34 research outputs found
OARE and SAMS on STS-94/MSL-1
Four microgravity acceleration measurement instruments were included on MSL-1 to measure the accelerations and vibrations to which science experiments were exposed during their operation on the mission. The data were processed and presented to the principal investigators in a variety of formats to aid their assessment of the microgravity environment during their experiment operations. Two accelerometer systems managed by the NASA Lewis Research Center (LeRC) supported the MSL-1 mission: the Orbital Acceleration Research Experiment (OARE), and the Space Acceleration Measurement System (SAMS). In addition, the Microgravity Measurement Assembly (MMA) and the Quasi- Steady Acceleration Measurement (QSAM) system, both sponsored by the Microgravity Research Division, collected acceleration data as a part of the MSL-1 mission. The NIMA was funded and designed by the European Space Agency in the Netherlands (ESA/ESTEC), and the QSAM system was funded and designed by the German Space Agency (DLR). The Principal Investigator Microgravity Services (PIMS) project at the NASA Lewis Research Center (LeRC) supports Principal Investigators (PIs) of the Microgravity science community as they evaluate the effects of acceleration on their experiments. PIMS primary responsibility is to support NASA-sponsored investigators in the area of acceleration data analysis and interpretation. A mission summary report was prepared and published by PIMS in order to furnish interested experiment investigators with a guide for evaluating the acceleration environment during the MSL-1 mission
PREVALENCE OF 'BORDERLINE' VALUES OF CARDIOVASCULAR RISK FACTORS IN THE CLINICAL PRACTICE OF GENERAL MEDICINE IN ITALY: RESULTS OF THE BORDERLINE STUDY.
INTRODUCTION:
The prevalence of patients with 'borderline' levels of cardiovascular risk factors has been rarely investigated, being often reported in studies evaluating abnormal values of these parameters. The BORDERLINE study represents a pilot experience to primarily identify the prevalence of 'high-normal' conditions, such as pre-hypertension, lipid and glucose levels in the upper range of normality in the setting of general practice in Italy.
AIM:
The aim of this study was to evaluate the prevalence of patients with 'borderline' values of cardiovascular risk factors in Italy.
METHODS:
Involved physicians were asked to evaluate the first 20 outpatients, consecutively seen in June 2009. Data were collected in a study-designed case-report form, in which physicians identified thresholds rather than reported absolute values of several clinical parameters. High-normal values were defined as follows: blood pressure (BP) 130-140/85-90âmmHg; total cholesterol 180-200âmg/dL; low-density lipoprotein cholesterol (LDL-C) 130-150âmg/dL; high-density lipoprotein cholesterol (HDL-C) 30-40âmg/dL in males and 40-50âmg/dL in females; triglycerides 130-150âmg/dL and fasting glucose 100-110âmg/dL.
RESULTS:
Fifty-three Italian physicians provided valuable clinical data on 826 individual outpatients, among which 692 (83.7%, 377 women, mean age 60.9â±â13.2 years, body mass index 26.6â±â5.0âkg/m2) were included in the present analysis. Prevalence of borderline values of systolic BP and total cholesterol levels were at least comparable with those in the normal limits of the corresponding parameters, whereas prevalence of borderline diastolic BP, LDL-C, HDL-C, triglycerides and fasting glucose levels was significantly lower than that of normal values, but higher than that of abnormal values of the corresponding parameters.
CONCLUSIONS:
Using this sample of healthy subjects in the setting of general practice in Italy, our results demonstrated a relatively high prevalence of borderline values of cardiovascular risk factors, which was at least comparable with that of normal, but significantly higher than that of abnormal thresholds. These preliminary findings may prompt more extensive investigations in the area of 'borderline' cardiovascular risk. This information may, in fact, potentially enable the design of more effective prevention strategies in the future to limit the burden of cardiovascular disease in the general population in Italy
PRISM (Polarized Radiation Imaging and Spectroscopy Mission): A White Paper on the Ultimate Polarimetric Spectro-Imaging of the Microwave and Far-Infrared Sky
PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to
ESA in response to the Call for White Papers for the definition of the L2 and
L3 Missions in the ESA Science Programme. PRISM would have two instruments: (1)
an imager with a 3.5m mirror (cooled to 4K for high performance in the
far-infrared---that is, in the Wien part of the CMB blackbody spectrum), and
(2) an Fourier Transform Spectrometer (FTS) somewhat like the COBE FIRAS
instrument but over three orders of magnitude more sensitive. Highlights of the
new science (beyond the obvious target of B-modes from gravity waves generated
during inflation) made possible by these two instruments working in tandem
include: (1) the ultimate galaxy cluster survey gathering 10e6 clusters
extending to large redshift and measuring their peculiar velocities and
temperatures (through the kSZ effect and relativistic corrections to the
classic y-distortion spectrum, respectively) (2) a detailed investigation into
the nature of the cosmic infrared background (CIB) consisting of at present
unresolved dusty high-z galaxies, where most of the star formation in the
universe took place, (3) searching for distortions from the perfect CMB
blackbody spectrum, which will probe a large number of otherwise inaccessible
effects (e.g., energy release through decaying dark matter, the primordial
power spectrum on very small scales where measurements today are impossible due
to erasure from Silk damping and contamination from non-linear cascading of
power from larger length scales). These are but a few of the highlights of the
new science that will be made possible with PRISM.Comment: 20 pages Late
Detection chain and electronic readout of the QUBIC instrument
The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10â»ÂčⶠW/âHz
Detection chain and electronic readout of the QUBIC instrument
The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10â»ÂčⶠW/âHz
CMB-S4: Forecasting Constraints on Primordial Gravitational Waves
CMB-S4---the next-generation ground-based cosmic microwave background (CMB)
experiment---is set to significantly advance the sensitivity of CMB
measurements and enhance our understanding of the origin and evolution of the
Universe, from the highest energies at the dawn of time through the growth of
structure to the present day. Among the science cases pursued with CMB-S4, the
quest for detecting primordial gravitational waves is a central driver of the
experimental design. This work details the development of a forecasting
framework that includes a power-spectrum-based semi-analytic projection tool,
targeted explicitly towards optimizing constraints on the tensor-to-scalar
ratio, , in the presence of Galactic foregrounds and gravitational lensing
of the CMB. This framework is unique in its direct use of information from the
achieved performance of current Stage 2--3 CMB experiments to robustly forecast
the science reach of upcoming CMB-polarization endeavors. The methodology
allows for rapid iteration over experimental configurations and offers a
flexible way to optimize the design of future experiments given a desired
scientific goal. To form a closed-loop process, we couple this semi-analytic
tool with map-based validation studies, which allow for the injection of
additional complexity and verification of our forecasts with several
independent analysis methods. We document multiple rounds of forecasts for
CMB-S4 using this process and the resulting establishment of the current
reference design of the primordial gravitational-wave component of the Stage-4
experiment, optimized to achieve our science goals of detecting primordial
gravitational waves for at greater than , or, in the
absence of a detection, of reaching an upper limit of at CL.Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note:
text overlap with arXiv:1907.0447
CMB-S4: Forecasting Constraints on Primordial Gravitational Waves
Abstract: CMB-S4âthe next-generation ground-based cosmic microwave background (CMB) experimentâis set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2â3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5Ï, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL