The Uniqueness Theorem for Entanglement Measures

We explore and develop the mathematics of the theory of entanglement measures. After a careful review and analysis of definitions, of preliminary results, and of connections between conditions on entanglement measures, we prove a sharpened version of a uniqueness theorem which gives necessary and sufficient conditions for an entanglement measure to coincide with the reduced von Neumann entropy on pure states. We also prove several versions of a theorem on extreme entanglement measures in the case of mixed states. We analyse properties of the asymptotic regularization of entanglement measures proving, for example, convexity for the entanglement cost and for the regularized relative entropy of entanglement.Comment: 22 pages, LaTeX, version accepted by J. Math. Phy

Activating NPPT distillation with an infinitesimal amount of bound entanglement

We show that bipartite quantum states of any dimension, which do not have a positive partial transpose, become 1-distillable when one adds an infinitesimal amount of bound entanglement. To this end we investigate the activation properties of a new class of symmetric bound entangled states of full rank. It is shown that in this set there exist universal activator states capable of activating the distillation of any NPPT state.Comment: 4 pages, revtex4, 1 figure, references correcte

Further results on the cross norm criterion for separability

In the present paper the cross norm criterion for separability of density matrices is studied. In the first part of the paper we determine the value of the greatest cross norm for Werner states, for isotropic states and for Bell diagonal states. In the second part we show that the greatest cross norm criterion induces a novel computable separability criterion for bipartite systems. This new criterion is a necessary but in general not a sufficient criterion for separability. It is shown, however, that for all pure states, for Bell diagonal states, for Werner states in dimension d=2 and for isotropic states in arbitrary dimensions the new criterion is necessary and sufficient. Moreover, it is shown that for Werner states in higher dimensions (d greater than 2), the new criterion is only necessary.Comment: REVTeX, 19 page

The Sirius Passet Lagerstätte of North Greenland—A geochemical window on early Cambrian low‐oxygen environments and ecosystems

The early Cambrian Sirius Passet fauna of northernmost Greenland (Cambrian Series 2, Stage 3) contains exceptionally preserved soft tissues that provide an important window to early animal evolution, while the surrounding sediment holds critical data on the palaeodepositional water‐column chemistry. The present study combines palaeontological data with a multiproxy geochemical approach based on samples collected in situ at high stratigraphic resolution from Sirius Passet. After careful consideration of chemical alterations during burial, our results demonstrate that fossil preservation and biodiversity show significant correlation with iron enrichments (FeHR/FeT), trace metal behaviour (V/Al), and changes in nitrogen cycling (δ15N). These data, together with Mo/Al and the preservation of organic carbon (TOC), are consistent with a water column that was transiently low in oxygen concentration, or even intermittently anoxic. When compared with the biogeochemical characteristics of modern oxygen minimum zones (OMZs), geochemical and palaeontological data collectively suggest that oxygen concentrations as low as 0.2–0.4 ml/L restricted bioturbation but not the development of a largely nektobenthic community of predators and scavengers. We envisage for the Sirius Passet biota a depositional setting where anoxic water column conditions developed and passed over the depositional site, possibly in association with sea‐level change, and where this early Cambrian biota was established in conditions with very low oxygen

Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer

<b>Background</b>: A pronounced tumour inflammatory infiltrate is known to confer a good outcome in colorectal cancer. Klintrup and colleagues reported a structured assessment of the inflammatory reaction at the invasive margin scoring low grade or high grade. The aim of the present study was to examine the prognostic value of tumour inflammatory infiltrate in node-negative colorectal cancer. <b>Methods</b>: Two hundred patients had undergone surgery for node-negative colorectal cancer between 1997 and 2004. Specimens were scored with Jass’ and Klintrup’s criteria for peritumoural infiltrate. Pathological data were taken from the reports at that time. <b>Results</b>: Low-grade inflammatory infiltrate assessed using Klintrup’s criteria was an independent prognostic factor in node-negative disease. In patients with a low-risk Petersen Index (n = 179), low-grade infiltrate carried a threefold increased risk of cancer death. Low-grade infiltrate was related to increasing T stage and an infiltrating margin. <b>Conclusion</b>: Assessment of inflammatory infiltrate using Klintrup’s criteria provides independent prognostic information on node-negative colorectal cancer. A high-grade local inflammatory response may represent effective host immune responses impeding tumour growth

Suppressing Speckle Noise for Simultaneous Differential Extrasolar Planet Imaging (SDI) at the VLT and MMT

We discuss the instrumental and data reduction techniques used to suppress speckle noise with the Simultaneous Differential Imager (SDI) implemented at the VLT and the MMT. SDI uses a double Wollaston prism and a quad filter to take 4 identical images simultaneously at 3 wavelengths surrounding the 1.62 um methane bandhead found in the spectrum of cool brown dwarfs and gas giants. By performing a difference of images in these filters, speckle noise from the primary can be significantly attenuated, resulting in photon noise limited data past 0.5''. Non-trivial data reduction tools are necessary to pipeline the simultaneous differential imaging. Here we discuss a custom algorithm implemented in IDL to perform this reduction. The script performs basic data reduction tasks but also precisely aligns images taken in each of the filters using a custom shift and subtract routine. In our survey of nearby young stars at the VLT and MMT (see Biller et al., this conference), we achieved H band contrasts >25000 (5 sigma Delta F1(1.575 um) > 10.0 mag, Delta H > 11.5 mag for a T6 spectral type object) at a separation of 0.5" from the primary star. We believe that our SDI images are among the highest contrast astronomical images ever made from ground or space for methane rich companions.Comment: 5 pages, 3 figures, 1 table. Presented at IAU Colloquium 200, Direct Imaging of Exoplanets: Science and Technique

Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation, but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in vivo. Genome-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell types. Here, we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion model. In addition, we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human cells. The combined modeling reproduced severe hypoxic conditions and the Warburg effect, and we found that limitations in enzymatic capacity contribute to cancer cells’ preferential use of glutamine as a substrate to the citric acid cycle. Furthermore, we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer cells. We identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts, but when limiting to metabolites previously identified to participate in such collaboration, no growth advantage was observed. Our work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments

Quantum dynamics as a physical resource

How useful is a quantum dynamical operation for quantum information processing? Motivated by this question we investigate several strength measures quantifying the resources intrinsic to a quantum operation. We develop a general theory of such strength measures, based on axiomatic considerations independent of state-based resources. The power of this theory is demonstrated with applications to quantum communication complexity, quantum computational complexity, and entanglement generation by unitary operations.Comment: 19 pages, shortened by 3 pages, mainly cosmetic change