Practical Computing with Pattern Structures in FCART Environment

International audienceA new general and efficient architecture for working with pattern structures, an extension of FCA for dealing with "complex" descriptions, is introduced and implemented in a subsystem of Formal Concept Analysis Research Toolbox (FCART). The architecture is universal in terms of possible dataset structures and formats, techniques of pattern structure manipulation

Concept Relation Discovery and Innovation Enabling Technology (CORDIET)

Concept Relation Discovery and Innovation Enabling Technology (CORDIET), is a toolbox for gaining new knowledge from unstructured text data. At the core of CORDIET is the C-K theory which captures the essential elements of innovation. The tool uses Formal Concept Analysis (FCA), Emergent Self Organizing Maps (ESOM) and Hidden Markov Models (HMM) as main artifacts in the analysis process. The user can define temporal, text mining and compound attributes. The text mining attributes are used to analyze the unstructured text in documents, the temporal attributes use these document's timestamps for analysis. The compound attributes are XML rules based on text mining and temporal attributes. The user can cluster objects with object-cluster rules and can chop the data in pieces with segmentation rules. The artifacts are optimized for efficient data analysis; object labels in the FCA lattice and ESOM map contain an URL on which the user can click to open the selected document

Collaborative Technologies in Education: How to Build an Effective System for Blended Learning?

Современное образование существенно изменилось под влиянием повсеместно проникающих в него цифровых решений, становятся популярными ранее невозможные формы организации учебного процесса. Одной из таких форм является гибридное обучение, поддержка которого стала возможной повсеместно благодаря глобальному распространению и конвергенции телекоммуникационных технологий, а также созданию облачных информационных систем учебного назначения. Цифровые технологии приносят не только видимые прелести автоматизации рутинных операций, но и становятся причиной переосмысления и трансформации ставших привычными процессов не только в преподавании, но и в управлении современным образованием. Данная работа сфокусирована на возможностях, предоставляемых коллаборативными информационными технологиями поддержки учебного процесса, и отвечает на некоторые важные вопросы, связанные с организацией эффективной поддержки гибридного обучения, в том числе на уровне управления.Nowadays education has been significantly transformed by the widespread use of digital solutions. This has made it popular to carry out the new approaches to educational processes, which cannot be easily implemented before. Оne of such forms is blended learning, and it becomes possible everywhere thanks to the global distribution and convergence of telecommunication technologies and to the appearance of cloud-based educational software. At the same time digital technologies have brought the apparent profit for the routines automatization and have become the reason of rethinking as in casual teaching and learning processes as in the modern educational management. This paper focuses on how to support educational processes with technologies. It is also answers several significant questions about effective blended learning support, especially at the administration level.Статья подготовлена в ходе работ в рамках Программы фундаментальных исследований Национального исследовательского университета «Высшая школа экономики» (НИУ ВШЭ) и с использованием средств субсидии в рамках государственной поддержки ведущих университетов Российской Федерации 5–100

Analysis of User Activity in Wireless Local Area Network of Petrozavodsk State University

Wireless networks are widely used for Internet access in public places, trading centers and educational institutions. The study of users' activity in these places can help solve problems of marketing, security, location, and monitoring of public transport. The article describes an experiment to measure the activity of users in wireless networks of Petrozavodsk State University because some educational and administrative processes are slowed because of a strict speed limit for all users. The authors developed a method to determine users' activity without the access to the service equipment and personal data, as well as a software complex to implement this method. Then they collected and analyzed data on the hours of the highest and lowliest activity, class schedule effect, and the dynamics of users' returns to the network. The information obtained was used to determine the allowed constraints of the Internet access speed for network users. A number of equations take into account the typical behavior of wireless network users, their activity and the capacity of external network channels. Computed rates for speed limits significantly exceed the established indicators in the network of Petrozavodsk University during hours of average and minimum network load. The results obtained can be used in corporate networks to dynamically calculate the permissible speed limit and to improve the quality of user service

Exonic enhancers: proceed with caution in exome and genome sequencing studies

Exonic enhancers (eExons) are coding exons that also function as enhancers of the gene in which they reside or (a) nearby gene(s). Mutations that affect the enhancer activity of these eExons have been associated with human disease. Therefore, eExon mutations should be taken into account in exome and genome sequencing projects, not only because of the ability of these mutations to modify the encoded proteins but also because of their effects on enhancer activity

Different Effect of Proteasome Inhibition on Vesicular Stomatitis Virus and Poliovirus Replication

Proteasome activity is an important part of viral replication. In this study, we examined the effect of proteasome inhibitors on the replication of vesicular stomatitis virus (VSV) and poliovirus. We found that the proteasome inhibitors significantly suppressed VSV protein synthesis, virus accumulation, and protected infected cells from toxic effect of VSV replication. In contrast, poliovirus replication was delayed, but not diminished in the presence of the proteasome inhibitors MG132 and Bortezomib. We also found that inhibition of proteasomes stimulated stress-related processes, such as accumulation of chaperone hsp70, phosphorylation of eIF2α, and overall inhibition of translation. VSV replication was sensitive to this stress with significant decline in replication process. Poliovirus growth was less sensitive with only delay in replication. Inhibition of proteasome activity suppressed cellular and VSV protein synthesis, but did not reduce poliovirus protein synthesis. Protein kinase GCN2 supported the ability of proteasome inhibitors to attenuate general translation and to suppress VSV replication. We propose that different mechanisms of translational initiation by VSV and poliovirus determine their sensitivity to stress induced by the inhibition of proteasomes. To our knowledge, this is the first study that connects the effect of stress induced by proteasome inhibition with the efficiency of viral infection

A Transcriptional Enhancer from the Coding Region of ADAMTS5

The revelation that the human genome encodes only approximately 25,000 genes and thus cannot account for phenotypic complexity has been one of the biggest surprises in the post-genomic era. However, accumulating evidence suggests that transcriptional regulation may be in large part responsible for this observed mammalian complexity. Consequently, there has been a strong drive to locate cis-regulatory regions in mammalian genomes in order to understand the unifying principles governing these regions, including their genomic distribution. Although a number of systematic approaches have been developed, these all discount coding sequence.Using the computational tool PRI (Pattern-defined Regulatory Islands), which does not mask coding sequence, we identified a regulatory region associated with the gene ADAMTS5 that encompasses the entirety of the essential coding exon 2. We demonstrate through a combination of chromatin immunoprecipitation and reporter gene studies that this region can not only bind the myogenic transcription factors MYOD and myogenin and the E-protein HEB but can also function as a very strong myogenic transcriptional enhancer.Thus, we report the identification and detailed characterization of an exonic enhancer. Ultimately, this leads to the interesting question of why evolution would be so parsimonious in the functional assignment of sequence

Патофизиологические механизмы, лежащие в основе антипсихотик-индуцированной тардивной дискинезии

Purpose. To analyze the results of classical and modern studies reflecting the pathophysiological mechanisms of antipsychotic-induced tardive dyskinesia.Materials and methods. We searched for full-text publications in Russian and English in the databases of E-Library, PubMed, Web of Science and Springer published over the past decade, using keywords (tardive dyskinesia (TD), drug-induced tardive dyskinesia, antipsychotics (AP), neuroleptics, typical antipsychotics, atypical antipsychotics, pathophysiology, etiology and combinations of these words). In addition, the review included earlier publications of historical interest.Results. The lecture proposed theories of development of AP-induced TD, examining its effect on dopaminergic receptors, dopaminergic neurons, neurons of the basal ganglia, and other theories: activation of estrogen receptors, disorders of melatonin metabolism, disorders of the endogenous opioid system, oxidative stress with predominant oxidation processes, blockade of 5-HT2-receptors, a decrease in the pyridoxine level, genetic predisposition, interaction of AP with the brain trace element – iron, carbonyl stress and immune inflammation and the role of the neurotrophic factor.Conclusion. The disclosure of the mechanisms of AP-induced TD will allow the development of a strategy for personalized prevention and therapy of the considered neurological complication of the AP-therapy for schizophrenia in real clinical practice. Цель – анализ результатов классических и современных исследований, отражающих патофизиологические механизмы антипсихотик-индуцированной тардивной дискинезии.Материалы и методы. Проведен поиск полнотекстовых публикаций на русском и английском языках за последнее десятилетие в базах данных еLibrary, PubMed, Web of Science, Springer, используя ключевые слова «тардивная дискинезия» (ТД), «лекарственно-индуцированная тардивная дискинезия», «антипсихотики» (АП), «нейролептики», «типичные антипсихотики», «атипичные антипсихотики», «патофизиология», «этиология» и комбинированные поиски слов. Кроме того, в лекцию включены более ранние публикации, имеющие исторический интерес.Результаты. В лекции предложены теории развития АП-индуцированной ТД, рассматривающие влияние на дофаминергические рецепторы, дофаминергические нейроны, на нейроны базальных ганглий, и прочие теории: активация эстрогеновых рецепторов, нарушение обмена мелатонина, нарушение эндогенной опиоидной системы, оксидативный стресс с преобладанием процессов окисления, блокада 5-НТ2 -рецепторов, снижение уровня пиридоксина, генетическая предрасположенность, взаимодействие АП с церебральным микроэлементом – железом, карбониловый стресс и имунновоспаление, роль нейротрофического фактора.Заключение. Раскрытие механизмов АП-индуцированной ТД даст ключ к разработке стратегии персонализированной профилактики и терапии рассматриваемого неврологического осложнения АП-терапии шизофрении в реальной клинической практике