Preliminary studies on the effect of herbs on the growth and health of suckling piglets

The effect of some herbs with strengthening immune system and antiphlogistic action from Bulgaria has been studied in two pilot trials, first with 8 litters (4 control and 4 with herbs in the water) and second with 15 litters (5 control, 5 with herbs in the water and 5 with herbs in the fodder). The growth and health status (score of diarrhoea) during the suckling period has been recorded. Treatment of diarrhoea with herbs has been applied to litters with manifestation of diarrhoea in second trial. The results showed that supplement of herbs in the water or in the fodder of suckling piglets improved growth and health status of piglets and further studies are needed for establishing the best combination of herbs

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice

Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse. Currently, other than supportive care and antibiotics, there are no treatments for this condition. We developed an in vitro assay to understand the role of the ER-stress-mediated apoptosis process in lymphocyte death during polymicrobial sepsis, which was reproducible in in vivo mouse models. Modulating ER stress using chemical chaperones significantly reduced the induction of the pro-apoptotic protein Bim both in vitro and in mice. Furthermore, in a ‘two-hit’ pneumonia model in mice, we have been able to demonstrate that administration of the chemical chaperone TUDCA helped to maintain lymphocyte homeostasis by significantly reducing lymphocyte apoptosis and this correlated with four-fold improvement in survival. Our results demonstrate a novel therapeutic opportunity for treating sepsis-induced lymphopenia in humans

The Stakes in Bayh-Dole: Public Values Beyond the Pace of Innovation

Evaluation studies of the Bayh-Dole Act are generally concerned with the pace of innovation or the transgressions to the independence of research. While these concerns are important, I propose here to expand the range of public values considered in assessing Bayh-Dole and formulating future reforms. To this end, I first examine the changes in the terms of the Bayh-Dole debate and the drift in its design. Neoliberal ideas have had a definitive influence on U.S. innovation policy for the last thirty years, including legislation to strengthen patent protection. Moreover, the neoliberal policy agenda is articulated and justified in the interest of “competitiveness.” Rhetorically, this agenda equates competitiveness with economic growth and this with the public interest. Against that backdrop, I use Public Value Failure criteria to show that values such as political equality, transparency, and fairness in the distribution of the benefits of innovation, are worth considering to counter the “policy drift” of Bayh-Dole

Beliefs and preferences regarding biological treatments for severe asthma

Background: Severe asthma is a serious condition with a significant burden on patients' morbidity, mortality, and quality of life. Some biological therapies targeting the IgE and interleukin-5 (IL5) mediated pathways are now available. Due to the lack of direct comparison studies, the choice of which medication to use varies. We aimed to explore the beliefs and practices in the use of biological therapies in severe asthma, hypothesizing that differences will occur depending on the prescribers’ specialty and experience. Methods: We conducted an online survey composed of 35 questions in English. The survey was circulated via the INterasma Scientific Network (INESNET) platform as well as through social media. Responses from allergists and pulmonologists, both those with experience of prescribing omalizumab with (OMA/IL5) and without (OMA) experience with anti-IL5 drugs, were compared. Results: Two hundred eighty-five (285) valid questionnaires from 37 countries were analyzed. Seventy-on percent (71%) of respondents prescribed biologics instead of oral glucocorticoids and believed that their side effects are inferior to those of Prednisone 5 mg daily. Agreement with ATS/ERS guidelines for identifying severe asthma patients was less than 50%. Specifically, significant differences were found comparing responses between allergists and pulmonologists (Chi-square test, p < 0.05) and between OMA/IL5 and OMA groups (p < 0.05). Conclusions: Uncertainties and inconsistencies regarding the use of biological medications have been shown. The accuracy of prescribers to correctly identify asthma severity, according to guidelines criteria, is quite poor. Although a substantial majority of prescribers believe that biological drugs are safer than low dose long-term treatment with oral steroids, and that they must be used instead of oral steroids, every effort should be made to further increase awareness. Efficacy as disease modifiers, biomarkers for selecting responsive patients, timing for outcomes evaluation, and checks need to be addressed by further research. Practices and beliefs regarding the use of asthma biologics differ between the prescriber's specialty and experience; however, the latter seems more significant in determining beliefs and behavior. Tailored educational measures are needed to ensure research results are better integrated in daily practice

What Stimulates Researchers to Make Their Research Usable? Towards an Openness Approach

Ambiguity surrounding the effect of external engagement on academic research has raised questions about what motivates researchers to collaborate with third parties. We argue that what matters for society is research that can be absorbed by users. We define openness as a willingness by researchers to make research more usable by external partners by responding to external influences in their own research practices. We ask what kinds of characteristics define those researchers who are more open to creating usable knowledge. Our empirical study analyses a sample of 1583 researchers working at the Spanish Council for Scientific Research (CSIC). Results demonstrate that it is personal factors (academic identity and past experience) that determine which researchers have open behaviours. The paper concludes that policies to encourage external engagement should focus on experiences which legitimate and validate knowledge produced through user encounters, both at the academic formation career stage as well as through providing ongoing opportunities to engage with third parties.The data used for this study comes from the IMPACTO project funded by the Spanish Council for Scientific Research - CSIC (Ref. 200410E639). The work also benefited from a mobility grant awarded by Eu-Spri Forum to Julia Olmos Penuela & Paul Benneworth for her visiting research to the Center of Higher Education Policy Studies. Finally, Julia Olmos Penuela also benefited from a post-doctoral grant funded by the Generalitat Valenciana (APOSTD-2014-A-006).Olmos-Peñuela, J.; Benneworth, P.; Castro-Martínez, E. (2015). What Stimulates Researchers to Make Their Research Usable? Towards an Openness Approach. Minerva. 53(4):381-410. https://doi.org/10.1007/s11024-015-9283-4S381410534Abreu, Maria, Vadim Grinevich, Alan Hughes, and Michael Kitson. 2009. Knowledge exchange between academics and the business, public and third sectors. Cambridge: Centre for Business Research and UK-IRC.Aghion, Philippe, Mathias Dewatripont, and Jeremy C. Stein. 2008. Academic freedom, private-sector focus, and the process of innovation. RAND Journal of Economics 39: 617–635.Ajzen, Icek. 2001. Nature and operation of attitudes. Annual Review of Psychology 52(1): 27–58.Alrøe, Hugo Fjelsted, and Erik Steen Kristensen. 2002. Towards a systemic research methodology in agriculture: Rethinking the role of values in science. Agriculture and Human Values 19(1): 3–23.Audretsch, David B., Werner Bönte, and Stefan Krabel. 2010. Why do scientists in public research institutions cooperate with private firms. In DRUID Working Paper, 10–27.Baldini, Nicola, Rosa Grimaldi, and Maurizio Sobrero. 2007. To patent or not to patent? A survey of Italian inventors on motivations, incentives, and obstacles to university patenting. Scientometrics 70(2): 333–354.Bandura, Albert. 1977. Social learning theory. Englewood Cliffs, NJ: Prentice-Hall.Barnett, R. 2009. Knowing and becoming in the higher education curriculum. Studies in Higher Education 34(4): 429–440.Becher, Tony. 1994. The significance of disciplinary differences. Studies in Higher Education 19(2): 151–161.Becher, Tony, and Paul Trowler. 2001. Academic tribes and territories: Intellectual enquiry and the culture of disciplines. McGraw-Hill International.Bekkers, Rudi, and Isabel Maria Bodas Freitas. 2008. Analysing knowledge transfer channels between universities and industry: To what degree do sectors also matter? Research Policy 37(10): 1837–1853.Belderbos, René, Martin Carree, Bert Diederen, Boris Lokshin, and Reinhilde Veugelers. 2004. Heterogeneity in R&D cooperation strategies. International Journal of Industrial Organization 22(8): 1237–1263.Benner, Mats, and Ulf Sandström. 2000. Institutionalizing the triple helix: Research funding and norms in the academic system. Research Policy 29(2): 291–301.Bercovitz, Janet, and Maryann Feldman. 2008. Academic entrepreneurs: Organizational change at the individual level. Organization Science 19(1): 69–89.Berman, Elizabeth Popp. 2011. Creating the market university: How academic science became an economic engine. Princeton University Press.Bleiklie, Ivar, and Roar Høstaker. 2004. Modernizing research training-education and science policy between profession, discipline and academic institution. Higher Education Policy 17(2): 221–236.Bozeman, Barry, Daniel Fay, and Catherine P. Slade. 2013. Research collaboration in universities and academic entrepreneurship: The-state-of-the-art. The Journal of Technology Transfer 38(1): 1–67.Collini, Stefan. 2009. Impact on humanities: Researchers must take a stand now or be judged and rewarded as salesmen. The Times Literary Supplement 5563: 18–19.D’Este, Pablo, and Markus Perkmann. 2011. Why do academics engage with industry? The entrepreneurial university and individual motivations. The Journal of Technology Transfer 36(3): 316–339.D’Este, Pablo, Oscar Llopis, and Alfredo Yegros. 2013. Conducting pro-social research: Cognitive diversity, research excellence and awareness about the social impact of research: INGENIO (CSIC-UPV) Working Paper Series.Deem, Rosemary, and Lisa Lucas. 2007. Research and teaching cultures in two contrasting UK policy contexts: Academic life in education departments in five English and Scottish universities. Higher Education 54(1): 115–133.DiMaggio, Paul J., and Walter W. Powell. 1983. The iron cage revisited: Institutional isomorphism and collective rationality in organizational fields. American Sociological Review 48(2): 147–160.Downing, David B. 2005. The knowledge contract: Politics and paradigms in the academic workplace. Lincoln: Nebraska University of Nebraska Press.Donovan, Claire. 2007. The qualitative future of research evaluation. Science and Public Policy 34(8): 585–597.Durning, Bridget. 2004. Planning academics and planning practitioners: Two tribes or a community of practice? Planning Practice and Research 19(4): 435–446.Edquist, Charles. 1997. System of innovation approaches: Their emergence and characteristics. In Systems of innovation: Technologies, institutions and organizations, ed. C. Edquist, 1–35. London: Pinter.Etzkowitz, Henry, and Loet Leydesdorff. 2000. The dynamics of innovation: from National Systems and “Mode 2” to a Triple Helix of university–industry–government relations. Research Policy 29(2): 109–123.Fromhold-Eisebith, Martina, Claudia Werker, and Marcel Vojnic. 2014. Tracing the social dimension in innovation networks. In The social dynamics of innovation networks, eds. Roel Rutten, Paul Benneworth, Frans Boekema, and Dessy Irawati. London: Routledge (in press).Geuna, Aldo, and Alessandro Muscio. 2009. The governance of university knowledge transfer: A critical review of the literature. Minerva 47(1): 93–114.Gibbons, Michael, Camille Limoges, Helga Nowotny, Simon Schwartzman, Peter Scott, and Martin Trow. 1994. The new production of knowledge: The dynamics of science and research in contemporary societies. London: Sage.Gläser, Jochen. 2012. How does Governance change research content? On the possibility of a sociological middle-range theory linking science policy studies to the sociology of scientific knowledge. Technical University Berlin. Technology Studies Working Papers. http://www.ts.tu-berlin.de/fileadmin/fg226/TUTS/TUTS-WP-1-2012.pdf . Accessed 16 Feb 2015.Goethner, Maximilian, Martin Obschonka, Rainer K. Silbereisen, and Uwe Cantner. 2012. Scientists’ transition to academic entrepreneurship: Economic and psychological determinants. Journal of Economic Psychology 33(3): 628–641.Gulbrandsen, Magnus, and Jens-Christian Smeby. 2005. Industry funding and university professors’ research performance. Research Policy 34(6): 932–950.Haeussler, Carolin, and Jeannette Colyvas. 2011. Breaking the ivory tower: Academic entrepreneurship in the life sciences in UK and Germany. Research Policy 40(1): 41–54.Hessels, Laurens K., Harro van Lente, John Grin, and Ruud E.H.M. Smits. 2011. Changing struggles for relevance in eight fields of natural science. Industry and Higher Education 25(5): 347–357.Hessels, Laurens K., and Harro Van Lente. 2008. Re-thinking new knowledge production: A literature review and a research agenda. Research Policy 37(4): 740–760.Hoye, Kate, and Fred Pries. 2009. ‘Repeat commercializers’, the ‘habitual entrepreneurs’ of university–industry technology transfer. Technovation 29(10): 682–689.Jacobson, Nora, Dale Butterill, and Paula Goering. 2004. Organizational factors that influence university-based researchers’ engagement in knowledge transfer activities. Science Communication 25(3): 246–259.Jain, Sanjay, Gerard George, and Mark Maltarich. 2009. Academics or entrepreneurs? Investigating role identity modification of university scientists involved in commercialization activity. Research Policy 38(6): 922–935.Jasanoff, Sheila, and Sang-Hyun Kim. 2013. Sociotechnical imaginaries and national energy policies. Science as Culture 22(2): 189–196.Jensen, Pablo. 2011. A statistical picture of popularization activities and their evolutions in France. Public Understanding of Science 20(1): 26–36.Kitcher, Philip. 2001. Science, truth, and democracy. Oxford: Oxford University Press.Knorr-Cetina, Karin. 1981. The manufacture of knowledge: An essay on the constructivist and contextual nature of science. Oxford: Pergamon Press.Kronenberg, Kristin, and Marjolein Caniëls. 2014. Professional proximity in research collaborations. In The social dynamics of innovation networks, eds. Roel Rutten, Paul Benneworth, Frans Boekema, and Dessy Irawati. London: Routledge (in press).Krueger, Rob, and David Gibbs. 2010. Competitive global city regions and sustainable development’: An interpretive institutionalist account in the South East of England. Environment and planning A 42: 821–837.Lam, Alice. 2011. What motivates academic scientists to engage in research commercialization: ‘Gold’, ‘ribbon’ or ‘puzzle’? Research Policy 40(10): 1354–1368.Landry, Réjean, Malek Saïhi, Nabil Amara, and Mathieu Ouimet. 2010. Evidence on how academics manage their portfolio of knowledge transfer activities. Research Policy 39(10): 1387–1403.Lee, Alison, and David Boud. 2003. Writing groups, change and academic identity: Research development as local practice. Studies in Higher Education 28(2): 187–200.Lee, Yong S. 1996. ‘Technology transfer’ and the research university: A search for the boundaries of university–industry collaboration. Research Policy 25(6): 843–863.Lee, Yong S. 2000. The sustainability of university–industry research collaboration: An empirical assessment. The Journal of Technology Transfer 25(2): 111–133.Leisyte, Liudvika, Jürgen Enders, and Harry De Boer. 2008. The freedom to set research agendas—illusion and reality of the research units in the Dutch Universities. Higher Education Policy 21(3): 377–391.Louis, Karen Seashore, David Blumenthal, Michael E. Gluck, and Michael A. Stoto. 1989. Entrepreneurs in academe: An exploration of behaviors among life scientists. Administrative Science Quarterly 34(1): 110–131.Lowe, Philip, Jeremy Phillipson, and Katy Wilkinson. 2013. Why social scientists should engage with natural scientists. Contemporary Social Science 8(3): 207–222.Martín-Sempere, María José, Belén Garzón-García, and Jesús Rey-Rocha. 2008. Scientists’ motivation to communicate science and technology to the public: Surveying participants at the Madrid Science Fair. Public Understanding of Science 17(3): 349–367.Martin, Ben. 2003. The changing social contract for science and the evolution of the university. In Science and innovation: Rethinking the rationales for funding and governance, eds. A. Geuna, A.J. Salter, and W.E. Steinmueller, 7–29. Cheltenhan: Edward Elgar.Merton, Robert K. 1973. The sociology of science: Theoretical and empirical investigations. Chicago: University of Chicago Press.Miller, Thaddeus R., and Mark W. Neff. 2013. De-facto science policy in the making: how scientists shape science policy and why it matters (or, why STS and STP scholars should socialize). Minerva 51(3): 295–315.Muthén, Bengt O. 1998–2004. Mplus Technical Appendices. Muthén & Muthén. Los Angeles, CA.: Muthén & Muthén.Nedeva, Maria. 2013. Between the global and the national: Organising European science. Research Policy 42(1): 220–230.Neff, Mark William. 2014. Research prioritization and the potential pitfall of path dependencies in coral reef science. Minerva 52(2): 213–235.Nelson, Richard R. 2001. Observations on the post-Bayh-Dole rise of patenting at American universities. The Journal of Technology Transfer 26(1): 13–19.Nowotny, Helga, Peter Scott, and Michael Gibbons. 2001. Re-thinking science: Knowledge and the public in an age of uncertainty. Cambridge: Polity Press.Olmos-Peñuela, Julia, Paul Benneworth, and Elena Castro-Martínez. 2014a. Are ‘STEM from Mars and SSH from Venus’? Challenging disciplinary stereotypes of research’s social value. Science and Public Policy 41: 384–400.Olmos-Peñuela, Julia, Elena Castro-Martínez, and Manuel Fernández-Esquinas. 2014b. Diferencias entre áreas científicas en las prácticas de divulgación de la investigación: un estudio empírico en el CSIC. Revista Española de Documentación Científica. doi: 10.3989/redc.2014.2.1096 .Ouimet, Mathieu, Nabil Amara, Réjean Landry, and John Lavis. 2007. Direct interactions medical school faculty members have with professionals and managers working in public and private sector organizations: A cross-sectional study. Scientometrics 72(2): 307–323.Perkmann, Markus, Valentina Tartari, Maureen McKelvey, Erkko Autio, Anders Brostrom, Pablo D’Este, Riccardo Fini, et al. 2013. Academic engagement and commercialisation: A review of the literature on university-industry relations. Research Policy 42(2): 423–442.Philpott, Kevin, Lawrence Dooley, Caroline O’Reilly, and Gary Lupton. 2011. The entrepreneurial university: Examining the underlying academic tensions. Technovation 31(4): 161–170.Rutten, Roel, and Frans Boekema. 2012. From learning region to learning in a socio-spatial context. Regional Studies 46(8): 981–992.Sarewitz, Daniel, and Roger A. Pielke. 2007. The neglected heart of science policy: reconciling supply of and demand for science. Environmental Science & Policy 10(1): 5–16.Sauermann, Henry, and Paula Stephan. 2013. Conflicting logics? A multidimensional view of industrial and academic science. Organization Science 24(3): 889–909.Schein, Edgar H. 1985. Organizational culture and leadership: A dynamic view. San Francisco, CA: Jossey-Bass.Shane, Scott. 2000. Prior knowledge and the discovery of entrepreneurial opportunities. Organization Science 11(4): 448–469.Spaapen, Jack, and Leonie van Drooge. 2011. Introducing ‘productive interactions’ in social impact assessment. Research Evaluation 20(3): 211–218.Stokes, Donald E. 1997. Pasteur’s quadrant: Basic science and technological innovation. Washington, DC: Brookings Institution Press.Tartari, Valentina, and Stefano Breschi. 2012. Set them free: scientists’ evaluations of the benefits and costs of university–industry research collaboration. Industrial and Corporate Change 21(5): 1117–1147.Tinker, Tony, and Rob Gray. 2003. Beyond a critique of pure reason: From policy to politics to praxis in environmental and social research. Accounting, Auditing & Accountability Journal 16(5): 727–761.van Rijnsoever, Frank J., Laurens K. Hessels, and Rens L.J. Vandeberg. 2008. A resource-based view on the interactions of university researchers. Research Policy 37(8): 1255–1266.Venkataraman, Sankaran. 1997. The distinctive domain of entrepreneurship research: An editor’s perspective. Advances in Entrepreneurship, Firm Emergence, and Growth 3: 119–138.Verspagen, Bart. 2006. University research, intellectual property rights and European innovation systems. Journal of Economic Surveys 20(4): 607–632.Villanueva-Felez, Africa, Jordi Molas-Gallart, and Alejandro Escribá-Esteve. 2013. Measuring personal networks and their relationship with scientific production. Minerva 51(4): 465–483.Watermeyer, Richard. 2015. Lost in the ‘third space’: the impact of public engagement in higher education on academic identity, research practice and career progression. European Journal of Higher Education (online first, doi: 10.1080/21568235.2015.1044546 ).Weingart, Peter. 2009. Editorial for Issue 47/3. Minerva 47(3): 237–239.Ziman, John. 1996. ‘Postacademic science’: Constructing knowledge with networks and norms. Science Studies 1: 67–80.Zomer, Arend H., Ben W.A. Jongbloed, and Jürgen Enders. 2010. Do spin-offs make the academics’ heads spin? The impacts of spin-off companies on their parent research organisation. Minerva 48(3): 331–353

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be bioavailable in various organs, and in-turn exert phenotypic changes is highly debatable. Here, we isolate EVs from both raw and commercial bovine milk and characterize them by electron microscopy, nanoparticle tracking analysis, western blotting, quantitative proteomics and small RNA sequencing analysis. Orally administered bovine milk-derived EVs survive the harsh degrading conditions of the gut, in mice, and is subsequently detected in multiple organs. Milk-derived EVs orally administered to mice implanted with colorectal and breast cancer cells reduce the primary tumor burden. Intriguingly, despite the reduction in primary tumor growth, milk-derived EVs accelerate metastasis in breast and pancreatic cancer mouse models. Proteomic and biochemical analysis reveal the induction of senescence and epithelial-to-mesenchymal transition in cancer cells upon treatment with milk-derived EVs. Timing of EV administration is critical as oral administration after resection of the primary tumor reverses the pro-metastatic effects of milk-derived EVs in breast cancer models. Taken together, our study provides context-based and opposing roles of milk-derived EVs as metastasis inducers and suppressors

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Leveraging knowledge as a competitive asset? The intensity, performance and structure of universities’ entrepreneurial knowledge exchange activities at a regional level

© 2016, The Author(s). Universities are no longer considered to be isolated islands of knowledge, but as institutions increasingly engaged with a range of external partners through entrepreneurial activities. This paper examines the associations between the intensity and performance of knowledge exchange activities undertaken in UK universities with non-academic actors. Drawing on data concerning the structural factors of interactions of universities in the UK with external partners, the paper sheds further light on the nature of these activities through a prism of competitive and uncompetitive regions in order to better understand how universities may be able to leverage both their knowledge and partnerships more effectively as competitive assets. On the one hand, it is found that academics in uncompetitive regions are more intensively engaged in entrepreneurial activities but generate less income from them than their counterparts in competitive regions, suggesting that there are differences in the income-generating capacity of academics across regions. On the other hand, academic knowledge is found to be more strongly bounded within a certain distance in uncompetitive regions whilst geographical distance seems less of a hindrance to academics in competitive regions

Investor v Host State in Oil and Gas Investment Agreements: A Case for Good Faith, Jurisdiction and Arbitrability for a Stable Investment Environment

Certainty and predictability are legal virtues which are considered essential, yet again unattainable in an absolute manner. However, oil and gas contracts are characterised with an investor-State relationship and endure a number of risks, which necessitate the guarantee of legal certainty. Their long duration, immense initial capital invested, irreversibility of national natural resources, and political, economic and commercial influences make petroleum agreements susceptible to instability. Hence, while certainty and predictability are required, a stable investment environment demands that these traditionally common law notions are comprehended in a more unconventional manner. In order to ensure the smooth running of the development project and the continuity of the business relationship, contractual stability needs to be balanced against the need for flexibility, which is a reflection of the vulnerability of oil and gas contracts to changes of events. The achievement of a stable investment environment includes an evaluation of the rights and interests of an international oil company and the objectives and public prerogatives of a sovereign state. Amongst the leading sources of uncertainty nowadays is the risk of indirect expropriation, which can be addressed with the help of contractual clauses and international legal principles found in treaty and contract. The task of ensuring a stable investment environment is further complicated by issues emanating from the role of arbitration and the neutrality of arbitrators. The thesis aims to ensure certainty and predictability in oil and gas contracts by examining the adversary and opposing investor-State relationship. It argues that a stable investment environment is achieved when the rights of both parties are recognised and balanced. In the construction of a stable investment environment come the principles of good faith, jurisdiction and arbitrability, and contractual stability measures