16 research outputs found
Data Sharing and Reanalyses Among Randomized Clinical Trials Published in Surgical Journals Before and After Adoption of a Data Availability and Reproducibility Policy
International audienceIMPORTANCE: Clinical trial data sharing holds promise for maximizing the value of clinical research. The International Committee of Medical Journal Editors (ICMJE) adopted a policy promoting data sharing in July 2018. OBJECTIVE: To evaluate the association of the ICMJE data sharing policy with data availability and reproducibility of main conclusions among leading surgical journals. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study, conducted in October 2021, examined randomized clinical trials (RCTs) in 10 leading surgical journals before and after the implementation of the ICMJE data sharing policy in July 2018. EXPOSURE: Implementation of the ICMJE data sharing policy. MAIN OUTCOMES AND MEASURES: To demonstrate a pre-post increase in data availability from 5% to 25% (αâ=â.05; ÎČâ=â0.1), 65 RCTs published before and 65 RCTs published after the policy was issued were included, and their data were requested. The primary outcome was data availability (ie, the receipt of sufficient data to enable reanalysis of the primary outcome). When data sharing was available, the primary outcomes reported in the journal articles were reanalyzed to explore reproducibility. The reproducibility features of these studies were detailed. RESULTS: Data were available for 2 of 65 RCTs (3.1%) published before the ICMJE policy and for 2 of 65 RCTs (3.1%) published after the policy was issued (odds ratio, 1.00; 95% CI, 0.07-14.19; Pâ>â.99). A data sharing statement was observed in 11 of 65 RCTs (16.9%) published after the policy vs none before the policy (risk ratio, 2.20; 95% CI, 1.81-2.68; P = .001). Data obtained for reanalysis (nâ=â4) were not from RCTs published with a data sharing statement. Of the 4 RCTs with available data, all of them had primary outcomes that were fully reproduced. However, discrepancies or inaccuracies that were not associated with study conclusions were identified in 3 RCTs. These concerned the number of patients included in 1 RCT, the management of missing values in another RCT, and discrepant timing for the principal outcome declared in the study registration and reported in the third RCT. CONCLUSIONS AND RELEVANCE: This cross-sectional study suggests that data sharing practices are rare in surgical journals despite the ICMJE policy and that most RCTs published in these journals lack transparency. The results of these studies may not be reproducible by external researchers
Oral Exposure to Paraquat Triggers Earlier Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice
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LIMA: Library for IMage Acquisition a Worldwide Project for 2D Detector Control
International audienceThe LIMA project started in 2009. The goal was to provide a software library for the unified control of 2D detectors. LIMA is a collaborative project involving synchrotrons, research facilities and industrial companies. LIMA supports most detectors used for X-ray detection or other scientific applications. Live display is supported via a video interface and most of the native video camera image formats are supported. LIMA provides a plug-in architecture for on-line processing which allows image pre-treatment before saving e.g. noise reduction algorithm or automatic X-ray beam attenuation during continuous scans. The library supports many file format including EDF, CBF, FITS, HDF5 and TIFF. To cope with increasing detector acquisition speed, the latest LIMA release includes multi-threaded, parallelized image saving with data compression (gzip or lz4). For even higher throughput a new design, based on a distributed multi-computer architecture, of the LIMA framework is envisaged. The paper will describe the LIMA roadmap for the coming years
ROBLâII at ESRF: a synchrotron toolbox for actinide research
ROBLâII provides four different experimental stations to investigate actinide and other alphaâ and betaâemitting radionuclides at the new EBS storage ring of ESRF within an energy range of 3 to 35â
keV. The XAFS station consists of a highly automatized, high sample throughput installation in a glovebox, to measure EXAFS and conventional XANES of samples routinely at temperatures down to 10â
K, and with a detection limit in the subâp.p.m. range. The XES station with its five bentâcrystal analyzer, Johannâtype setup with Rowland circles of 1.0 and 0.5â
m radii provides highâenergy resolution fluorescence detection (HERFD) for XANES, XES, and RIXS measurements, covering both actinide L and M edges together with other elements accessible in the 3 to 20â
keV energy range. The sixâcircle heavy duty goniometer of XRDâ1 is equipped for both highâresolution powder diffraction as well as surfaceâsensitive CTR and RAXR techniques. Single crystal diffraction, powder diffraction with high temporal resolution, as well as Xâray tomography experiments can be performed at a Pilatus 2M detector stage (XRDâ2). Elaborate radioprotection features enable a safe and easy exchange of samples between the four different stations to allow the combination of several methods for an unprecedented level of information on radioactive samples for both fundamental and applied actinide and environmental research.ROBLâII at ESRF provides four experimental stations to investigate actinides with Xâray absorption and emission spectroscopy, and with surface, highâresolution powder, and singleâcrystal Xâray diffractometry