra ditions on the roles adopted by Irish media. It concludes that Ireland's "small state" and post-colonial status, its consequent lack of "hard power", or "vital" foreign policy interests in the Middle East, as well as its official dependency on UN and EU foreign policy perspectives, are likely to have exerted significant contextual influences on the ways in which the sampled newspapers covered the Israeli-Palestinian conflict. Chapter 5 explores the ways in which the changed political environment surrounding Israeli-Palestinian relations during the period of July 2000 to July 2004 had significant constructivist implications for how international media, including the Irish media, covered the Israeli-Palestinian conflict. This case study's descriptive analysis of randomly sampled coverage by The Irish Times, the Irish Independent, the Sunday Independent and the Sunday Tribune during the period of July 2000 to July 2004 generated a number of significant findings. Firstly, it was concluded that the regular patterns of attention that the sampled newspapers devoted to the Israeli-Palestinian conflict were reflective of the dynamics and politics of that conflict itself, as well as its ongoing international resonance. However, this coverage was frequently of a semi- or non-prominent nature, while the sampled newspapers accorded only miniscule amounts of frontpage, analytical and editorial attention to the Israeli-Palestinian conflict. It was concluded that Ireland's "small state" status and its lack of appreciable national or foreign policy interests in Israel and the Palestinian territories influenced these latter trends. However, in addition to the formative influences exerted by the national politico-cultural context, media contextual factors and intrinsic news factors also had discernible constructivist implications for news outcomes. For instance, the finding that the majority of news items were sourced from foreign-based jourrialists and news agencies was related to the operation of news factors, such as editorial judgements and criteria, as well as reporting norms and values. Most significantly, the intense competition characterising the Irish media market overall, as well as the lack of historical grounding of Irish media within a "tradition" of foreign news analysis, exerted substantial influence on these news-sourcing patterns by constraining the sampled newspapers' commitment to foreign news coverage. In relation to the findings generated by this case study's topical analysis, it was also concluded that the operation of news factors, in relation to the wider politico-cultural context, influenced the ways in which the sampled newspapers topicalised the Israeli-Palestinian conflict. Thus, while news values tilted editorial decisions towards covering "conflict"/"political violence" topics, these values also served to reduce newspaper coverage of "peace" and other topics. Additionally, politico-cultural factors, such as the relative isolationist and dependent nature of Irish foreign policy worldviews, supplied an important context within which the sampled newspapers neglected to appreciably cover the international diplomaticsecurity context surrounding the Israeli-Palestinian conflict. Moreover, the low levels of coverage devoted to domestic Israeli and Palestinian topics reflected Ireland's lack of any "vital" interests in the Israeli-Palestinian conflict and its relatively weak politico-cultural and personal ties with Israel and the Palestinians. Finally, in relation to source access and representation trends, it was found that the sampled newspapers tended to be more or less contested sites (albeit unequal sites). variously featuring the assertions of competing Israeli and Palestinian politicaU"official" sources, rather than exclusively transmitting so-called consensual, hegemonic and elitist constructions of the Israeli-Palestinian conflict. This emerged as a key finding of this research, as it challenges one of the primary theoretical assumptions of the propaganda, indexing, hegemonic and political control hypotheses - namely, that politically-powerful and economically resourceful conflict protagonists consistently have greater levels of media access than politically weaker protagonists, simply by virtue of the power disparities that pertain between them. Instead, this thesis argues that, within highly contested foreign conflict arenas, the protagonist sources' degree of access to international media attention is best viewed as a constructed and achieved outcome, which changes in line with developments in the wider political and media environments and changes in the operation of news factors. Thus, this case-study's descriptive content analysis concluded that, overall, the sampled newspapers' sourcing trends, as well as their patterns of issue-attention and issue-topicalisation, are best analysed not as the pre-determined outcomes of structural power relations and resources, but as the socially constructed outcomes of interactions between relevant politico-cultural contexts, the wider media environment and a range of news factors (such as journalistic conventions, values and norms). This case study's qualitative frame analysis of newspaper discourses also adopted this social constructivist focus. The key finding of this analysis was that divergent rates of access and representation were achieved by partisan Israeli law and order/terrorism frames and partisan Palestinian injustice/defiance frames across the sampled newspapers. Jewish injustice/national homeland frames were virtually excluded from the sampled newspapers. The Irish Times and the Sunday Independent tended to be more favourable towards including law and order/terrorism frames, while the Sunday Tribune and the Irish Independent featured Palestinian injustice/defiance frames more frequently than law and order/terrorism frames. In contrast, Palestinian injustice/defiance frames were entirely absent from the Sunday Independent sample. Another significant trend that emerged from this frame analysis was that non-partisan frames; namely, reconciliation/dual rights frames, nihilistic violence/warring tribes frames and regional stability/international security frames - were relatively under-represented within each sampled newspaper. Taken together, therefore, these frame analytic findings confirm this thesis' theoretical critique of propaganda, indexing, hegemonic and political control perspectives. These latter perspectives hypothesise that external political and structural factors, such as state propaganda, elite hegemony and/or political information controls, determine foreign news coverage in ways that reduce the media's role to that of monolithically framing foreign coverage within the confines of hegemonic and elitist ideologies. In contrast, this case study's primary theoretical argument is that a social constructivist and multi-variable perspective is inherently more appropriate for undertaking analyses of media foreign coverage roles. Principally, rather than assuming, a priori, that extrinsic factors wholly determine news, this perspective enables the researcher to explore the varying media influences exerted over time by different contexts and intrinsic news factors

Progressive intellectual impairment in children with encephalopathy related to status epilepticus during slow sleep

We investigated whether Encephalopathy related to Status Epilepticus during slow Sleep (ESES) in childhood was associated with progressive intellectual decline. Participants were identified from the caseload of a single paediatric neurosciences centre and EEG department. A retrospective review of overnight sleep EEG reports (n=2200) over a five-year period identified twenty-two children as having the neurophysiological characteristics of ESES. All had repeat neuropsychological assessment using the WISC-III (UK) and/or WPPSI-R (UK). There was a statistically significant reduction in Full-Scale IQ and Performance IQ across a mean and median time interval of two years. Around a third of the participants showed a clinically significant regression in intellectual functioning evidenced by =>12-point reduction in IQ. These patients were not distinguishable from the rest of the cohort in terms of clinical history, imaging or duration of ESES. The reduction in IQ reflected reduced processing speed, working memory and overall cognitive efficiency. Children with a history of ESES require close monitoring in order to support educational planning and provide families with accurate information about prognosis

Glucocerebrosidase Mutations in Parkinson Disease.

Following the discovery of a higher than expected incidence of Parkinson Disease (PD) in Gaucher disease, a lysosomal storage disorder, mutations in the glucocerebrocidase (GBA) gene, which encodes a lysosomal enzyme involved in sphingolipid degradation were explored in the context of idiopathic PD. GBA mutations are now known to be the single largest risk factor for development of idiopathic PD. Clinically, on imaging and pharmacologically, GBA PD is almost identical to idiopathic PD, other than certain features that can be identified in the specialist research setting but not in routine clinical practice. In patients with a known GBA mutation, it is possible to monitor for prodromal signs of PD. The clinical similarity with idiopathic PD and the chance to identify PD at a pre-clinical stage provides a unique opportunity to research therapeutic options for early PD, before major irreversible neurodegeneration occurs. However, to date, the molecular mechanisms which lead to this increased PD risk in GBA mutation carriers are not fully elucidated. Experimental models to define the molecular mechanisms and test therapeutic options include cell culture, transgenic mice and other in vivo models amenable to genetic manipulation, such as drosophilia. Some key pathological pathways of interest in the context of GBA mutations include alpha synuclein aggregation, lysosomal-autophagy axis changes and endoplasmic reticulum stress. Therapeutic agents that exploit these pathways are being developed and include the small molecule chaperone Ambroxol. This review aims to summarise the main features of GBA-PD and provide insights into the pathological relevance of GBA mutations on molecular pathways and the therapeutic implications for PD resulting from investigation of the role of GBA in PD

The pesticide adjuvant, Toximul™, alters hepatic metabolism through effects on downstream targets of PPARα

AbstractPrevious studies demonstrated that chronic dermal exposure to the pesticide adjuvant (surfactant), Toximul™ (Tox), has significant detrimental effects on hepatic lipid metabolism. This study demonstrated that young mice dermally exposed to Tox for 12 days have significant increases in expression of peroxisomal acyl-CoA oxidase (mRNA and protein), bifunctional enzyme (mRNA) and thiolase (mRNA), as well as the P450 oxidizing enzymes Cyp4A10 and Cyp4A14 (mRNA and protein). Tox produced a similar pattern of increases in wild type adult female mice but did not induce these responses in PPARα-null mice. These data support the hypothesis that Tox, a heterogeneous blend of nonionic and anionic surfactants, modulates hepatic metabolism at least in part through activation of PPARα. Notably, all three groups of Tox-treated mice had increased relative liver weights due to significant accumulation of lipid. This could be endogenous in nature and/or a component(s) of Tox or a metabolite thereof. The ability of Tox and other hydrocarbon pollutants to induce fatty liver despite being PPARα agonists indicates a novel consequence of exposure to this class of chemicals, and may provide a new understanding of fatty liver in populations with industrial exposure

Group problem-solving skills training for self-harm: randomised controlled trial

Background: Rates of self-harm are high and have recently increased. This trend and the repetitive nature of self-harm pose a significant challenge to mental health services. Aims: To determine the efficacy of a structured group problem-solving skills training (PST) programme as an intervention approach for self-harm in addition to treatment as usual (TAU) as offered by mental health services. Method: A total of 433 participants (aged 18-64 years) were randomly assigned to TAU plus PST or TAU alone. Assessments were carried out at baseline and at 6-week and 6-month follow-up and repeated hospital-treated self-harm was ascertained at 12-month follow-up. Results: The treatment groups did not differ in rates of repeated self-harm at 6-week, 6-month and 12-month follow-up. Both treatment groups showed significant improvements in psychological and social functioning at follow-up. Only one measure (needing and receiving practical help from those closest to them) showed a positive treatment effect at 6-week (P = 0.004) and 6-month (P = 0.01) follow-up. Repetition was not associated with waiting time in the PST group. Conclusions: This brief intervention for self-harm is no more effective than treatment as usual. Further work is required to establish whether a modified, more intensive programme delivered sooner after the index episode would be effective

De novo point mutations in patients diagnosed with ataxic cerebral palsy

Cerebral palsy is commonly attributed to perinatal asphyxia. However, Schnekenberg et al. describe here four individuals with ataxic cerebral palsy likely due to de novo dominant mutations associated with increased paternal age. Therefore, patients with cerebral palsy should be investigated for genetic causes before the disorder is ascribed to asphyxi

Early childhood epilepsies:epidemiology, classification, aetiology, and socio-economic determinants

Epilepsies of early childhood are frequently resistant to therapy and often associated with cognitive and behavioural comorbidity. Aetiology focused precision medicine, notably gene-based therapies, may prevent seizures and comorbidities. Epidemiological data utilizing modern diagnostic techniques including whole genome sequencing and neuroimaging can inform diagnostic strategies and therapeutic trials. We present a 3-year, multicentre prospective cohort study, involving all children under 3 years of age in Scotland presenting with epilepsies. We used two independent sources for case identification: clinical reporting and EEG record review. Capture-recapture methodology was then used to improve the accuracy of incidence estimates. Socio-demographic and clinical details were obtained at presentation, and 24 months later. Children were extensively investigated for aetiology. Whole genome sequencing was offered for all patients with drug-resistant epilepsy for whom no aetiology could yet be identified. Multivariate logistic regression modelling was used to determine associations between clinical features, aetiology, and outcome. Three hundred and ninety children were recruited over 3 years. The adjusted incidence of epilepsies presenting in the first 3 years of life was 239 per 100 000 live births [95% confidence interval (CI) 216–263]. There was a socio-economic gradient to incidence, with a significantly higher incidence in the most deprived quintile (301 per 100 000 live births, 95% CI 251–357) compared with the least deprived quintile (182 per 100 000 live births, 95% CI 139–233), χ2 odds ratio = 1.7 (95% CI 1.3–2.2). The relationship between deprivation and incidence was only observed in the group without identified aetiology, suggesting that populations living in higher deprivation areas have greater multifactorial risk for epilepsy. Aetiology was determined in 54% of children, and epilepsy syndrome was classified in 54%. Thirty-one per cent had an identified genetic cause for their epilepsy. We present novel data on the aetiological spectrum of the most commonly presenting epilepsies of early childhood. Twenty-four months after presentation, 36% of children had drug-resistant epilepsy (DRE), and 49% had global developmental delay (GDD). Identification of an aetiology was the strongest determinant of both DRE and GDD. Aetiology was determined in 82% of those with DRE, and 75% of those with GDD. In young children with epilepsy, genetic testing should be prioritized as it has the highest yield of any investigation and is most likely to inform precision therapy and prognosis. Epilepsies in early childhood are 30% more common than previously reported. Epilepsies of undetermined aetiology present more frequently in deprived communities. This likely reflects increased multifactorial risk within these populations

Information on preparing for birth & parenthood

A handbook for parents-to-be attending the Preparation for Birth and Parenthood Education programme at Cork University Maternity Hospital

De novo point mutations in patients diagnosed with ataxic cerebral palsy

Cerebral palsy is a sporadic disorder with multiple likely aetiologies, but frequently considered to be caused by birth asphyxia. Genetic investigations are rarely performed in patients with cerebral palsy and there is little proven evidence of genetic causes. As part of a large project investigating children with ataxia, we identified four patients in our cohort with a diagnosis of ataxic cerebral palsy. They were investigated using either targeted next generation sequencing or trio-based exome sequencing and were found to have mutations in three different genes, KCNC3, ITPR1 and SPTBN2. All the mutations were de novo and associated with increased paternal age. The mutations were shown to be pathogenic using a combination of bioinformatics analysis and in vitro model systems. This work is the first to report that the ataxic subtype of cerebral palsy can be caused by de novo dominant point mutations, which explains the sporadic nature of these cases. We conclude that at least some subtypes of cerebral palsy may be caused by de novo genetic mutations and patients with a clinical diagnosis of cerebral palsy should be genetically investigated before causation is ascribed to perinatal asphyxia or other aetiologies.peer-reviewe

Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families.

Discovery of most autosomal recessive disease-associated genes has involved analysis of large, often consanguineous multiplex families or small cohorts of unrelated individuals with a well-defined clinical condition. Discovery of new dominant causes of rare, genetically heterogeneous developmental disorders has been revolutionized by exome analysis of large cohorts of phenotypically diverse parent-offspring trios. Here we analyzed 4,125 families with diverse, rare and genetically heterogeneous developmental disorders and identified four new autosomal recessive disorders. These four disorders were identified by integrating Mendelian filtering (selecting probands with rare, biallelic and putatively damaging variants in the same gene) with statistical assessments of (i) the likelihood of sampling the observed genotypes from the general population and (ii) the phenotypic similarity of patients with recessive variants in the same candidate gene. This new paradigm promises to catalyze the discovery of novel recessive disorders, especially those with less consistent or nonspecific clinical presentations and those caused predominantly by compound heterozygous genotypes